Myeloid maturation potentiates STAT3-mediated atypical IFN-γ signaling and upregulation of PD-1 ligands in AML and MDS

Dual requirement for STAT signaling in dendritic cell immunobiology

(2018) Gloria Donninelli et al.   IMMUNOBIOLOGY

PD-L1 on host cells is essential for PD-L1 blockade–mediated tumor regression

(2018) Haidong Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

Checkpoint inhibitors and acute myelogenous leukemia: promises and challenges

(2018) Mansour Alfayez et al.   Expert Review of Hematology

Translational control of tumor immune escape via the eIF4F–STAT1–PD-L1 axis in melanoma

(2018) Michaël Cerezo et al.   NATURE MEDICINE

Mechanisms of Immune Tolerance in Leukemia and Lymphoma

(2017) Emily K. Curran et al.   TRENDS IN IMMUNOLOGY

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

Diagnosis and Therapy of Acute Myeloid Leukemia in the Era of Molecular Risk Stratification

(2016) Krishna V. Komanduri et al.   Annual Review of Medicine

The untold story of IFN-γ in cancer biology

(2016) M. Alper Kursunel et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Functional exhaustion of CD4+T cells induced by co-stimulatory signals from myeloid leukaemia cells

(2016) Didem Ozkazanc et al.   IMMUNOLOGY

Acute Myeloid Leukemia: A Concise Review

(2016) Jennifer Saultz et al.   Journal of Clinical Medicine

CRAM-A indicates IFN-γ-associated inflammatory response in breast cancer

(2015) Parisa Sarmadi et al.   MOLECULAR IMMUNOLOGY

Prognostic Value of CD11b Expression Level for Acute Myeloid Leukemia Patients: A Meta-Analysis

(2015) Shuangnian Xu et al.   PLoS One

Correlation of CD11b and CD56 expression in adult acute myeloid leukemia with cytogenetic risk groups and prognosis

(2014) Jordi Juncà et al.   ANNALS OF HEMATOLOGY

Recent developments in myelodysplastic syndromes

(2014) R. Bejar et al.   BLOOD

STAT3 as a possible therapeutic target in human malignancies: lessons from acute myeloid leukemia

(2014) Øystein Bruserud et al.   Expert Review of Hematology

Negative Interactions and Feedback Regulations Are Required for Transient Cellular Response

(2014) Mohammad Mobashir et al.   Scientific Reports

Adaptive resistance: A tumor strategy to evade immune attack

(2013) Sheng Yao et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immune evasion in acute myeloid leukemia: current concepts and future directions

(2013) Ryan M Teague et al.   Journal for ImmunoTherapy of Cancer

Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations

(2012) B. Will et al.   BLOOD

Myeloid leukemia cells with a B7-2+subpopulation provoke Th-cell responses and become immuno-suppressive through the modulation of B7 ligands

(2012) Yusuf Dolen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inhibition of Intracellular Antiviral Defense Mechanisms Augments Lentiviral Transduction of Human Natural Killer Cells: Implications for Gene Therapy

(2012) Tolga Sutlu et al.   HUMAN GENE THERAPY

Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape

(2012) J. M. Taube et al.   Science Translational Medicine

Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor

(2011) M. S. Redell et al.   BLOOD

Interferon-  and tumor necrosis factor-  induce an immunoinhibitory molecule, B7-H1, via nuclear factor- B activation in blasts in myelodysplastic syndromes

(2010) A. Kondo et al.   BLOOD

In acute myeloid leukemia, B7-H1 (PD-L1) protection of blasts from cytotoxic T cells is induced by TLR ligands and interferon-gamma and can be reversed using MEK inhibitors

(2010) Céline Berthon et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

PD-L1 expression on tolerogenic APCs is controlled by STAT-3

(2010) Sabine J. Wölfle et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cross-talk between tumor and myeloid cells: how to tip the balance in favor of antitumor immunity

(2010) Jelle J Lindenberg et al.   Immunotherapy

Sorafenib Inhibits STAT3 Activation to Enhance TRAIL-Mediated Apoptosis in Human Pancreatic Cancer Cells

(2010) S. Huang et al.   MOLECULAR CANCER THERAPEUTICS

How I treat acute promyelocytic leukemia

(2009) M. S. Tallman et al.   BLOOD

Cross-regulation of Signaling Pathways by Interferon-γ: Implications for Immune Responses and Autoimmune Diseases

(2009) Xiaoyu Hu et al.   IMMUNITY

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

The High-Mobility Group A1a/Signal Transducer and Activator of Transcription-3 Axis: An Achilles Heel for Hematopoietic Malignancies?

(2008) J. Hillion et al.   CANCER RESEARCH

Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

(2008) M. Marzec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA