Defective Proliferation and Osteogenic Potential with Altered Immunoregulatory phenotype of Native Bone marrow-Multipotential Stromal Cells in Atrophic Fracture Non-Union
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Defective Proliferation and Osteogenic Potential with Altered Immunoregulatory phenotype of Native Bone marrow-Multipotential Stromal Cells in Atrophic Fracture Non-Union
Authors
Keywords
-
Journal
Scientific Reports
Volume 9, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-11-22
DOI
10.1038/s41598-019-53927-3
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Do Systemic Factors Influence the Fate of Nonunions to Become Atrophic? A Retrospective Analysis of 162 Cases
- (2019) Markus Rupp et al. Biomed Research International
- IL-8 Enhances Therapeutic Effects of BMSCs on Bone Regeneration via CXCR2-Mediated PI3k/Akt Signaling Pathway
- (2018) Aijun Yang et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Inducible indoleamine 2,3-dioxygenase 1 and programmed death ligand 1 expression as the potency marker for mesenchymal stromal cells
- (2018) Qingdong Guan et al. CYTOTHERAPY
- Vertebral body versus iliac crest bone marrow as a source of multipotential stromal cells: Comparison of processing techniques, tri-lineage differentiation and application on a scaffold for spine fusion
- (2018) Evangelos M. Fragkakis et al. PLoS One
- Impact of bone marrow mesenchymal stem cell immunomodulation on the osteogenic effects of laponite
- (2018) Tao Li et al. Stem Cell Research & Therapy
- S100A8/A9 in Inflammation
- (2018) Siwen Wang et al. Frontiers in Immunology
- T cell immunomodulation by clinically used allogeneic human cancellous bone fragments: a potential novel immunotherapy tool
- (2018) Yasser M. El-Sherbiny et al. Scientific Reports
- A Pronounced Inflammatory Activity Characterizes the Early Fracture Healing Phase in Immunologically Restricted Patients
- (2017) Paula Hoff et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The CD45lowCD271high Cell Prevalence in Bone Marrow Samples May Provide a Useful Measurement of the Bone Marrow Quality for Cartilage and Bone Regenerative Therapy
- (2017) Jehan J. El-Jawhari et al. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
- Mesenchymal stem cells inhibit T cell activation by releasing TGF-β1 from TGF-β1/GARP complex
- (2017) Jian Niu et al. Oncotarget
- Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro
- (2017) Elena Redondo-Castro et al. Stem Cell Research & Therapy
- The effect of pro-inflammatory cytokines on immunophenotype, differentiation capacity and immunomodulatory functions of human mesenchymal stem cells
- (2016) Arash Pourgholaminejad et al. CYTOKINE
- Quantification of TGF-ß1, PDGF and IGF-1 cytokine expression after fracture treatment vs. non-union therapy via masquelet
- (2016) Christian Fischer et al. INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
- The roles of immune cells in bone healing; what we know, do not know and future perspectives
- (2016) Jehan J. El-Jawhari et al. INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
- Biomarkers of inflammation and innate immunity in atrophic nonunion fracture
- (2016) Dominique de Seny et al. Journal of Translational Medicine
- Interleukin-22 drives the proliferation, migration and osteogenic differentiation of mesenchymal stem cells: a novel cytokine that could contribute to new bone formation in spondyloarthropathies
- (2016) Ahmed A. El-Zayadi et al. RHEUMATOLOGY
- Double-edged-sword effect of IL-1β on the osteogenesis of periodontal ligament stem cells via crosstalk between the NF-κB, MAPK and BMP/Smad signaling pathways
- (2016) C-y Mao et al. Cell Death & Disease
- IL-17-producing γδ T cells enhance bone regeneration
- (2016) Takehito Ono et al. Nature Communications
- Aging, inflammation, stem cells, and bone healing
- (2016) Emmanuel Gibon et al. Stem Cell Research & Therapy
- Mesenchymal stem cell implantation in atrophic nonunion of the long bones
- (2016) H.D. Ismail et al. Bone & Joint Research
- BST2 Mediates Osteoblast Differentiation via the BMP2 Signaling Pathway in Human Alveolar-Derived Bone Marrow Stromal Cells
