Article
Oncology
Leisha A. Emens, Sylvia Adams, Ashley Cimino-Mathews, Mary L. Disis, Margaret E. Gatti-Mays, Alice Y. Ho, Kevin Kalinsky, Heather L. McArthur, Elizabeth A. Mittendorf, Rita Nanda, David B. Page, Hope S. Rugo, Krista M. Rubin, Hatem Soliman, Patricia A. Spears, Sara M. Tolaney, Jennifer K. Litton
Summary: In recent years, the use of immune checkpoint inhibitors in combination with chemotherapy for advanced/metastatic TNBC has shown efficacy, leading to FDA approval and expanding treatment options for patients. Questions remain regarding optimal chemotherapy backbone, patient selection, and treatment strategies, highlighting the importance of further research and guidance for healthcare providers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Ann W. Silk, Christopher A. Barker, Shailender Bhatia, Kathryn B. Bollin, Sunandana Chandra, Zeynep Eroglu, Brian R. Gastman, Kari L. Kendra, Harriet Kluger, Evan J. Lipson, Kathleen Madden, David M. Miller, Paul Nghiem, Anna C. Pavlick, Igor Puzanov, Guilherme Rabinowits, Emily S. Ruiz, Vernon K. Sondak, Edward A. Tavss, Michael T. Tetzlaff, Isaac Brownell
Summary: Nonmelanoma skin cancers (NMSCs) are commonly diagnosed malignancies, with some patients facing more challenging treatment. Immune checkpoint inhibitors (ICIs) have shown activity against NMSCs, but their clinical use may be more challenging due to various factors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Ramaswamy Govindan, Charu Aggarwal, Scott J. Antonia, Marianne Davies, Steven M. Dubinett, Andrea Ferris, Patrick M. Forde, Edward B. Garon, Sarah B. Goldberg, Raffit Hassan, Matthew D. Hellmann, Fred R. Hirsch, Melissa L. Johnson, Shakun Malik, Daniel Morgensztern, Joel W. Neal, Jyoti D. Patel, David L. Rimm, Sarah Sagorsky, Lawrence H. Schwartz, Boris Sepesi, Roy S. Herbst
Summary: Immunotherapy has significantly impacted lung cancer care, providing durable responses and extended survival outcomes in various treatment settings. Although challenges remain in therapy selection, biomarker identification, special patient populations, and toxicity management, education and support for patients and caregivers are crucial for maximizing the benefits of immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Tim F. Greten, Ghassan K. Abou-Alfa, Ann-Lii Cheng, Austin G. Duffy, Anthony B. El-Khoueiry, Richard S. Finn, Peter R. Galle, Lipika Goyal, Aiwu Ruth He, Ahmed O. Kaseb, Robin Kate Kelley, Riccardo Lencioni, Amaia Lujambio, Donna Mabry Hrones, David J. Pinato, Bruno Sangro, Roberto Troisi, Andrea Wilson Woods, Thomas Yau, Andrew X. Zhu, Ignacio Melero
Summary: The standard of care for advanced HCC has been transformed by the combination of immunotherapy and anti-VEGF therapy, showing improved overall survival rates. The use of immunotherapy in later stages of treatment has been proven safe and effective, with ongoing research focusing on novel combinations of ICI and TKI for earlier intervention in HCC treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Matthew D. Galsky, Arjun Balar, Peter C. Black, Matthew T. Campbell, Gail S. Dykstra, Petros Grivas, Shilpa Gupta, Christoper J. Hoimes, Lidia P. Lopez, Joshua J. Meeks, Elizabeth R. Plimack, Jonathan E. Rosenberg, Neal Shore, Gary D. Steinberg, Ashish M. Kamat
Summary: Immunotherapies play a significant role in the treatment of urothelial cancer, with a focus on selecting the right agents and treatment scheduling while considering patient management. A panel of experts has developed a clinical practice guideline to provide guidance for healthcare professionals treating patients with urothelial cancer.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Ryan Sun, Zachary McCaw, Lu Tian, Hajime Uno, Fangxin Hong, Dae Hyun Kim, Lee-Jen Wei
