Nucleus pulposus primary cilia alter their length in response to changes in extracellular osmolarity but do not control TonEBP-mediated osmoregulation

NFAT5/TonEBP controls early acquisition of notochord phenotypic markers, collagen composition, and sonic hedgehog signaling during mouse intervertebral disc embryogenesis

(2019) Steven Tessier et al.   DEVELOPMENTAL BIOLOGY

COX-2 expression mediated by calcium-TonEBP signaling axis under hyperosmotic conditions serves osmoprotective function in nucleus pulposus cells

(2018) Hyowon Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early onset of disc degeneration in SM/J mice is associated with changes in ion transport systems and fibrotic events

(2018) Ying Zhang et al.   MATRIX BIOLOGY

A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis

(2018) Hyowon Choi et al.   MATRIX BIOLOGY

Glycosaminoglycan synthesis in the nucleus pulposus: Dysregulation and the pathogenesis of disc degeneration

(2018) Elizabeth S. Silagi et al.   MATRIX BIOLOGY

Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus

(2017) Chao Liu et al.   Scientific Reports

RNA Sequencing Reveals a Role of TonEBP Transcription Factor in Regulation of Pro-inflammatory Genes in Response to Hyperosmolarity in Healthy Nucleus Pulposus Cells

(2016) Zariel I. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: Evolving role of TonEBP

(2014) Zariel I. Johnson et al.   MATRIX BIOLOGY

Inflammatory Cytokines Associated with Degenerative Disc Disease Control Aggrecanase-1 (ADAMTS-4) Expression in Nucleus Pulposus Cells through MAPK and NF-κB

(2013) Ye Tian et al.   AMERICAN JOURNAL OF PATHOLOGY

Smelling the roses and seeing the light: gene therapy for ciliopathies

(2013) Jeremy C. McIntyre et al.   TRENDS IN BIOTECHNOLOGY

A Smoothened-Evc2 Complex Transduces the Hedgehog Signal at Primary Cilia

(2012) Karolin V. Dorn et al.   DEVELOPMENTAL CELL

Tonicity enhancer binding protein (TonEBP) and hypoxia-inducible factor (HIF) coordinate heat shock protein 70 (Hsp70) expression in hypoxic nucleus pulposus cells: Role of Hsp70 in HIF-1α degradation

(2012) Shilpa S Gogate et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Chondrocyte primary cilia shorten in response to osmotic challenge and are sites for endocytosis

(2012) D.R. Rich et al.   OSTEOARTHRITIS AND CARTILAGE

TNF-α and IL-1β Promote a Disintegrin-like and Metalloprotease with Thrombospondin Type I Motif-5-mediated Aggrecan Degradation through Syndecan-4 in Intervertebral Disc

(2011) Jianru Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T1ρ Magnetic Resonance Imaging and Discography Pressure as Novel Biomarkers for Disc Degeneration and Low Back Pain

(2011) Arijitt Borthakur et al.   SPINE

Culturing Bovine Nucleus Pulposus Explants by Balancing Medium Osmolarity

(2011) Bart van Dijk et al.   TISSUE ENGINEERING PART C-METHODS

Mechanical loading modulates chondrocyte primary cilia incidence and length

(2010) Susan R McGlashan et al.   CELL BIOLOGY INTERNATIONAL

Identification of Signaling Pathways Regulating Primary Cilium Length and Flow-Mediated Adaptation

(2010) Tatiana Y. Besschetnova et al.   CURRENT BIOLOGY

Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes

(2009) Mimi N. Phan et al.   ARTHRITIS AND RHEUMATISM

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

(2009) M.-H. Chen et al.   GENES & DEVELOPMENT

Activation of TonEBP by Calcium Controls β1,3-Glucuronosyltransferase-I Expression, a Key Regulator of Glycosaminoglycan Synthesis in Cells of the Intervertebral Disc

(2009) Akihiko Hiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osmolarity and Intracellular Calcium Regulate Aquaporin2 Expression Through TonEBP in Nucleus Pulposus Cells of the Intervertebral Disc

(2009) Sachin Gajghate et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Multiple Primary Cilia Modulate the Fluid Transcytosis in Choroid Plexus Epithelium

(2009) Keishi Narita et al.   TRAFFIC

The Primary Cilium of Connective Tissue Cells: Imaging by Multiphoton Microscopy

(2008) Eve Donnelly et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology