Article
Food Science & Technology
Yang Li, Junfei Chen, Dong Sun, Jingwei Liu, Zhe Wang, Aiwu Li
Summary: LGG administration can alleviate intestinal lesions in NEC by restoring intestinal flora, activating Wnt/β-catenin signaling pathway, promoting ISC regeneration, increasing the number of TJs, and improving intestinal barrier function.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Cell & Tissue Engineering
Junquan Tian, Yuying Li, Xuetai Bao, Fan Yang, Xiongzhuo Tang, Qian Jiang, Yulong Yin, Kang Yao
Summary: Early weaning inhibits the self-renewal and function of intestinal stem cells, leading to intestinal atrophy. This is potentially due to the suppression of Wnt signaling and activation of proinflammatory cytokines. These findings may offer a potential therapeutic approach for alleviating intestinal problems caused by early weaning.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Pediatrics
Alexia Gomart, Alexandre Vallee, Yves Lecarpentier
Summary: NEC is a major cause of morbidity and mortality in premature infants. The pathophysiology of this disease involves multiple intracellular pathways such as Wnt/beta-catenin signaling, PPAR gamma, GSK-3 beta, NF-kappa B, TGF-beta/Smads, and PI3K-Akt pathways. Understanding these complex mechanisms is crucial for better management and treatment of NEC.
FRONTIERS IN PEDIATRICS
(2021)
Article
Hematology
Antonina Kurtova, Melanie Heinlein, Simon Haas, Lars Velten, Gerrit J. P. Dijkgraaf, Elaine E. Storm, Noelyn M. Kljavin, Soufiane Boumahdi, Patricia Himmels, Aurelie Herault, Andrew Mancini, Hartmut Koeppen, Monique Dail, Qingxiang Yan, Jianhuan Zhang, Ute Koch, Freddy Radtke, Zora Modrusan, Ciara Metcalfe, Robert Piskol, Frederic J. de Sauvage
Summary: The self-renewal and differentiation of stem and progenitor cells are regulated by systemic and local cues. RSPO3 is important for Wnt signaling and is usually expressed in the stem cell niche to regulate stem cell expansion and differentiation. Disrupting the niche-restricted expression of RSPO3 can affect tissue organization and lead to disorders and cancers.
Article
Biochemistry & Molecular Biology
Dan Dang, Zhaoli Meng, Chuan Zhang, Zhenyu Li, Jiaqi Wei, Hui Wu
Summary: This study discovered the mechanism of ferroptosis in transfusion-associated necrotising enterocolitis (TANEC) and identified heme as a trigger for ferroptosis in intestinal epithelial cells through mitochondrial dysfunction. Heme-induced ferroptosis may be a potential therapeutic target for TANEC.
Article
Cell Biology
Zimin Xiang, Shuai Zhang, Xiaodong Yao, Libin Xu, Jianwei Hu, Chenghui Yin, Jianmei Chen, Hao Xu
Summary: Resveratrol can promote function recovery and axonal regeneration, improve histological damage, and inhibit apoptosis level after SCI by regulating the Wnt/beta-catenin signaling pathway. This study expanded the regulatory mechanism of resveratrol in SCI injury.
Article
Pediatrics
Shan He, Gang Liu, Xueping Zhu
Summary: This study demonstrates the beneficial effects of human breast milk-derived exosomes in preventing necrotizing enterocolitis by reducing inflammation and injury, and restoring intestinal tight-junction proteins.
PEDIATRIC RESEARCH
(2021)
Article
Virology
Ning Yang, Yunhang Zhang, Yuguang Fu, Yang Li, Shanshan Yang, Jianing Chen, Guangliang Liu
Summary: This study investigated the effects of transmissible gastroenteritis virus (TGEV) infection on the small intestine of pigs and its impact on intestinal stem cells (ISCs). The results revealed that TGEV infection activates the Wnt/beta-catenin pathway to promote the self-renewal of ISCs and facilitate intestinal epithelium regeneration.
JOURNAL OF VIROLOGY
(2022)
Review
Toxicology
Lu-lu Ren, Jia-yi Zhou, Shao-jie Liang, Xiu-qi Wang
Summary: This review discusses the impact of ETEC-induced diarrhea pathways and Wnt/β-catenin signaling pathway on the fate of intestinal stem cells, and highlights the current deficits in understanding the relationship between enterotoxins and intestinal epithelial cell activity.
ARCHIVES OF TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Judith C. W. de Jong, Noortje Ijssennagger, Saskia W. C. van Mil
Summary: NEC, a deadly inflammatory disease of the preterm intestine, is likely triggered by a damaged epithelial layer due to incomplete maturation of different cell lineages. Dysregulation of Wnt and Notch signaling pathways by Toll-like-receptor-4 hyperactivation is observed in NEC. Breastfeeding decreases the risk of NEC, and interventions targeting these pathways may reduce the risk of NEC development in preterm infants.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Engineering, Biomedical
Qi Zhou, Xiaoyan Ren, Michelle K. Oberoi, Meiwand Bedar, Rachel M. Caprini, Marley J. Dewey, Vasiliki Kolliopoulos, Dean T. Yamaguchi, Brendan A. C. Harley, Justine C. Lee
Summary: The nanoparticulate mineralized collagen glycosaminoglycan (MC-GAG) scaffold promotes skull regeneration in vivo without exogenous growth factors or progenitor cells. Modulation of MC-GAG stiffness affects the expression of primary human bone marrow-derived mesenchymal stem cells (hMSCs) and canonical Wnt (cWnt) signaling. Stiffness-induced activation of the Wnt and mechanotransduction pathways promotes osteogenesis on MC-GAG, while activated beta-catenin serves as a limiting agent and a potential target for optimal modulation of stiffness in skeletal regenerative materials.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Cell & Tissue Engineering
Hao Yu, Yan Liu, Xiangwen Yang, Jiajing He, Fan Zhang, Qun Zhong, Xiaojing Guo
Summary: Strontium ranelate can promote BMSCs chondrogenic differentiation by inhibiting the Wnt/beta-catenin signaling pathway and accelerate cartilage regeneration in rat femoral condyle defects.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Jia-yi Zhou, Deng-gui Huang, Chun-qi Gao, Hui-chao Yan, Shi-geng Zou, Xiu-qi Wang
Summary: The study found that STp inhibits intestinal stem cell expansion and disrupts intestinal mucosa integrity by downregulating the Wnt/beta-catenin signaling pathway.
Article
Gastroenterology & Hepatology
Nuria Oliva-Vilarnau, Christian M. Beusch, Pierre Sabatier, Eirini Sakaraki, Amelie Tjaden, Lukas Graetz, Florian A. Buettner, Debra Dorotea, My Nguyen, Filip Bergqvist, Yvonne Sundstrom, Susanne Mueller, Roman A. Zubarev, Gunnar Schulte, Claudia Tredup, Roberto Gramignoli, Uwe J. F. Tietge, Volker M. Lauschke
Summary: This study identified the signaling network that controls human hepatocyte regeneration and highlighted the essential roles of NF-κB, TGFβ, and Wnt/β-catenin in this process.
Article
Cell Biology
Shanshan Xue, Xuanjin Du, Minghui Yu, Haixin Ju, Lihong Tan, Yaxin Li, Jialu Liu, Chunyan Wang, Xiaohui Wu, Hong Xu, Qian Shen
Summary: This study investigates the role of lncRNA in renal hypoplasia, specifically focusing on the overexpression of Rik. The findings suggest that excessive Rik expression may inhibit the Wnt/beta-catenin signaling pathway, leading to renal hypoplasia. This research provides insights into the pathogenesis of CAKUT and offers guidance for the development of preventive and therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Nutrition & Dietetics
Riikka Gunnar, Annika Mutanen, Laura Merras-Salmio, Mikko P. Pakarinen
Summary: High doses of parenteral glucose, amino acids, and energy are associated with steatosis in infants with short bowel syndrome (SBS).
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Article
Pediatrics
Carlos Zozaya, Niloofar Ganji, Bo Li, Maarten Janssen Lok, Carol Lee, Yuhki Koike, Estelle Gauda, Martin Offringa, Simon Eaton, Prakeshkumar S. Shah, Agostino Pierro
Summary: This study assessed the feasibility and safety of remote ischaemic conditioning (RIC) in preterm infants with suspected or confirmed NEC. The results showed that RIC was feasible and safe in these patients, which is of significance for designing future clinical trials.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Biochemical Research Methods
Laween Meran, Lucinda Tullie, Simon Eaton, Paolo De Coppi, Vivian S. W. Li
Summary: The authors present a protocol for bioengineering human intestinal mucosal grafts using patient-derived materials. This technology has significant potential for treating intestinal failure and studying human gastrointestinal diseases.
Article
Rheumatology
Meredyth G. Ll Wilkinson, Dale Moulding, Thomas C. R. McDonnell, Michael Orford, Chris Wincup, Joanna Y. J. Ting, Georg W. Otto, Restuadi Restuadi, Daniel Kelberman, Charalampia Papadopoulou, Sergi Castellano, Simon Eaton, Claire T. Deakin, Elizabeth C. Rosser, Lucy R. Wedderburn
Summary: This study identifies a novel pathway in which altered mitochondrial biology in CD14+ monocytes of Juvenile dermatomyositis (JDM) patients leads to the production of oxidized mitochondrial DNA (oxmtDNA) and stimulates the expression of interferon (IFN) type 1 signature genes. Targeting this pathway has therapeutic potential in JDM and other IFN type 1-driven autoimmune diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Pediatrics
Ian Howard Jones, Denise Tao, Bhumita Vagdama, Michael Orford, Simon Eaton, Jane Collins, Nigel John Hall
Summary: Remote ischaemic conditioning (RIC) has therapeutic potential for intestinal diseases in the newborn by reducing the extent and severity of bowel injury and decreasing neutrophil infiltration/activation.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Letter
Pediatrics
Alexandra Stewart, Christina H. Smith, Jo Wray
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Critical Care Medicine
Gareth A. L. Jones, Simon Eaton, Michael Orford, Samiran Ray, Daisy Wiley, Padmanabhan Ramnarayan, David Inwald, Michael P. W. Grocott, Michael Griksaitis, John Pappachan, Lauran R. O'Neill, Paul A. Mouncey, David M. Harrison, Kathryn J. Rowan, Mark Peters
Summary: The study aimed to compare the effects of conservative oxygenation targets and liberal oxygenation targets on the oxidative status of pediatric patients in the intensive care unit. The results showed that the conservative oxygenation group had higher levels of urinary nitrate/nitrite and lower expression of hypoxia-inducible factor (HIF)-1a mRNA in blood.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Neurosciences
Jenny Lange, Olivia Gillham, Michael Flower, Heather Ging, Simon Eaton, Sneha Kapadia, Andreas Neueder, Michael R. Duchen, Patrizia Ferretti, Sarah J. Tabrizi
Summary: Huntington's Disease is a neurodegenerative disease caused by a genetic mutation. Astrocyte dysfunction, specifically changes in gene expression and metabolic activity, plays a role in the pathogenesis of the disease. Additionally, all Huntington's Disease astrocytes exhibit increased DNA damage and a DNA damage response, suggesting a potential mechanism for their dysfunction.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Health Care Sciences & Services
Maria Chorozoglou, Isabel Reading, Simon Eaton, Shehryer Naqvi, Caroline Pardy, Keren Sloan, Christina Major, Natasha Demellweek, Nigel J. Hall
Summary: We conducted a health economic sub-study to compare the non-operative treatment pathway with surgery for uncomplicated acute appendicitis in children. Our objectives were to assess data collection tools and methods, determine indicative costs and benefits, and evaluate the feasibility of conducting a full economic evaluation.
QUALITY OF LIFE RESEARCH
(2023)
Article
Biology
Lijun Chi, Ling Zhong, Dorothy Lee, Xinwen Yu, Amalia Caballero, Brian Nieman, Paul Delgado-Olguin
Summary: G9a is crucial for embryogenesis and is involved in the development of the nervous system. Its inactivation leads to abnormal development of structures associated with Dandy-Walker syndrome.
Article
Medicine, General & Internal
Ravi Jagatia, Ewald J. Doornebal, Una Rastovic, Nicola Harris, Moyosoreoluwa Feyide, Anabel Martinez Lyons, Rosa Miquel, Yoh Zen, Ane Zamalloa, Farooq Malik, Andreas Prachalias, Krishna Menon, Luke Boulter, Simon Eaton, Nigel Heaton, Sandra Phillips, Shilpa Chokshi, Elena Palma
Summary: In this study, patient-specific immunocompetent disease models of primary liver cancer (PLC) were created using precision-cut tissue slices (PCTS) derived from resected tumors, which effectively captured the multifaceted and intricate heterogeneity of the tumor and its microenvironment. The PCTS model maintained tissue architecture and tumor-specific immunophenotype, making it a robust preclinical tool for investigating immunotherapeutic drug efficacy and non-responsiveness.
Article
Pediatrics
Athanasios Tyraskis, Joseph Davidson, Jennifer Billington, Simon Blackburn, Joseph Curry, Dhanya Mullassery, Stefano Giuliani, Simon Eaton, Kate Cross, Paolo De Coppi
Summary: The purpose of this study was to identify markers of previous ovarian torsion and assess the outcomes according to ultrasound appearance and operative management. The study found that simple cysts have a higher rate of spontaneous regression and ovarian preservation, while complex cysts are more likely to require operative treatment. The presence of fluid-debris level in complex cysts is significantly associated with ovarian loss. Therefore, ultrasound examination and operative treatment are crucial for identifying and managing ovarian torsion.
PEDIATRIC SURGERY INTERNATIONAL
(2023)
Meeting Abstract
Rheumatology
Meredyth G. L. L. Wilkinson, Dale Moulding, Thomas C. R. McDonnell, Mi-Chael Orford, Chris Wincup, Joanna Ting, Georg Otto, Daniel Kelberman, Sergi Castellano, Simon Eaton, Claire T. Deakin, Elizabeth C. Rosser, Lucy R. Wedderburn
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Surgery
Omid Madadi-Sanjani, Joachim F. Kuebler, Julia Brendel, Soeren Wiesner, Annika Mutanen, Simon Eaton, Anja Domenghino, Pierre-Alain Clavien, Benno M. Ure
Summary: To address the inconsistent definitions of surgical complications and unexpected events, a multidisciplinary expert group modified the Clavien-Dindo classification and introduced the Clavien-Madadi classification, which includes organizational and management errors. Unexpected events were documented in a cohort of 17,502 children undergoing surgery and compared with procedure complexity. The results showed that the Clavien-Madadi classification identified additional events and had a higher correlation with procedure complexity.
BRITISH JOURNAL OF SURGERY
(2023)
Letter
Surgery
Barbora Patkova, Anna Svenningsson, Markus Almstroem, Jan F. Svensson, Staffan Eriksson, Tomas Wester, Simon Eaton
