Letter
Environmental Sciences
Song Qin Qin, Wang Yan Hai, Wang Xin Ling, Shi Bing Tian, Wang Rui Fang, Song Juan, Wang Wen Jun, Xia Dong, Xia Zhi Qiang, Wei Qiang, Han Jun
Summary: In this study, we investigated the changes in miRNA levels in HRV16-infected cells and found associations between differentially expressed miRNAs and genes associated with cellular differentiation and transcriptional regulation.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Davide Barbagallo, Concetta Ilenia Palermo, Cristina Barbagallo, Rosalia Battaglia, Angela Caponnetto, Vittoria Spina, Marco Ragusa, Cinzia Di Pietro, Guido Scalia, Michele Purrello
Summary: This study found that SARS-CoV-2 can synthesize a circular RNA called circ_3205 upon host cell infection. It interacts with miRNA and contributes to the upregulation of KCNMB4 and PRKCE mRNA, which are associated with blood coagulation and immune response.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Oncology
Yu Chen, Shanshan Zhu, Yuru Pei, Jiao Hu, Zenglei Hu, Xiaowen Liu, Xiaoquan Wang, Min Gu, Shunlin Hu, Xiufan Liu
Summary: This study identified significant changes in the cellular miRNA expression profile in HeLa cells after NDV infection, with promotion of certain miRNAs and suppression of others. These miRNAs are predicted to target genes involved in virus replication and antiviral immunity, providing valuable insights for further investigation into the roles of miRNAs in NDV-mediated oncolysis.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Shintaro Komatsu, Hiroki Kitai, Hiroshi I. Suzuki
Summary: MicroRNAs (miRNAs) act as versatile regulators of gene expression at the post-transcriptional level. Recent studies have uncovered the mechanisms involved in miRNA biogenesis, including the processing of both canonical and non-canonical miRNAs. Additionally, the complex interactions between miRNAs and their targets have been explored, revealing target-mediated miRNA degradation and cooperative regulation by multiple miRNAs. These findings highlight the coordinated regulation of miRNA biogenesis and miRNA-target interaction in miRNA biology.
Article
Biochemistry & Molecular Biology
Andras Makkos, Bence Agg, Zoltan V. Varga, Zoltan Giricz, Mariann Gyongyosi, Dominika Lukovic, Rainer Schulz, Monika Bartekova, Aniko Gorbe, Peter Ferdinandy
Summary: This study aimed to identify key molecular targets of ProtectomiRs and confirm their association with cardioprotection. The results demonstrated that Rictor is the central molecular target of ProtectomiRs and may be a potential novel drug target for acute cardioprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Li Guo, Yongsheng Li, Kara M. Cirillo, Robert A. Marick, Zhe Su, Xing Yin, Xu Hua, Gordon B. Mills, Nidhi Sahni, S. Stephen Yi
Summary: miRNA is not a single sequence, but a series of multiple variants with sequence and expression heterogeneity. Variations in isomiRs generated from the same miRNA locus often exhibit remarkable variation in their sequence, expression, and function, leading to potential novel target discovery and expansion of interaction capabilities between small RNAs and mRNAs, rewiring regulatory networks and increasing signaling circuit complexity. The widespread expansion of isomiR and mRNA interaction networks suggests global gene regulation network perturbations by alternative small RNA variants or isoforms, playing a far more complex and plastic role in gene regulation than previously anticipated.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Biology
Satarupa Ganguly, Bartika Ghoshal, Ishani Banerji, Shreya Bhattacharjee, Sreemoyee Chakraborty, Avijit Goswami, Kamalika Mukherjee, Suvendra N. Bhattacharyya
Summary: Leishmania regulates host cell miRNA transport to restrict inflammation. It inhibits inflammation by preventing host cell uptake of miR-122-containing vesicles and promotes inflammation by up-regulating the export of miR-146a, which affects cytokine expression and polarization of other macrophages.
LIFE SCIENCE ALLIANCE
(2022)
Review
Immunology
Amene Saghazadeh, Nima Rezaei
Summary: This systematic review analyzed studies on miRNA expression profiles in peripheral blood and mononuclear cells of myasthenia gravis (MG) patients. The results showed several miRNAs consistently dysregulated across different studies, which contribute to various pathways such as neural apoptosis and autophagy, inflammation, T regulatory cell development, and T helper cell balance.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Health Care Sciences & Services
Aleksander Turk, Tanja Kunej, Borut Peterlin
Summary: Alzheimer's Disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia, making early diagnosis challenging. Research on miRNAs as biomarkers for AD diagnostics has potential. An analysis using tools such as Cytoscape, STRING, and mirPath revealed potential disease modules for further biomarker development from experimentally validated AD-associated MTIs obtained from miRTarBase.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sandra Schreiber, Patrick Daum, Heike Danzer, Manuela Hauke, Hans-Martin Jaeck, Juergen Wittmann
Summary: This study provides new insights into the expression and function of miR-128 by validating novel target mRNAs expressed in B cells and identifying additional pathways likely controlled by this miRNA in the immune system.
Article
Immunology
Luyao Liu, Xi Chen, Ting Tang, Li Chen, Qiaoling Huang, Zhongyu Li, Qinqin Bai, Lili Chen
Summary: Using small RNA sequencing technology, a large amount of differentially expressed miRNAs were identified in human bronchial epithelial cells infected with Chlamydia psittaci. Functional annotation and pathway analysis revealed that these miRNAs mainly target genes involved in transcriptional regulation and ATP binding, with potential implications in key signaling pathways. The qRT-PCR results confirmed the consistency between the validated miRNAs and the sRNA sequencing data.
MICROBIAL PATHOGENESIS
(2021)
Article
Agriculture, Dairy & Animal Science
Wen-Bin Zheng, Lang Cai, Yang Zou, Wen-Wei Gao, Qing Liu, Xing-Quan Zhu
Summary: This study examined the expression of miRNAs in the serum of Beagle dogs infected with T. canis using RNA sequencing technology and identified several differently expressed miRNAs. The results indicated that T. canis infection can alter the expression of miRNAs in the serum of Beagle dogs and provided baseline data for further research on the regulatory signaling networks involved in the pathogenesis of toxocariasis.
Article
Biochemistry & Molecular Biology
Andrey Zhelankin, Liliia N. Iulmetova, Elena Sharova
Summary: The type of anticoagulant in blood collection tubes has a significant impact on the circulating plasma miRNA profiles. This study found that EDTA samples have distinct miRNA profiles compared to samples obtained using other anticoagulants, primarily due to an increased level of hemolysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Xuefeng Zhou, Qi Zhou, Di Zhou, Fen Li, Chunyan Zhang, Yan Yang
Summary: This study found that miRNA expression profiles were altered in senescent neuroblastoma cells and extracellular vesicles, mainly affecting cellular metabolic pathways. These results provide important reference for evaluating the efficacy of chemotherapy in clinical tumor treatment.
TRANSLATIONAL CANCER RESEARCH
(2022)
Review
Oncology
Wen Jess Li, Xiaozhuo Liu, Emily M. Dougherty, Dean G. Tang
Summary: The article reviews the tumor suppressive role of miRNA-34a in prostate cancer and discusses therapeutic development strategies for advanced prostate cancer patients.