Rare variants in non-coding regulatory regions of the genome that affect gene expression in systemic lupus erythematosus

Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus

(2019) Simon H. Jiang et al.   Nature Communications

A plausibly causal functional lupus-associated risk variant in the STAT1–STAT4 locus

(2018) Zubin H Patel et al.   HUMAN MOLECULAR GENETICS

Association of IRF5 polymorphisms with increased risk for systemic lupus erythematosus in population of Crete, a southern-eastern European Greek island

(2017) M.I. Zervou et al.   GENE

The transcriptional repressor Gfi1 prevents lupus autoimmunity by restraining TLR7 signaling

(2016) Benoit Desnues et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Introducing a New Dimension to Molecular Disease Classifications

(2016) Noémie Jourde-Chiche et al.   TRENDS IN MOLECULAR MEDICINE

Clinical associations of IL-10 and IL-37 in systemic lupus erythematosus

(2016) Jack Godsell et al.   Scientific Reports

Association of MIF, but not type I interferon-induced chemokines, with increased disease activity in Asian patients with systemic lupus erythematosus

(2016) K. L. Connelly et al.   Scientific Reports

Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture

(2016) Marta E. Alarcón-Riquelme et al.   Arthritis & Rheumatology

Glucocorticoid-induced leucine zipper (GILZ) inhibits B cell activation in systemic lupus erythematosus

(2015) Sarah A Jones et al.   ANNALS OF THE RHEUMATIC DISEASES

ChIP-nexus enables improved detection of in vivo transcription factor binding footprints

(2015) Qiye He et al.   NATURE BIOTECHNOLOGY

Two Functional Lupus-Associated BLK Promoter Variants Control Cell-Type- and Developmental-Stage-Specific Transcription

(2014) Joel M. Guthridge et al.   AMERICAN JOURNAL OF HUMAN GENETICS

GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region

(2014) D L Armstrong et al.   GENES AND IMMUNITY

The IRF5–TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share

(2014) Leah C. Kottyan et al.   HUMAN MOLECULAR GENETICS

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

Expression of Ets-1 and FOXP3 mRNA in CD4+CD25+ T regulatory cells from patients with systemic lupus erythematosus

(2013) Nan Xiang et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Analysis of Sequence Variation Underlying Tissue-specific Transcription Factor Binding and Gene Expression

(2013) Karen M. Lower et al.   HUMAN MUTATION

The CD11b-integrin (ITGAM) and systemic lupus erythematosus

(2013) SC Fagerholm et al.   LUPUS

The Systemic Lupus Erythematosus IRF5 Risk Haplotype Is Associated with Systemic Sclerosis

(2013) F. David Carmona et al.   PLoS One

Clinical associations of serum interleukin-17 in systemic lupus erythematosus

(2013) Fabien B Vincent et al.   ARTHRITIS RESEARCH & THERAPY

Meta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians

(2012) Wanling Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Association of two independent functional risk haplotypes inTNIP1with systemic lupus erythematosus

(2012) Indra Adrianto et al.   ARTHRITIS AND RHEUMATISM

Emerging roles for TNIP1 in regulating post-receptor signaling

(2012) Vincent P. Ramirez et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Annotation of functional variation in personal genomes using RegulomeDB

(2012) A. P. Boyle et al.   GENOME RESEARCH

Focus on systemic lupus erythematosus in Indigenous Australians: towards a better understanding of autoimmune diseases

(2012) F. B. Vincent et al.   INTERNAL MEDICINE JOURNAL

Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways

(2012) Samuel E. Vaughn et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Integrating Autoimmune Risk Loci with Gene-Expression Data Identifies Specific Pathogenic Immune Cell Subsets

(2011) Xinli Hu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Preferential Association of Interferon Regulatory Factor 5 Gene Variants with Seronegative Rheumatoid Arthritis in 2 Swedish Case-Control Studies

(2011) CHUAN WANG et al.   JOURNAL OF RHEUMATOLOGY

9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response

(2011) Olivier Harismendy et al.   NATURE

Replication of GWAS-identified systemic lupus erythematosus susceptibility genes affirms B-cell receptor pathway signalling and strengthens the role of IRF5 in disease susceptibility in a Northern European population

(2011) T. M. Jarvinen et al.   RHEUMATOLOGY

Differential Genetic Associations for Systemic Lupus Erythematosus Based on Anti–dsDNA Autoantibody Production

(2011) Sharon A. Chung et al.   PLoS Genetics

Regulatory polymorphisms in EGR2 are associated with susceptibility to systemic lupus erythematosus

(2010) K. Myouzen et al.   HUMAN MOLECULAR GENETICS

Transcriptional Activation of the cAMP-responsive Modulator Promoter in Human T Cells Is Regulated by Protein Phosphatase 2A-mediated Dephosphorylation of SP-1 and Reflects Disease Activity in Patients with Systemic Lupus Erythematosus

(2010) Yuang-Taung Juang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells

(2010) Julia K. Polansky et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Association of ITGAM polymorphism with systemic lupus erythematosus: a meta-analysis

(2010) Y Fan et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

IL-37 is a fundamental inhibitor of innate immunity

(2010) Marcel F Nold et al.   NATURE IMMUNOLOGY

Genome-Wide Association Study in Asian Populations Identifies Variants in ETS1 and WDFY4 Associated with Systemic Lupus Erythematosus

(2010) Wanling Yang et al.   PLoS Genetics

ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry

(2009) X. Kim-Howard et al.   ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: The randomized, double-blind, phase ii/iii systemic lupus erythematosus evaluation of rituximab trial

(2009) Joan T. Merrill et al.   ARTHRITIS AND RHEUMATISM

ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai

(2009) Wanling Yang et al.   HUMAN MOLECULAR GENETICS

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

(2009) Jian-Wen Han et al.   NATURE GENETICS

Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjögren's syndrome

(2008) G Nordmark et al.   GENES AND IMMUNITY

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS