Single point mutation in adeno-associated viral vectors -DJ capsid leads to improvement for gene delivery in vivo

Somatic Correction of Junctional Epidermolysis Bullosa by a Highly Recombinogenic AAV Variant

(2014) Sandra P Melo et al.   MOLECULAR THERAPY

Kidney-specific expression of GFP by in-utero delivery of pseudotyped adeno-associated virus 9

(2014) Jason L Picconi et al.   Molecular Therapy-Methods & Clinical Development

Optimization of the Capsid of Recombinant Adeno-Associated Virus 2 (AAV2) Vectors: The Final Threshold?

(2013) George V. Aslanidi et al.   PLoS One

Targeted Modifications in Adeno-Associated Virus Serotype 8 Capsid Improves Its Hepatic Gene Transfer Efficiency In Vivo

(2013) Dwaipayan Sen et al.   Human Gene Therapy Methods

Bioengineering of AAV2 Capsid at Specific Serine, Threonine, or Lysine Residues Improves Its Transduction Efficiency in Vitro and in Vivo

(2013) Nishanth Gabriel et al.   Human Gene Therapy Methods

K137R Mutation on Adeno-Associated Viral Capsids Had Minimal Effect on Enhancing Gene Delivery In Vivo

(2013) Chunping Qiao et al.   Human Gene Therapy Methods

Hoechst increases adeno-associated virus-mediated transgene expression in airway epithelia by inducing the cytomegalovirus promoter

(2012) David D. Dickey et al.   JOURNAL OF GENE MEDICINE

Structure of AAV-DJ, a Retargeted Gene Therapy Vector: Cryo-Electron Microscopy at 4.5 Å Resolution

(2012) Thomas F. Lerch et al.   STRUCTURE

High-efficiency transduction of human monocyte-derived dendritic cells by capsid-modified recombinant AAV2 vectors

(2012) George V. Aslanidi et al.   VACCINE

Comparison of Adeno-Associated Virus Serotypes and Delivery Methods for Cardiac Gene Transfer

(2012) Hongfei Fang et al.   Human Gene Therapy Methods

Single Tyrosine Mutation in AAV8 and AAV9 Capsids Is Insufficient to Enhance Gene Delivery to Skeletal Muscle and Heart

(2012) Chunping Qiao et al.   Human Gene Therapy Methods

AAV vectors transduce hepatocytes in vivo as efficiently in cirrhotic as in healthy rat livers

(2011) L Sobrevals et al.   GENE THERAPY

Efficient production of Fah -null heterozygote pigs by chimeric adeno-associated virus-mediated gene knockout and somatic cell nuclear transfer

(2011) Raymond D. Hickey et al.   HEPATOLOGY

Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B

(2011) Amit C. Nathwani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Production, Purification and Characterization of Adeno-Associated Vectors

(2010) Eduard Ayuso et al.   CURRENT GENE THERAPY

Enhanced Long-Term Transduction and Multilineage Engraftment of Human Hematopoietic Stem Cells Transduced with Tyrosine-Modified Recombinant Adeno-Associated Virus Serotype 2

(2010) M. Ariel Kauss et al.   HUMAN GENE THERAPY

High-efficiency Transduction and Correction of Murine Hemophilia B Using AAV2 Vectors Devoid of Multiple Surface-exposed Tyrosines

(2010) David M Markusic et al.   MOLECULAR THERAPY

Polymers for Improving the In Vivo Transduction Efficiency of AAV2 Vectors

(2010) Gilles Moulay et al.   PLoS One

Gene Therapy for Leber's Congenital Amaurosis is Safe and Effective Through 1.5 Years After Vector Administration

(2009) Francesca Simonelli et al.   MOLECULAR THERAPY

Gene Therapy Using Adeno-Associated Virus Vectors

(2008) S. Daya et al.   CLINICAL MICROBIOLOGY REVIEWS

In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated Viruses

(2008) D. Grimm et al.   JOURNAL OF VIROLOGY

High-efficiency Transduction of the Mouse Retina by Tyrosine-mutant AAV Serotype Vectors

(2008) Hilda Petrs-Silva et al.   MOLECULAR THERAPY

Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

(2008) Albert M. Maguire et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Gene Therapy on Visual Function in Leber's Congenital Amaurosis

(2008) James W.B. Bainbridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Next generation of adeno-associated virus 2 vectors: Point mutations in tyrosines lead to high-efficiency transduction at lower doses

(2008) L. Zhong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA