Review
Biochemistry & Molecular Biology
Sandra Winning, Joachim Fandrey
Summary: Oxygen deprivation is a common feature at inflamed sites, and immune cells adapt to this condition by activating HIF. HIF plays a significant role in regulating the inflammatory phenotype of immune cells, including migration, phagocytosis, and induction of inflammatory cytokines. However, further research is needed to understand the specific roles of HIF-1 and HIF-2 in different cell types.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Oncology
Yu Gu, Weiming Liu, Gaoqin Liu, Xin Li, Peirong Lu
Summary: Cryptotanshinone (CT) has protective effects on retinal pigment epithelium (RPE) cells under hypoxic conditions induced by cobalt chloride (CoCl2), reducing apoptosis and inflammation. Further in vivo studies are needed to explore its potential as a drug for treating hypoxic eye diseases.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Cell & Tissue Engineering
Xiaohui Fu, Yimiao Feng, Bingyi Shao, Yanzhen Zhang
Summary: Taxifolin significantly reduces DPSC apoptosis under hypoxia and inflammatory conditions by increasing the expression of CA9.
CELL TRANSPLANTATION
(2021)
Review
Biochemistry & Molecular Biology
Wenjing Xu, Yumei Yang, Na Li, Jinlian Hua
Summary: Fractures are common trauma in humans, and while initial inflammation promotes bone healing, chronic inflammation does not. Bone marrow mesenchymal stem cells not only differentiate into bone but also interact with the immune system to promote healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Ning Zhao, Conner Bardine, Andre Luiz Lourenco, Yung-hua Wang, Yangjie Huang, Simon J. Cleary, David M. Wilson, David Y. Oh, Lawrence Fong, Mark R. Looney, Michael J. Evans, Charles S. Craik
Summary: The study presents a strategy to investigate the biology of human granzymes in vivo using Cu-64-GRIP B as a radiotracer, which can specifically detect GZMB proteolysis. The results demonstrate that this imaging modality is capable of assessing granzyme biochemistry in living subjects, showing potential for future applications in humans.
ACS CENTRAL SCIENCE
(2021)
Article
Immunology
Wei-wei Li, Dan Li, Yao Qin, Cheng-xin Sun, Yong-ling Wang, Lei Gao, Lang Ling-Hu, Feng Zhang, Wen Cai, Lei Zhu, Gang Wang
Summary: The study demonstrated that AME has significant protective effects against myocardial ischemia-reperfusion injury by reducing inflammation levels and cell apoptosis rate. The therapeutic potential of AME for managing myocardial ischemia-reperfusion injury is highlighted in this study.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Jiatong Liu, Xi Lin, Andrew McDavid, Yutiancheng Yang, Hengwei Zhang, Brendan F. F. Boyce, Lianping Xing
Summary: Cellular senescence plays a crucial role in age-related diseases, such as musculoskeletal disorders, but the interaction between senescent cells (SCs) and inflammatory cells (Inf-Cs) during fracture repair is not well understood. This study analyzed single cell RNA sequencing data of aged mouse fracture callus stromal cells and identified three cell subclusters associated with inflammation and senescence. The researchers found that Inf-SCs and SCs had similar gene expression profiles and upregulated pathways related to DNA damage/oxidation-reduction and cellular senescence, while Inf-Cs expressed different gene signatures mainly related to inflammation. They also demonstrated that SCs and Inf-SCs could potentially affect Inf-Cs as target cells through the production of active ligands. Furthermore, cell culture experiments showed that SC-conditioned medium promoted inflammatory gene expression and reduced osteoblast differentiation capacity in callus-derived mesenchymal progenitor cells.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Margherita Sisto, Sabrina Lisi
Summary: Fibrosis, which can develop spontaneously or as a result of underlying diseases, is characterized by immune cells infiltration and the production of pro-inflammatory molecules. Defects in the abilities of non-immune cells to regulate immune responses may contribute to the pathogenesis of inflammatory diseases. However, the precise cellular mechanisms involved in this process have not been fully elucidated.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Zhewei Zhang, Ke Xiao, Sheng Wang, Abdur Rahman Ansari, Xiaoyu Niu, Wenjie Yang, Mengqi Lu, Zhi Yang, Zia ur Rehman, Weihua Zou, Weicheng Bei, Hui Song
