FTY720 induces non-canonical phosphatidylserine externalization and cell death in acute myeloid leukemia

The NMR-based characterization of the FTY720-SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET-PP2A interaction

(2019) Ryan M. De Palma et al.   FASEB JOURNAL

TMEM16F/Anoctamin 6 in Ferroptotic Cell Death

(2019) Jiraporn Ousingsawat et al.   Cancers

TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition

(2018) Santiago Lima et al.   Autophagy

Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6

(2018) Brendan T. Finicle et al.   JOURNAL OF CELL SCIENCE

Contribution of TMEM16F to pyroptotic cell death

(2018) Jiraporn Ousingsawat et al.   Cell Death & Disease

Pb(II) Induces Scramblase Activation and Ceramide-Domain Generation in Red Blood Cells

(2018) Hasna Ahyayauch et al.   Scientific Reports

Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA–dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis

(2018) Rose Nganga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking

(2017) Santiago Lima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of TMEM16A/ANO1 and TMEM16F/ANO6 ion currents and phospholipid scrambling by Ca2+ and plasma membrane lipid

(2017) Rainer Schreiber et al.   JOURNAL OF PHYSIOLOGY-LONDON

Phosphatidylserine externalization, “necroptotic bodies” release, and phagocytosis during necroptosis

(2017) Sefi Zargarian et al.   PLOS BIOLOGY

FTY720 Induces Autophagy-Associated Apoptosis in Human Oral Squamous Carcinoma Cells, in Part, through a Reactive Oxygen Species/Mcl-1-Dependent Mechanism

(2017) Li-Yuan Bai et al.   Scientific Reports

A systematic evaluation of the safety and toxicity of fingolimod for its potential use in the treatment of acute myeloid leukaemia

(2016) Anoop K. Enjeti et al.   ANTI-CANCER DRUGS

Effects of stereochemistry, saturation, and hydrocarbon chain length on the ability of synthetic constrained azacyclic sphingolipids to trigger nutrient transporter down-regulation, vacuolation, and cell death

(2016) Michael S. Perryman et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Sphingosine-1-Phosphate Modulator FTY720 Targets Multiple Myeloma via the CXCR4/CXCL12 Pathway

(2016) Katia Beider et al.   CLINICAL CANCER RESEARCH

Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways

(2016) Seong M. Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

The phospholipid flippase ATP9A is required for the recycling pathway from the endosomes to the plasma membrane

(2016) Yoshiki Tanaka et al.   MOLECULAR BIOLOGY OF THE CELL

Lipid somersaults: Uncovering the mechanisms of protein-mediated lipid flipping

(2016) Thomas Günther Pomorski et al.   PROGRESS IN LIPID RESEARCH

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

(2016) Megan M. Young et al.   Cell Reports

Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells in Vivo

(2015) Bin Chen et al.   ACS Chemical Biology

Transport through recycling endosomes requires EHD1 recruitment by a phosphatidylserine translocase

(2015) S. Lee et al.   EMBO JOURNAL

The antineoplastic properties of FTY720: evidence for the repurposing of fingolimod

(2015) Sathya Narayanan Patmanathan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

FTY720 Induces Apoptosis of M2 Subtype Acute Myeloid Leukemia Cells by Targeting Sphingolipid Metabolism and Increasing Endogenous Ceramide Levels

(2014) Limin Chen et al.   PLoS One

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure

(2014) K. Segawa et al.   SCIENCE

FTY720 induces apoptosis of chronic myelogenous leukemia cells via dual activation of BIM and BID and overcomes various types of resistance to tyrosine kinase inhibitors

(2013) Miki Kiyota et al.   APOPTOSIS

Phosphatidylserine flipping enhances membrane curvature and negative charge required for vesicular transport

(2013) Peng Xu et al.   JOURNAL OF CELL BIOLOGY

Study of aqueous phase aggregation of FTY720 (fingolimod hydrochloride) and its effect on DMPC liposomes using fluorescent molecular probes

(2013) Jitendriya Swain et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

(2013) J. Suzuki et al.   SCIENCE

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

(2012) Sahar A. Saddoughi et al.   EMBO Molecular Medicine

Autophagy induced by FTY720 promotes apoptosis in U266 cells

(2012) Aijun Liao et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis

(2012) Megan M. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells

(2011) Craig T. Wallington-Beddoe et al.   Autophagy

Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins

(2011) Kimberly Romero Rosales et al.   BIOCHEMICAL JOURNAL

Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia

(2011) A. Liao et al.   BLOOD

Reactivating PP2A by FTY720 as a Novel therapy for AML with C-KIT tyrosine kinase domain mutation

(2011) Yan Yang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Dynamin Chemical Inhibitor Dynasore Impairs Cholesterol Trafficking and Sterol-Sensitive Genes Transcription in Human HeLa Cells and Macrophages

(2011) Emmanuelle Girard et al.   PLoS One

FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: A protective role of autophagy

(2010) Ning Zhang et al.   Autophagy

Essential Requirement for PP2A Inhibition by the Oncogenic Receptor c-KIT Suggests PP2A Reactivation as a Strategy to Treat c-KIT+ Cancers

(2010) K. G. Roberts et al.   CANCER RESEARCH

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

(2010) Francesca Tonelli et al.   CELLULAR SIGNALLING

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

(2010) Jeffrey A. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

(2009) Vandhana Muralidharan-Chari et al.   CURRENT BIOLOGY

FTY720 Inhibits Ceramide Synthases and Up-regulates Dihydrosphingosine 1-Phosphate Formation in Human Lung Endothelial Cells

(2009) Evgeny V. Berdyshev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramide starves cells to death by downregulating nutrient transporter proteins

(2008) G. G. Guenther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA