Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography
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Title
Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography
Authors
Keywords
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Journal
Scientific Reports
Volume 9, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-10-31
DOI
10.1038/s41598-019-51844-z
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- (2012) Ronald J. Jenkins et al. ACS Chemical Biology
- Structure determination of LpxA from the lipopolysaccharide-synthesis pathway ofAcinetobacter baumannii
- (2012) John Badger et al. Acta Crystallographica Section F-Structural Biology and Crystallization Communications
- Structure determination of LpxD from the lipopolysaccharide-synthesis pathway ofAcinetobacter baumannii
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