Monalizumab: inhibiting the novel immune checkpoint NKG2A

The HLA-B -21 dimorphism impacts on NK cell education and clinical outcome of immunotherapy in acute myeloid leukemia

(2019) Alexander Hallner et al.   BLOOD

The Emergence of Natural Killer Cells as a Major Target in Cancer Immunotherapy

(2019) Fernando Souza-Fonseca-Guimaraes et al.   TRENDS IN IMMUNOLOGY

Neoantigen-directed immune escape in lung cancer evolution

(2019) Rachel Rosenthal et al.   NATURE

Targeting natural killer cells in solid tumors

(2019) Guillaume Habif et al.   Cellular & Molecular Immunology

Tissue-Resident T Cells and Other Resident Leukocytes

(2019) David Masopust et al.   Annual Review of Immunology

The role of cytokines in the regulation of NK cells in the tumor environment

(2019) Gordana M. Konjević et al.   CYTOKINE

Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells

(2019) Takahiro Kamiya et al.   JOURNAL OF CLINICAL INVESTIGATION

Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity

(2019) Laurent Gauthier et al.   CELL

Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment

(2019) Rachael M. Zemek et al.   Science Translational Medicine

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

(2019) Branca I. Pereira et al.   Nature Communications

NKG2A is a NK cell exhaustion checkpoint for HCV persistence

(2019) Chao Zhang et al.   Nature Communications

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

(2018) Jan P. Böttcher et al.   CELL

Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor

(2018) Alexander D. Barrow et al.   CELL

NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis

(2018) Ariella Glasner et al.   IMMUNITY

Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

(2018) Peter Savas et al.   NATURE MEDICINE

A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments

(2018) Kevin C. Barry et al.   NATURE MEDICINE

ElevatedHLA-Aexpression impairs HIV control through inhibition of NKG2A-expressing cells

(2018) Veron Ramsuran et al.   SCIENCE

Combining Immune Checkpoint Blockade and Tumor-Specific Vaccine for Patients With Incurable Human Papillomavirus 16–Related Cancer

(2018) Erminia Massarelli et al.   JAMA Oncology

NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines

(2018) Nadine van Montfoort et al.   CELL

Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells

(2018) Pascale André et al.   CELL

Actively personalized vaccination trial for newly diagnosed glioblastoma

(2018) Norbert Hilf et al.   NATURE

NK cell–mediated cytotoxicity contributes to tumor control by a cytostatic drug combination

(2018) Marcus Ruscetti et al.   SCIENCE

NK cell heparanase controls tumor invasion and immune surveillance

(2017) Eva M. Putz et al.   JOURNAL OF CLINICAL INVESTIGATION

Sequence and Phylogenetic Analysis of the Untranslated Promoter Regions forHLAClass I Genes

(2017) Veron Ramsuran et al.   JOURNAL OF IMMUNOLOGY

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

An immunogenic personal neoantigen vaccine for patients with melanoma

(2017) Patrick A. Ott et al.   NATURE

Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy

(2017) Diego Chowell et al.   SCIENCE

Coinhibitory Pathways in Immunotherapy for Cancer

(2016) Susanne H. Baumeister et al.   Annual Review of Immunology

Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

(2016) Joseph L. Benci et al.   CELL

The urgent need to recover MHC class I in cancers for effective immunotherapy

(2016) Federico Garrido et al.   CURRENT OPINION IN IMMUNOLOGY

Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells

(2016) Pleun Hombrink et al.   NATURE IMMUNOLOGY

Targeting natural killer cells in cancer immunotherapy

(2016) Camille Guillerey et al.   NATURE IMMUNOLOGY

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

Epigenetic regulation of differentialHLA-Aallelic expression levels

(2015) Veron Ramsuran et al.   HUMAN MOLECULAR GENETICS

The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8+ T Cells in Response to a Lethal Poxvirus Infection

(2015) Aaron S. Rapaport et al.   IMMUNITY

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

Non-classical HLA-class I expression in serous ovarian carcinoma: Correlation with the HLA-genotype, tumor infiltrating immune cells and prognosis

(2015) Emilia Andersson et al.   OncoImmunology

Alterations in classical and nonclassical HLA expression in recurrent and progressive HPV-induced usual vulvar intraepithelial neoplasia and implications for immunotherapy

(2014) E.M.G. van Esch et al.   INTERNATIONAL JOURNAL OF CANCER

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

SHP-1-mediated inhibitory signals promote responsiveness and anti-tumour functions of natural killer cells

(2014) Charlotte Viant et al.   Nature Communications

NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs

(2013) V. Beziat et al.   BLOOD

A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application

(2013) Taku Okazaki et al.   NATURE IMMUNOLOGY

Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity

(2011) Emilie Mamessier et al.   JOURNAL OF CLINICAL INVESTIGATION

CD8+ T cells with an intraepithelial phenotype upregulate cytotoxic function upon influenza infection in human lung

(2011) Berber Piet et al.   JOURNAL OF CLINICAL INVESTIGATION

A Structural Basis for Antigen Presentation by the MHC Class Ib Molecule, Qa-1

(2011) L. Zeng et al.   JOURNAL OF IMMUNOLOGY

HLA-E expression by gynecological cancers restrains tumor-infiltrating CD8+ T lymphocytes

(2011) M. Gooden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HLA-E and HLA-G Expression in Classical HLA Class I-Negative Tumors Is of Prognostic Value for Clinical Outcome of Early Breast Cancer Patients

(2010) E. M. de Kruijf et al.   JOURNAL OF IMMUNOLOGY

The other Janus face of Qa-1 and HLA-E: diverse peptide repertoires in times of stress

(2010) Thorbald van Hall et al.   MICROBES AND INFECTION

HLA antigen changes in malignant cells: epigenetic mechanisms and biologic significance

(2008) M Campoli et al.   ONCOGENE