HSC70 expression is reduced in lymphomonocytes of sporadic ALS patients and contributes to TDP-43 accumulation

Lymphoblastoid cell lines as a model to understand amyotrophic lateral sclerosis disease mechanisms

(2018) Orietta Pansarasa et al.   Disease Models & Mechanisms

Analysis of HSPA8 and HSPA9 mRNA Expression and Promoter Methylation in the Brain and Blood of Alzheimer's Disease Patients

(2018) Patricia Natalia Silva et al.   JOURNAL OF ALZHEIMERS DISEASE

Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS

(2017) Alyssa N. Coyne et al.   Cell Reports

The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases

(2017) Paola Rusmini et al.   Frontiers in Molecular Neuroscience

The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity

(2016) Valeria Crippa et al.   HUMAN MOLECULAR GENETICS

MEF2D and MEF2C pathways disruption in sporadic and familial ALS patients

(2016) Alessandro Arosio et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Monocytes of patients with amyotrophic lateral sclerosis linked to gene mutations display altered TDP-43 subcellular distribution

(2016) G. De Marco et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Rotenone down-regulates HSPA8/hsc70 chaperone protein in vitro : A new possible toxic mechanism contributing to Parkinson’s disease

(2016) Gessica Sala et al.   NEUROTOXICOLOGY

Role of autophagy in the pathogenesis of amyotrophic lateral sclerosis

(2015) Jae Keun Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A central role for HSC70 in regulating antigen trafficking and MHC class II presentation

(2015) Sarah N. Deffit et al.   MOLECULAR IMMUNOLOGY

Metabolism and mis-metabolism of the neuropathological signature protein TDP-43

(2014) C.-C. Huang et al.   JOURNAL OF CELL SCIENCE

Reduced expression of the chaperone-mediated autophagy carrier hsc70 protein in lymphomonocytes of patients with Parkinson's disease

(2013) Gessica Sala et al.   BRAIN RESEARCH

Altered Intracellular Localization of SOD1 in Leukocytes from Patients with Sporadic Amyotrophic Lateral Sclerosis

(2013) Cristina Cereda et al.   PLoS One

Exploring limits of neuropsychological screening in ALS: The FAB problem

(2013) Lucio Tremolizzo et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Autoregulation of TDP-43 mRNA levels involves interplay between transcription, splicing, and alternative polyA site selection

(2012) S. E. Avendano-Vazquez et al.   GENES & DEVELOPMENT

Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

(2012) I.-F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins

(2011) Martin Gamerdinger et al.   EMBO REPORTS

The Hsc/Hsp70 Co-Chaperone Network Controls Antigen Aggregation and Presentation during Maturation of Professional Antigen Presenting Cells

(2011) Nadja Kettern et al.   PLoS One

Amyotrophic Lateral Sclerosis Multiprotein Biomarkers in Peripheral Blood Mononuclear Cells

(2011) Giovanni Nardo et al.   PLoS One

Dysfunction of constitutive and inducible ubiquitin-proteasome system in amyotrophic lateral sclerosis: Implication for protein aggregation and immune response

(2011) Caterina Bendotti et al.   PROGRESS IN NEUROBIOLOGY

Cytoplasmic accumulation of TDP-43 in circulating lymphomonocytes of ALS patients with and without TARDBP mutations

(2010) Giovanni De Marco et al.   ACTA NEUROPATHOLOGICA

Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains

(2010) Lydia Alvarez-Erviti et al.   ARCHIVES OF NEUROLOGY

TDP-43 regulates its mRNA levels through a negative feedback loop

(2010) Youhna M Ayala et al.   EMBO JOURNAL

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)

(2010) Valeria Crippa et al.   HUMAN MOLECULAR GENETICS

Vesicular monoamine transporter 2 mRNA levels are reduced in platelets from patients with Parkinson’s disease

(2010) Gessica Sala et al.   JOURNAL OF NEURAL TRANSMISSION

Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system

(2009) Xiaoju Wang et al.   NEUROSCIENCE LETTERS

Regulation of Neuronal Survival Factor MEF2D by Chaperone-Mediated Autophagy

(2009) Q. Yang et al.   SCIENCE

Potentiation of Amyotrophic Lateral Sclerosis (ALS)-associated TDP-43 Aggregation by the Proteasome-targeting Factor, Ubiquilin 1

(2008) Sang Hwa Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY