WEE1 Inhibition Enhances Anti-Apoptotic Dependency as a Result of Premature Mitotic Entry and DNA Damage

Intracellular BH3 Profiling Reveals Shifts in Antiapoptotic Dependency in Human B Cell Maturation and Mitogen-Stimulated Proliferation

(2018) Joanne Dai et al.   JOURNAL OF IMMUNOLOGY

Identification of relevant drugable targets in diffuse large B-cell lymphoma using a genome-wide unbiased CD20 guilt-by association approach

(2018) Mathilde R. W. de Jong et al.   PLoS One

Targeting WEE1 to enhance conventional therapies for acute lymphoblastic leukemia

(2018) Andrea Ghelli Luserna Di Rorà et al.   Journal of Hematology & Oncology

BCL-W has a fundamental role in B cell survival and lymphomagenesis

(2017) Clare M. Adams et al.   JOURNAL OF CLINICAL INVESTIGATION

WEE1 inhibition by MK1775 as a single-agent therapy inhibits ovarian cancer viability

(2017) Minghui Zhang et al.   Oncology Letters

Dynamics of the mitochondrial network during mitosis

(2016) Gil Kanfer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

MCL-1 Depletion Impairs DNA Double-Strand Break Repair and Reinitiation of Stalled DNA Replication Forks

(2016) Abid R. Mattoo et al.   MOLECULAR AND CELLULAR BIOLOGY

Drug-Induced Death Signaling Strategy Rapidly Predicts Cancer Response to Chemotherapy

(2015) Joan Montero et al.   CELL

Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma

(2015) M. Klanova et al.   CLINICAL CANCER RESEARCH

Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells

(2015) Pedro Zuazua-Villar et al.   NUCLEIC ACIDS RESEARCH

AZD1775 sensitizes T cell acute lymphoblastic leukemia cells to cytarabine by promoting apoptosis over DNA repair

(2015) James B. Ford et al.   Oncotarget

Constitutive activation of the DNA damage response pathway as a novel therapeutic target in diffuse large B-cell lymphoma

(2015) Enrico Derenzini et al.   Oncotarget

A regimen combining the Wee1 inhibitor AZD1775 with HDAC inhibitors targets human acute myeloid leukemia cells harboring various genetic mutations

(2014) L Zhou et al.   LEUKEMIA

BH3 profiling in whole cells by fluorimeter or FACS

(2013) Jeremy Ryan et al.   METHODS

Preclinical Evaluation of the WEE1 Inhibitor MK-1775 as Single-Agent Anticancer Therapy

(2013) A. D. Guertin et al.   MOLECULAR CANCER THERAPEUTICS

BaxΔ2 Is a Novel Bax Isoform Unique to Microsatellite Unstable Tumors

(2012) Bonnie Haferkamp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress

(2012) W. Qian et al.   JOURNAL OF CELL SCIENCE

Cyclin-Dependent Kinase Suppression by WEE1 Kinase Protects the Genome through Control of Replication Initiation and Nucleotide Consumption

(2012) H. Beck et al.   MOLECULAR AND CELLULAR BIOLOGY

Forced Mitotic Entry of S-Phase Cells as a Therapeutic Strategy Induced by Inhibition of WEE1

(2012) Marieke Aarts et al.   Cancer Discovery

Chromosomal Instability Substantiates Poor Prognosis in Patients with Diffuse Large B-cell Lymphoma

(2011) S. F. Bakhoum et al.   CLINICAL CANCER RESEARCH

BCL2 Predicts Survival in Germinal Center B-cell-like Diffuse Large B-cell Lymphoma Treated with CHOP-like Therapy and Rituximab

(2011) J. Iqbal et al.   CLINICAL CANCER RESEARCH

BCL2 mutations in diffuse large B-cell lymphoma

(2011) J M Schuetz et al.   LEUKEMIA

Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase

(2010) Halfdan Beck et al.   JOURNAL OF CELL BIOLOGY

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

(2010) Wyndham H Wilson et al.   LANCET ONCOLOGY

Cyclin-Dependent Kinase 1-Mediated Bcl-xL/Bcl-2 Phosphorylation Acts as a Functional Link Coupling Mitotic Arrest and Apoptosis

(2009) D. T. Terrano et al.   MOLECULAR AND CELLULAR BIOLOGY