Summary: This study investigated the regulatory mechanisms of visfatin in inflammation and apoptosis in RAW264.7 cells and mice immune organs. The results showed that visfatin can modulate inflammation and apoptosis by regulating various signaling pathways and the expression levels of cytokines.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Le Sun, Zhenzhen Sun, Qian Wang, Yue Zhang, Zhanjun Jia
Summary: This article reviews the research progress on the involvement of PXR in immunity and inflammatory diseases and provides insights into the development of therapeutic interventions targeting PXR.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Navid Mohammad Mirzaei, Wenrui Hao, Leili Shahriyari
Summary: The complex network of cell and molecule interactions in the tumor microenvironment creates a diverse ecosystem. The proximity of cells and molecules to their activators and inhibitors is crucial for tumor progression. Using a combination of partial differential equations and linear elasticity, we investigate the impact of spatial interactions on the tumor microenvironment. Our findings reveal interesting patterns of cell and cytokine distribution influenced by macrophages. We also observe the recruitment and suppression of cytotoxic T cells at macrophage sites. Additionally, anti-tumor macrophages reorganize patterns in favor of a more spatially restricted cancer and necrotic core. Sensitivity analysis suggests that macrophages play a key role in controlling cancer cell population and spatial arrangement in the tumor microenvironment.
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Medicine, Research & Experimental
Daphne N. Pariser, Zachary T. Hilt, Sara K. Ture, Sara K. Blick-Nitko, Mark R. Looney, Simon J. Cleary, Estheany Roman-Pagan, Jerry Saunders, Steve N. Georas, Janelle Veazey, Ferralita Madere, Laura Tesoro Santos, Allison Arne, Nguyen P. T. Huynh, Alison C. Livada, Selena M. Guerrero-Martin, Claire Lyons, Kelly A. Metcalf-Pate, Kathleen E. McGrath, James Palis, Craig N. Morrell
Summary: Platelets, previously known as cellular mediators of thrombosis, are also immune cells that interact with immune cells, impacting their activation and differentiation. Lung megakaryocytes (Mk(L)) have gene expression patterns similar to antigen-presenting cells, and have key immune regulatory roles influenced by the tissue environment. This indicates the plasticity of the immune phenotype of Mk(L) and their ability to induce T cell activation.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Immunology
Olalekan Chris Akinsulie, Sammuel Shahzad, Seto Charles Ogunleye, Ifeoluwa Peace Oladapo, Melina Joshi, Charles Egede Ugwu, Joy Olaoluwa Gbadegoye, Fasilat Oluwakemi Hassan, Richard Adeleke, Qudus Afolabi Akande, Ridwan Olamilekan Adesola
Summary: There are reports on the influence of hypoxia on cancer cells, but there may be more interesting functions of a hypoxic cellular micro-environment. The interaction between HIF and NF-κB is complex and has common factors and targets. This understanding could lead to novel therapeutic targets for infectious diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yurou Wang, Minmin Zeng, Lin Xia, Chinasa Valerie Olovo, Zhaoliang Su, Ying Zhang
Summary: The bacterial type VI secretion system (T6SS) is used by bacteria to infect the host, but bacteria have developed strategies to evade the host immune system. T6SS and its secreted effector proteins play an important role in the interaction between bacteria and host immune system, and can be used to develop vaccines. This review mainly discusses the impact of T6SS effector proteins on inflammation, autophagy, and apoptosis in the host immune system, as well as T6SS-based vaccines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Orthopedics
F. Graef, M. Ruehling, C. Gwinner, H. Hommel, S. Tsitsilonis, C. Perka
Summary: This study suggests that frontal deformities of the knee joint do not affect the rotation stability and range of motion of the ankle joint.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Biochemistry & Molecular Biology
Martin Textor, Arnd Hoburg, Rex Lehnigk, Carsten Perka, Georg N. N. Duda, Simon Reinke, Antje Blankenstein, Sarah Hochmann, Andreas Stockinger, Herbert Resch, Martin Wolf, Dirk Strunk, Sven Geissler
Summary: This study found that loose bodies (LBs) from patients with osteochondritis dissecans (OCD) contain sufficient viable and functional chondrocytes that can be used for autologous chondrocyte implantation (ACI) without affecting their phenotype during prolonged in vitro expansion. The chondrocyte populations from LBs (LB-CH) showed no significant differences in cell yield per isolation and expression of chondrocyte progenitor cell markers compared to control chondrocytes from non-weight-bearing joint regions. LB-CH exhibited comparable viability, proliferation rates, and chondrogenic differentiation potential to control chondrocytes, and had a higher ability to form a hyaline cartilage matrix compared to bone marrow mesenchymal stromal cells (BMSCs).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Alexander Paping, Clara Basler, Kerstin Melchior, Loreen Ehrlich, Mario Thiele, Georg N. Duda, Wolfgang Henrich, Thorsten Braun
Summary: The study aimed to evaluate the reliability of intraoperative ultrasound in identifying histologically confirmed uterine scar tissue. The results showed that intraoperative ultrasound was more accurate in identifying scar tissue compared to preoperative ultrasound. This is important for studying uterine wound healing and preventing uterine wall rupture.
JOURNAL OF PERINATAL MEDICINE
(2023)
Letter
Rheumatology
Zhivana Boyadzhieva, Sabrina Mai Nielsen, Frank Buttgereit, Robin Christensen, Andriko Palmowski
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2023)
Article
Rheumatology
Frank Buttgereit, Jacob Aelion, Bernadette Rojkovich, Anna Zubrzycka-Sienkiewicz, Su Chen, Yang Yang, Dilek Arikan, Ronilda D'Cunha, Yinuo Pang, Hartmut Kupper, Timothy Radstake, Howard Amital
Summary: This study aimed to assess the efficacy and safety of ABBV-3373, a novel antibody-drug conjugate (ADC), compared to adalimumab in patients with rheumatoid arthritis (RA). The results showed that ABBV-3373 had superior efficacy and safety compared to historical adalimumab, supporting its continued development for RA treatment.
ARTHRITIS & RHEUMATOLOGY
(2023)
Editorial Material
Rheumatology
Frank Buttgereit, Andriko Palmowski, Idil Esen, Elisabeth Brouwer
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Orthopedics
Marlene Ruehling, Stephanie Kirschbaum, Carsten Perka, Frank Graef
Summary: The purpose of this study was to assess dynamic foot posture during gait using pressure-sensitive wireless insoles in patients with knee osteoarthritis and frontal knee deformities. The results showed that static radiologic measurements only found compensation of varus and valgus deformities of the knee by eversion and inversion movements. However, gait analysis revealed that the hindfoot is not able to sufficiently compensate for frontal malalignments of the knee joint, leading to a narrowing of the joint space of the ankle medially in varus and laterally in valgus knee osteoarthritis.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Orthopedics
Vincent J. Leopold, Paula Krull, Sebastian Hardt, Christian Hipfl, Oliver Melsheimer, Arnd Steinbrueck, Carsten Perka, Gregor M. Giebel
Summary: The study found that nonagenarians undergoing elective total hip arthroplasty (THA) had higher morbidity and mortality rates, with major risk factors including congestive heart failure, pulmonary circulation disorders, insulin-dependent diabetes, among others. However, careful patient selection and adequate preparation can help control mortality rates, as shown by the fact that mortality rates in nonagenarians were lower than in the general population.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Editorial Material
Cell Biology
Georg N. Duda, David W. Grainger, Robert E. Guldberg, Gady Goldsobel, Glenn D. Prestwich, Brenna Rauw, Hans-Dieter Volk
Summary: Translational impact assessment is crucial in determining the potential of biomedical research discoveries to be transformed into practical, beneficial products for human health. However, measuring translational success is challenging as it goes beyond commercial achievements and may vary from case to case. Prioritizing societal impact is essential in a globalized society.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Mariya M. Kucherenko, Pengchao Sang, Juquan Yao, Tara Gransar, Saphala Dhital, Jana Grune, Szandor Simmons, Laura Michalick, Dag Wulsten, Mario Thiele, Orr Shomroni, Felix Hennig, Ruhi Yeter, Natalia Solowjowa, Gabriela Salinas, Georg N. Duda, Volkmar Falk, Naren R. Vyavahare, Wolfgang M. Kuebler, Christoph Knosalla
Summary: Pulmonary hypertension worsens prognosis in left heart disease. Increased stiffness of the pulmonary artery may contribute to this by causing right ventricular dysfunction and lung vascular remodeling. Targeting extracellular matrix remodeling may be a therapeutic approach for pulmonary hypertension in left heart disease.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Laura Kim, Claudia Kedor, Frank Buttgereit, Harald Heidecke, Desiree Schaumburg, Carmen Scheibenbogen
Summary: Fatigue is a common and debilitating symptom in primary Sjogren's syndrome (pSS) patients. This study aimed to evaluate fatigue and other symptoms in pSS patients and investigate if there is symptom overlap with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The severity of pSS symptoms and disease activity were assessed, and hand grip strength (HGS) and autoantibody levels were measured. Some pSS patients experienced severe fatigue and exhibited higher levels of pain, depression, and sleep disturbances. Four out of eighteen pSS patients met the criteria for ME/CFS. HGS parameters correlated strongly with fatigue severity but fully recovered after exertion, unlike ME/CFS. Elevated levels of certain autoantibodies were associated with disease activity but not fatigue severity. Only a small subgroup of pSS patients fulfilled the criteria for ME/CFS, and post-exertional malaise was primarily triggered by mental/emotional exertion rather than physical exertion. HGS assessment is an objective measure for overall fatigue severity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Vincent Justus Leopold, Carsten Perka, Sebastian Hardt
Summary: Periacetabular osteotomy (PAO) is a surgical technique used to treat hip dysplasia by improving femoral head coverage and achieving physiological values through multidimensional reorientation. Adequate fixation of the acetabulum in the corrected position is necessary until bony consolidation is reached. Various fixation techniques, such as screws and Kirschner wires, are available with comparable stability. Differences exist in implant-associated complications, but there is no difference in patient satisfaction and joint-specific function.
Article
Orthopedics
Paula Krull, Arnd Steinbrueck, Alexander W. Grimberg, Oliver Melsheimer, Michael M. Morlock, Carsten Perka
Summary: Instability is a common issue in revision hip arthroplasties. Modified polyethylene liners aim to improve stability of hip replacements. A study using data from the German Arthroplasty Registry (EPRD) examined the mechanical failure of standard and modified liner designs in primary, cementless total hip arthroplasty.
Article
Rheumatology
Marcel Niemann, Melanie Ort, Luis Lauterbach, Mathias Streitz, Andreas Wilhelm, Gerald Gruetz, Florian N. Fleckenstein, Frank Graef, Antje Blankenstein, Simon Reinke, Ulrich Stoeckle, Carsten Perka, Georg N. Duda, Sven Geissler, Tobias Winkler, Tazio Maleitzke
Summary: This study compared the leukocyte and cytokine distributions of different PRP products and assessed the effect of pro-inflammatory cytokines on chondrocytes. The results showed that all three PRP products contained elevated levels of leukocytes, and the nSTRIDE APS product had significantly higher concentrations of the pro-inflammatory cytokines IFN-gamma and TNF-alpha. Furthermore, treatment with IFN-gamma and TNF-alpha negatively affected chondrocyte proliferation and cartilage formation. These findings suggest that both the individual's immune profile and the concentration method impact the composition of PRP products.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Orthopedics
M. Ruehling, S. M. Kirschbaum, C. Perka, F. Graef
Summary: About 25% of patients developed ankle pain after TKA. Standing radiographs of the ankle and a gait analysis could help detect malaligned TT or pathological gait in patients complaining about ankle symptoms after TKA.
BONE & JOINT JOURNAL
(2023)
