The evolving world of pseudoenzymes: proteins, prejudice and zombies

Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling

(2016) Neil S. Dhawan et al.   NATURE

Structural Basis for the Non-catalytic Functions of Protein Kinases

(2016) Jennifer E. Kung et al.   STRUCTURE

The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner

(2015) Fiona P. Bailey et al.   BIOCHEMICAL JOURNAL

Pseudoproteases: mechanisms and function

(2015) Simone L. Reynolds et al.   BIOCHEMICAL JOURNAL

Tribbles pseudokinases: novel targets for chemical biology and drug discovery?

(2015) D. M. Foulkes et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Molecular insights into regulation of JAK2 in myeloproliferative neoplasms

(2015) O. Silvennoinen et al.   BLOOD

Higher-Order Assembly of BRCC36–KIAA0157 Is Required for DUB Activity and Biological Function

(2015) Elton Zeqiraj et al.   MOLECULAR CELL

Molecular Mechanism of CCAAT-Enhancer Binding Protein Recruitment by the TRIB1 Pseudokinase

(2015) James M. Murphy et al.   STRUCTURE

Kinases and Pseudokinases: Lessons from RAF

(2014) A. S. Shaw et al.   MOLECULAR AND CELLULAR BIOLOGY

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

(2014) Joanne M. Hildebrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations

(2014) P. Littlefield et al.   Science Signaling

Day of the dead: pseudokinases and pseudophosphatases in physiology and disease

(2014) Veronika Reiterer et al.   TRENDS IN CELL BIOLOGY

Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses

(2013) Leila N. Varghese et al.   BIOCHEMICAL JOURNAL

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL

(2013) James M. Murphy et al.   BIOCHEMICAL JOURNAL

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

(2013) James M. Murphy et al.   BIOCHEMICAL JOURNAL

Dawn of the dead: protein pseudokinases signal new adventures in cell biology

(2013) Patrick A. Eyers et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

New lives for old: evolution of pseudoenzyme function illustrated by iRhoms

(2012) Colin Adrain et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pseudophosphatases: Grab and Hold on

(2009) Nicholas K. Tonks   CELL

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

(2009) Elton Zeqiraj et al.   PLOS BIOLOGY