Article
Clinical Neurology
Evyn M. Peters, Lloyd Balbuena, Rohit J. Lodhi
Summary: The study found that emotional responsiveness improved in all treatment groups among adult outpatients with acute major depressive disorder. Only a minority experienced more emotional blunting post-treatment, with similar correlations between emotional blunting and negative outcomes in the placebo group.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Medicine, General & Internal
Daniel Marcos-Frutos, Virginia Lopez-Alonso, Irene Mera-Gonzalez, Jose Andres Sanchez-Molina, David Colomer-Poveda, Gonzalo Marquez
Summary: This systematic review examines the chronic effects of combining transcranial direct current stimulation (tDCS) and exercise on motor function and performance outcomes. The findings suggest that the chronic use of tDCS in combination with strength training does not enhance motor function in healthy adults. In neurological disorders, combining tDCS with exercise programs that include movements to be improved does not have an additive effect. However, in musculoskeletal conditions characterized by pain as a limiting factor of motor function, tDCS may enhance exercise-induced adaptations, although evidence is limited.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dermatology
Kevin S. Kim, An-Wen Chan, Emilie P. Belley-Cote, Aaron M. Drucker
Summary: Noninferiority trials, which assess the comparability of a new treatment with the standard of care, have increased significantly in publication from 2005 to 2015. These trials differ from superiority trials in various aspects of trial design and have unique considerations.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Michalina Sikorska, Anna Z. Z. Antosik-Wojcinska, Monika Dominiak
Summary: Depression is a major mental disorder, and the current pharmacological treatment may not be as effective. Probiotic therapy has shown potential in reducing depressive symptoms, but the exact mechanisms are still unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Behavioral Sciences
Shizheng Du, Jianshu Dong, Shengji Jin, Heng Zhang, Yuqun Zhang
Summary: ACT shows positive immediate effects on functioning for chronic pain patients, but the sustainability of the effects remains uncertain. More RCTs within specific chronic pain conditions are needed.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Ji-Hee Shin, Chong-Su Kim, Lina Cha, Sojeong Kim, Seokoh Lee, Suyeon Chae, Woo Young Chun, Dong-Mi Shin
Summary: The study showed that daily intake of dark chocolate can significantly reduce negative emotions, especially in the DC85 group; the gut microbial diversity was significantly higher in the DC85 group compared to the CON group; the prebiotic effects of dark chocolate may improve negative emotional states by restructuring the intestinal bacteria.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Marigoula Vlassopoulou, Mary Yannakoulia, Vasiliki Pletsa, Georgios I. Zervakis, Adamantini Kyriacou
Summary: Beta-glucans are polysaccharides with potential health benefits, primarily manifested through enhancing the immune system, improving psychological wellbeing, and potentially reducing comorbid conditions associated with obesity. Further research is needed to confirm additional beneficial effects, establish optimal dosage, and unveil underlying molecular mechanisms.
Article
Neurosciences
Natsumi Mutoh, Izumi Kakiuchi, Kumiko Kato, Chendong Xu, Noriyuki Iwabuchi, Masayo Ayukawa, Kyoko Kiyosawa, Kazumi Igarashi, Miyuki Tanaka, Masahiko Nakamura, Mitsunaga Miyasaka
Summary: Heat-killed L. helveticus MCC1848 effectively enhances positive mood and improves overall well-being.
Review
Psychiatry
Jian Zhang, Guojun Wang, Xi Yang, Keming Gao
Summary: A meta-analysis compared the efficacy and safety of ECT combination with medication versus medication alone in treating acute mania. ECT-combo was found to outperform Med-alone in reducing manic symptoms, but also had increased memory impairment. Larger studies are needed to further confirm these findings due to high heterogeneity in the included studies.
PSYCHIATRY RESEARCH
(2021)
Review
Psychiatry
Josiane Bourque, Stephane Potvin
Summary: This review focuses on the acute and long-term association between cannabis use and cognitive functioning, discussing factors such as THC levels, previous cannabis use, and comorbidity with psychosis-spectrum disorders. Evidence suggests mild to moderate acute effects on memory, processing speed, and executive functions, with residual impairing effects persisting even days or weeks following abstinence. Adolescent-onset cannabis use seems to have a longer lasting impact compared to adult-onset, supporting the neurotoxic hypothesis of cannabis.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychology, Clinical
Nur Hani Zainal, Michelle G. Newman
Summary: This study conducted a comprehensive meta-analysis of the effects of mindfulness-based interventions (MBIs) on global cognition and 15 cognitive subdomains. The results showed that MBIs had small-to-moderate significant effects on global cognition and several specific cognitive functions. However, MBIs did not impact certain aspects of executive functioning and cognitive performance. The treatment effects were stronger in certain participant groups and under specific conditions.
HEALTH PSYCHOLOGY REVIEW
(2023)
Review
Clinical Neurology
Mairead O'Donoghue, Siobhan Leahy, Pauline Boland, Rose Galvin, John McManus, Sara Hayes
Summary: This systematic review and meta-analysis evaluated the effectiveness of rehabilitation interventions for cognitive function poststroke. The findings suggest that multiple component interventions, physical activity interventions, and noninvasive brain stimulation may improve cognitive function. However, caution is needed due to the moderate to high risk of bias, heterogeneity of interventions, and outcome measures in the included studies.
Review
Medicine, General & Internal
Adam Gedek, Zofia Szular, Anna Z. Antosik, Pawel Mierzejewski, Monika Dominiak
Summary: This study systematically summarized the effects of celecoxib on mood disorders and inflammatory parameters. The results showed that celecoxib had antidepressant efficacy in the treatment of major depression and mania, and it was also safe for up to 12 weeks. However, the effectiveness of celecoxib in bipolar depression is still uncertain, and more research is needed to explore the relationship between celecoxib treatment and inflammatory markers.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Gunilla Onning, Caroline Montelius, Magnus Hillman, Niklas Larsson
Summary: This exploratory study aimed to evaluate the effect of the probiotic strain Lactiplantibacillus plantarum HEAL9 on the gut-brain axis in subjects with moderate stress. The results showed that intake of LPHEAL9 significantly improved cognitive functions, potentially by ameliorating aspects of mood and sleep.
Article
Nutrition & Dietetics
Kylie E. Walden, Jessica M. Moon, Anthony M. Hagele, Leah E. Allen, Connor J. Gaige, Joesi M. Krieger, Ralf Jaeger, Petey W. Mumford, Marco Pane, Chad M. Kerksick
Summary: The efficacy of supplementing with a multi-strain probiotic was examined in improving mood, anxiety, and neurotransmitter levels.
FRONTIERS IN NUTRITION
(2023)