Voltage-Gated Calcium Channels and α-Synuclein: Implications in Parkinson’s Disease

How is alpha‐synuclein cleared from the cell?

(2019) Leonidas Stefanis et al.   JOURNAL OF NEUROCHEMISTRY

Mechanistic insights into the SNARE complex disassembly

(2019) Xuan Huang et al.   Science Advances

Alpha‐synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation

(2018) Cristine Betzer et al.   EMBO REPORTS

Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress

(2018) Jaime N. Guzman et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellular α-synuclein levels are regulated by neuronal activity

(2018) Kaoru Yamada et al.   Molecular Neurodegeneration

Internalization, axonal transport and release of fibrillar forms of alpha-synuclein

(2018) Gregor Bieri et al.   NEUROBIOLOGY OF DISEASE

C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction

(2018) Janin Lautenschläger et al.   Nature Communications

Molecular Role of Ca2+ and Hard Divalent Metal Cations on Accelerated Fibrillation and Interfibrillar Aggregation of α-Synuclein

(2018) Jong Yoon Han et al.   Scientific Reports

Release and uptake mechanisms of vesicular Ca2+ stores

(2018) Junsheng Yang et al.   Protein & Cell

Recruitment of calbindin into nigral dopamine neurons protects against MPTP-Induced parkinsonism

(2018) Ken-ichi Inoue et al.   MOVEMENT DISORDERS

T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease

(2018) Yoshikuni Tabata et al.   Stem Cell Reports

Lower Affinity of Isradipine for L-Type Ca 2+ Channels during Substantia Nigra Dopamine Neuron-Like Activity: Implications for Neuroprotection in Parkinson's Disease

(2017) Nadine J. Ortner et al.   JOURNAL OF NEUROSCIENCE

The Synucleinopathies: Twenty Years On

(2017) Michel Goedert et al.   Journal of Parkinsons Disease

A novel design of a Phase III trial of isradipine in early Parkinson disease (STEADY-PD III)

(2017) Kevin M. Biglan et al.   Annals of Clinical and Translational Neurology

GABA transmission via ATP-dependent K+channels regulates α-synuclein secretion in mouse striatum

(2016) Evangelia Emmanouilidou et al.   BRAIN

Ca2+is a key factor in α-synuclein-induced neurotoxicity

(2016) Plamena R. Angelova et al.   JOURNAL OF CELL SCIENCE

Alpha-synuclein aggregates are excluded from calbindin-D28k-positive neurons in dementia with Lewy bodies and a unilateral rotenone mouse model

(2016) Alexandre N. Rcom-H'cheo-Gauthier et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Synaptic failure and α-synuclein

(2016) Laura Calo et al.   MOVEMENT DISORDERS

Targeting voltage-gated calcium channels in neurological and psychiatric diseases

(2015) Gerald W. Zamponi   NATURE REVIEWS DRUG DISCOVERY

Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice

(2014) Meike Diepenbroek et al.   HUMAN MOLECULAR GENETICS

Exogenous  -Synuclein Decreases Raft Partitioning of Cav2.2 Channels Inducing Dopamine Release

(2014) G. Ronzitti et al.   JOURNAL OF NEUROSCIENCE

The T-type calcium channel as a new therapeutic target for Parkinson’s disease

(2014) Ya-Chin Yang et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

T-type calcium channel blockers as neuroprotective agents

(2014) Benjamin J. Kopecky et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Parkinson’s disease is associated with altered expression of CaV1 channels and calcium-binding proteins

(2013) Michael J. Hurley et al.   BRAIN

The Changing Landscape of Voltage-Gated Calcium Channels in Neurovascular Disorders and in Neurodegenerative Diseases

(2013) Mauro Cataldi   Current Neuropharmacology

Deregulation of calcium homeostasis mediates secreted α–synuclein-induced neurotoxicity

(2013) Katerina Melachroinou et al.   NEUROBIOLOGY OF AGING

Physiological Phenotype and Vulnerability in Parkinson's Disease

(2013) D. J. Surmeier et al.   Cold Spring Harbor Perspectives in Medicine

The genetics and neuropathology of Parkinson’s disease

(2012) Henry Houlden et al.   ACTA NEUROPATHOLOGICA

Use of Calcium Channel Blockers and Parkinson’s Disease

(2012) Björn Pasternak et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Calcium entry induces mitochondrial oxidant stress in vagal neurons at risk in Parkinson's disease

(2012) Joshua A Goldberg et al.   NATURE NEUROSCIENCE

Potassium Depolarization and Raised Calcium Induces α-Synuclein Aggregates

(2012) Jordan Follett et al.   NEUROTOXICITY RESEARCH

Modulation of subthalamic T-type Ca2+ channels remedies locomotor deficits in a rat model of Parkinson disease

(2011) Chun-Hwei Tai et al.   JOURNAL OF CLINICAL INVESTIGATION

The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease

(2011) E. Ilijic et al.   NEUROBIOLOGY OF DISEASE

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Raised calcium promotes α-synuclein aggregate formation

(2010) S. Nath et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

(2010) Jaime N. Guzman et al.   NATURE

L-type calcium channel blockers and Parkinson's disease in Denmark

(2009) Beate Ritz et al.   ANNALS OF NEUROLOGY

Endogenous Calcium Buffering Capacity of Substantia Nigral Dopamine Neurons

(2009) R. C. Foehring et al.   JOURNAL OF NEUROPHYSIOLOGY

Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons

(2009) Eugene V. Mosharov et al.   NEURON

A critical reappraisal of current staging of Lewy-related pathology in human brain

(2008) Kurt A. Jellinger   ACTA NEUROPATHOLOGICA