Role of angiocrine signals in bone development, homeostasis and disease

Restricted Hematopoietic Progenitors and Erythropoiesis Require SCF from Leptin Receptor+ Niche Cells in the Bone Marrow

(2019) Stefano Comazzetto et al.   Cell Stem Cell

Loss of Endothelial Derived WNT5A is Associated with Reduced Pericyte Recruitment and Small Vessel Loss in Pulmonary Arterial Hypertension

(2019) Ke Yuan et al.   CIRCULATION

Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy

(2019) Patrick Carlson et al.   NATURE CELL BIOLOGY

Nidogen-1 Contributes to the Interaction Network Involved in Pro-B Cell Retention in the Peri-sinusoidal Hematopoietic Stem Cell Niche

(2019) Marielle Balzano et al.   Cell Reports

Endothelial proteolytic activity and interaction with non-resorbing osteoclasts mediate bone elongation

(2019) Sara G. Romeo et al.   NATURE CELL BIOLOGY

Bone vascular niche E-selectin induces mesenchymal–epithelial transition and Wnt activation in cancer cells to promote bone metastasis

(2019) Mark Esposito et al.   NATURE CELL BIOLOGY

Where Hematopoietic Stem Cells Live: The Bone Marrow Niche

(2018) Krzysztof Szade et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML

(2018) Delfim Duarte et al.   Cell Stem Cell

Targeting skeletal endothelium to ameliorate bone loss

(2018) Ren Xu et al.   NATURE MEDICINE

Characterization of Endothelial Cells Associated with Hematopoietic Niche Formation in Humans Identifies IL-33 As an Anabolic Factor

(2018) Keane Jared Guillaume Kenswil et al.   Cell Reports

Interactions between rheumatoid arthritis synovial fibroblast migration and endothelial cells

(2018) Birgit Zimmermann-Geller et al.   IMMUNOLOGY AND CELL BIOLOGY

Diagnosis and Management of Rheumatoid Arthritis

(2018) Daniel Aletaha et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Endothelial transplantation rejuvenates aged hematopoietic stem cell function

(2017) Michael G. Poulos et al.   JOURNAL OF CLINICAL INVESTIGATION

Human type H vessels are a sensitive biomarker of bone mass

(2017) Liang Wang et al.   Cell Death & Disease

The skeletal vascular system – Breathing life into bone tissue

(2017) Steve Stegen et al.   BONE

Chemosensitizing AML cells by targeting bone marrow endothelial cells

(2016) Raphael C. Bosse et al.   EXPERIMENTAL HEMATOLOGY

NOTCH signaling in skeletal progenitors is critical for fracture repair

(2016) Cuicui Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of BMP-2 in Vascular Endothelial Cells of Recipient May Predict Delayed Graft Function After Renal Transplantation

(2016) Nikolina Basic-Jukic et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche

(2016) James Y. Chen et al.   NATURE

Angiocrine functions of organ-specific endothelial cells

(2016) Shahin Rafii et al.   NATURE

Age-dependent modulation of vascular niches for haematopoietic stem cells

(2016) Anjali P. Kusumbe et al.   NATURE

Blood flow controls bone vascular function and osteogenesis

(2016) Saravana K. Ramasamy et al.   Nature Communications

Interleukin-1β, lipocalin 2 and nitric oxide synthase 2 are mechano-responsive mediators of mouse and human endothelial cell-osteoblast crosstalk

(2016) Vimal Veeriah et al.   Scientific Reports

Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone

(2015) Zhuang Cui et al.   ANNALS OF THE RHEUMATIC DISEASES

Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation

(2015) Takanori Takebe et al.   Cell Stem Cell

Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal

(2015) Melih Acar et al.   NATURE

Sample preparation for high-resolution 3D confocal imaging of mouse skeletal tissue

