Article
Oncology
Michela Campolo, Marika Lanza, Giovanna Casili, Irene Paterniti, Alessia Filippone, Maria Caffo, Salvatore M. Cardali, Ivana Puliafito, Cristina Colarossi, Gabriele Raciti, Salvatore Cuzzocrea, Emanuela Esposito
Summary: The study revealed that 5Z-7-oxozeaenol plays an important role in increasing the sensitivity of glioblastoma cells to chemotherapy, potentially serving as an effective adjuvant to current chemotherapeutic regimens. It also highlighted the continuous involvement of mitogen-activated protein kinase in tumorigenesis following chemotherapy.
Article
Multidisciplinary Sciences
Edikan A. Ogunnaike, Alain Valdivia, Mostafa Yazdimamaghani, Ernesto Leon, Seema Nandi, Hannah Hudson, Hongwei Du, Simon Khagi, Zhen Gu, Barbara Savoldo, Frances S. Ligler, Shawn Hingtgen, Gianpietro Dotti
Summary: The delivery of CAR-T cells within the surgical cavity using a fibrin-based gel demonstrates superior antitumor activity compared to direct inoculation into the tumor resection cavity in a model of subtotal glioblastoma resection.
Article
Chemistry, Multidisciplinary
Fawad Ur Rehman, Yang Liu, Qingshan Yang, Haoying Yang, Runhan Liu, Dongya Zhang, Pir Muhammad, Yanjie Liu, Sumaira Hanif, Muhammad Ismail, Meng Zheng, Bingyang Shi
Summary: This study explores the use of exosomes secreted by allogeneic bone marrow mesenchymal stem cells as a nanocarrier for glioblastoma therapy. With the decoration of a specific peptide, the nanocarrier exhibits enhanced targeting ability for TMZ resistant GBM. Additionally, the system can deliver targeted siRNA to restore drug sensitivity and achieve treatment of drug-resistant GBM.
JOURNAL OF CONTROLLED RELEASE
(2022)
Editorial Material
Cell Biology
Samuel A. Sprowls, Justin D. Lathia
Summary: Maraviroc, an FDA-approved therapy, may be a potentially viable treatment option for patients diagnosed with glioblastoma harboring a high amount of pericyte support cells.
Review
Biochemistry & Molecular Biology
Tzu-Jen Kao, Chien-Liang Lin, Wen-Bin Yang, Hao-Yi Li, Tsung- Hsu
Summary: In this review, the researchers summarize current knowledge on lipid metabolism in GBM, specifically focusing on the development of TMZ resistance. Dysregulated lipid metabolism has been identified as a contributing factor to TMZ resistance in GBM, and targeting lipid metabolism may offer a promising approach for overcoming resistance and improving outcomes. The review highlights key metabolites and proteins involved in lipid synthesis, uptake, and utilization, as well as recent advances in metabolomics to study lipid metabolism in GBM.
LIPIDS IN HEALTH AND DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Hyunkoo Kang, Haksoo Lee, Dahye Kim, Byeongsoo Kim, JiHoon Kang, Hae Yu Kim, HyeSook Youn, BuHyun Youn
Summary: Glioblastoma (GBM) is a highly malignant brain tumor that is resistant to current therapies. This review focuses on the resistance mechanisms of GBM, particularly towards temozolomide (TMZ), and summarizes the recent findings on the intrinsic and extrinsic mechanisms of chemoresistance in GBM stem cells (GSCs). It also discusses novel therapeutic strategies, such as molecular targeting, autophagy inhibition, oncolytic viral therapy, drug repositioning, and targeting of GSC niches, to eliminate GSCs and improve GBM therapy.
Article
Oncology
Zijin Zhao, Miaomiao Liu, Wenyong Long, Jian Yuan, Haoyu Li, Chi Zhang, Guodong Tang, Weixi Jiang, Xianrui Yuan, Minghua Wu, Qing Liu
Summary: CRNDE is a poor prognosis factor for GBM patients, upregulated in TMZ-resistant patients, and closely associated with chemotherapeutic response to TMZ treatment. Knockdown of CRNDE significantly reduces glioma cell viability and proliferation, enhances cell apoptosis, and improves sensitivity to TMZ treatment.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Amber B. Jones, Taylor L. Schanel, Mikayla R. Rigsby, Corinne E. Griguer, Braden C. Mcfarland, Joshua C. Anderson, Christopher D. Willey, Anita B. Hjelmeland
Summary: Treatment for glioblastoma has been improved through the non-invasive addition of tumor treating fields (TTFields). TTFields decrease the growth of glioblastoma cells and may have therapy-specific vulnerabilities. The activity of PDGFR alpha may serve as a pro-survival mechanism for TTFields.
Article
Medicine, Research & Experimental
Eryan Yang, Lin Wang, Weili Jin, Xing Liu, Qixue Wang, Ye Wu, Yanli Tan, Yunfei Wang, Xiaoteng Cui, Jixing Zhao, Fei Tong, Biao Hong, Menglin Xiao, Xiaomin Liu, Chuan Fang, Chunsheng Kang
Summary: This study highlights the importance of PTRF in glioblastoma and its role as a predictor of prognosis in GBM patients treated with temozolomide. It also identifies a novel mechanism contributing to temozolomide resistance. Furthermore, this study provides a new idea for GBM therapy.
Article
Clinical Neurology
Tetsuya Yamada, Shohei Tsuji, Shinsuke Nakamura, Yusuke Egashira, Masamitsu Shimazawa, Noriyuki Nakayama, Hirohito Yano, Toru Iwama, Hideaki Hara
Summary: Riluzole demonstrates significant growth-inhibitory effects on all GBM cell lines in a time- and dose-dependent manner. It synergistically enhances the antitumor effect of TMZ in MGMT-positive GBM cell lines, while suppressing MGMT expression and TMZ-induced MGMT upregulation. Combinatorial TMZ/riluzole treatment significantly suppresses tumor growth in an intracranial MGMT-positive GBM model, suggesting it as a promising therapeutic regimen for MGMT-positive GBMs.
JOURNAL OF NEUROSURGERY
(2021)
Article
Biochemistry & Molecular Biology
Moli Wu, Danyang Song, Hui Li, Nisar Ahmad, Hong Xu, Xiaobo Yang, Qian Wang, Xiaoxin Cheng, Sa Deng, Xiaohong Shu
Summary: Chemoresistance is a challenge in the treatment of glioblastoma (GBM), and the activity of O6-methylguanine-DNA methyltransferase (MGMT) and signal transducer and of transcription 3 (STAT3) have been linked to GBM resistance. Resveratrol (Res) inhibits tumor growth and improves chemosensitivity by targeting STAT3 signaling. This study found that Res effectively improved chemosensitivity of GBM cells to temozolomide (TMZ) and downregulated STAT3 activity, leading to inhibition of cell proliferation, migration, and induction of apoptosis. The combination therapy of Res and TMZ also reversed TMZ resistance and decreased MGMT and STAT3 levels. Therefore, Res may be an ideal candidate for combined chemotherapy with TMZ in GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shota Ando, Chiami Moyama, Naoto Kojima, Mitsugu Fujita, Kaito Ohta, Yukina Kohno, Hiromi Ii, Susumu Nakata
Summary: JCI-20679, a mitochondrial complex I inhibitor, enhances the anti-proliferative effects of temozolomide in glioblastoma cells. It inhibits temozolomide-induced autophagy and blocks the increase of ATP levels, leading to improved therapeutic efficacy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Reena Jatyan, Prabhjeet Singh, Deepak Kumar Sahel, Y. G. Karthik, Anupama Mittal, Deepak Chitkara
Summary: Temozolomide (TMZ) is an important first-line treatment drug for glioblastoma multiforme (GBM), but it has limitations. Nanocarriers and conjugation approaches have been used to improve the therapeutic potential of TMZ.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Puja Sandbhor, Jayant Goda, Bhabani Mohanty, Pradip Chaudhari, Shilpee Dutt, Rinti Banerjee
Summary: The study suggests that targeted nanovesicles delivered through the intranasal route have the potential to bypass the blood-brain barrier, significantly increase brain drug bioavailability, and achieve better therapeutic outcomes in the treatment of glioblastoma.
Article
Cell & Tissue Engineering
Weimin Dai, An Wu, Yunping Li, Guofeng Yu, Xinjiang Yan
Summary: This study reveals the crucial role of XPA-dependent nucleotide excision repair in the resistance of glioma cells to temozolomide. By suppressing XPA, the efficacy of temozolomide-based glioblastoma treatment can be enhanced and temozolomide resistance can be alleviated.
CELL TRANSPLANTATION
(2022)
Review
Oncology
Nisha Kumari, Seung Hong Choi
Summary: Cancer immunotherapy has had limited success, but nanoparticles have emerged as crucial tools in targeting tumor-associated macrophages (TAMs) and improving therapy outcomes. Current strategies include restricting TAMs survival, inhibiting TAMs recruitment, and repolarizing tumor-supportive TAMs to an antitumor phenotype.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Roh-Eul Yoo, Seung Hong Choi, Sung-Won Youn, Moonjung Hwang, Eunkyung Kim, Byung-Mo Oh, Ji Ye Lee, Inpyeong Hwang, Koung Mi Kang, Tae Jin Yun, Ji-Hoon Kim, Chul-Ho Sohn
Summary: This study found that mTBI patients with PCS had lower average MVF in the bilateral cerebral WM compared to controls, as well as significantly decreased myelin volume in the corpus callosum and brainstem. Total myelin volume was also reduced in these patients. Additionally, there was a significant correlation between myelin volume and neuropsychological test scores only in the bilateral cerebral WM and verbal learning test.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ju G. Nam, Hyunsook Hong, Seung Hong Choi, Chang Min Park, Jin Mo Goo, Young Tae Kim, Hyungjin Kim
Summary: There is no difference in terms of brain metastasis-free survival, time to brain metastasis, and overall survival between asymptomatic patients with clinical stage IA non-small cell lung cancer who underwent staging brain MRI and those who did not.
Review
Oncology
Muhammad Joan Ailia, Nishant Thakur, Jamshid Abdul-Ghafar, Chan Kwon Jung, Kwangil Yim, Yosep Chong
Summary: The integration of digital pathology with artificial intelligence enables faster, more accurate, and thorough diagnoses, leading to more precise personalized treatment. In the past five years, there has been an increasing trend in patent filings, primarily focusing on the digitization of pathological images and AI technologies that support the vital role of pathologists.
Review
Oncology
Mohammad Rizwan Alam, Jamshid Abdul-Ghafar, Kwangil Yim, Nishant Thakur, Sung Hak Lee, Hyun-Jong Jang, Chan Kwon Jung, Yosep Chong
Summary: This study assessed the current status of artificial intelligence (AI) applications for microsatellite instability (MSI) prediction based on whole slide images (WSIs), and suggested a better study design. The AI models showed promising results in predicting MSI, but the limitations included small datasets and lack of external validation. Future studies with larger datasets are needed to implement AI models in routine diagnostic practice for MSI prediction.
Review
Oncology
Muhammad Joan Ailia, Nishant Thakur, Yosep Chong, Kwangil Yim
Summary: This study investigated the role of tumor budding (TB) in gynecological cancers and found that TB is associated with poor survival outcomes. TB is related to epithelial-mesenchymal transition, microvessel density, and decreased hormone receptor expression. TB can be used as a poor prognostic marker for gynecologic cancers.
Review
Clinical Neurology
Na Rae Kim, Seong-Ik Kim, Jin Woo Park, Chul-Kee Park, Chun Kee Chung, Seung-Hong Choi, Hongseok Yun, Sung-Hye Park
Summary: In this study, two cases of rare angiomatoid fibrous histiocytomas (AFH) were reported, one in the brain parenchyma and the other in the spinal cord. Molecular investigations revealed that both cases harbored FET:CREB fusion. A comprehensive review of 40 cases of central nervous system AFHs/myxoid mesenchymal tumors showed that they predominantly occurred in children and young adults, were dura-based, and were associated with EWSR1 rearrangements.
Review
Oncology
Nishant Thakur, Mohammad Rizwan Alam, Jamshid Abdul-Ghafar, Yosep Chong
Summary: Artificial intelligence has shown promising results in non-gynecological cancer cytology, especially in classification and segmentation tasks. However, the lack of large-scale, well-annotated datasets is a major limitation in current studies.
Article
Clinical Neurology
H. Chung, H. Seo, S. H. Choi, C. -k. Park, T. M. Kim, S. -h. Park, J. K. Won, J. H. Lee, S. -t. Lee, J. Y. Lee, I. Hwang, K. M. Kang, T. J. Yun
Summary: This study developed a machine learning-based model to identify preoperative multiparametric MR imaging markers associated with prognosis in glioblastoma patients. The model found that nonenhancing T2 high-signal-intensity lesions with the relatively low normalized CBV, low volume transfer constant values, and the lowest ADC values could serve as useful prognostic imaging markers for predicting survival outcomes in patients with glioblastoma.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Otorhinolaryngology
In Gul Kim, Yanru Wu, Su A. Park, Ji Suk Choi, Seong Keun Kwon, Seung Hong Choi, Kyeong Cheon Jung, Jung-Woog Shin, Eun-Jae Chung
Summary: This study evaluated the potential of a double-layered polymeric scaffold and a custom-designed mesenchymal stem cell-based bioreactor system for esophageal tissue engineering. The results showed that electrospun polyurethane scaffolds cultured in a custom bioreactor can be a promising approach for esophageal reconstruction.
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
(2023)
Article
Clinical Neurology
Ye Yoon Suh, Kwanghoon Lee, Yu-Mi Shim, Ji Hoon Phi, Chul-Kee Park, Seung-Ki Kim, Seung Hong Choi, Hongseok Yun, Sung-Hye Park
Summary: The MYB/MYBL1::QKI fusion activates the oncogene MYB and deletes the tumor suppressor gene QKI. Previously, this fusion was only reported in angiocentric glioma (AG) and diffuse low-grade glioma. This study compares two tumors with the MYB/MYBL1::QKI fusion: a diffuse pediatric-type high-grade glioma (DPedHGG) in an 11-year-old boy and an AG in a 46-year-old woman. Characterization using immunohistochemistry, next-generation sequencing, and methylation profiling reveals their molecular characteristics and supports the presence of MYB/MYBL1 alterations in higher-grade gliomas.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2023)
Article
Oncology
Beomseok Sohn, Kisung Park, Sung Soo Ahn, Yae Won Park, Seung Hong Choi, Seok-Gu Kang, Se Hoon Kim, Jong Hee Chang, Seung-Koo Lee
Summary: A radiomics model based on dynamic contrast-enhanced (DCE) MRI was developed and validated to predict epidermal growth factor receptor (EGFR) amplification in patients with glioblastoma, isocitrate dehydrogenase (IDH) wildtype.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Review
Clinical Neurology
Hyunhee Kim, Kwanghoon Lee, Ji Hoon Phi, Sun Ha Paek, Hongseok Yun, Seung Hong Choi, Sung-Hye Park
Summary: This study presents the clinicopathological and molecular genetic characteristics of a neuroepithelial tumor (NET) with EWSR1::PATZ1 fusion, which has recently been discovered in rare central nervous system tumors and soft tissue sarcomas. Two cases of this fusion were identified, with the pediatric case showing a high-grade tumor and longer survival compared to conventional glioblastoma. The TERT promoter mutation may serve as an indicator of high-grade behavior in PATZ1 fusion NET.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2023)
Article
Oncology
Beomseok Sohn, Kisung Park, Sung Soo Ahn, Yae Won Park, Seung Hong Choi, Seok-Gu Kang, Se Hoon Kim, Jong Hee Chang, Seung-Koo Lee
Summary: The study developed and validated a radiomics model based on dynamic contrast-enhanced (DCE) MRI to predict EGFR amplification in glioblastoma patients. The radiomics model using the K-trans map showed higher accuracy than conventional MRI in predicting EGFR amplification.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Huijin Song, Seun Ah Lee, Sang Won Jo, Suk-Ki Chang, Yunji Lim, Yeong Seo Yoo, Jae Ho Kim, Seung Hong Choi, Chul-Ho Sohn
Summary: This study aimed to compare the agreement and reliability of NeuroQuant (NQ), DeepBrain (DB), and FreeSurfer (FS) software programs in estimating the volumes and normative percentiles (N%) of segmented brain regions. The results showed significant differences and limited agreement and reliability between NQ and DB in measuring volume and N%.
KOREAN JOURNAL OF RADIOLOGY
(2022)
