Spatial Distribution of Macrophages During Callus Formation and Maturation Reveals Close Crosstalk Between Macrophages and Newly Forming Vessels

Collagen I-based scaffolds negatively impact fracture healing in a mouse-osteotomy-model although used routinely in research and clinical application

(2019) Annemarie Lang et al.   Acta Biomaterialia

VEGFA from Early Osteoblast Lineage Cells (Osterix+) is Required in Mice for Fracture Healing

(2019) Evan G. Buettmann et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Age‐related changes in the mechanical regulation of bone healing are explained by altered cellular mechanoresponse

(2019) E Borgiani et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Endothelial proteolytic activity and interaction with non-resorbing osteoclasts mediate bone elongation

(2019) Sara G. Romeo et al.   NATURE CELL BIOLOGY

Sox9+ messenger cells orchestrate large-scale skeletal regeneration in the mammalian rib

(2019) Stephanie T Kuwahara et al.   eLife

Administration of Tramadol or Buprenorphine via the drinking water for post-operative analgesia in a mouse-osteotomy model

(2019) Paulin Jirkof et al.   Scientific Reports

Role of angiocrine signals in bone development, homeostasis and disease

(2019) Unnikrishnan Sivan et al.   Open Biology

Macrophages in bone fracture healing: Their essential role in endochondral ossification

(2018) Claudia Schlundt et al.   BONE

Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression

(2018) David B Gurevich et al.   EMBO JOURNAL

Engineering in-vitro stem cell-based vascularized bone models for drug screening and predictive toxicology

(2018) Alessandro Pirosa et al.   Stem Cell Research & Therapy

A Unidirectional Transition from Migratory to Perivascular Macrophage Is Required for Tumor Cell Intravasation

(2018) Esther N. Arwert et al.   Cell Reports

A review of biomaterials in bone defect healing, remaining shortcomings and future opportunities for bone tissue engineering

(2018) T. Winkler et al.   Bone & Joint Research

Origin of Reparative Stem Cells in Fracture Healing

(2018) Beth C. Bragdon et al.   Current Osteoporosis Reports

Transplanted interleukin-4--secreting mesenchymal stromal cells show extended survival and increased bone mineral density in the murine femur

(2018) TZUHUA LIN et al.   CYTOTHERAPY

NFκB sensing IL-4 secreting mesenchymal stem cells mitigate the proinflammatory response of macrophages exposed to polyethylene wear particles

(2018) Tzuhua Lin et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model

(2018) Denver D. Britto et al.   Disease Models & Mechanisms

Cellular biology of fracture healing

(2018) Chelsea S. Bahney et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice

(2018) Linda Vi et al.   Nature Communications

A Pronounced Inflammatory Activity Characterizes the Early Fracture Healing Phase in Immunologically Restricted Patients

(2017) Paula Hoff et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Data-analysis strategies for image-based cell profiling

(2017) Juan C Caicedo et al.   NATURE METHODS

Longitudinal intravital imaging of the femoral bone marrow reveals plasticity within marrow vasculature

(2017) David Reismann et al.   Nature Communications

Osteomacs and Bone Regeneration

(2017) Lena Batoon et al.   Current Osteoporosis Reports

Perivascular Macrophages Limit PermeabilityHighlights

(2016) Huanhuan He et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The roles of vascular endothelial growth factor in bone repair and regeneration

(2016) Kai Hu et al.   BONE

Immunological characterization of the early human fracture hematoma

(2016) Paula Hoff et al.   IMMUNOLOGIC RESEARCH

Resting and injury-induced inflamed periosteum contain multiple macrophage subsets that are located at sites of bone growth and regeneration

(2016) Kylie Anne Alexander et al.   IMMUNOLOGY AND CELL BIOLOGY

Osteotomy models – the current status on pain scoring and management in small rodents

(2016) Annemarie Lang et al.   LABORATORY ANIMALS

Blood flow controls bone vascular function and osteogenesis

(2016) Saravana K. Ramasamy et al.   Nature Communications

Macrophages Promote Osteoblastic Differentiation In Vivo: Implications in Fracture Repair and Bone Homeostasis

(2015) Linda Vi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Fracture Healing via Periosteal Callus Formation Requires Macrophages for Both Initiation and Progression of Early Endochondral Ossification

(2014) Liza J. Raggatt et al.   AMERICAN JOURNAL OF PATHOLOGY

Initiation and early control of tissue regeneration – bone healing as a model system for tissue regeneration

(2014) Katharina Schmidt-Bleek et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Macrophage heterogeneity in tissues: phenotypic diversity and functions

(2014) Siamon Gordon et al.   IMMUNOLOGICAL REVIEWS

Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo

(2014) M. K. Chang et al.   JOURNAL OF IMMUNOLOGY

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

(2014) Anjali P. Kusumbe et al.   NATURE

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

(2014) Saravana K. Ramasamy et al.   NATURE

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

(2014) Hui Xie et al.   NATURE MEDICINE

Fracture healing: mechanisms and interventions

(2014) Thomas A. Einhorn et al.   Nature Reviews Rheumatology

Hepatic Localization of Macrophage Phenotypes during Fibrogenesis and Resolution of Fibrosis in Mice and Humans

(2014) Leonie Beljaars et al.   Frontiers in Immunology

Monocyte/macrophage interactions with myogenic precursor cells during skeletal muscle regeneration

(2013) Marielle Saclier et al.   FEBS Journal

Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages

(2012) H. He et al.   BLOOD

Time-lapse microscopy of macrophages during embryonic vascular development

(2012) Sarah Al-Roubaie et al.   DEVELOPMENTAL DYNAMICS

A call for bioimaging software usability

(2012) Anne E Carpenter et al.   NATURE METHODS

Fracture healing under healthy and inflammatory conditions

(2012) Lutz Claes et al.   Nature Reviews Rheumatology

Human Early Fracture Hematoma Is Characterized by Inflammation and Hypoxia

(2011) Paula Kolar et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model

(2011) Kylie A Alexander et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction

(2010) A. Fantin et al.   BLOOD

IL-10 regulation of macrophage VEGF production is dependent on macrophage polarisation and hypoxia

(2010) Wei-Kang Wu et al.   IMMUNOBIOLOGY

Spatial and temporal variations of mechanical properties and mineral content of the external callus during bone healing

(2009) I. Manjubala et al.   BONE

Regulation of Angiogenesis by Macrophages, Dendritic Cells, and Circulating Myelomonocytic Cells

(2009) Zhao (David) Dong et al.   CURRENT PHARMACEUTICAL DESIGN

Differential regulation of blood vessel formation between standard and delayed bone healing

(2009) Jasmin Lienau et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Skeletal Cell Fate Decisions Within Periosteum and Bone Marrow During Bone Regeneration

(2008) Céline Colnot   JOURNAL OF BONE AND MINERAL RESEARCH