Summary: In a comparative oncology study, stratified analyses based on patients' baseline characteristics may not be valid or interpretable, especially in immunotherapy studies. This article presents alternative approaches using data from KEYNOTE-189 trial to address the limitations of conventional stratified analyses.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Julie R. Brahmer, Hamzah Abu-Sbeih, Paolo Antonio Ascierto, Jill Brufsky, Laura C. Cappelli, Frank B. Cortazar, David E. Gerber, Lamya Hamad, Eric Hansen, Douglas B. Johnson, Mario E. Lacouture, Gregory A. Masters, Jarushka Naidoo, Michele Nanni, Miguel-Angel Perales, Igor Puzanov, Bianca D. Santomasso, Satish P. Shanbhag, Rajeev Sharma, Dimitra Skondra, Jeffrey A. Sosman, Michelle Turner, Marc S. Ernstoff
Summary: ICIs are standard treatments for cancer, but come with risks of immune-related adverse events. The SITC convened an expert panel to develop guidelines for managing irAEs, aiming to improve patient outcomes through evidence-based recommendations.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Jarushka Naidoo, Catherine Murphy, Michael B. Atkins, Julie R. Brahmer, Stephane Champiat, David Feltquate, Lee M. Krug, Javid Moslehi, M. Catherine Pietanza, Joanne Riemer, Caroline Robert, Elad Sharon, Maria E. Suarez-Almazor, Karthik Suresh, Michelle Turner, Jeffrey Weber, Laura C. Cappelli
Summary: Immune checkpoint inhibitor (ICI) therapy can lead to immune-related adverse events (irAEs) that vary in their clinical presentation, making it challenging to apply clinical guidelines due to inconsistent terminology. A consensus panel composed of international experts developed clinical definitions for irAE terminology to establish a standardized vocabulary and improve the uniform application of guidelines and future clinical trials.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Michael B. Atkins, Hamzah Abu-Sbeih, Paolo A. Ascierto, Michael R. Bishop, Daniel S. Chen, Madhav Dhodapkar, Leisha A. Emens, Marc S. Ernstoff, Robert L. Ferris, Tim F. Greten, James L. Gulley, Roy S. Herbst, Rachel W. Humphrey, James Larkin, Kim A. Margolin, Luca Mazzarella, Suresh S. Ramalingam, Meredith M. Regan, Brian Rini, Mario Sznol
Summary: The activity of agents blocking PD-(L)1 axis has revolutionized oncology, but not all patients benefit from these therapies. Many drug development programs have combined anti-PD-(L)1 with other therapies, but there is a lack of predictive biomarkers and optimized clinical trial designs.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Thomas A. Odeny, Kathryn Lurain, Julius Strauss, Steven P. Fling, Elad Sharon, Anna Wright, Javier Martinez-Picado, Teresa Moran, James L. Gulley, Maria Gonzalez-Cao, Thomas S. Uldrick, Robert Yarchoan, Ramya Ramaswami
Summary: There was no significant difference in the baseline CD4 counts or the proportions of any TEAE and grade ≥ 3 TEAE between HIV-positive and HIV-negative patients receiving immune checkpoint inhibitor (ICI) treatment. CD4 count thresholds for cancer clinical trials should be carefully reviewed to avoid unnecessarily excluding patients with HIV and cancer.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Endocrinology & Metabolism
Caipeng Qin, Jing Wang, Yiqing Du, Tao Xu
Summary: The study reveals that ADT treatment induces immunosuppression in the tumor microenvironment of prostate cancer, suggesting the potential clinical significance of combining ADT with immunotherapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Paul Johannet, Amelia Sawyers, Nicholas Gulati, Douglas Donnelly, Samuel Kozloff, Yingzhi Qian, Alfredo Floristan, Eva Hernando, Judy Zhong, Iman Osman
