Article
Materials Science, Multidisciplinary
Pooyan Makvandi, Rezvan Jamaledin, Guojun Chen, Zahra Baghbantaraghdari, Ehsan Nazarzadeh Zare, Concetta Di Natale, Valentina Onesto, Raffaele Vecchione, Jesse Lee, Franklin R. Tay, Paolo Netti, Virgilio Mattoli, Ana Jaklenec, Zhen Gu, Robert Langer
Summary: Microneedle (MN) patches, made up of miniature needles, have emerged as a promising tool for minimally invasive translocation of biomolecules into the dermis. Stimuli-responsive MN patches are a new drug delivery system that can release cargos in response to internal or external triggers, with various mechanisms of action for different indications. Future opportunities and challenges in clinical translation are also discussed.
Review
Chemistry, Multidisciplinary
Weiqi Cai, Tianli Luo, Lanqun Mao, Ming Wang
Summary: Recent innovations in genome editing have led to precise manipulation of genetic information in mammals using stimuli-responsive nanoparticles for the delivery and release of CRISPR/Cas9 genome editing machinery. These approaches can utilize biological signals or external signals to achieve improved genome editing outcomes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Zhichu Xiang, Mouquan Liu, Jun Song
Summary: Biocompatible nanosystems based on polymeric materials show promise as drug delivery nanocarriers for antitumor therapy, but their efficacy is hindered by nonspecific accumulation and drug release in normal tissues. Stimuli-responsive nanosystems triggered by tumor-specific stimuli have recently garnered interest for their controllable drug release properties. This review discusses various polymers and external stimuli for developing stimuli-responsive polymeric nanosystems, and outlines the challenges in designing such Nanomedicine to enhance therapeutic efficacy.
APPLIED SCIENCES-BASEL
(2021)
Review
Chemistry, Multidisciplinary
Yuzhe Sun, Edward Davis
Summary: The translation mentioned that achieving the promise of stimuli-responsive drug delivery systems for cancer treatment involves challenges like avoiding premature clearance, accumulating in tumors, and exhibiting appropriate payload release. However, the expanding toolbox of design tools from proof-of-concept studies each year helps address these requirements. Recent advances in targeting and stimuli-responsiveness, as well as challenges and potential solutions are discussed to assist researchers in overcoming interdisciplinary knowledge barriers and speeding up development in cancer therapy.
Review
Chemistry, Multidisciplinary
Jinpeng Han, Tao Sheng, Yuqi Zhang, Hao Cheng, Jianqing Gao, Jicheng Yu, Zhen Gu
Summary: The human immune system plays a crucial role in various diseases. Manipulating the immune response network with bioresponsive immunotherapeutic materials can maximize therapeutic efficacy and minimize side effects. Integration of smart bioresponsive materials with immunoactive agents allows targeted release of agents to reduce toxicity and manipulate immune cells for desired responses. This review emphasizes the design principles of bioresponsive immunotherapeutic materials and discusses their critical roles in immune response manipulation.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Shan Mohanan, Xinwei Guan, Mingtao Liang, Ajay Karakoti, Ajayan Vinu
Summary: The design of novel drug delivery systems is crucial in disease treatments, and mesoporous silica nanoparticles (MSNs) have shown great promise due to their stability, tunable morphologies/sizes, and loading capability. Functionalization of MSNs with drugs, imaging, and targeting agents is enabled by the presence of surface silanol groups, making them versatile and popular among researchers. Stimuli-responsive silanol conjugates have emerged as an effective way to deliver therapeutic drugs precisely and on-demand, and it is important to understand the role of surface silanols in MSN as a drug delivery platform. This review provides an analytical understanding of surface silanols, their chemistry, identification methods, and their correlation with properties and performance.
Review
Chemistry, Multidisciplinary
Peng Yang, Fang Zhu, Zhengbiao Zhang, Yiyun Cheng, Zhao Wang, Yiwen Li
Summary: PDA is a promising candidate for stimuli-responsive smart materials, with excellent photo-responsive properties and active surface functionality for loading various responsive motifs. This review summarizes recent advances in design strategies, responsive mechanisms, and diverse applications of stimuli-responsive PDA-based materials, covering stimuli such as light, pH, chemicals, temperature, etc.
CHEMICAL SOCIETY REVIEWS
(2021)
Review
Polymer Science
Siphokazi B. K. Dludla, Leshasha T. Mashabela, Brian Ng'andwe, Pedzisai A. Makoni, Bwalya A. Witika
Summary: The application of nanotechnology in ophthalmic drug delivery systems shows great potential to overcome barriers faced by traditional ophthalmic formulations. Stimuli-responsive nano drug carriers have attracted significant attention due to their unique functionalities and therapeutic efficacy, playing a crucial role in the treatment and alleviation of ocular diseases.
Article
Polymer Science
Kyoung Nan Kim, Keun Sang Oh, Jiwook Shim, Isabel R. Schlaepfer, Sana D. Karam, Jung-Jae Lee
Summary: Light-sensitive polymeric micelles have been developed as promising drug delivery systems, with the ability to release drugs under UV light. The diazonaphthoquinone (DNQ)-conjugated micellar nanoparticles show high stability and hydrophobicity.
Article
Pharmacology & Pharmacy
Roshni Iyer, Harish Ramachandramoorthy, Trinh Nguyen, Cancan Xu, Huikang Fu, Tanviben Kotadia, Benjamin Chen, Yi Hong, Debabrata Saha, Kytai Truong Nguyen
Summary: Lung cancer is a major cause of cancer-related deaths worldwide. Conventional clinical therapies have limitations in treating lung cancer, but a new study has developed dual-stimuli nanoparticles that target cancer cells and release chemotherapy drugs and radiation sensitizer, potentially improving treatment efficacy and reducing side effects.
Article
Medicine, Research & Experimental
Mohammad Arad Zandieh, Melika Heydari Farahani, Mahshid Daryab, Alireza Motahari, Sarah Gholami, Farshid Salmani, Fatemeh Karimi, Seyedeh Setareh Samaei, Aryan Rezaee, Parham Rahmanian, Ramin Khorrami, Shokooh Salimimoghadam, Noushin Nabavi, Rongjun Zou, Gautam Sethi, Mohsen Rashidi, Kiavash Hushmandi
Summary: The use of phytochemicals in cancer therapy has been accelerated due to tumor cell resistance to conventional chemotherapy drugs. However, the poor bioavailability and lack of specific accumulation at tumor sites pose challenges. The use of nanocarriers for targeted delivery of phytochemicals shows promise in improving pharmacokinetics and therapeutic indices. Stimuli-responsive nanostructures and surface functionalization with ligands further enhance the internalization and cytotoxicity of natural compounds in cancer cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Kangkang Li, Xinlong Zang, Mingyang Cheng, Xuehong Chen
Summary: Recent progresses in fighting against cancer include better understanding of tumor microenvironment and rapid development in nanoscale drug delivery system. Nanocarriers based on polymeric acrylic derivatives have shown high drug encapsulation rate and satisfactory therapeutic outcome in tumor treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Sachin Bhaladhare, Sulagna Bhattacharjee
Summary: The development of nanotechnology has had a significant impact on biomedical and pharmaceutical fields, particularly in the design and formulation of stimuli-responsive nano-drug delivery systems. These systems, known as smart drug delivery systems, are able to respond to various external and internal stimuli and deliver drugs to targeted sites in a controlled manner. They offer improved patient compliance, treatment efficiency, and reduced side effects on healthy tissue. Polymeric nanogels with stimuli-responsive characteristics have shown great potential in biomedical, tissue engineering, and pharmaceutical applications due to their small size, biocompatibility, stimuli-triggered drug deliverability, high payload capacity, and tailored functionality.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Polymer Science
Elham Khadem, Mahshid Kharaziha, Hamid Reza Bakhsheshi-Rad, Oisik Das, Filippo Berto
Summary: With the development of intelligent materials, intelligent bioadhesives that respond to chemical, physical, or biological stimuli have been widely used in biomedical applications. These bioadhesives can undergo a phase shift in response to stimuli such as light, temperature, pH, and electric field, and they have advantages such as ease of use, sustained release, and reduced side effects. Fields such as tissue engineering, drug delivery, and cancer therapy have benefited from smart bioadhesives. However, the development of multifunctional bioadhesives for various biomedical applications is still not fully explored.
Review
Nanoscience & Nanotechnology
Ruixin Jia, Lesheng Teng, Lingyu Gao, Ting Su, Lu Fu, Zhidong Qiu, Ye Bi
Summary: Nanomedicines offer unique advantages in tumor therapy, but traditional nanomedicines are hindered by complex physiological fluids and tumor microenvironments. Stimuli-responsive drug-delivery systems have emerged as a promising tool to overcome these barriers and deliver therapeutic agents to target sites effectively.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)