Article
Pharmacology & Pharmacy
Shu-Yue Qu, Xiao-Yue Li, Xia Heng, Yi-Yu Qi, Ping-Yuan Ge, Sai-jia Ni, Zeng-Ying Yao, Rui Guo, Nian-Yun Yang, Yi Cao, Qi-Chun Zhang, Hua-Xu Zhu
Summary: Depressive disorder is a prevalent mental disorder characterized by depressed mood and lack of interest or pleasure. Herbal medicine, such as Huang-lian Jie-du Decoction (HLJDD), has been explored as a complementary therapy for depression. This study demonstrates that HLJDD exhibits antidepressant effects by modulating tryptophan metabolism, serotonergic and dopaminergic synaptic activities, cAMP signaling pathway, and calcium signaling pathway, suggesting potential targets for its antidepressant action.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Chenlu Li, Jingjing Pan, Chang Xu, Zhenlin Jin, Xupeng Chen
Summary: This study preliminarily analyzed the potential mechanism of Huang-Lian-Jie-Du decoction (HLJDD) in treating rheumatoid arthritis (RA) using network pharmacology and molecular docking. The results showed that the key ingredients of HLJDD may play a role in treating RA by inhibiting the immune-inflammatory response, reducing the release of chemokines, and alleviating the destruction of the extracellular matrix (ECM).
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Li Li, Weixing Dai, Wenting Li, Yumao Zhang, Yanqin Wu, Chenfeng Guan, Anye Zhang, Hui Huang, Yuzhen Li
Summary: By integrating network pharmacology, pharmacodynamics, and metabonomics, the study explored the molecular mechanism and potential targets of Huang-Lian-Jie-Du-Tang in the treatment of myocardial ischemia. The in vivo efficacy of the traditional Chinese prescription was validated in a rat model, demonstrating a myocardial protection effect through a multicomponent-multitarget mode. The study emphasizes the reliability and effectiveness of a network pharmacology-based approach for identifying and validating natural compound complexes in Huang-Lian-Jie-Du-Tang for treating myocardial ischemia.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Tang Dan, He Wen-Jiao, Zhang Zhi-Tong, Shi Jing-Jing, Wang Xue, Gu Wen-Ting, Chen Zhi-Quan, Xu You-Hua, Chen Yun-Bo, Wang Shu-Mei
Summary: This study revealed the potential mechanism and nephroprotective effects of Huang-Lian-Jie-Du Decoction (HLJDD) against diabetic nephropathy through a comprehensive approach of network pharmacology, pharmacodynamics, molecular biology, and metabolomics. The findings suggest that HLJDD ameliorates diabetic nephropathy by regulating the AGEs/RAGE/Akt/Nrf2 pathway and metabolic profiling.
Article
Plant Sciences
Jia-Yi Zheng, Xiao-Xiao Li, Wei-Yao Lin, Shan Su, Hai-Cui Wu, Rui-Dan Hu, Hua-Feng Pan, Jiang-Hong Ye, Ye-Feng Cai, Shi-Jie Zhang
Summary: This study aimed to investigate the effect and underlying mechanism of Huang-Lian-Jie-Du decoction (HLJD) on colitis-induced depression. The results showed that HLJD alleviated depressive-like behaviors in colitis mice by inhibiting the Trem2/Dap12 pathway in microglia of the lateral habenula (LHb).
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Mei-Yi Lin, Lih-Geeng Chen, Ying-Yu Siao, Tao-Hsuan Lin, I-An Huang, Yi-Wen Liu, Chin-Chin Huang
Summary: The study found that the modified Huang-Lian-Jie-Du (mHLJD) decoction effectively alleviated skin toxicity caused by epidermal growth factor receptor inhibitors (EGFRIs) and tyrosine kinase inhibitors (TKIs). The mHLJD decoction primarily consisted of geniposide, berberine chloride, baicalin, coptisine, and palmatine. The extract of the mHLJD decoction showed anti-inflammatory effects by reducing cytokine expression, and exhibited antibacterial effects against Staphylococcus aureus.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Plant Sciences
Ruimin Tian, Xianfeng Liu, Lijia Jing, Lu Yang, Na Xie, Ya Hou, Honglin Tao, Yiwen Tao, Jiasi Wu, Xianli Meng
Summary: Huang-Lian-Jie-Du decoction (HLJDD) has neuroprotective effects in rats with type 2 diabetes, exerted through the modulation of glucose and lipid metabolism, upregulation of autophagy, and inhibition of NLRP3 inflammasome signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Physical
Yanjiao Qi, Hong Zhang, Dongmei Wang, Gongtao Ding, Zhongren Ma, Xueyan Zhou, Xingping Luo, Nengzhi Jin, Mingyang Wang, Huining Lu
Summary: The Traditional Chinese Prescription HLJDD has an inhibitory effect on the phytopathogenic bacteria P. carotovorum PC1 by changing the intracellular membrane permeability and damaging the cell wall. The main ingredients like berberine show relatively low MIC values compared to the positive control. Molecular docking suggests that electrostatic, hydrophobic, and van der Waals interactions play a significant role in the active site.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Review
Pharmacology & Pharmacy
Zhipeng Hu, Maoyi Yang, Ya Liu, Qiyue Yang, Hongyan Xie, Sihan Peng, Juan Gao, Chunguang Xie
Summary: This study summarized the clinical evidence of HLJDD for T2DM, showing that combination treatment of HLJDD and metformin may improve some indicators, but evidence comparing HLJDD and metformin or no intervention or placebo was insufficient and of low quality. More high-quality studies are needed to firmly establish the clinical efficacy and safety of HLJJD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Wang Liu, Yu Zeng, Yanda Li, Nanhong Li, Min Peng, Junfen Cheng, Binbin Tian, Mingdi Chen
Summary: This study utilized network pharmacology to explore the potential targets and signaling pathways of Huang Lian Jie Du decoction (HLJDD) during the treatment of COVID-19, providing a basis for the research and development of drugs for COVID-19 treatment.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Plant Sciences
Lan Wang, Zhen Hu, Wen Yang, Steven King Fan Loo, Siu Po Ip, Yan-Fang Xian, Zhi Xiu Lin
Summary: This study developed a modified Huang-Lian-Jie-Du Decoction (MHLJDD) and demonstrated its potential efficacy in treating atopic dermatitis (AD) using mouse models. MHLJDD improved AD-like symptoms, including skin thickening, dryness, and inflammation, and regulated gut microbiota.
Article
Engineering, Chemical
Ming-Yang Lee, Mei-Yi Lin, Yu-Ju Chang, Yu-Ting Tseng, I-An Huang, Wan-Ting Huang, Yi-Wen Liu
Summary: The modified Huang-Lian-Jie-Du decoction cream provides benefits for alleviation of EGFRIs/TKIs-induced skin rash acneiform and dry skin, with no obvious side effects found in patients using it.
Article
Medicine, Research & Experimental
I-Jung Lee, Che-Yi Chao, Ying-Chen Yang, Jing-Jy Cheng, Chuen-Lin Huang, Chun-Tang Chiou, Hung-Tse Huang, Yao-Haur Kuo, Nai-Kuei Huang
Summary: Huang Lian Jie Du Tang is used to treat Parkinson's disease and this study found that it can mitigate paraquat-induced cell death by regulating mitophagy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemical Research Methods
Zhi-Tong Zhang, Guang-Xiao Huang, Wen-Jiao He, Wen-Ting Gu, Xue Wang, Zhi-Quan Chen, Fu-Jun Bi, Lu-Yong Zhang, Shu-Mei Wang, Dan Tang
Summary: This study demonstrated that Huang-Lian-Jie-Du Decoction contains bioactive compounds that exhibit binding affinity to PC12 cells and exert cytoprotective effects by inhibiting oxidative stress and cell apoptosis, suggesting their potential for the treatment of neurodegenerative diseases. The use of live cell biospecific extraction coupled with LC-HRMS/MS technique is an efficient method for rapid screening potential bioactive components in traditional Chinese medicines.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Physiology
Yinhe Cai, Junmao Wen, Siwen Ma, Zhexing Mai, Qunzhang Zhan, Yijun Wang, Yueyao Zhang, He Chen, Haiyi Li, Wei Wu, Rong Li, Chuanjin Luo
Summary: Huang-Lian-Jie-Du Decoction attenuates atherosclerosis and promotes plaque stability by suppressing M1 polarization and enhancing M2 polarization.
FRONTIERS IN PHYSIOLOGY
(2021)