Summary: The study found that patients receiving anticoagulation therapy did not experience better treatment outcomes when receiving immune checkpoint inhibitors, and were instead more likely to suffer from major or clinically relevant bleeding complications.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Mehmet Akce, Batoul Farran, Jeffrey M. Switchenko, Manali Rupji, Sandra Kang, Lana Khalil, Amanda Ruggieri-Joyce, Brian Olson, Walid L. Shaib, Christina Wu, Olatunji B. Alese, Maria Diab, Gregory B. Lesinski, Bassel F. El-Rayes
Summary: The combination of nivolumab and metformin did not demonstrate efficacy in patients with MSS CRC. While metformin alone did not show significant immune modulation effects, the dual treatment showed trends in increasing tumor-infiltrating leukocytes and decreasing naive CD8+T cells in patient tissues.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Pasquale Saggese, Cesar A. Martinez, Linh M. Tran, Raymond Lim, Camelia Dumitras, Tristan Grogan, David Elashoff, Salehi-Rad Ramin, Steven M. Dubinett, Bin Liu, Claudio Scafoglio
Summary: Immunotherapy has shown promise in treating lung cancer, but current models have limitations in replicating human cancer biology. Researchers have developed a hybrid model combining genetically engineered mice with carcinogen-induced models to better mimic the complexity of human lung cancer, suitable for pre-clinical immunotherapy studies. Further improvements are needed to enhance the efficacy of immune checkpoint inhibitors for lung cancer treatment.
Article
Oncology
Niklas Kluemper, Jonas Saal, Fiamma Berner, Christa Lichtensteiger, Nina Wyss, Annkristin Heine, Franz Georg Bauernfeind, Joerg Ellinger, Peter Brossart, Stefan Diem, Sabine Schmid, Markus Joerger, Martin Frueh, Manuel Ritter, Michael Hoelzel, Lukas Flatz, Tobias Bald
Summary: Early dynamics of C reactive protein (CRP) can serve as a predictive biomarker for response to anti-PD-1 immune checkpoint blockade (ICB) in non-small cell lung cancer (NSCLC). CRP flare-responders can predict ICB response and survival as early as 4 weeks after therapy initiation. Early CRP kinetics have no predictive value for chemoimmunotherapy or when steroids are administered concurrently.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Toxicology
Nga T. Nguyen, David S. Umbaugh, Giselle Sanchez-Guerrero, Anup Ramachandran, Hartmut Jaeschke
Summary: This study investigates the relationship between resident macrophages (Kupffer cells) and hepatocytes, focusing on the chemokine receptor CXCR2, in facilitating liver repair. Results show that Kupffer cells regulate CXCR2 expression and pro-regenerative gene expression in surviving hepatocytes through production of IL-10. Depletion of Kupffer cells prevents CXCR2 induction on hepatocytes, suggesting a crucial role of Kupffer cells in promoting hepatocyte proliferation.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Environmental Sciences
Ayane Nakamura, Nobutake Nakatani, Fumito Maruyama, So Fujiyoshi, Rodrigo Marquez-Reyes, Ricardo Fernandez, Jun Noda
Summary: This study clarifies the source of PM2.5 in Osorno, Chile by analyzing its chemical composition and comparing it with meteorological conditions. The results indicate that biomass combustion, such as wood burning, is the dominant source of PM2.5. The study also highlights the impact of low temperature, low precipitation, and low wind speed on the formation of a thermal inversion layer.
Article
Public, Environmental & Occupational Health
Carlos Barrera-Avalos, Roberto Luraschi, Claudio Acuna-Castillo, Mabel Vidal, Andrea Mella-Torres, Ailen Inostroza-Molina, Rodrigo Vera, Sergio Vargas, Ivan Hernandez, Christian Perez, Eva Vallejos-Vidal, Daniel Valdes, Monica Imarai, Felipe E. Reyes-Lopez, Ana Maria Sandino
Summary: Vaccine administration is an efficient way to control the COVID-19 pandemic, but the emergence of SARS-CoV-2 variants can evade vaccine-induced immunity. This report provides evidence of clinical symptom differences between vaccinated and unvaccinated patients infected with the VOI B.1.621 (Mu) variant, suggesting the protective effects of CoronaVac against this variant.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Claudio Acuna-Castillo, Mabel Vidal, Ailen Inostroza-Molina, Eva Vallejos-Vidal, Roberto Luraschi, Maximiliano Figueroa, Carlos Barrera-Avalos, Rodrigo Vera, Sergio Vargas, Daniel Valdes, Kevin Maisey, Monica Imarai, Elias Leiva-Salcedo, Alejandro Escobar, Sebastian Reyes-Cerpa, Alexis Gaete, Ricardo Palma-Vejares, Dante Travisany, Leonel E. Rojo, Felipe E. Reyes-Lopez, Ana Maria Sandino
Summary: The identification and tracking of SARS-CoV-2 infected patients are essential for limiting the spread of COVID-19. This study identified a case of reinfection in a homeless person, highlighting the importance of genomic surveillance programs.
JOURNAL OF ENVIRONMENTAL AND PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Roberto Luraschi, Carlos Barrera-Avalos, Eva Vallejos-Vidal, Javiera Alarcon, Andrea Mella-Torres, Felipe Hernandez, Ailen Inostroza-Molina, Daniel Valdes, Monica Imarai, Claudio Acuna-Castillo, Felipe E. Reyes-Lopez, Ana Maria Sandino
Summary: This study analyzes the performance of two commercial RT-qPCR kits used in Chile and finds that the TAAG kit has lower sensitivity, potentially leading to false negatives and local outbreaks of infection.
CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Claudio Acuna-Castillo, Ailen Inostroza-Molina, Sergio A. Castro, Sonia Molina-Cabrera, Elias Leiva-Salcedo, Denise Riquelme, Roberto Luraschi, Carlos Barrera-Avalos, Eva Vallejos-Vidal, Andrea Mella-Torres, Daniel Valdes, Claudio Torres, Kevin Maisey, Alejandro Escobar, Sebastian Reyes-Cerpa, Daniela Toro-Ascuy, Monica Imarai, Felipe E. Reyes-Lopez, Ana Maria Sandino
Summary: This study provides a retrospective and comparative analysis of the behavior during the first and second waves of the COVID-19 pandemic in Chile. The findings suggest a decrease in mortality rate and a shift towards infections in young patients with reduced comorbidities in the second wave. Vaccinated individuals experience shorter duration of symptoms, while patients with more comorbidities are more likely to develop severe illness. This report contributes to our partial understanding of the behavior and critical factors in the severity of the COVID-19 pandemic in the population of Santiago, Chile.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Carlos Barrera-Avalos, Javier Mena, Roberto Luraschi, Patricio Rojas, Carlos Mateluna-Flores, Eva Vallejos-Vidal, Monica Imarai, Ana Maria Sandino, Daniel Valdes, Rodrigo Vera, Ivan Hernandez, Felipe E. Reyes-Lopez, Claudio Acuna-Castillo
Summary: The COVID-19 pandemic is still a global concern, and rapid antigen tests (RATs) have been widely used to increase the efficiency of testing. This study evaluates the sensitivity of different RATs in detecting the Omicron variant, highlighting the importance of considering viral load and limiting the use of RATs as an active search method.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Virology
Linmar Rodriguez-Guilarte, Mario A. Ramirez, Catalina A. Andrade, Alexis M. Kalergis
Summary: LAG-3 is an inhibitory receptor expressed on immune cells, which regulates T cell activation and effector functions in the immune response. Immunotherapies targeting immune checkpoints, including LAG-3, have shown promise in controlling malignant tumors and chronic viral diseases.
Article
Toxicology
Nga T. Nguyen, David S. Umbaugh, Sawyer Smith, Olamide B. Adelusi, Giselle Sanchez-Guerrero, Anup Ramachandran, Hartmut Jaeschke
Summary: Acetaminophen (APAP) overdose is a major cause of acute liver failure, and the role of neutrophils in APAP-induced liver injury is controversial. This study found that neutrophils, recruited through the neutrophil chemoattractant Cxcl2, have no effect on liver injury after a low dose of APAP (300 mg/kg), but aggravate the injury after a high dose (600 mg/kg). Treating mice with an anti-Cxcl2 antibody reduced neutrophil accumulation and liver injury. These findings suggest that neutrophils play a role in APAP-induced liver injury only at severe overdoses.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Eduardo I. Tognarelli, Luisa F. Duarte, Monica A. Farias, Felipe A. Cancino, Nicolas Corrales, Francisco J. Ibanez, Claudia A. Riedel, Susan M. Bueno, Alexis M. Kalergis, Pablo A. Gonzalez
Summary: Stimulating HO-1 expression in HSV-infected dendritic cells can promote cell viability and inhibit viral egress. It also promotes the expression of anti-inflammatory molecules and activation of virus-specific CD4(+) T cells. Transferring HSV-infected dendritic cells with induced HO-1 expression can enhance virus-specific T cell activation and improve the outcome of HSV-1 skin infection.
Article
Biotechnology & Applied Microbiology
Daniela Carrillo, Natalie Edwards, David Arancibia-Altamirano, Fabiola Otarola, Cynthia Villarroel, Catalina P. Prieto, Maria Gabriela Villamizar-Sarmiento, Daniela Sauma, Fernando Valenzuela, Jose Lattus, Felipe Oyarzun-Ampuero, Veronica Palma
Summary: This study evaluated the effect of Wharton's gelatin MSC secretome (hWJCM) in a psoriasiform-like dermatitis (PD) mouse model and found that hWJCM significantly improved the PD phenotype and reduced aberrant angiogenesis and discomfort. The topical application of HA hWJCM may be an effective noninvasive therapeutic solution for psoriasis and other skin diseases.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Sebastian Mondaca, Benjamin Walbaum, Nicole Le Corre, Marcela Ferres, Alejandro Valdes, Constanza Martinez-Valdebenito, Cinthya Ruiz-Tagle, Patricia Macanas-Pirard, Patricio Ross, Betzabe Cisternas, Patricia Perez, Olivia Cabrera, Valentina Cerda, Ivana Ormazabal, Aldo Barrera, Maria E. Prado, Maria I. Venegas, Silvia Palma, Richard Broekhuizen, Alexis M. Kalergis, Susan M. Bueno, Manuel A. Espinoza, M. Elvira Balcells, Bruno Nervi
Summary: Cancer patients receiving chemotherapy treatment have a lower immune response to SARS-CoV-2 vaccines. Our study demonstrated that booster vaccines elicit strong humoral and cellular responses among cancer patients receiving chemotherapy, regardless of the type of vaccine used as a priming dose. The homologous vaccine regimen was associated with higher neutralizing antibody positivity and total antibody levels.
Review
Microbiology
Xanthippi Topalidou, Alexis M. Kalergis, Georgios Papazisis
Summary: RSV is a significant cause of morbidity and mortality in young children and older adults. The development of RSV vaccines is guided by epidemiologic and pathophysiological evidence, using various vaccine technologies. Currently, there are 24 vaccines in clinical development, including two licensed vaccines.
Article
Public, Environmental & Occupational Health
Claudio Acuna-Castillo, Carlos Barrera-Avalos, Vivienne C. Bachelet, Luis A. Milla, Ailen Inostroza-Molina, Mabel Vidal, Roberto Luraschi, Eva Vallejos-Vidal, Andrea Mella-Torres, Daniel Valdes, Felipe E. E. Reyes-Lopez, Monica Imarai, Patricio Rojas, Ana Maria Sandino
Summary: This study reveals that the Omicron variant is responsible for the highest number of reinfection cases in Chile, highlighting its potential for immune evasion. This important epidemiological information contributes to the development and implementation of effective public health policies.
FRONTIERS IN PUBLIC HEALTH
(2023)