The IL-2/IL-2R system: from basic science to therapeutic applications to enhance immune regulation
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Title
The IL-2/IL-2R system: from basic science to therapeutic applications to enhance immune regulation
Authors
Keywords
Treg cells, IL-2, Autoimmunity, Tolerance, Type 1 diabetes, Insulin
Journal
IMMUNOLOGIC RESEARCH
Volume 57, Issue 1-3, Pages 197-209
Publisher
Springer Nature America, Inc
Online
2013-11-08
DOI
10.1007/s12026-013-8452-5
References
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- (2011) Bart O Roep et al. CURRENT OPINION IN IMMUNOLOGY
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- Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial
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- Deletional Tolerance Mediated by Extrathymic Aire-Expressing Cells
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- The Biology of Interleukin-2
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