The S phase checkpoint promotes the Smc5/6 complex dependent SUMOylation of Pol2, the catalytic subunit of DNA polymerase ε

Site-specific ubiquitylation and SUMOylation using genetic-code expansion and sortase

(2019) Maximilian Fottner et al.   Nature Chemical Biology

Structural evidence for an essential Fe–S cluster in the catalytic core domain of DNA polymerase ϵ

(2019) Josy ter Beek et al.   NUCLEIC ACIDS RESEARCH

DNA activates the Nse2/Mms21 SUMO E3 ligase in the Smc5/6 complex

(2018) Nathalia Varejão et al.   EMBO JOURNAL

Structural Basis for the Recruitment of Ctf18-RFC to the Replisome

(2018) Daniel B. Grabarczyk et al.   STRUCTURE

Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place

(2018) Panagiotis Kotsantis et al.   Cancer Discovery

Mrc1 and Rad9 cooperate to regulate initiation and elongation of DNA replication in response to DNA damage

(2018) Julien Bacal et al.   EMBO JOURNAL

SUMO-Mediated Regulation of Nuclear Functions and Signaling Processes

(2018) Xiaolan Zhao   MOLECULAR CELL

Helicase Subunit Cdc45 Targets the Checkpoint Kinase Rad53 to Both Replication Initiation and Elongation Complexes after Fork Stalling

(2018) Geylani Can et al.   MOLECULAR CELL

Checkpoint Kinase Rad53 Couples Leading- and Lagging-Strand DNA Synthesis under Replication Stress

(2017) Haiyun Gan et al.   MOLECULAR CELL

How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication

(2017) Joseph T.P. Yeeles et al.   MOLECULAR CELL

CMG–Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome

(2017) Jin Chuan Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomics Reveals Global Regulation of Protein SUMOylation by ATM and ATR Kinases during Replication Stress

(2017) Stephanie Munk et al.   Cell Reports

PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL

(2016) Chihiro Horigome et al.   GENES & DEVELOPMENT

Sgs1's roles in DNA end resection, HJ dissolution, and crossover suppression require a two-step SUMO regulation dependent on Smc5/6

(2016) Marcelino Bermúdez-López et al.   GENES & DEVELOPMENT

Conserved interaction of Ctf18-RFC with DNA polymerase ε is critical for maintenance of genome stability inSaccharomyces cerevisiae

(2016) Hiroko Okimoto et al.   GENES TO CELLS

Chromosome Duplication in Saccharomyces cerevisiae

(2016) S. P. Bell et al.   GENETICS

Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase

(2016) Fabrizio Villa et al.   MOLECULAR CELL

A comprehensive compilation of SUMO proteomics

(2016) Ivo A. Hendriks et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A new MCM modification cycle regulates DNA replication initiation

(2016) Lei Wei et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks

(2016) Chunshui Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new MCM modification cycle regulates DNA replication initiation

(2016) Lei Wei et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates

(2016) Jaclyn N. Bonner et al.   Cell Reports

JASSA: a comprehensive tool for prediction of SUMOylation sites and SIMs

(2015) Guillaume Beauclair et al.   BIOINFORMATICS

Mec1-dependent phosphorylation of Mms21 modulates its SUMO ligase activity

(2015) Kristian K. Carlborg et al.   DNA REPAIR

NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity

(2015) A. Jacome et al.   EMBO JOURNAL

The SUMO (Small Ubiquitin-like Modifier) Ligase PIAS3 Primes ATR for Checkpoint Activation

(2015) Ching-Shyi Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage

(2015) Ian Gibbs-Seymour et al.   MOLECULAR CELL

Rtt107 Is a Multi-functional Scaffold Supporting Replication Progression with Partner SUMO and Ubiquitin Ligases

(2015) Lisa E. Hang et al.   MOLECULAR CELL

Essential Roles of the Smc5/6 Complex in Replication through Natural Pausing Sites and Endogenous DNA Damage Tolerance

(2015) Demis Menolfi et al.   MOLECULAR CELL

Heterochromatic breaks move to the nuclear periphery to continue recombinational repair

(2015) Taehyun Ryu et al.   NATURE CELL BIOLOGY

A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1

(2015) Luis J. García-Rodríguez et al.   NUCLEIC ACIDS RESEARCH

Cross-Talk between Carbon Metabolism and the DNA Damage Response in S. cerevisiae

(2015) Kobi J. Simpson-Lavy et al.   Cell Reports

SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway

(2014) C.-S. Wu et al.   GENES & DEVELOPMENT

Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex

(2014) S.-i. Hiraga et al.   GENES & DEVELOPMENT

A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome

(2014) Aline C. Simon et al.   NATURE

Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication

(2014) Marija Maric et al.   SCIENCE

Rif1 Controls DNA Replication Timing in Yeast through the PP1 Phosphatase Glc7

(2014) Stefano Mattarocci et al.   Cell Reports

The Chromosomal Association of the Smc5/6 Complex Depends on Cohesion and Predicts the Level of Sister Chromatid Entanglement

(2014) Kristian Jeppsson et al.   PLoS Genetics

Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51–Rad52 interaction

(2013) Steven Bergink et al.   NATURE CELL BIOLOGY

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation

(2013) Danielle L Swaney et al.   NATURE METHODS

Structural basis for processive DNA synthesis by yeast DNA polymerase ɛ

(2013) Matthew Hogg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distinct SUMO Ligases Cooperate with Esc2 and Slx5 to Suppress Duplication-Mediated Genome Rearrangements

(2013) Claudio P. Albuquerque et al.   PLoS Genetics

Protein Group Modification and Synergy in the SUMO Pathway as Exemplified in DNA Repair

(2012) Ivan Psakhye et al.   CELL

SUMOylation of the α-Kleisin Subunit of Cohesin Is Required for DNA Damage-Induced Cohesion

(2012) Alexandra McAleenan et al.   CURRENT BIOLOGY

Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl

(2012) N. Wu et al.   GENES & DEVELOPMENT

During Replication Stress, Non-Smc Element 5 (Nse5) Is Required for Smc5/6 Protein Complex Functionality at Stalled Forks

(2012) Denise E. Bustard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cohesin Association to Replication Sites Depends on Rad50 and Promotes Fork Restart

(2012) Mireille Tittel-Elmer et al.   MOLECULAR CELL

Replisome Stability at Defective DNA Replication Forks Is Independent of S Phase Checkpoint Kinases

(2012) Giacomo De Piccoli et al.   MOLECULAR CELL

Extensive DNA Damage-Induced Sumoylation Contributes to Replication and Repair and Acts in Addition to the Mec1 Checkpoint

(2012) Catherine A. Cremona et al.   MOLECULAR CELL

DNA-repair scaffolds dampen checkpoint signalling by counteracting the adaptor Rad9

(2012) Patrice Y. Ohouo et al.   NATURE

Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2

(2012) Anthony A. Armstrong et al.   NATURE

Eukaryotic Origin-Dependent DNA Replication In Vitro Reveals Sequential Action of DDK and S-CDK Kinases

(2011) Ryan C. Heller et al.   CELL

Origin Association of Sld3, Sld7, and Cdc45 Proteins Is a Key Step for Determination of Origin-Firing Timing

(2011) Seiji Tanaka et al.   CURRENT BIOLOGY

Quantitative Proteomic Analysis of Chromatin Reveals that Ctf18 Acts in the DNA Replication Checkpoint

(2011) Takashi Kubota et al.   MOLECULAR & CELLULAR PROTEOMICS

DNA Repair and Global Sumoylation Are Regulated by Distinct Ubc9 Noncovalent Complexes

(2011) J. Prudden et al.   MOLECULAR AND CELLULAR BIOLOGY

Chromosome length influences replication-induced topological stress

(2011) Andreas Kegel et al.   NATURE

Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes

(2011) Daili J A Netz et al.   Nature Chemical Biology

Surviving chromosome replication: the many roles of the S-phase checkpoint pathway

(2011) K. Labib et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The RAD6 DNA Damage Tolerance Pathway Operates Uncoupled from the Replication Fork and Is Functional Beyond S Phase

(2010) Georgios I. Karras et al.   CELL

A Proteome-wide Analysis of Kinase-Substrate Network in the DNA Damage Response

(2010) Sheng-hong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mec1 Is One of Multiple Kinases that Prime the Mcm2-7 Helicase for Phosphorylation by Cdc7

(2010) John C.W. Randell et al.   MOLECULAR CELL

GINS motion reveals replication fork progression is remarkably uniform throughout the yeast genome

(2010) Matthew D Sekedat et al.   Molecular Systems Biology

Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation

(2010) Philip Zegerman et al.   NATURE

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

(2010) Jaclyn R. Gareau et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Analysis of replication profiles reveals key role of RFC-Ctf18 in yeast replication stress response

(2010) Laure Crabbé et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase α within the eukaryotic replisome

(2009) Agnieszka Gambus et al.   EMBO JOURNAL

Differential regulation of homologous recombination at DNA breaks and replication forks by the Mrc1 branch of the S-phase checkpoint

(2009) Constance Alabert et al.   EMBO JOURNAL

Csm3, Tof1, and Mrc1 Form a Heterotrimeric Mediator Complex That Associates with DNA Replication Forks

(2009) Masashige Bando et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Saccharomyces cerevisiae Esc2 and Smc5-6 Proteins Promote Sister Chromatid Junction-mediated Intra-S Repair

(2009) Julie Sollier et al.   MOLECULAR BIOLOGY OF THE CELL

Global Map of SUMO Function Revealed by Protein-Protein Interaction and Genetic Networks

(2009) Taras Makhnevych et al.   MOLECULAR CELL

An auxin-based degron system for the rapid depletion of proteins in nonplant cells

(2009) Kohei Nishimura et al.   NATURE METHODS

Rad53 regulates replication fork restart after DNA damage in Saccharomyces cerevisiae

(2008) S. J. Szyjka et al.   GENES & DEVELOPMENT

A Multidimensional Chromatography Technology for In-depth Phosphoproteome Analysis

(2008) Claudio P. Albuquerque et al.   MOLECULAR & CELLULAR PROTEOMICS