(2015) Anjali P Kusumbe et al.   Nature Protocols

Regulation of tissue morphogenesis by endothelial cell-derived signals

(2015) Saravana K. Ramasamy et al.   TRENDS IN CELL BIOLOGY

Vascular Platform to Define Hematopoietic Stem Cell Factors and Enhance Regenerative Hematopoiesis

(2015) Michael G. Poulos et al.   Stem Cell Reports

Angiocrine Factors Deployed by Tumor Vascular Niche Induce B Cell Lymphoma Invasiveness and Chemoresistance

(2014) Zhongwei Cao et al.   CANCER CELL

Direct measurement of local oxygen concentration in the bone marrow of live animals

(2014) Joel A. Spencer et al.   NATURE

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

(2014) Anjali P. Kusumbe et al.   NATURE

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

(2014) Saravana K. Ramasamy et al.   NATURE

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

(2014) Hui Xie et al.   NATURE MEDICINE

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

(2013) Adam Greenbaum et al.   NATURE

Arteriolar niches maintain haematopoietic stem cell quiescence

(2013) Yuya Kunisaki et al.   NATURE

The perivascular niche regulates breast tumour dormancy

(2013) Cyrus M. Ghajar et al.   NATURE CELL BIOLOGY

Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

(2013) César Nombela-Arrieta et al.   NATURE CELL BIOLOGY

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE

Development of the Endochondral Skeleton

(2013) F. Long et al.   Cold Spring Harbor Perspectives in Biology

Endothelial Jagged-1 Is Necessary for Homeostatic and Regenerative Hematopoiesis

(2013) Michael G. Poulos et al.   Cell Reports

Wnt5a signaling is a substantial constituent in bone morphogenetic protein-2-mediated osteoblastogenesis

(2012) Eiji Nemoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration

(2012) A. Nakamura-Ishizu et al.   BLOOD

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Osteoprotection by semaphorin 3A

(2012) Mikihito Hayashi et al.   NATURE

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Semaphorins in bone development, homeostasis, and disease

(2012) Sujin Kang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Endothelial-Derived Angiocrine Signals Induce and Sustain Regenerative Lung Alveolarization

(2011) Bi-Sen Ding et al.   CELL

Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells

(2010) Jason M. Butler et al.   Cell Stem Cell

Osteoblast Precursors, but Not Mature Osteoblasts, Move into Developing and Fractured Bones along with Invading Blood Vessels

(2010) Christa Maes et al.   DEVELOPMENTAL CELL

The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche

(2010) Yoshiki Omatsu et al.   IMMUNITY

Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration

(2010) Bi-Sen Ding et al.   NATURE

Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells

(2010) Hideki Kobayashi et al.   NATURE CELL BIOLOGY

Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis

(2010) D. A. Walsh et al.   RHEUMATOLOGY

Repulsive axon guidance molecule Slit3 is a novel angiogenic factor

(2009) B. Zhang et al.   BLOOD

Engraftment and Reconstitution of Hematopoiesis Is Dependent on VEGFR2-Mediated Regeneration of Sinusoidal Endothelial Cells

(2009) Andrea T. Hooper et al.   Cell Stem Cell

Gene Expression Profiling of Bone Marrow Endothelial Cells in Patients with Multiple Myeloma

(2009) R. Ria et al.   CLINICAL CANCER RESEARCH

The forming limb skeleton serves as a signaling center for limb vasculature patterning via regulation of Vegf

(2009) I. Eshkar-Oren et al.   DEVELOPMENT

Increased skeletal VEGF enhances β-catenin activity and results in excessively ossified bones

(2009) Christa Maes et al.   EMBO JOURNAL

Increased capillary vascularity in the femur of aged rats by exercise training

(2009) Sheepsumon Viboolvorakul et al.   MICROVASCULAR RESEARCH

Effect of age on vascularization during fracture repair

(2008) Chuanyong Lu et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Activation of the hypoxia-inducible factor-1  pathway accelerates bone regeneration

(2008) C. Wan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA