Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells
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Title
Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells
Authors
Keywords
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Journal
NUCLEIC ACIDS RESEARCH
Volume -, Issue -, Pages gkv835
Publisher
Oxford University Press (OUP)
Online
2015-08-14
DOI
10.1093/nar/gkv835
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Note: Only part of the references are listed.- DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe
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- (2013) E. Blackwood et al. MOLECULAR CANCER THERAPEUTICS
- Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress
- (2012) S. Liu et al. NUCLEIC ACIDS RESEARCH
- Human Embryonic Stem Cells Fail to Activate CHK1 and Commit to Apoptosis in Response to DNA Replication Stress
- (2012) Joëlle A. Desmarais et al. STEM CELLS
- Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase
- (2011) Samuel McNeely et al. CELL CYCLE
- Unleashing Chk1 in cancer therapy
- (2011) Laura Carrassa et al. CELL CYCLE
- Assessment of Chk1 Phosphorylation as a Pharmacodynamic Biomarker of Chk1 Inhibition
- (2011) L. A. Parsels et al. CLINICAL CANCER RESEARCH
- Analysis of protein dynamics at active, stalled, and collapsed replication forks
- (2011) B. M. Sirbu et al. GENES & DEVELOPMENT
- Targeting the Replication Checkpoint Using SCH 900776, a Potent and Functionally Selective CHK1 Inhibitor Identified via High Content Screening
- (2011) T. J. Guzi et al. MOLECULAR CANCER THERAPEUTICS
- Structure-Specific DNA Endonuclease Mus81/Eme1 Generates DNA Damage Caused by Chk1 Inactivation
- (2011) Josep V. Forment et al. PLoS One
- RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma
- (2011) K. A. Cole et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The role of RPA2 phosphorylation in homologous recombination in response to replication arrest
- (2010) Wei Shi et al. CARCINOGENESIS
- Enhanced H2AX Phosphorylation, DNA Replication Fork Arrest, and Cell Death in the Absence of Chk1
- (2010) Mary E. Gagou et al. MOLECULAR BIOLOGY OF THE CELL
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- The DNA Damage Response: Making It Safe to Play with Knives
- (2010) Alberto Ciccia et al. MOLECULAR CELL
- Pathways of mammalian replication fork restart
- (2010) Eva Petermann et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination
- (2010) Dong-Hyun Lee et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
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- (2010) Mark Meuth Cell Division
- Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress
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- Protein Phosphatase 2A-Dependent Dephosphorylation of Replication Protein A Is Required for the Repair of DNA Breaks Induced by Replication Stress
- (2009) J. Feng et al. MOLECULAR AND CELLULAR BIOLOGY
- The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication
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- (2008) R Rodriguez et al. CELL DEATH AND DIFFERENTIATION
- A PP4-Phosphatase Complex Dephosphorylates γ-H2AX Generated during DNA Replication
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- ATR: an essential regulator of genome integrity
- (2008) Karlene A. Cimprich et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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