T Regulatory Cells From Non-obese Diabetic Mice Show Low Responsiveness to IL-2 Stimulation and Exhibit Differential Expression of Anergy-Related and Ubiquitination Factors

Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells

(2019) Veerle Fleskens et al.   Cell Reports

Signaling and Function of Interleukin-2 in T Lymphocytes

(2018) Sarah H. Ross et al.   Annual Review of Immunology

Foxp3+ T Regulatory Cells: Still Many Unanswered Questions—A Perspective After 20 Years of Study

(2018) Ethan M. Shevach   Frontiers in Immunology

Immunization with Recombinantly Expressed LRP4 Induces Experimental Autoimmune Myasthenia Gravis in C57BL/6 Mice

(2017) Canan Ulusoy et al.   IMMUNOLOGICAL INVESTIGATIONS

Active site-targeted covalent irreversible inhibitors of USP7 impair the functions of Foxp3+ T-regulatory cells by promoting ubiquitination of Tip60

(2017) Feng Wang et al.   PLoS One

GRAIL and Otubain-1 are Related to T Cell Hyporesponsiveness during Trypanosoma cruzi Infection

(2017) Cinthia C. Stempin et al.   PLoS Neglected Tropical Diseases

Reduced interleukin-2 responsiveness impairs the ability of Treg cells to compete for IL-2 in nonobese diabetic mice

(2016) Cini R James et al.   IMMUNOLOGY AND CELL BIOLOGY

Control of Foxp3 stability through modulation of TET activity

(2016) Xiaojing Yue et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Are Regulatory T Cells Defective in Type 1 Diabetes and Can We Fix Them?

(2016) Anabelle Visperas et al.   JOURNAL OF IMMUNOLOGY

CD25 signaling regulates the function and stability of peripheral Foxp3+ regulatory T cells derived from the spleen and lymph nodes of mice

(2016) Kunpeng Wang et al.   MOLECULAR IMMUNOLOGY

Unstable FoxP3+T regulatory cells in NZW mice

(2016) Fabien Dépis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breaking Free of Control: How Conventional T Cells Overcome Regulatory T Cell Suppression

(2016) Emily R. Mercadante et al.   Frontiers in Immunology

Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3 + T-regulatory Cell Function and Promotes Antitumor Immunity

(2016) Liqing Wang et al.   EBioMedicine

Ubiquitin-dependent regulation of Foxp3 and Treg function

(2015) Joseph Barbi et al.   IMMUNOLOGICAL REVIEWS

Altered Connexin 43 Expression Underlies Age-Dependent Decrease of Regulatory T Cell Suppressor Function in Nonobese Diabetic Mice

(2015) Michal Kuczma et al.   JOURNAL OF IMMUNOLOGY

Combination Therapy Using IL-2/IL-2 Monoclonal Antibody Complexes, Rapamycin, and Islet Autoantigen Peptides Increases Regulatory T Cell Frequency and Protects against Spontaneous and Induced Type 1 Diabetes in Nonobese Diabetic Mice

(2015) J. N. Manirarora et al.   JOURNAL OF IMMUNOLOGY

Function of a Foxp3 cis -Element in Protecting Regulatory T Cell Identity

(2014) Xudong Li et al.   CELL

Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus

(2014) Yongqiang Feng et al.   CELL

Interleukin 2 in the Pathogenesis and Therapy of Type 1 Diabetes

(2014) Michelle Rosenzwajg et al.   Current Diabetes Reports

Dysregulation of anergy-related factors involved in regulatory T cells defects in Systemic Lupus Erythematosus patients: Rapamycin and Vitamin D efficacy in restoring regulatory T cells

(2014) Leontina M. Banica et al.   International Journal of Rheumatic Diseases

Cutting Edge: The Transmembrane E3 Ligase GRAIL Ubiquitinates the Costimulatory Molecule CD40 Ligand during the Induction of T Cell Anergy

(2014) N. B. Lineberry et al.   JOURNAL OF IMMUNOLOGY

Ubiquitous points of control over regulatory T cells

(2014) Fan Pan et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The Ubiquitin Ligase Stub1 Negatively Modulates Regulatory T Cell Suppressive Activity by Promoting Degradation of the Transcription Factor Foxp3

(2013) Zuojia Chen et al.   IMMUNITY

Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity

(2013) Jorg van Loosdregt et al.   IMMUNITY

The IL-2/IL-2R system: from basic science to therapeutic applications to enhance immune regulation

(2013) Allison L. Bayer et al.   IMMUNOLOGIC RESEARCH

Integrated Enrichment Analysis of Variants and Pathways in Genome-Wide Association Studies Indicates Central Role for IL-2 Signaling Genes in Type 1 Diabetes, and Cytokine Signaling Genes in Crohn's Disease

(2013) Peter Carbonetto et al.   PLoS Genetics

T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

(2012) Naganari Ohkura et al.   IMMUNITY

Decreased frequencies of CD4+CD25+Foxp3+cells and the potent CD103+subset in peripheral lymph nodes correlate with autoimmune disease predisposition in some strains of mice

(2011) Colleen F. Tucker et al.   AUTOIMMUNITY

Global Identification of Modular Cullin-RING Ligase Substrates

(2011) Michael J. Emanuele et al.   CELL

Ganglioside GM1 Deficiency in Effector T Cells From NOD Mice Induces Resistance to Regulatory T-Cell Suppression

(2011) G. Wu et al.   DIABETES

The E3 Ubiquitin Ligase GRAIL Regulates T Cell Tolerance and Regulatory T Cell Function by Mediating T Cell Receptor-CD3 Degradation

(2010) Roza I. Nurieva et al.   IMMUNITY

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

(2010) Ye Zheng et al.   NATURE

Stability of the Regulatory T Cell Lineage in Vivo

(2010) Y. P. Rubtsov et al.   SCIENCE

Regulation of cullin-RING E3 ubiquitin-ligases by neddylation and dimerization

(2009) J. Merlet et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects

(2009) S. A. Long et al.   DIABETES

Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions

(2009) João H. Duarte et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Transmembrane E3 Ligase GRAIL Ubiquitinates and Degrades CD83 on CD4 T Cells

(2009) L. L. Su et al.   JOURNAL OF IMMUNOLOGY

The IL-2/CD25 Pathway Determines Susceptibility to T1D in Humans and NOD Mice

(2008) Calliope A. Dendrou et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors

(2008) A. M. D'Alise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA