Article
Multidisciplinary Sciences
Haoran Zhang, Wenqiu Wang, Junjie Lin, Junbo Qiao, Xinjun Wang, Bin Fang, Changkuan Chen, Yujiao Wang, Gaozan Zhu, Wenbo Liu
Summary: In this study, it was found that lncRNA LEF1-AS1 was upregulated in venous malformations. By competitively binding to miR-489-3p, LEF1-AS1 promoted the expression of S100A11, thereby enhancing the proliferation, migration, and angiogenesis of HUVEC cells.
Article
Medicine, Research & Experimental
Jizi Zhou, Ying Zhao, Ping An, Huanqiang Zhao, Xiaotian Li, Yu Xiong
Summary: This study reveals that circRNA hsa_circ_0002348 is significantly increased in preeclampsia placentas and correlates with the severity of clinical manifestations. It functions as an endogenous sponge for miR-126-3p to upregulate BAK1 expression, thereby regulating trophoblast proliferation and apoptosis. Hsa_circ_0002348 may serve as a potential therapeutic target for preeclampsia.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Xiao Feng, Shuangbai Zhou, Weilin Cai, Jincai Guo
Summary: miR-93-3p plays a crucial role in skin wound healing by promoting keratinocyte proliferation and migration through the ZFP36L1/ZFX axis.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Kang Wang, Qing Luo, Yingfeng Zhang, Xin Xie, Wenhao Cheng, Qiunan Yao, Yingying Chen, Hong Ren, Jiuping Li, Zuanqin Pan
Summary: This study investigated the functions and potential molecular mechanism of LINC01296 in the progression of cutaneous malignant melanoma (CMM) through the regulation of the miR-324-3p/MAPK1 axis. The up-regulation of LINC01296 was found in CMM tissues and cell lines, and its over-expression promoted cell proliferation in CMM cell lines. Further investigations revealed that LINC01296 interacted with miR-324-3p and that MAPK1 was the target mRNA of miR-324-3p. Rescue experiments suggested a positive regulatory association between LINC01296 and MAPK1 in CMM cells.
Article
Multidisciplinary Sciences
Yerin Kim, Namhee Yu, Ye Eun Jang, Eunkyung Lee, Yeonjoo Jung, Doo Jae Lee, W. Robert Taylor, Hanjoong Jo, Jaesang Kim, Sanghyuk Lee, Sang Won Kang
Summary: Endothelial dysfunction and inflammatory immune response induce dedifferentiation of vascular smooth muscle cells (SMCs) and contribute to arterial occlusion. This study reveals that specific miRNAs are upregulated in injured rat carotids and synthetic-type human vascular SMCs. Inhibiting these miRNAs prevents neointimal hyperplasia in injured rat carotid arteries and directs SMC proliferation. Furthermore, bone morphogenic protein (BMP)-7 is identified as a significant target gene regulated by miR-370-3p, influencing SMC proliferation in both rodent and human systems.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Chih-Hsin Hsu, I-Fan Liu, Hsuan-Fu Kuo, Chia-Yang Li, Wei-Shiung Lian, Chia-Yuan Chang, Yung-Hsiang Chen, Wei-Lun Liu, Chi-Yu Lu, Yu-Ru Liu, Tzu-Chieh Lin, Tsung-Ying Lee, Chi-Yuan Huang, Chong-Chao Hsieh, Po-Len Liu
Summary: miR-29a-3p exerts a direct anti-fibrotic effect on PAH-induced cardiac fibrosis by targeting THBS2 expression, with circulating levels of both miR-29a-3p and THBS2 correlating with PAH diagnosis and showing independent prognostic value.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Hao Zhang, Yang Du, Peng Xin, Xiaojun Man
Summary: In this study, the researchers found that LINC00852 is highly expressed in prostate cancer tissue and its up-regulation can promote the proliferation, migration, and invasion of prostate cancer cells. They also identified that LINC00852 regulates the expression of JARID2 through miR-29a-3p induction. The LINC00852/miR-29a-3p/JARID2 axis could be a potential target for prostate cancer treatment.
Article
Cardiac & Cardiovascular Systems
Yini Guo, Zongli Sun, Minghe Chen, Junjie Lun
Summary: TUG1 was found to play a crucial role in the proliferation of cardiac fibroblasts, acting as a competing endogenous RNA for miR-29b-3p and regulating the miR-29b-3p/TGF-beta 1 axis. Knockdown of TUG1 inhibited CF proliferation induced by AngII, and miR-29b-3p targeted directly to TGF-beta 1.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Shiliang Dong, Minrui Ma, Ming Li, Yuexin Guo, Xiaoxiao Zuo, Xiaobin Gu, Mingzhi Zhang, Yonggang Shi
Summary: MEG3 and RBMS3 are low-expressed in breast cancer, negatively correlated with miR-141-3p, and positively correlated with each other. MEG3 inhibits BC cell proliferation and promotes apoptosis by down-regulating miR-141-3p and up-regulating RBMS3.
Article
Agriculture, Dairy & Animal Science
Bolin Cai, Manting Ma, Zhen Zhou, Shaofen Kong, Jing Zhang, Xiquan Zhang, Qinghua Nie
Summary: This study identified a novel circRNA circPTPN4 and demonstrated its important role in chicken skeletal muscle development by promoting the proliferation and differentiation of myoblasts, suppressing mitochondrial biogenesis, and activating the fast-twitch muscle phenotype. circPTPN4 functions as a ceRNA that regulates NAMPT expression by sponging miR-499-3p, thus influencing AMPK signaling.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qin Li, Shuo Li, Jin Ding, Bo Pang, Ranran Li, Hui Cao, Li Ling
Summary: A study found that the proliferation of trophoblasts in early-onset preeclampsia (ePE) is regulated by lncRNA MALAT1. The level of MALAT1 was decreased in placental tissue samples from ePE patients, and it was positively correlated with neonate birth-weight. Knockdown of MALAT1 inhibited trophoblast cell growth and migration, and promoted cell apoptosis. Moreover, MALAT1 reduction affected cell proliferation and growth through the regulation of miR-101-3p and VEGFA.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Peiwen Zhang, Xinrong Li, Shunhua Zhang, Shuang Wu, Qian Xiao, Yang Gu, Xinyu Guo, Xutao Lin, Lei Chen, Ye Zhao, Lili Niu, Guoqing Tang, Yanzhi Jiang, Linyuan Shen, Li Zhu
Summary: The study showed that miR-370-3p reduces lipid accumulation by suppressing the expression of adipogenic markers, inhibits 3T3-L1 preadipocyte proliferation, and promotes differentiation. Additionally, the target gene of miR-370-3p, Mknk1, plays opposing roles in preadipocyte proliferation and differentiation.
Article
Oncology
Dan Zhang, Zhiwei He, Yiyi Shen, Jie Wang, Tao Liu, Jianxin Jiang
Summary: In this study, miR-489-3p was identified as a novel therapeutic target for pancreatic cancer, inhibiting proliferation, metastasis, and glycolysis by targeting LDHA and PKM. Further research is needed to explore its diagnostic value.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Wenjing Zhang, Bingshi Liu, Yanfang Wang, Lixian Sun Phd, Chao Liu, Haoran Zhang, Wei Qin, Jingyi Liu, Leng Han, Weichao Shan
Summary: In this study, the expression and role of microRNA-195-3p and brain-derived neurotrophic factor (BDNF) in hypoxic-treated human umbilical vein endothelial cells (HUVECs) were investigated. It was found that microRNA-195-3p and BDNF levels were upregulated and apoptosis was increased under hypoxic conditions. Additionally, BDNF/P-ERK1/2 was shown to regulate the expression of mitochondrial apoptosis pathway proteins Bcl-2/BAX. The results suggest that therapeutic intervention targeting the microRNA-195-3p/BDNF/P-ERK1/2/Bcl-2/BAX axis could be a new treatment strategy for coronary heart disease (CHD).
Article
Biochemistry & Molecular Biology
Xian Shi, Xidan Xu, Nian Shi, Yongjun Chen, Manni Fu
Summary: MiR-767-3p has been found to inhibit the expression of ASF1B, thus reducing melanoma tumorigenesis. This has potential implications for the treatment of melanoma.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Xuhui Yang, Hui Zhao, Jing Yang, Yongfu Ma, Zihao Liu, Chenxi Li, Tao Wang, Zhifeng Yan, Nan Du
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Oncology
Chenxi Li, Yan Fu, Qiuwen Li, Xuhui Yang, Wenying Wang, Xin Jin, Lihua Bian, Hui Zhao, Donghui Li, Jie Gao, Nan Du, Liang Peng
Summary: The relationship between preoperative and postoperative serum lipid levels and prognosis in patients with gastric cancer was investigated in this study. The results indicate that low postoperative HDL-C level may serve as an independent prognostic factor in gastric cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xiang Zhu, Xiaojie Xu, Lin Zhang, Xuhui Yang
Summary: This study identified CPVL as a key factor in regulating breast cancer resistance to CDK4/6 inhibitors through bioinformatics analysis and experimental validation. CPVL was found to be more abundantly expressed in resistant cells and its manipulation influenced the effects of CDK4/6 inhibitors. The findings suggest that CPVL negatively regulates PTEN and impacts the anticancer effects of CDK4/6 inhibitors both in vitro and in vivo.