Article
Biochemistry & Molecular Biology
Li Geng, Chi Zhang, Chao He, Ka Zhang, Hao Kan, Aiqin Mao, Xin Ma
Summary: Endothelial calcium signaling, regulated by fluid shear stress (FSS), plays a significant role in vasodilation. TRPV4 channels mediate calcium influx in response to certain levels of FSS, leading to endothelial cell hyperpolarization and subsequent vasodilation.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Review
Cell Biology
Sebastien Chaigne, Solene Barbeau, Thomas Ducret, Romain Guinamard, David Benoist
Summary: The TRPV4 channel plays a role in intracellular calcium handling in cardiac cells and is involved in various physiological functions in the cardiovascular system. It modulates mitochondrial activity, calcium homeostasis, electrical activity and contractility of cardiomyocytes, as well as vascular permeability, dilatation and constriction. Furthermore, TRPV4 channels are implicated in cardiac pathological processes such as fibrosis, hypertrophy, ischemia-reperfusion injuries, heart failure, myocardial infarction and arrhythmia. This manuscript provides an overview of the implications of TRPV4 channel in cardiac physiology and discusses its potential as a therapeutic target for cardiovascular diseases.
Article
Cell Biology
Jordan N. Haidey, Govind Peringod, Adam Institoris, Kelsea A. Gorzo, Wilten Nicola, Milene Vandal, Kenichi Ito, Shiying Liu, Cameron Fielding, Frank Visser, Minh Dang Nguyen, Grant R. Gordon
Summary: The study reveals that enhancing tone can trigger a Ca2+ elevation in astrocyte end-feet, leading to feedback vasodilators that limit vasoconstriction and constrain vasomotion. Additionally, in vivo experiments show that knocking out the Ptgs1 gene in astrocytes increases the energy of arteriole oscillations, while clamping astrocyte Ca2+ decreases vasomotion energy.
Article
Mathematics, Applied
I. B. Tagne Nkounga, N. Marwan, F. M. Moukam Kakmeni, R. Yamapi, Juergen Kurths
Summary: In a new memristive generalized FitzHugh-Nagumo bursting model, the phenomenon of adaptive resonance is examined, which improves the response of the neuron system to a varied stimulus by adjusting the intensity of adaptation currents. The presence and impact of electromagnetic induction on the resonance peak and the system behavior are analyzed.
Article
Pharmacology & Pharmacy
Aiqin Mao, Peng Zhang, Ka Zhang, Hao Kan, Dongxu He, Xiping Han, Zhiwei Wang, Chunlei Tang, Xin Ma
Summary: This study used single-cell RNA-sequencing, single-cell functional study, and drug screening to identify a subpopulation of CD106(+) TRPV4(high)NOS3(high) endothelial cells (ECs) in the aorta. The impaired TRPV4-eNOS interaction was found to be important in the progression of hypertension, and a small molecule drug, JNc-463, was designed to improve this interaction. This research provides valuable insights into endothelial dysfunction and offers potential therapeutic targets for treating hypertension.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Mathematics, Applied
Lou Zonca, David Holcman
Summary: This study developed a bursting model based on synaptic dynamics to simulate the bursts and interburst intervals of neuronal networks. Bursting is defined by long deterministic excursions away from the attractor, while interburst intervals correspond to escape induced by random fluctuations.
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION
(2021)
Article
Nanoscience & Nanotechnology
Ophelie Germande, Magalie Baudrimont, Fabien Beaufils, Veronique Freund-Michel, Thomas Ducret, Jean-Francois Quignard, Marie-Helene Errera, Sabrina Lacomme, Etienne Gontier, Stephane Mornet, Megi Bejko, Bernard Muller, Roger Marthan, Christelle Guibert, Juliette Deweirdt, Isabelle Baudrimont
Summary: This study focuses on evaluating the cytotoxic effects of nickel oxide nanoparticles on human pulmonary artery endothelial cells. The results indicate that these nanoparticles induce oxidative stress, inflammation, and mitochondrial dysfunction in the endothelial cells.
Article
Mathematics, Applied
Evdokiia Slepukhina, Irina Bashkirtseva, Lev Ryashko, Philipp Kuegler
Summary: Motivated by a biophysical problem related to neural activity, this study investigates a three-dimensional model with the Lukyanov-Shilnikov bifurcation. It reveals that additive white noise can induce a transition from spiking oscillations to bursting oscillations, accompanied by coherence resonance and subsequent chaos.
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION
(2023)
Article
Immunology
Oleg Yarishkin, Tam T. T. Phuong, Felix Vazquez-Chona, Jacques Bertrand, Joseph van Battenburg-Sherwood, Sarah N. Redmon, Christopher N. Rudzitis, Monika Lakk, Jackson M. Baumann, Marc Freichel, Eun-Mi Hwang, Darryl Overby, David Krizaj
Summary: The trabecular meshwork (TM) cells in the eyes actively regulate intraocular pressure by employing mechanotransduction and calcium signaling. The activation of TRPV4 channels stimulates TRPM4 channels, leading to dynamic calcium signaling in TM cells. This finding provides insights into the importance of pressure regulation in the eyes and potential therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nissrin Alachkar, Dale Norton, Zsofia Wolkensdorfer, Mark Muldoon, Pawel Paszek
Summary: We conducted a global analysis of toll-like receptor (TLR)-induced gene expression variability using single cell genomics data and stochastic transcription models. Our findings demonstrate that the variability in gene expression in single cells can be described by a linear function of the population mean. We further reveal different regulatory modes of TLR response heterogeneity and provide new insights into the control of innate immune response variability.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Mathematics, Applied
Mehran Fazli, Theodore Vo, Richard Bertram
Summary: This passage discusses the focus of study on electrical bursting oscillations in neurons and endocrine cells, the usefulness of mathematical modeling in understanding bursting patterns, and a new mechanism involving stochastic opening and closing of key ion channels. It also highlights the importance of stochastic element in enabling bursting in the system and its application for explaining stochastic bursting in pituitary cells.
