Review
Chemistry, Applied
Amol D. Gholap, Satish Rojekar, Harshad S. Kapare, Nikhar Vishwakarma, Sarjana Raikwar, Atul Garkal, Tejal A. Mehta, Harsh Jadhav, Mahendra Kumar Prajapati, Uday Annapure
Summary: Chitosan, a natural polysaccharide derived from chitin, holds great potential as a biomaterial in various biomedical applications due to its biocompatibility, biodegradability, antibacterial activity, and ease of modification. This review provides an overview of the use of chitosan scaffolds in tissue engineering, regenerative medicine, and drug delivery systems. It highlights the structural and biological properties of chitosan and explores different fabrication methods, such as gelation, electrospinning, and 3D printing. The review emphasizes the role of chitosan scaffolds in promoting cell adhesion, proliferation, and differentiation for tissue regeneration, as well as their potential in wound healing and infection management. Additionally, it discusses the challenges and future objectives in scaffold design, mechanical properties, and understanding interactions with host tissues.
CARBOHYDRATE POLYMERS
(2024)
Review
Engineering, Biomedical
Guanyin Zhu, Tianxu Zhang, Miao Chen, Ke Yao, Xinqi Huang, Bo Zhang, Yazhen Li, Jun Liu, Yunbing Wang, Zhihe Zhao
Summary: Bone-tissue defects are a global issue, with autologous and allogeneic bone grafting failing to achieve ideal therapeutic effects. This has led researchers to explore novel bone-regeneration methods, with the development of BTE scaffolds at the forefront. By delving into bone physiology and healing mechanisms, biomimicking and bioinspired BTE scaffolds are making progress.
BIOACTIVE MATERIALS
(2021)
Editorial Material
Chemistry, Physical
Antonio Boccaccio
Summary: The recent advancements in manufacturing technologies and innovative biocompatible materials have enabled the fabrication of high-performing scaffolds for bone tissue engineering. Researchers worldwide are focused on identifying the optimal material, geometry, and surface properties for scaffolds to stimulate bone formation efficiently.
Review
Biotechnology & Applied Microbiology
Shuai Chen, Carmen J. Gil, Liqun Ning, Linqi Jin, Lilanni Perez, Gabriella Kabboul, Martin L. Tomov, Vahid Serpooshan
Summary: This article discusses the significance of Adhesive Tissue Engineering Scaffolds (ATESs), reviewing their key characteristics and requirements, exploring mechanisms of action for securing the scaffold onto tissue, and presenting strategies for assessing adhesive properties. Current applications and future prospects of advanced ATES systems in regenerative medicine therapies are highlighted, along with key challenges in various fields of tissue engineering.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Zongtai Liu, Jiabo Zhu, Zhuohan Li, Hanyan Liu, Changfeng Fu
Summary: Bones are crucial for motor function and organ support, but bone diseases can be burdensome. Repairing critical-sized bone defects is challenging, and current methods rely on metal implants or bone grafts with limitations such as removal surgeries, limited donor availability, and immune rejection. Tissue engineering and understanding of bone regeneration have led to a focus on promoting endogenous bone self-regeneration using biomaterials. Macrophages play an essential role in bone regeneration, and this review discusses design strategies and therapeutic interventions for biomaterials to regulate macrophage function in all stages of bone regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Bruno Zwingenberger, Corina Vater, Roland L. Bell, Julia Bolte, Elisabeth Mehnert, Ronny Bruenler, Dilbar Aibibu, Stefan Zwingenberger
Summary: The study found that CHS scaffolds exhibited higher osteogenic properties in vitro, but resulted in lower bone-healing outcomes compared to CBA and MCM in vivo. Future improvements on CHS scaffolds are needed for better mechanical stability and osteoconductivity.
Review
Biotechnology & Applied Microbiology
Hengliang Dong, Tongtong Zhu, Mingran Zhang, Dapeng Wang, Xukai Wang, Guanning Huang, Shuaishuai Wang, Minglei Zhang
Summary: Failure to treat osteonecrosis effectively in the early stages can lead to the collapse of the articular surface and result in arthritis. Polymers have shown great potential in osteonecrosis therapy, especially when combined with other substances to meet a broad range of treatment requirements.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Materials Science, Multidisciplinary
Yiyuan Li, Yufeng Meng, Yuning Wang, Yun Wang, Zuolin Wang
Summary: Chitosan is a natural cationic polysaccharide with excellent biological properties and potential applications. Mineralized chitosan scaffolds, as ideal biomaterials for repairing hard tissue defects, have made significant progress in the past decade. This study summarizes the structures, properties, preparation methods, and applications of mineralized chitosan scaffolds, and discusses their defects and possible improvement measures.
Article
Chemistry, Multidisciplinary
Charlotte Garot, Georges Bettega, Catherine Picart
Summary: This paper reviews the state-of-the-art materials and AM techniques used in the fabrication of 3D-printed bone scaffolds in bone tissue engineering. The advantages and drawbacks of these materials and techniques are highlighted, with specific criteria for material selection identified. Different combinations of materials and AM techniques are found to be most relevant for specific clinical applications.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Biotechnology & Applied Microbiology
Mingming Zhang, Yi Li, Taojin Feng, Ran Li, Zhongqi Wang, Licheng Zhang, Pengbin Yin, Peifu Tang
Summary: The treatment of bone defects is challenging, and bone engineering scaffolds and exosomes have shown promise in promoting bone tissue regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Polymer Science
Mohammad Reza Aghazadeh, Sheyda Delfanian, Pouria Aghakhani, Shahin Homaeigohar, Atefeh Alipour, Hosein Shahsavarani
Summary: Natural cellulose, obtained from bacterial and plant-based sources, shows potential as a biomaterial for tissue engineering by mimicking the extracellular matrix. Current research progress suggests that while meeting clinical application criteria is still a challenge, it is not an unachievable goal.
Article
Materials Science, Multidisciplinary
Yuxiao Zhou, Warren Grayson
Summary: This article summarizes the application of 3D printing technology in craniofacial bone reconstruction. Through layer-by-layer manufacturing techniques, patient-specific craniofacial structures can be produced for esthetic purposes and functional restoration. The article also discusses the remaining hurdles and opportunities for growth in this technology.
Review
Biotechnology & Applied Microbiology
Minjee Kang, Chung-Sung Lee, Min Lee
Summary: With population aging and increased life expectancy, Bone Tissue Engineering (BTE) has become a promising approach for bone graft substitutes due to clinical complications with traditional treatments. Significant advancements have been made in developing ideal BTE scaffolds integrated with bioactive molecules, specifically synthetic liposomal vesicles or extracellular vesicles. Liposomes provide sustained release of bioactive molecules, while extracellular vesicles are emerging as an advanced substitute for synthetic nanoparticles and novel cell-free therapy for bone regeneration.
BIOENGINEERING-BASEL
(2021)
Article
Engineering, Biomedical
Yubo Shi, Lei Wang, Liguo Sun, Zhennan Qiu, Xiaoli Qu, Jingyi Dang, Zhao Zhang, Jiankang He, Hongbin Fan
Summary: Melt electrospinning writing (MEW) is a promising 3D printing technology for scaffold fabrication. This study investigated the use of NaOH treatment to enhance the cytocompatibility and osteoinductive properties of polycaprolactone (PCL) scaffolds. The NaOH-treated PCL scaffold exhibited nanopits and nanogrooves on the surface, which increased surface roughness and wettability, leading to improved cell proliferation and adhesion. In vitro experiments demonstrated that the NaOH-treated surface could induce osteogenic differentiation of bone marrow mesenchymal stem cells via the integrin alpha 2/beta 1-PI3K-Akt signaling pathway. Animal studies showed that the NaOH-treated PCL scaffold promoted new bone formation. The study concluded that NaOH treatment is a simple and effective method to enhance the cellular affinity and osteoinductive property of MEW PCL scaffolds.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Review
Biochemistry & Molecular Biology
R. Bharathi, S. Shree Ganesh, G. Harini, Kumari Vatsala, R. Anushikaa, S. Aravind, S. Abinaya, N. Selvamurugan
Summary: The bone tissue engineering approach becomes necessary for treating large bone defects when the tissue damage exceeds the body's inherent regenerative ability. Chitosan is a promising bone scaffold material that supports cell attachment, proliferation, and mineralization of the bone matrix. Smart drug delivery scaffolds based on chitosan have been developed to respond to environmental stimuli and provide localized sustained drug delivery in the area of large bone defects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Engineering, Biomedical
Jie Liao, Shuai Wu, Kun Li, Yubo Fan, Nicholas Dunne, Xiaoming Li
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2019)
Review
Chemistry, Multidisciplinary
Tanya J. Levingstone, Simona Herbaj, John Redmond, Helen O. McCarthy, Nicholas J. Dunne
Article
Engineering, Biomedical
Wei Wang, Zhenbo Wang, Yating Fu, Nicholas Dunne, Chen Liang, Xue Luo, Keda Liu, Xiaoming Li, Xining Pang, Ke Lu
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2020)
Review
Materials Science, Biomaterials
Xuewei Bi, Bo Liu, Zhinan Mao, Cunyang Wang, Nicholas Dunne, Yubo Fan, Xiaoming Li
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Chemistry, Physical
Monika Ziminska, Jordan J. Wilson, Emma McErlean, Nicholas Dunne, Helen O. McCarthy
Article
Materials Science, Biomaterials
Le-Ping Yan, Irene Mencia Castano, Rukmani Sridharan, Domhnall Kelly, Mark Lemoine, Brenton L. Cavanagh, Nicholas J. Dunne, Helen O. McCarthy, Fergal J. O'Brien
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Review
Materials Science, Biomaterials
Adrian D. Juncos Bombin, Nicholas J. Dunne, Helen O. McCarthy
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Michelle O'Doherty, Eoghan J. Mulholland, Philip Chambers, Sreekanth Pentlavalli, Monika Ziminska, Marine J. Chalanqui, Hannah M. Pauly, Binulal N. Sathy, Tammy H. Donahue, Daniel J. Kelly, Nicholas Dunne, Helen O. McCarthy
Article
Chemistry, Multidisciplinary
Eva Paz, Yolanda Ballesteros, Juana Abenojar, Nicholas Dunne, Juan C. del Real
Summary: This study successfully enhanced the dispersion of graphene in polymethyl methacrylate bone cement and improved its mechanical properties through silanisation, with a particularly significant improvement in fatigue performance.
Article
Chemistry, Multidisciplinary
Sara Lopez de Armentia, Juana Abenojar, Yolanda Ballesteros, Juan Carlos del Real, Nicholas Dunne, Eva Paz
Summary: This study investigated the influence of incorporating graphene-based nanomaterials (GBN) and methyl methacrylate (MMA) on the polymerization kinetics of an acrylic photocurable resin. It was found that MMA catalyzed the polymerization reaction and GBN significantly modified the polymerization mechanism. Adjusting the printing parameters is necessary to achieve printability of these nanocomposites.
Article
Biochemistry & Molecular Biology
Federica Banche-Niclot, Ilaria Corvaglia, Caterina Cavalera, Elena Boggio, Casimiro Luca Gigliotti, Umberto Dianzani, Antzela Tzagiollari, Nicholas Dunne, Antonio Manca, Sonia Fiorilli, Chiara Vitale-Brovarone
Summary: This study developed an injectable calcium sulphate-based composite cement for the treatment of vertebral compression fractures. The cement was able to stimulate bone regeneration and inhibit osteoclast bone resorption by incorporating strontium-containing mesoporous glass particles and a recombinant protein. Radiopaque zirconia nanoparticles were also added to visualize the cement injection. The cement showed suitable setting times, comparable compressive strength to human vertebral bodies, and sustained release of biologically active molecules.
Review
Biotechnology & Applied Microbiology
Nikoletta Sargioti, Tanya J. J. Levingstone, Eoin D. D. O'Cearbhaill, Helen O. O. McCarthy, Nicholas J. J. Dunne
Summary: Current procedures for transdermal drug delivery have limitations in administering nucleic acid and small or large drug molecules, and causing pain and stress for needle phobic individuals. The development of a painless micro-sized device for efficient drug delivery is still needed. Recent advances in 3D printing have made it possible to fabricate metallic microneedle arrays, which have the potential to overcome the limitations of traditional systems. This review summarizes the types and modes of drug delivery of microneedles in transdermal drug delivery, discusses their applications in the treatment of diseases, and explores the fabrication techniques and geometrical characteristics of solid metallic microneedles.
BIOENGINEERING-BASEL
(2023)
Review
Biotechnology & Applied Microbiology
Ghayadah Al-Kharusi, Nicholas J. Dunne, Suzanne Little, Tanya J. Levingstone
Summary: Design of Experiments (DoE) methods are commonly used for quantitative data analysis and optimisation, while machine learning (ML) provides greater flexibility in data analysis for various types of data. Research has explored the application of ML in the fields of biomaterials and tissue engineering, particularly in optimizing 3D bioprinting processes.
BIOENGINEERING-BASEL
(2022)
Review
Biotechnology & Applied Microbiology
Antzela Tzagiollari, Helen O. McCarthy, Tanya J. Levingstone, Nicholas J. Dunne
Summary: Bone defects and complex fractures pose challenges for orthopaedic surgeons, as current surgical procedures often lead to poor healing. The development of an injectable, biocompatible, and biodegradable bone adhesive could provide an attractive solution, but such an adhesive that meets clinical requirements has not yet been developed. This systematic review summarizes conventional approaches and recent developments in bone adhesives for orthopaedic applications, highlighting the necessary properties for successful bone repair adhesives.
BIOENGINEERING-BASEL
(2022)
Review
Biotechnology & Applied Microbiology
Sophie McGivern, Halima Boutouil, Ghayadah Al-Kharusi, Suzanne Little, Nicholas J. Dunne, Tanya J. Levingstone
Summary: Cartilage is a avascular tissue with limited self-regeneration capabilities. Current treatments are ineffective in stopping deterioration or reversing effects, making cartilage damage a ongoing challenge in orthopaedics. Recent developments in 3D bioprinting show great potential in cartilage repair applications and offer advantages over conventional techniques.
BIOENGINEERING-BASEL
(2021)