- (2016) Su-Hyang Yoo et al. PLoS One
- Reaming in treatment of non-unions in long bones: cytokine expression course as a tool for evaluation of non-union therapy
- (2015) Fabian Westhauser et al. ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
- The systemic influence of platelet-derived growth factors on bone marrow mesenchymal stem cells in fracture patients
- (2015) Hiang Boon Tan et al. BMC Medicine
- Multiple roles of tumor necrosis factor-alpha in fracture healing
- (2015) Jonathan M. Karnes et al. BONE
- Percutaneous injection of bone marrow mesenchymal stem cells for ankle non-unions decreases complications in patients with diabetes
- (2015) Philippe Hernigou et al. INTERNATIONAL ORTHOPAEDICS
- Inflammatory Cytokine Response Following Acute Tibial Plateau Fracture
- (2015) Justin M. Haller et al. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
- Biological and molecular profile of fracture non-union tissue: current insights
- (2015) Michalis Panteli et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Collagen-containing scaffolds enhance attachment and proliferation of non-cultured bone marrow multipotential stromal cells
- (2015) Jehan J. El-Jawhari et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Interactions between MSCs and Immune Cells: Implications for Bone Healing
- (2015) Tracy K. Kovach et al. Journal of Immunology Research
- Multiparameter Analysis of Human Bone Marrow Stromal Cells Identifies Distinct Immunomodulatory and Differentiation-Competent Subtypes
- (2015) Sally James et al. Stem Cell Reports
- Examining the Feasibility of Clinical Grade CD271+ Enrichment of Mesenchymal Stromal Cells for Bone Regeneration
- (2015) Richard J. Cuthbert et al. PLoS One
- T and B cells participate in bone repair by infiltrating the fracture callus in a two-wave fashion
- (2014) Ireen Könnecke et al. BONE
- Tibia shaft fractures: costly burden of nonunions
- (2013) Evgeniya Antonova et al. BMC MUSCULOSKELETAL DISORDERS
- Decreased pool of mesenchymal stem cells is associated with altered chemokines serum levels in atrophic nonunion fractures
- (2013) Myrielle Mathieu et al. BONE
- Human immune cells' behavior and survival under bioenergetically restricted conditions in an in vitro fracture hematoma model
- (2013) Paula Hoff et al. Cellular & Molecular Immunology
- Benefits of small volume and small syringe for bone marrow aspirations of mesenchymal stem cells
- (2013) Philippe Hernigou et al. INTERNATIONAL ORTHOPAEDICS
- Effect of Low-Intensity Pulsed Ultrasound on Bone Morphogenetic Protein 7-Induced Osteogenic Differentiation of Human Nonunion Tissue-Derived Cells In Vitro
- (2013) Takaaki Koga et al. JOURNAL OF ULTRASOUND IN MEDICINE
- Serum EGF and NGF levels of patients with brain injury and limb fracture
- (2013) Yan-Feng Zhuang et al. Asian Pacific Journal of Tropical Medicine
- Circulating bone morphogenetic protein levels and delayed fracture healing
- (2012) Laurens J. van Baardewijk et al. INTERNATIONAL ORTHOPAEDICS
- Serum levels of fibroblast growth factor 2 in children with orthopedic diseases: Potential role in predicting bone healing
- (2012) Donatella Granchi et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Initial immune reaction and angiogenesis in bone healing
- (2012) Katharina Schmidt-Bleek et al. Journal of Tissue Engineering and Regenerative Medicine
- T-Lymphocytes Enable Osteoblast Maturation via IL-17F during the Early Phase of Fracture Repair
- (2012) Diane Nam et al. PLoS One
- High abundance of CD271+ multipotential stromal cells (MSCs) in intramedullary cavities of long bones
- (2011) George Cox et al. BONE
- Inflammatory phase of bone healing initiates the regenerative healing cascade
- (2011) Katharina Schmidt-Bleek et al. CELL AND TISSUE RESEARCH
- Immunologically restricted patients exhibit a pronounced inflammation and inadequate response to hypoxia in fracture hematomas
- (2011) Paula Hoff et al. IMMUNOLOGIC RESEARCH
- Mesenchymal Stromal Cells Engage Complement and Complement Receptor Bearing Innate Effector Cells to Modulate Immune Responses
- (2011) Guido Moll et al. PLoS One
- In vivo microfocal computed tomography and micro-magnetic resonance imaging evaluation of antiresorptive and antiinflammatory drugs as preventive treatments of osteoarthritis in the rat
- (2010) Michael D. Jones et al. ARTHRITIS AND RHEUMATISM
- TRACP 5b and CTX as osteological markers of delayed fracture healing
- (2010) A. Moghaddam et al. INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
- Effect of basic fibroblast growth factor on the growth and differentiation of adult stromal bone marrow cells: Enhanced development of mineralized bone-like tissue in culture
- (2010) Sandu Pitaru et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Fracture healing is accelerated in the absence of the adaptive immune system
- (2010) Daniel Toben et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Inflammatory Cytokine-Induced Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 in Mesenchymal Stem Cells Are Critical for Immunosuppression
- (2010) Guangwen Ren et al. JOURNAL OF IMMUNOLOGY
- The Early Fracture Hematoma and Its Potential Role in Fracture Healing
- (2010) Paula Kolar et al. TISSUE ENGINEERING PART B-REVIEWS
- Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells
- (2009) Stefan Bajada et al. BONE
- IL-17 stimulates the proliferation and differentiation of human mesenchymal stem cells: implications for bone remodeling
- (2009) H Huang et al. CELL DEATH AND DIFFERENTIATION
- Levels of Expression for BMP-7 and Several BMP Antagonists May Play an Integral Role in a Fracture Nonunion: A Pilot Study
- (2009) Marc Fajardo et al. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
- Elevated levels of macrophage colony-stimulating factor in human fracture healing
- (2009) Kambiz Sarahrudi et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- VEGF serum concentrations in patients with long bone fractures: A comparison between impaired and normal fracture healing
- (2009) Kambiz Sarahrudi et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- The effects of shockwave on bone healing and systemic concentrations of nitric oxide (NO), TGF-β1, VEGF and BMP-2 in long bone non-unions
- (2009) Ching-Jen Wang et al. NITRIC OXIDE-BIOLOGY AND CHEMISTRY
- Regenerative Effects of Transplanted Mesenchymal Stem Cells in Fracture Healing
- (2009) Froilán Granero-Moltó et al. STEM CELLS
- Human Alternatives to Fetal Bovine Serum for the Expansion of Mesenchymal Stromal Cells from Bone Marrow
- (2009) Karen Bieback et al. STEM CELLS
- Insight into the Molecular Pathophysiology of Delayed Bone Healing in a Sheep Model
- (2009) Jasmin Lienau et al. TISSUE ENGINEERING PART A
- Cell viability, osteoblast differentiation, and gene expression are altered in human osteoblasts from hypertrophic fracture non-unions
- (2008) A. Hofmann et al. BONE
- Sequential Changes of Bone Metabolism in Normal and Delayed Union of the Spine
- (2008) Tsuyoshi Ohishi et al. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
- Genetic and epigenetic instability of human bone marrow mesenchymal stem cells expanded in autologous serum or fetal bovine serum
- (2008) John-Arne Dahl et al. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
- The Osteogenic Potential of Pseudoarthrosis Tissue and Bone from Human Scaphoid Non-Unions
- (2008) G. QU et al. Journal of Hand Surgery-European Volume
- Human hypertrophic nonunion tissue contains mesenchymal progenitor cells with multilineage capacity in vitro
- (2008) Takashi Iwakura et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Altered relative expression of BMPs and BMP inhibitors in cartilaginous areas of human fractures progressing towards nonunion
- (2008) Francois N.K. Kwong et al. JOURNAL OF ORTHOPAEDIC RESEARCH
- Standard Operating Procedures for Serum and Plasma Collection: Early Detection Research Network Consensus StatementStandard Operating Procedure Integration Working Group
- (2008) Melissa K. Tuck et al. JOURNAL OF PROTEOME RESEARCH
- Systemic response of the GH/IGF-I axis in timely versus delayed fracture healing
- (2007) Stefan Weiss et al. GROWTH HORMONE & IGF RESEARCH
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started