Article
Medicine, Research & Experimental
Takayoshi Sumioka, Hiroki Iwanishi, Shingo Yasuda, Kana Ichikawa, Masayasu Miyazima, Masahide Kokado, Yuka Okada, Shizuya Saika
Summary: In this study, the effects of the loss of TRPV4 expression on neovascularization in the corneal stroma were investigated. It was found that TRPV4 gene knockout suppressed the growth of neovascularization and reduced the infiltration of macrophages. Furthermore, the TRPV4 signal was involved in injury-induced inflammation and neovascularization activity in a mouse corneal stroma.
LABORATORY INVESTIGATION
(2023)
Article
Multidisciplinary Sciences
Mikael Lundqvist, Jonas Rose, Scott L. Brincat, Melissa Warden, Tim Buschman, Pawel Herman, Earl Miller
Summary: This study found that working memory is better characterized by intermittent bursts of activity rather than persistent spiking. By analyzing the electrical activity of monkeys' brains, the researchers discovered that reductions in variability of spiking during working memory tasks were consistent with reductions in variability of associated gamma bursts. These findings not only support the intermittent activity models of working memory, but also provide new mechanistic insights into how spike variability is reduced during cognitive tasks.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Jie Shao, Da-Shuang Gao, Yun-Hui Liu, Shan-Ping Chen, Nian Liu, Lu Zhang, Xin-Yi Zhou, Qian Xiao, Li-Ping Wang, Hai-Lan Hu, Fan Yang
Summary: This study identified a crucial role of Cav3.1-driven bursting firing in dmVMH neurons in regulating anxiety-like behavior and energy expenditure in response to chronic stress. Fluoxetine was found to inhibit Cav3.1 expression and rescue the detrimental effects on anxiety and metabolism caused by chronic stress. These findings suggest potential therapeutic targets for treating emotional dysfunction and metabolic disorders induced by chronic stress.
MOLECULAR PSYCHIATRY
(2022)
Article
Gastroenterology & Hepatology
Naima Endesh, Eulashini Chuntharpursat-Bon, Charlotte Revill, Nadira Y. Yuldasheva, T. Simon Futers, Gregory Parsonage, Neil Humphreys, Antony Adamson, Lara C. Morley, Richard M. Cubbon, K. Raj Prasad, Richard Foster, Laeticia Lichtenstein, David J. Beech
Summary: The study aimed to determine the relevance and relationship of PIEZO1 and TRPV4 channels in the contractile tone of the hepatic portal vein, which experiences mechanical and osmotic variations as it delivers blood to the liver. Results showed that activation of PIEZO1 leads to vessel relaxation while activation of TRPV4 causes contraction. The modulation of these channels could provide important opportunities for manipulating liver perfusion and regeneration.
LIVER INTERNATIONAL
(2023)
Article
Biophysics
Alexander Williams, Sana Nasim, Manuel Salinas, Arash Moshkforoush, Nikolaos Tsoukias, Sharan Ramaswamy
JOURNAL OF BIOMECHANICS
(2017)
Article
Pharmacology & Pharmacy
Jaimit Parikh, Viatcheslav Gurev, John J. Rice
FRONTIERS IN PHARMACOLOGY
(2017)
Article
Cell & Tissue Engineering
Kenneth A. Barbee, Jaimit B. Parikh, Yien Liu, Donald G. Buerk, Dov Jaron
CELLULAR AND MOLECULAR BIOENGINEERING
(2018)
Article
Hematology
Adam Kapela, Erik J. Behringer, Steven S. Segal, Nikolaos M. Tsoukias
Review
Hematology
Masayo Koide, Arash Moshkforoush, Nikolaos M. Tsoukias, David C. Hill-Eubanks, George C. Wellman, Mark T. Nelson, Fabrice Dabertrand
Article
Multidisciplinary Sciences
Arash Moshkforoush, Baarbod Ashenagar, Nikolaos M. Tsoukias, B. Rita Alevriadou
SCIENTIFIC REPORTS
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
Lina Bernier, Baarbod Ashenagar, Arash Moshkforoush, Nikolaos Tsoukias
Article
Multidisciplinary Sciences
Arash Moshkforoush, Baarbod Ashenagar, Osama F. Harraz, Fabrice Dabertrand, Thomas A. Longden, Mark T. Nelson, Nikolaos M. Tsoukias
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Albert L. Gonzales, Nicholas R. Klug, Arash Moshkforoush, Jane C. Lee, Frank K. Lee, Bo Shui, Nikolaos M. Tsoukias, Michael I. Kotlikoff, David Hill-Eubanks, Mark T. Nelson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Baarbod Ashenagar, Arash Moshkforoush, Asad Mirza, Nikolaos Tsoukias
Meeting Abstract
Biochemistry & Molecular Biology
Asad M. Mirza, Arash Moshkforoush, Wayne R. Giles, Nikolaos Tsoukias
Meeting Abstract
Biochemistry & Molecular Biology
Arash Moshkforoush, Thomas Longden, Fabrice Dabertrand, Osama F. Harraz, Mark Nelson, Nikolaos Tsoukias
Meeting Abstract
Biochemistry & Molecular Biology
Arash Moshkforoush, Thomas Longden, Fabrice Dabertrand, Mark Nelson, Nikolaos Tsoukias
Article
Cardiac & Cardiovascular Systems
Jaimit Parikh, Adam Kapela, Nikolaos M. Tsoukias
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2017)