Ketogenic Diet: A New Light Shining on Old but Gold Biochemistry

Role of Ketogenic Diets in Neurodegenerative Diseases (Alzheimer’s Disease and Parkinson’s Disease)

(2019) Dariusz Włodarek   Nutrients

Low-carbohydrate diets differing in carbohydrate restriction improve cardiometabolic and anthropometric markers in healthy adults: A randomised clinical trial

(2019) Cliff J. d. C. Harvey et al.   PeerJ

Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency

(2019) Vikram Jakkamsetti et al.   Science Translational Medicine

β-hydroxybutyrate attenuates renal ischemia-reperfusion injury through its anti-pyroptotic effects

(2019) Takaya Tajima et al.   KIDNEY INTERNATIONAL

Modified ketogenic diets in adults with refractory epilepsy: Efficacious improvements in seizure frequency, seizure severity, and quality of life

(2019) Kelly Roehl et al.   EPILEPSY & BEHAVIOR

How often is antiseizure drug-free ketogenic diet therapy achieved?

(2019) Lochan M. Shah et al.   EPILEPSY & BEHAVIOR

2-Deoxy-d-glucose reduces epileptiform activity by presynaptic mechanisms

(2019) Yu-Zhen Pan et al.   JOURNAL OF NEUROPHYSIOLOGY

Impact of the Ketogenic Diet on Linear Growth in Children: A Single-Center Retrospective Analysis of 34 Cases

(2019) Ferraris et al.   Nutrients

LIPT1 deficiency presenting as early infantile epileptic encephalopathy, Leigh disease, and secondary pyruvate dehydrogenase complex deficiency

(2018) Robert C. Stowe et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Changes in regional cerebral blood flow associated with a 45 day course of the ketogenic agent, caprylidene, in patients with mild to moderate Alzheimer's disease: Results of a randomized, double-blinded, pilot study

(2018) Nare Torosyan et al.   EXPERIMENTAL GERONTOLOGY

OUP accepted manuscript

(2018)   JOURNAL OF NUTRITION

How Can a Ketogenic Diet Improve Motor Function?

(2018) Charlotte Veyrat-Durebex et al.   Frontiers in Molecular Neuroscience

Increases in circulating levels of ketone bodies and cardiovascular protection with SGLT2 inhibitors: Is low-grade inflammation the neglected component?

(2018) Francesco Prattichizzo et al.   DIABETES OBESITY & METABOLISM

Low-fat versus ketogenic diet in Parkinson's disease: A pilot randomized controlled trial

(2018) Matthew C.L. Phillips et al.   MOVEMENT DISORDERS

Ketogenic Diets for Adult Neurological Disorders

(2018) Tanya J. W. McDonald et al.   Neurotherapeutics

Favorable Effects of a Ketogenic Diet on Physical Function, Perceived Energy, and Food Cravings in Women with Ovarian or Endometrial Cancer: A Randomized, Controlled Trial

(2018) Caroline Cohen et al.   Nutrients

Serial MRI Imaging Reveals Minimal Impact of Ketogenic Diet on Established Liver Tumor Growth

(2018) Frances Byrne et al.   Cancers

The Potential Use of a Ketogenic Diet in Pancreatobiliary Cancer Patients After Pancreatectomy

(2018) JU HYE OK et al.   ANTICANCER RESEARCH

Mast Cell-Derived Histamine Regulates Liver Ketogenesis via Oleoylethanolamide Signaling

(2018) Alessandra Misto et al.   Cell Metabolism

Treatment of malignant gliomas with ketogenic or caloric restricted diets: A systematic review of preclinical and early clinical studies

(2018) Lotte Noorlag et al.   CLINICAL NUTRITION

The emerging role of ketogenic diets in cancer treatment

(2018) Rainer Johannes Klement   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Bi-allelic mutations of LONP1 encoding the mitochondrial LonP1 protease cause pyruvate dehydrogenase deficiency and profound neurodegeneration with progressive cerebellar atrophy

(2018) Graeme A M Nimmo et al.   HUMAN MOLECULAR GENETICS

Efficacy of ketogenic diet for pyruvate dehydrogenase complex deficiency

(2018) Rie Chida et al.   PEDIATRICS INTERNATIONAL

The ketogenic diet as a potential treatment and prevention strategy for Alzheimer's disease

(2018) Gina M. Broom et al.   NUTRITION

The effect of the ketogenic diet on the developing skeleton

(2017) Peter J. Simm et al.   EPILEPSY RESEARCH

Beneficial effects of ketogenic diets for cancer patients: a realist review with focus on evidence and confirmation

(2017) Rainer J. Klement   MEDICAL ONCOLOGY

Complications During Ketogenic Diet Initiation: Prevalence, Treatment, and Influence on Seizure Outcomes

(2017) Abigail Lin et al.   PEDIATRIC NEUROLOGY

Safety and tolerability of the ketogenic diet used for the treatment of refractory childhood epilepsy: a systematic review of published prospective studies

(2017) Qian-Yun Cai et al.   World Journal of Pediatrics

β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares

(2017) Emily L. Goldberg et al.   Cell Reports

Practice Paper of the Academy of Nutrition and Dietetics: Classic and Modified Ketogenic Diets for Treatment of Epilepsy

(2017) Kelly Roehl et al.   Journal of the Academy of Nutrition and Dietetics

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

(2016) Zhongyu Xie et al.   MOLECULAR CELL

A ketogenic diet increases transport and oxidation of ketone bodies in RG2 and 9L gliomas without affecting tumor growth

(2016) Henk M. De Feyter et al.   NEURO-ONCOLOGY

Prevalence and incidence of epilepsy

(2016) Kirsten M. Fiest et al.   NEUROLOGY

Liver-derived ketone bodies are necessary for food anticipation

(2016) Rohit Chavan et al.   Nature Communications

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

(2016) Sama F Sleiman et al.   eLife

Tumor Metabolism, the Ketogenic Diet and β-Hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumor Therapy

(2016) Eric C. Woolf et al.   Frontiers in Molecular Neuroscience

Resolvins and omega three polyunsaturated fatty acids: Clinical implications in inflammatory diseases and cancer

(2016) Kazuki Moro et al.   World Journal of Clinical Cases

Anti-Tumor Effects of Ketogenic Diets in Mice: A Meta-Analysis

(2016) Rainer J. Klement et al.   PLoS One

Effects of low-carbohydrate diets v. low-fat diets on body weight and cardiovascular risk factors: a meta-analysis of randomised controlled trials

(2015) Nadia Mansoor et al.   BRITISH JOURNAL OF NUTRITION

The MCT-ketogenic diet as a treatment option in refractory childhood epilepsy: A prospective study with 2-year follow-up

(2015) Danielle A.J.E. Lambrechts et al.   EPILEPSY & BEHAVIOR

Ten-Year Single-Center Experience of the Ketogenic Diet: Factors Influencing Efficacy, Tolerability, and Compliance

(2015) Cinthya Wibisono et al.   JOURNAL OF PEDIATRICS

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

Dietary Intervention for Overweight and Obese Adults: Comparison of Low-Carbohydrate and Low-Fat Diets. A Meta-Analysis

(2015) Jonathan Sackner-Bernstein et al.   PLoS One

Regulation of Hepatic Energy Metabolism and Gluconeogenesis by BAD

(2014) Alfredo Giménez-Cassina et al.   Cell Metabolism

Glucose metabolism transporters and epilepsy: Only GLUT1 has an established role

(2014) Michael S. Hildebrand et al.   EPILEPSIA

Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia

(2014) David G. Cotter et al.   JOURNAL OF CLINICAL INVESTIGATION

The ketogenic diet for the treatment of malignant glioma

(2014) Eric C. Woolf et al.   JOURNAL OF LIPID RESEARCH

Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications - a review

(2014) Bogna Grygiel-Górniak   Nutrition Journal

Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials

(2013) Nassib Bezerra Bueno et al.   BRITISH JOURNAL OF NUTRITION

The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes

(2013) Gregory Gaich et al.   Cell Metabolism

The Role of Metallothionein in Oxidative Stress

(2013) Branislav Ruttkay-Nedecky et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

(2013) William A Flavahan et al.   NATURE NEUROSCIENCE

Ketone bodies as signaling metabolites

(2013) John C. Newman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mechanisms of Action of Bcl-2 Family Proteins

(2013) A. Shamas-Din et al.   Cold Spring Harbor Perspectives in Biology

A Quantitative Map of the Liver Mitochondrial Phosphoproteome Reveals Posttranslational Control of Ketogenesis

(2012) Paul A. Grimsrud et al.   Cell Metabolism

Long-Acting FGF21 Has Enhanced Efficacy in Diet-Induced Obese Mice and in Obese Rhesus Monkeys

(2012) Murielle M. Véniant et al.   ENDOCRINOLOGY

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Christopher J L Murray et al.   LANCET

BAD-Dependent Regulation of Fuel Metabolism and KATP Channel Activity Confers Resistance to Epileptic Seizures

(2012) Alfredo Giménez-Cassina et al.   NEURON

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction

(2011) Jeffrey D Browning et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Modulation of oxidative stress and mitochondrial function by the ketogenic diet

(2011) Julie Milder et al.   EPILEPSY RESEARCH

Ketogenic diet-induced peroxisome proliferator-activated receptor-γ activation decreases neuroinflammation in the mouse hippocampus after kainic acid-induced seizures

(2011) Eun Ae Jeong et al.   EXPERIMENTAL NEUROLOGY

A ketogenic diet suppresses seizures in mice through adenosine A1 receptors

(2011) Susan A. Masino et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of oxidative stress in epileptic seizures

(2011) Eun-Joo Shin et al.   NEUROCHEMISTRY INTERNATIONAL

Ketogenic diet treatment in adults with refractory epilepsy

(2010) Pavel Klein et al.   EPILEPSY & BEHAVIOR

Acute oxidative stress and systemic Nrf2 activation by the ketogenic diet

(2010) Julie B. Milder et al.   NEUROBIOLOGY OF DISEASE

Brain Energy Metabolism During Experimental Neonatal Seizures

(2010) Claude G. Wasterlain et al.   NEUROCHEMICAL RESEARCH

Metabolic Control of Vesicular Glutamate Transport and Release

(2010) Narinobu Juge et al.   NEURON

Novel mutation (R263X) of the E1α subunit in pyruvate dehydrogenase complex deficiency

(2010) Satoshi Sato et al.   PEDIATRICS INTERNATIONAL

Long-term outcome and tolerability of the ketogenic diet in drug-resistant childhood epilepsy—The Austrian experience

(2010) Anastasia Dressler et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy models

(2009) Carl E. Stafstrom et al.   ANNALS OF NEUROLOGY

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial

(2009) Samuel T Henderson et al.   Nutrition & Metabolism

Empiric Use of Potassium Citrate Reduces Kidney-Stone Incidence With the Ketogenic Diet

(2009) M. A. McNally et al.   PEDIATRICS

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

(2008) J. Xu et al.   DIABETES

Fenofibrate, a peroxisome proliferator-activated receptor-α agonist, exerts anticonvulsive properties

(2008) Natacha Porta et al.   EPILEPSIA

Dose-dependent anticonvulsant effects of linoleic and α-linolenic polyunsaturated fatty acids on pentylenetetrazol induced seizures in rats

(2008) Ameer Y. Taha et al.   EPILEPSIA

A randomized trial of polyunsaturated fatty acids for refractory epilepsy

(2008) Edward Bromfield et al.   EPILEPSY & BEHAVIOR

The ketogenic diet increases mitochondrial glutathione levels

(2008) Stuart G. Jarrett et al.   JOURNAL OF NEUROCHEMISTRY

Dual role of proapoptotic BAD in insulin secretion and beta cell survival

(2008) Nika N Danial et al.   NATURE MEDICINE