Insights into the Regulation of Tumor Angiogenesis by Micro-RNAs

Silencing microRNA‐221/222 cluster suppresses glioblastoma angiogenesis by suppressor of cytokine signaling‐3‐dependent JAK/STAT pathway

(2019) Chun‐Hua Xu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MicroRNA-221 and MicroRNA-222 in Common Human Cancers: Expression, Function, and Triggering of Tumor Progression as a Key Modulator

(2019) Sima Amini et al.   Labmedicine

Trends and Challenges in Tumor Anti-Angiogenic Therapies

(2019) József Jászai et al.   Cells

MicroRNA Key to Angiogenesis Regulation: MiRNA Biology and Therapy

(2018) Ankit Tiwari et al.   CURRENT CANCER DRUG TARGETS

MicroRNA-134 inhibits osteosarcoma angiogenesis and proliferation by targeting the VEGFA/VEGFR1 pathway

(2018) Long Zhang et al.   FEBS Journal

New insights into the regulatory role of microRNA in tumor angiogenesis and clinical implications

(2018) Ye Wang et al.   Molecular Cancer

Regulation of tumor angiogenesis by microRNAs: State of the art

(2018) Nasser H. Goradel et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Overview of advances in vasculogenic mimicry – a potential target for tumor therapy

(2018) Hong Ge et al.   Cancer Management and Research

Exosomal miR-155 Derived from Hepatocellular Carcinoma Cells Under Hypoxia Promotes Angiogenesis in Endothelial Cells

(2018) Yusuke Matsuura et al.   DIGESTIVE DISEASES AND SCIENCES

MicroRNA let-7a regulates angiogenesis by targeting TGFBR3 mRNA

(2018) Shao Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Melanoma cell-secreted exosomal miR-155-5p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1/JAK2/STAT3 signaling pathway

(2018) Xiaocheng Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Homotypic and Heterotypic Activation of the Notch Pathway in Multiple Myeloma–Enhanced Angiogenesis: A Novel Therapeutic Target?

(2018) Ilaria Saltarella et al.   NEOPLASIA

miR-218 inhibited tumor angiogenesis by targeting ROBO1 in gastric cancer

(2017) Xiangyuan Zhang et al.   GENE

Linc00511 acts as a competing endogenous RNA to regulate VEGFA expression through sponging hsa-miR-29b-3p in pancreatic ductal adenocarcinoma

(2017) Xiaohui Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A pilot study on plasma levels of micro-RNAs involved in angiogenesis and vascular maturation in patients with breast cancer

(2017) Emmanuel Kontomanolis et al.   MEDICAL ONCOLOGY

MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF

(2017) B Li et al.   ONCOGENE

The temporal basis of angiogenesis

(2017) Katie Bentley et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Vascular Mimicry: A Novel Neovascularization Mechanism Driving Anti-Angiogenic Therapy (AAT) Resistance in Glioblastoma

(2017) Kartik Angara et al.   Translational Oncology

MicroRNA-140-5p inhibits cell proliferation and invasion by regulating VEGFA/MMP2 signaling in glioma

(2017) Yuan Hu et al.   TUMOR BIOLOGY

miR-135a inhibits tumor metastasis and angiogenesis by targeting FAK pathway

(2017) Zhenguo Cheng et al.   Oncotarget

Tumor vasculogenic mimicry predicts poor prognosis in cancer patients: a meta-analysis

(2016) J. P. Yang et al.   ANGIOGENESIS

Downregulation of microRNA-206 promotes invasion and angiogenesis of triple negative breast cancer

(2016) Zhongxing Liang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR-155 expression level changes might be associated with initial phases of breast cancer pathogenesis and lymph-node metastasis

(2016) Nina Petrović et al.   Cancer Biomarkers

Cell-derived microvesicles mediate the delivery of miR-29a/c to suppress angiogenesis in gastric carcinoma

(2016) Haiyang Zhang et al.   CANCER LETTERS

microRNA-497 inhibits invasion and metastasis of colorectal cancer cells by targeting vascular endothelial growth factor-A

(2016) Yanyan Qiu et al.   CELL PROLIFERATION

The crucial role of miR-126 on suppressing progression of esophageal cancer by targeting VEGF-A

(2016) Ranran Kong et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

MicroRNAs as Regulators, Biomarkers and Therapeutic Targets in the Drug Resistance of Colorectal Cancer

(2016) Tao Xie et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cell behaviors and dynamics during angiogenesis

(2016) Charles Betz et al.   DEVELOPMENT

Dynamics of circulating hypoxia-mediated miRNAs and tumor response in patients with high-grade glioma treated with bevacizumab

(2016) Tali Siegal et al.   JOURNAL OF NEUROSURGERY

MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like 1 in hepatocellular carcinoma

(2016) Yun Yang et al.   ONCOLOGY REPORTS

miR-218 suppresses gastric cancer cell proliferation and invasion via regulation of angiopoietin-2

(2016) Sifeng Tang et al.   Experimental and Therapeutic Medicine

MiR-206 inhibits HGF-induced epithelial-mesenchymal transition and angiogenesis in non-small cell lung cancer via c-Met /PI3k/ Akt/mTOR pathway

(2016) Qing-yong Chen et al.   Oncotarget

MicroRNA-206 attenuates the growth and angiogenesis in non-small cell lung cancer cells by blocking the 14-3-3ζ/STAT3/HIF-1α/VEGF signaling

(2016) Dong Xue et al.   Oncotarget

Tumor-suppressive microRNA-218 inhibits tumor angiogenesis via targeting the mTOR component RICTOR in prostate cancer

(2016) Bing Guan et al.   Oncotarget

Acquired resistance to anti-PD1 therapy: checkmate to checkpoint blockade?

(2016) Jake S. O’Donnell et al.   Genome Medicine

miRNA let-7b modulates macrophage polarization and enhances tumor-associated macrophages to promote angiogenesis and mobility in prostate cancer

(2016) Zhigang Wang et al.   Scientific Reports

Changes in circulating microRNA-126 during treatment with chemotherapy and bevacizumab predicts treatment response in patients with metastatic colorectal cancer

(2015) T F Hansen et al.   BRITISH JOURNAL OF CANCER

The Contribution of Angiogenesis to the Process of Metastasis

(2015) Diane R. Bielenberg et al.   CANCER JOURNAL

MicroRNA-140-5p Inhibits the Progression of Colorectal Cancer by Targeting VEGFA

(2015) Wenbo Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

VEGF-Induced Expression of miR-17–92 Cluster in Endothelial Cells Is Mediated by ERK/ELK1 Activation and Regulates AngiogenesisNovelty and Significance

(2015) Aránzazu Chamorro-Jorganes et al.   CIRCULATION RESEARCH

MicroRNA-566 modulates vascular endothelial growth factor by targeting Von Hippel-Landau in human glioblastoma in vitro and in vivo

(2015) BING XIAO et al.   Molecular Medicine Reports

miR-221/222 Are Involved in Response to Sunitinib Treatment in Metastatic Renal Cell Carcinoma

(2015) Heba W Z Khella et al.   MOLECULAR THERAPY

miR-497 suppresses angiogenesis in breast carcinoma by targeting HIF-1α

(2015) ZHIHAO WU et al.   ONCOLOGY REPORTS

Broad targeting of angiogenesis for cancer prevention and therapy

(2015) Zongwei Wang et al.   SEMINARS IN CANCER BIOLOGY

MiR-221/222 promote human glioma cell invasion and angiogenesis by targeting TIMP2

(2015) Fan Yang et al.   TUMOR BIOLOGY

Plasma DCLK1 is a marker of hepatocellular carcinoma (HCC): Targeting DCLK1 prevents HCC tumor xenograft growth via a microRNA-dependent mechanism

(2015) Sripathi M. Sureban et al.   Oncotarget

Hypoxia-inducible miR-182 enhances HIF1α signaling via targeting PHD2 and FIH1 in prostate cancer

(2015) Yan Li et al.   Scientific Reports

miR-155 and miR-484 Are Associated with Time to Progression in Metastatic Renal Cell Carcinoma Treated with Sunitinib

(2015) Jana Merhautova et al.   Biomed Research International

Hypoxia-Inducible Factor-1 in Physiological and Pathophysiological Angiogenesis: Applications and Therapies

(2015) Agnieszka Zimna et al.   Biomed Research International

Systemic miRNA-7 delivery inhibits tumor angiogenesis and growth in murine xenograft glioblastoma

(2015) Negar Babae et al.   Oncotarget

XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism

(2014) Sripathi M. Sureban et al.   CANCER LETTERS

A HGF/cMET Autocrine Loop Is Operative in Multiple Myeloma Bone Marrow Endothelial Cells and May Represent a Novel Therapeutic Target

(2014) A. Ferrucci et al.   CLINICAL CANCER RESEARCH

Global microRNA depletion suppresses tumor angiogenesis

(2014) S. Chen et al.   GENES & DEVELOPMENT

MiR-378 as a biomarker for response to anti-angiogenic treatment in ovarian cancer

(2014) John K. Chan et al.   GYNECOLOGIC ONCOLOGY

MicroRNA-566 activates EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab

(2014) Kai-Liang Zhang et al.   Molecular Cancer

Acquired and intrinsic resistance in cancer immunotherapy

(2014) Sander Kelderman et al.   Molecular Oncology

MicroRNA-377 inhibited proliferation and invasion of human glioblastoma cells by directly targeting specificity protein 1

(2014) R. Zhang et al.   NEURO-ONCOLOGY

Interplay of VEGFa and MMP2 regulates invasion of glioblastoma

(2014) Jie Gong et al.   TUMOR BIOLOGY

Repression of miR-126 and upregulation of adrenomedullin in the stromal endothelium by cancer-stromal cross talks confers angiogenesis of cervical cancer

(2013) T-H Huang et al.   ONCOGENE

Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cancer

(2013) W Kong et al.   ONCOGENE

DCLK1 Regulates Pluripotency and Angiogenic Factors via microRNA-Dependent Mechanisms in Pancreatic Cancer

(2013) Sripathi M. Sureban et al.   PLoS One

miR-221 Is Required for Endothelial Tip Cell Behaviors during Vascular Development

(2012) Stefania Nicoli et al.   DEVELOPMENTAL CELL

Expression of miRNAs Involved in Angiogenesis, Tumor Cell Proliferation, Tumor Suppressor Inhibition, Epithelial-Mesenchymal Transition and Activation of Metastasis in Bladder Cancer

(2012) Apostolos Zaravinos et al.   JOURNAL OF UROLOGY

miR-210 activates notch signaling pathway in angiogenesis induced by cerebral ischemia

(2012) Yuan-Lei Lou et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Cancer: Limitations of therapies exposed

(2012) Oriol Casanovas   NATURE

The microcosmos of cancer

(2012) Amaia Lujambio et al.   NATURE

microRNA-125b inhibits tube formation of blood vessels through translational suppression of VE-cadherin

(2012) F Muramatsu et al.   ONCOGENE

Regulation of Vascular Endothelial Cell Polarization and Migration by Hsp70/Hsp90-Organizing Protein

(2012) Jingyu Li et al.   PLoS One

Hypoxia-Induced Aggressiveness of Pancreatic Cancer Cells Is Due to Increased Expression of VEGF, IL-6 and miR-21, Which Can Be Attenuated by CDF Treatment

(2012) Bin Bao et al.   PLoS One

Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration

(2011) Ni Zhu et al.   ATHEROSCLEROSIS

Deadly Teamwork: Neural Cancer Stem Cells and the Tumor Microenvironment

(2011) Justin D. Lathia et al.   Cell Stem Cell

MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression

(2011) Jian-Hong Fang et al.   HEPATOLOGY

miRNA Profiling for Clear Cell Renal Cell Carcinoma: Biomarker Discovery and Identification of Potential Controls and Consequences of miRNA Dysregulation

(2011) Nicole M.A. White et al.   JOURNAL OF UROLOGY

MicroRNA-378 is associated with non-small cell lung cancer brain metastasis by promoting cell migration, invasion and tumor angiogenesis

(2011) Lan-tao Chen et al.   MEDICAL ONCOLOGY

Endothelial-specific intron-derived miR-126 is down-regulated in human breast cancer and targets both VEGFA and PIK3R2

(2011) Ni Zhu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression

(2011) Ling-Zhi Liu et al.   PLoS One

microRNA-222 Controls Neovascularization by Regulating Signal Transducer and Activator of Transcription 5A Expression

(2010) Patrizia Dentelli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer

(2010) Antonis Giannakakis et al.   CANCER BIOLOGY & THERAPY

Hypoxic regulation of miR-210: Shrinking targets expand HIF-1’s Influence

(2010) Paul G. Corn   CANCER BIOLOGY & THERAPY

A MicroRNA Targeting Dicer for Metastasis Control

(2010) Graziano Martello et al.   CELL

Regulation of the Expression and Activity of the Antiangiogenic Homeobox Gene GAX/MEOX2 by ZEB2 and MicroRNA-221

(2010) Y. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeted Delivery of Antisense Inhibitor of miRNA for Antiangiogenesis Therapy Using cRGD-Functionalized Nanoparticles

(2010) Xi-Qiu Liu et al.   MOLECULAR PHARMACEUTICS

MicroRNA-132–mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis

(2010) Sudarshan Anand et al.   NATURE MEDICINE

Targeting microRNAs in cancer: rationale, strategies and challenges

(2010) Ramiro Garzon et al.   NATURE REVIEWS DRUG DISCOVERY

Expression of CD44 3′-untranslated region regulates endogenous microRNA functions in tumorigenesis and angiogenesis

(2010) Zina Jeyapalan et al.   NUCLEIC ACIDS RESEARCH

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

AngiomiRs—Key regulators of angiogenesis

(2009) Shusheng Wang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model

(2009) S. L. C. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The angiogenic switch in carcinogenesis

(2009) Vanessa Baeriswyl et al.   SEMINARS IN CANCER BIOLOGY

High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-β1

(2008) Biyun Qian et al.   BREAST CANCER RESEARCH AND TREATMENT

miR-296 Regulates Growth Factor Receptor Overexpression in Angiogenic Endothelial Cells

(2008) Thomas Würdinger et al.   CANCER CELL

Identification of Hypoxia-Inducible Factor-1  as a Novel Target for miR-17-92 MicroRNA Cluster

(2008) A. Taguchi et al.   CANCER RESEARCH

hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer

(2008) C. Camps et al.   CLINICAL CANCER RESEARCH

miR-126 Regulates Angiogenic Signaling and Vascular Integrity

(2008) Jason E. Fish et al.   DEVELOPMENTAL CELL

The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis

(2008) Shusheng Wang et al.   DEVELOPMENTAL CELL

MicroRNA-210 Modulates Endothelial Cell Response to Hypoxia and Inhibits the Receptor Tyrosine Kinase Ligand Ephrin-A3

(2008) Pasquale Fasanaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice

(2008) Motoyuki Otsuka et al.   JOURNAL OF CLINICAL INVESTIGATION