Article
Cardiac & Cardiovascular Systems
Hao-Yu Wang, Bo Xu, Kefei Dou, Changdong Guan, Lei Song, Yunfei Huang, Rui Zhang, Lihua Xie, Min Zhang, Hongbing Yan, Weixian Yang, Yongjian Wu, Yuejin Yang, Shubin Qiao, Runlin Gao, Gregg W. Stone
Summary: This study found that in patients undergoing LM PCI, high levels of peak postprocedural CK-MB were independently associated with 3-year CV mortality, while elevated post-PCI cTnI did not predict mortality. The SCAI definition of PMI was significantly associated with mortality after LM PCI, while ARC-2 and UDMI definitions were not.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cell Biology
Marta Clos-Sansalvador, Marta Monguio-Tortajada, Santiago Roura, Marcella Franquesa, Francesc E. Borras
Summary: Extracellular vesicles (EVs) have great potential in clinical application for disease research and biomarker development. However, standardized techniques for EV isolation and detailed reporting of methodology are crucial for ensuring reliable and comparable results.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2022)
Article
Geochemistry & Geophysics
Xueping Yang, Zhixue Du, Yuan Li
Summary: By simulating the core-mantle differentiation process of terrestrial planets, we discovered that the partition coefficients of chlorine between metallic melt and silicate melt range from 0.003 to 1.38, indicating its siderophile behavior. These findings provide insights into the core formation processes of Earth and Mars, offering additional constraints for understanding the dynamics of core formation and volatile accretion.
GEOCHIMICA ET COSMOCHIMICA ACTA
(2023)
Article
Multidisciplinary Sciences
Matthew Olsen, Anna Lohning, Mariana Campos, Peter Jones, Simon McKirdy, Rashed Alghafri, Lotti Tajouri
Summary: An increasing number of medical staff use mobile phones at work, but a survey found that a majority of paediatric healthcare workers do not regularly clean their devices. Of particular concern is the finding that half of the respondents use their phones in the bathroom, highlighting potential hygiene issues.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Chevise L. Thomas, Harshavardhan Thippareddi, Sanjay Kumar, Macc Rigdon, Robert W. McKee, Alexander M. Stelzleni
Summary: The study found that lactic acid was the most effective in reducing surrogate E.coli on veal carcasses, with results similar to peroxyacetic acid. These findings are important for improving food safety during veal slaughter and chilling processes.
JOURNAL OF FOOD PROTECTION
(2021)
Article
Geochemistry & Geophysics
Mohammed S. Hashim, Janet E. Burke, Dalton S. Hardisty, Stephen E. Kaczmarek
Summary: Iodine concentrations in sedimentary carbonate minerals can be used as a proxy to reconstruct the redox landscape in shallow oceans throughout Earth history. This study experimentally validates the use of the iodine proxy in dolomite and shows that iodate is incorporated into dolomite while iodide is not. The iodine content and partition coefficient in dolomite are determined by its chemical and structural characteristics. These findings provide further support for previous studies using the iodine proxy and contribute to a better understanding of the variations in oxygen levels in shallow oceans throughout Earth history.
GEOCHIMICA ET COSMOCHIMICA ACTA
(2022)
Article
Materials Science, Paper & Wood
Bingrui Chen, Xiujiao Yu, Wengang Hu
Summary: This study investigated the cantilevered leg joint commonly used in modern wood furniture using numerical and experimental methods. A novel joint was proposed and compared with the typical joint. Experimental results showed that the novel joint had a higher bending moment capacity and better mechanical performance. Numerical analysis revealed that the stresses of the typical joint were concentrated on the wooden components, while the stresses of the novel joint were concentrated on the metal connectors. The stress concentration obtained by the finite element method (FEM) correlated with the failure modes observed in the experimental tests, providing a reliable method for evaluating and optimizing the novel furniture structure.
Article
Thermodynamics
Mohamed Ouakarrouch, Najma Laaroussi, Mohammed Garoum, Amine Hajji
Summary: The thermal properties of hollow concrete blocks commonly used in Morocco were identified and improved through experimental and numerical studies. Experimental characterization of thermal conductivity and thermal capacity was conducted, and the obtained data were utilized in numerical simulations. The results showed that the differences between 1D and 3D calculations were less than 7.5%, and increasing the width and number of cavities led to a significant reduction in heat loss and an increase in thermal resistance.
JOURNAL OF THERMAL SCIENCE AND ENGINEERING APPLICATIONS
(2022)
Article
Toxicology
Nadine Leubner, Sascha Pawlowski, Edward R. Salinas, Adriana Wigh, Martina Dammann, Alina Preibisch, Christian Schmitt
Summary: Phenolic benzotriazoles (BTZs) are widely used as light stabilizers in plastic products, but their potential for environmental persistence and bioaccumulation raises concerns. Fish bioaccumulation studies were conducted to evaluate the bioaccumulation potential of four commonly used BTZs, and the results showed that UV 326 had high bioaccumulation potential while UV 234, UV 329, and UV P had low bioaccumulation potential. Current in silico approaches for predicting bioaccumulation are weak, but more sophisticated methods provide better results.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Environmental Sciences
Cassandra D. Querdibitty, Marianna S. Wetherill, Susan B. Sisson, Bethany Williams, Kan Aithinne, Haeyn Seo, Nancy R. Inhofe, Janis Campbell, Megan Slawinski, Alicia L. Salvatore
Summary: This study investigated the cleaning products used by Oklahoma-licensed family child care homes and identified potential respiratory risks associated with their chemical contents. Some products were found to contain sensitizers and irritants that could cause allergy or asthma symptoms and respiratory tract irritation, respectively. Additionally, many products contained chemicals that could react with other substances in the air and produce secondary air pollutants. Some products also contained carcinogens. It is necessary to implement policy, educational, and technical assistance interventions to promote the use of safer products and reduce health risks in Oklahoma FCCHs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Geochemistry & Geophysics
Kierstin Daviau, Kanani K. M. Lee
Summary: Astronomical surveys have discovered thousands of transiting exoplanets, showing that rocky planets are common in the galaxy. Experimental and theoretical results suggest that sequestering nitrogen in the mantle of an oxygen-poor rocky planet can alter the distribution of nitrogen between the planet's interior and atmosphere.
JOURNAL OF GEOPHYSICAL RESEARCH-PLANETS
(2021)
Article
Environmental Sciences
Kirk O'Reilly, Dimitrios Athanasiou, Melanie Edwards
Summary: The use of receptor models like EPA's Chemical Mass Balance to develop source control policies requires careful consideration of the validity of model inputs. This study investigates the origins of Li's profiles and evaluates their accuracy in representing claimed sources using statistical methods. The results suggest that Li's profiles should not be used as generic PAH source inputs due to high intrasource variability and intersource similarities. The implications of misusing receptor models for promoting source control policies are discussed, questioning the claim that refined tar pavement sealers are a significant source of PAHs in urban sediments.
ENVIRONMENTAL FORENSICS
(2023)
Article
Public, Environmental & Occupational Health
Loren C. Tholcke, William H. Fang, Bryn R. Gornick, John A. Schlechter
Summary: This study aimed to investigate the difference in particulate count from different hand drying methods after surgical hand preparation. The results showed that both reusable and disposable towels produced more particles compared to the alcohol scrub control group. The alcohol dry scrub produced significantly fewer particles compared to both the disposable towels and reusable towels. Disposable towels produced significantly more particles in the 0.3 mm count compared to reusable towels.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Article
Chemistry, Analytical
Ghada Salama, Alaa El Gindy, Eman A. Abdel Hameed
Summary: In this study, a Quick, Easy, Cheap, Effective, Rugged and Safe method (QuEChERS) was optimized for extracting commonly used pesticides in Egyptian soil and drainage water. The method combined with GC-MS analysis showed good recoveries and accuracy. 12 pesticides were detected and quantified, highlighting the need for risk assessment on human health.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2022)
Article
Education, Special
Pam Hunt, Kathleen Mortier, Corrine Aramburo, Danielle Fleming, Lakshmi Balasubramanian
Summary: This study examined the characteristics of commonly used early literacy instruction for students with extensive support needs, designed by special education teachers. The results showed that teachers placed the most emphasis on vocabulary and comprehension development, while there was variation in the selection of other literacy instructional components.
EDUCATION AND TRAINING IN AUTISM AND DEVELOPMENTAL DISABILITIES
(2022)
Article
Immunology
Hannah F. Jones, Velda X. Han, Shrujna Patel, Brian S. Gloss, Nicolette Soler, Alvin Ho, Suvasini Sharma, Kavitha Kothur, Margherita Nosadini, Louise Wienholt, Chris Hardwick, Elizabeth H. Barnes, Jacqueline R. Lim, Sarah Alshammery, Timothy C. Nielsen, Melanie Wong, Markus J. Hofer, Natasha Nassar, Wendy Gold, Fabienne Brilot, Shekeeb S. Mohammad, Russell C. Dale
Summary: Genetic variation is a major risk factor for neurodevelopmental disorders, but environmental factors during pregnancy and early life also play a significant role. Studies show that mothers and families of children with tic disorders and OCD have higher rates of autoimmune diseases and other pro-inflammatory states, implying a potential link between maternal inflammation and childhood neurodevelopmental disorders.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Cell & Tissue Engineering
K. Futrega, E. Music, P. G. Robey, S. Gronthos, R. Crawford, S. Saifzadeh, T. J. Klein, M. R. Doran
Summary: The study characterized ovine BMSC and evaluated their ability to repair cartilage defects, concluding that micro-pellets manufactured from ovine articular chondrocytes were more effective than those from ovine BMSC. While ovine BMSC could form cartilage-like tissue in vitro, their effective application in cartilage repair will require successful mitigation of hypertrophy and tissue integration issues.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biology
Kathryn Futrega, Pamela G. Robey, Travis J. Klein, Ross W. Crawford, Michael R. Doran
Summary: The study challenges the long-standing belief that BMSC differentiation requires over 2 weeks of continuous TGF-beta 1 exposure, showing that differentiation can be triggered by just a single day of exposure through the use of a micro-pellet model.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Melissa E. Monterosso, Kathryn Futrega, William B. Lott, Ian Vela, Elizabeth D. Williams, Michael R. Doran
Summary: Researchers optimized a microwell platform, the Microwell-mesh, to assemble precise numbers of prostate cancer cells into microtissue arrays and implanted them into mice for studying microtissue growth. This microtumour model could potentially improve the resolution of drug response in prostate cancer PDXs and enhance the efficiency of animal use.
SCIENTIFIC REPORTS
(2021)
Article
Cell & Tissue Engineering
Bianca Nowlan, Kathryn Futrega, Elizabeth Deborah Williams, Michael Robert Doran
Summary: The study demonstrates that a large number of human bone marrow-derived stromal cells (hBMSC) can be deposited into the mouse bone marrow through direct bone marrow injection, with the population declining over time. Irradiation of the mice prior to transplantation delays the decline rate, and the injected hBMSC are found to colonize distal marrow cavities, potentially forming clusters.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Immunology
Ya Wang, Brian Gloss, Benjamin Tang, Suat Dervish, Brigitte Santner-Nanan, Christina Whitehead, Kristy Masters, Kristen Skarratt, Sally Teoh, Stephen Schibeci, Nicole Fewings, Chrystelle Brignone, Frederic Triebel, David Booth, Anthony McLean, Marek Nalos
Summary: Sepsis is associated with dysregulated inflammatory response and immune suppression, leading to susceptibility to secondary infections. Using high-dimensional flow cytometry, researchers identified two major immune response subgroups in septic patients: hypo-responsive and hyper-responsive. Pre-treatment with IFN-gamma or LAG-3Ig showed that cells from the hypo-responsive group were more responsive to immunostimulants compared to the hyper-responsive group.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Saeed Esmaili, Peter Langfelder, T. Grant Belgard, Daniele Vitale, Mahmoud Karimi Azardaryany, Ghazal Alipour Talesh, Mehdi Ramezani-Moghadam, Vikki Ho, Daniel Dvorkin, Suat Dervish, Brian S. Gloss, Henning Gronbaek, Christopher Liddle, Jacob George
Summary: This study suggests that alterations in immune responses and metabolism core modules occur in both humans and mice when hepatic homeostasis is disrupted. The extent of derailment in core modules can predict survival in liver cancer patients.
Article
Immunology
Scott A. Read, Brian S. Gloss, Christopher Liddle, Jacob George, Golo Ahlenstiel
Summary: IFN-lambda s play a critical role in eliminating acute infections by activating interferon stimulated genes, but excessive production can lead to tissue inflammation and barrier disruption. In vitro experiments showed that IFN-lambda 3 exacerbated inflammatory responses triggered by different microbial ligands. Additionally, in SARS-CoV-2 infections, IFN-lambda s were implicated in myeloid cell-driven pathogenesis.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Florencia Haase, Brian S. Gloss, Patrick P. L. Tam, Wendy A. Gold
Summary: Rett Syndrome is an X linked neurodevelopmental disorder caused by mutations in the MECP2 gene, with symptoms typically appearing between 6 to 18 months of age. Recent studies have found subtle cellular and molecular changes in neural cells before symptoms onset, suggesting global translational dysregulation may start prior to neuronal lineage commitment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Multidisciplinary Sciences
Yuan Yuan, Inge Seim, A. Rus Hoelzel, Yaolei Zhang, Peijun Zhang, Hui Kang, Ding Wang, Guangyi Fan, Kun Wang, Songhai Li
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Hui Kang, Qun Liu, Inge Seim, Wenwei Zhang, Hanbo Li, Haiyu Gao, Wenzhi Lin, Mingli Lin, Peijun Zhang, Yaolei Zhang, Haoyang Gao, Yang Wang, Yating Qin, Mingming Liu, Lijun Dong, Zixin Yang, Yingying Zhang, Lei Han, Guangyi Fan, Songhai Li
Summary: In this study, a single-nucleus transcriptome atlas of a short-finned pilot whale's brain was constructed to understand the cellular composition and compare it with terrestrial mammals. The research identified six major cell lineages in the cerebral cortex and categorized excitatory neurons, inhibitory neurons, and other cell types. Additionally, a comparison of transcriptome data from different species revealed a broadly conserved cellular makeup of brain cell types. This study provides valuable genomic resources and molecular insights into the evolution of cetacean brains.
MOLECULAR ECOLOGY RESOURCES
(2023)
Article
Biochemical Research Methods
Dmitrii Shek, Brian Gloss, Joey Lai, Li Ma, Hui E. Zhang, Matteo S. Carlino, Hema Mahajan, Adnan Nagrial, Bo Gao, Scott A. Read, Golo Ahlenstiel
Summary: Increasing evidence supports the crucial role of the tumour microenvironment in response to systemic therapy, especially immune checkpoint inhibitors (ICIs). The immune component of the tumour microenvironment, though poorly understood, has the potential to provide valuable insights for improving the efficacy and safety of ICI therapy. The use of advanced spatial and single-cell technologies can help identify and validate factors that may lead to the development of broad acting adjunct therapies and personalised cancer immunotherapies in the future.
METHODS AND PROTOCOLS
(2023)
Article
Genetics & Heredity
Suyu Zhang, Yue Song, Meiru Liu, Zengbao Yuan, Mengqi Zhang, He Zhang, Inge Seim, Guangyi Fan, Shanshan Liu, Xin Liu
Summary: In this study, genomes of three butterflyfish species and a closely related species from the Pomacanthidae family were reported, providing valuable genomic resources for further investigations into the genetic diversity and evolutionary adaptations of reef fish.
Article
Multidisciplinary Sciences
Zhenpeng Yu, Inge Seim, Mengxin Yin, Ran Tian, Di Sun, Wenhua Ren, Guang Yang, Shixia Xu
Summary: By comparing the evolution of 115 aging-related genes in 11 long-lived species and 25 mammals with non-increased lifespan, researchers identified key genes related to the insulin/IGF-1 signaling (IIS) pathway and immune response in exceptional mammalian longevity. Additionally, long-lived mammals may have evolved convergent or similar mechanisms of cancer resistance, extending their lifespan. This study also identified 12 robust candidates for longevity-related genes closely related to cancer.
Article
Immunology
David Jonathan Gottlieb, Leighton Edward Clancy, Barbara Withers, Helen Marie McGuire, Fabio Luciani, Mandeep Singh, Brendan Hughes, Brian Gloss, David Kliman, Chun Kei Kris Ma, Shyam Panicker, David Bishop, Ming-Celine Dubosq, Ziduo Li, Selmir Avdic, Kenneth Micklethwaite, Emily Blyth
Summary: Adoptive immunotherapy using donor-derived antigen-specific T-cells can effectively prevent and treat infections after allogeneic haemopoietic stem cell transplant. The study showed that rapid reconstitution of immunity to a broad range of viral and fungal infections can be achieved using a multi-pathogen-specific T-cell product, but precautions should be taken to control the development of graft-versus-host disease.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)