Stem cells for spinal cord injury: Strategies to inform differentiation and transplantation

Generation of highly enriched V2a interneurons from mouse embryonic stem cells

(2016) Nisha R. Iyer et al.   EXPERIMENTAL NEUROLOGY

Cell-seeded alginate hydrogel scaffolds promote directed linear axonal regeneration in the injured rat spinal cord

(2015) Manuel Ingo Günther et al.   Acta Biomaterialia

Combination therapy of stem cell derived neural progenitors and drug delivery of anti-inhibitory molecules for spinal cord injury

(2015) Thomas S. Wilems et al.   Acta Biomaterialia

Recent therapeutic approaches for spinal cord injury

(2015) Andrea Raspa et al.   BIOTECHNOLOGY AND BIOENGINEERING

Therapeutically targeting astrocytes with stem and progenitor cell transplantation following traumatic spinal cord injury

(2015) Aditi Falnikar et al.   BRAIN RESEARCH

Direct Conversion of Normal and Alzheimer’s Disease Human Fibroblasts into Neuronal Cells by Small Molecules

(2015) Wenxiang Hu et al.   Cell Stem Cell

Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons

(2015) Xiang Li et al.   Cell Stem Cell

Transplanted Human Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Do Not Promote Functional Recovery of Pharmacologically Immunosuppressed Mice with Contusion Spinal Cord Injury

(2015) Yuriy Pomeshchik et al.   CELL TRANSPLANTATION

Beneficial Effect of Human Induced Pluripotent Stem Cell-Derived Neural Precursors in Spinal Cord Injury Repair

(2015) Nataliya Romanyuk et al.   CELL TRANSPLANTATION

Micropatterned, clickable culture substrates enable in situ spatiotemporal control of human PSC-derived neural tissue morphology

(2015) G. T. Knight et al.   CHEMICAL COMMUNICATIONS

How to make an oligodendrocyte

(2015) S. A. Goldman et al.   DEVELOPMENT

Modeling mouse and human development using organoid cultures

(2015) M. Huch et al.   DEVELOPMENT

Sustained dual drug delivery of anti-inhibitory molecules for treatment of spinal cord injury

(2015) Thomas S. Wilems et al.   JOURNAL OF CONTROLLED RELEASE

Sponge-mediated lentivirus delivery to acute and chronic spinal cord injuries

(2015) Aline M. Thomas et al.   JOURNAL OF CONTROLLED RELEASE

Drug delivery, cell-based therapies, and tissue engineering approaches for spinal cord injury

(2015) Shushi Kabu et al.   JOURNAL OF CONTROLLED RELEASE

Click-crosslinked injectable hyaluronic acid hydrogel is safe and biocompatible in the intrathecal space for ultimate use in regenerative strategies of the injured spinal cord

(2015) T. Führmann et al.   METHODS

Generation and isolation of oligodendrocyte progenitor cells from human pluripotent stem cells

(2015) Panagiotis Douvaras et al.   Nature Protocols

Structural and functional reorganization of propriospinal connections promotes functional recovery after spinal cord injury

(2015) Linard Filli et al.   Neural Regeneration Research

Cell replacement therapy for central nervous system diseases

(2015) RandallD McKinnon et al.   Neural Regeneration Research

Directed Differentiation of V3 Interneurons from Mouse Embryonic Stem Cells

(2015) Hao Xu et al.   STEM CELLS AND DEVELOPMENT

A puromycin selectable cell line for the enrichment of mouse embryonic stem cell-derived V3 interneurons

(2015) Hao Xu et al.   Stem Cell Research & Therapy

Direct Conversion of Fibroblasts into Functional Astrocytes by Defined Transcription Factors

(2015) Massimiliano Caiazzo et al.   Stem Cell Reports

Deterministic HOX Patterning in Human Pluripotent Stem Cell-Derived Neuroectoderm

(2015) Ethan S. Lippmann et al.   Stem Cell Reports

Transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis and spinal cord injury

(2015) Charles Nicaise   World Journal of Stem Cells

A new method for generating high purity motoneurons from mouse embryonic stem cells

(2014) Dylan A. McCreedy et al.   BIOTECHNOLOGY AND BIOENGINEERING

How to make spinal motor neurons

(2014) B. N. Davis-Dusenbery et al.   DEVELOPMENT

Functional regeneration beyond the glial scar

(2014) Jared M. Cregg et al.   EXPERIMENTAL NEUROLOGY

Human Mesenchymal Stem Cells Modulate Inflammatory Cytokines after Spinal Cord Injury in Rat

(2014) Lucia Urdzíková et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic Potential of Induced Neural Stem Cells for Spinal Cord Injury

(2014) Jin Young Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

3D bioprinting of tissues and organs

(2014) Sean V Murphy et al.   NATURE BIOTECHNOLOGY

Selective conversion of fibroblasts into peripheral sensory neurons

(2014) Joel W Blanchard et al.   NATURE NEUROSCIENCE

Long-Distance Axonal Growth from Human Induced Pluripotent Stem Cells after Spinal Cord Injury

(2014) Paul Lu et al.   NEURON

The Effects of Controlled Release of Neurotrophin-3 from PCLA Scaffolds on the Survival and Neuronal Differentiation of Transplanted Neural Stem Cells in a Rat Spinal Cord Injury Model

(2014) Shuo Tang et al.   PLoS One

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Generation of V2a Interneurons from Mouse Embryonic Stem Cells

(2014) Chelsea R. Brown et al.   STEM CELLS AND DEVELOPMENT

Activation of Neural Cell Fate Programs Toward Direct Conversion of Adult Human Fibroblasts into Tri-Potent Neural Progenitors Using OCT-4

(2014) Ryan R. Mitchell et al.   STEM CELLS AND DEVELOPMENT

Repair of injured spinal cord using biomaterial scaffolds and stem cells

(2014) Bikesh Shrestha et al.   Stem Cell Research & Therapy

Survival, differentiation, and migration of high-purity mouse embryonic stem cell-derived progenitor motor neurons in fibrin scaffolds after sub-acute spinal cord injury

(2014) D. A. McCreedy et al.   Biomaterials Science

3D Reconstitution of the Patterned Neural Tube from Embryonic Stem Cells

(2014) Andrea Meinhardt et al.   Stem Cell Reports

The Potential for iPS-Derived Stem Cells as a Therapeutic Strategy for Spinal Cord Injury: Opportunities and Challenges

(2014) Mohamad Khazaei et al.   Journal of Clinical Medicine

Biomaterial-based drug delivery systems for the controlled release of neurotrophic factors

(2013) Nima Khadem Mohtaram et al.   Biomedical Materials

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

(2013) Ziyuan Guo et al.   Cell Stem Cell

Chromatin modulators as facilitating factors in cellular reprogramming

(2013) Luis Luna-Zurita et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Caudalized human iPSC-derived neural progenitor cells produce neurons and glia but fail to restore function in an early chronic spinal cord injury model

(2013) Samuel E. Nutt et al.   EXPERIMENTAL NEUROLOGY

Host reaction to poly(2-hydroxyethyl methacrylate) scaffolds in a small spinal cord injury model

(2013) Hong Ying Li et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

SIKVAV-modified highly superporous PHEMA scaffolds with oriented pores for spinal cord injury repair

(2013) Šárka Kubinová et al.   Journal of Tissue Engineering and Regenerative Medicine

Nanomedicine for treating spinal cord injury

(2013) Jacqueline Y. Tyler et al.   Nanoscale

Generation of oligodendroglial cells by direct lineage conversion

(2013) Nan Yang et al.   NATURE BIOTECHNOLOGY

Transcription factor–mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells

(2013) Fadi J Najm et al.   NATURE BIOTECHNOLOGY

Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity

(2013) Esteban O Mazzoni et al.   NATURE NEUROSCIENCE

Emerging roles of astrocytes in neural circuit development

(2013) Laura E. Clarke et al.   NATURE REVIEWS NEUROSCIENCE

Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells

(2013) Yingsha Zhang et al.   NEURON

Circuits for Grasping: Spinal dI3 Interneurons Mediate Cutaneous Control of Motor Behavior

(2013) Tuan V. Bui et al.   NEURON

Hox Genes: Choreographers in Neural Development, Architects of Circuit Organization

(2013) Polyxeni Philippidou et al.   NEURON

Plasticity for recovery after partial spinal cord injury – Hierarchical organization

(2013) Tadashi Isa et al.   NEUROSCIENCE RESEARCH

From basics to clinical: A comprehensive review on spinal cord injury

(2013) Nuno A. Silva et al.   PROGRESS IN NEUROBIOLOGY

Long-Term Characterization of Axon Regeneration and Matrix Changes Using Multiple Channel Bridges for Spinal Cord Regeneration

(2013) Hannah M. Tuinstra et al.   TISSUE ENGINEERING PART A

Human Stem Cell-Derived Spinal Cord Astrocytes with Defined Mature or Reactive Phenotypes

(2013) Laurent Roybon et al.   Cell Reports

Templated agarose scaffolds for the support of motor axon regeneration into sites of complete spinal cord transection

(2012) Mingyong Gao et al.   BIOMATERIALS

Direct Reprogramming of Fibroblasts into Neural Stem Cells by Defined Factors

(2012) Dong Wook Han et al.   Cell Stem Cell

Direct Reprogramming of Mouse and Human Fibroblasts into Multipotent Neural Stem Cells with a Single Factor

(2012) Karen L. Ring et al.   Cell Stem Cell

Direct reprogramming of human astrocytes into neural stem cells and neurons

(2012) Stefania Corti et al.   EXPERIMENTAL CELL RESEARCH

Engineering an in situ crosslinkable hydrogel for enhanced remyelination

(2012) Xiaowei Li et al.   FASEB JOURNAL

Functional characterization of dI6 interneurons in the neonatal mouse spinal cord

(2012) Jason Dyck et al.   JOURNAL OF NEUROPHYSIOLOGY

Spinal Cord Injury Induces Serotonin Supersensitivity without Increasing Intrinsic Excitability of Mouse V2a Interneurons

(2012) A. Husch et al.   JOURNAL OF NEUROSCIENCE

Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors

(2012) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs

(2012) Jiekai Chen et al.   NATURE GENETICS

Motor Circuits in Action: Specification, Connectivity, and Function

(2012) Silvia Arber   NEURON

Single Collateral Reconstructions Reveal Distinct Phases of Corticospinal Remodeling after Spinal Cord Injury

(2012) Claudia Lang et al.   PLoS One

Pre-Evaluated Safe Human iPSC-Derived Neural Stem Cells Promote Functional Recovery after Spinal Cord Injury in Common Marmoset without Tumorigenicity

(2012) Yoshiomi Kobayashi et al.   PLoS One

Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells

(2012) E. Lujan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multifunctional, multichannel bridges that deliver neurotrophin encoding lentivirus for regeneration following spinal cord injury

(2011) Hannah M. Tuinstra et al.   BIOMATERIALS

Direct Reprogramming of Adult Human Fibroblasts to Functional Neurons under Defined Conditions

(2011) Rajesh Ambasudhan et al.   Cell Stem Cell

Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons

(2011) Esther Y. Son et al.   Cell Stem Cell

High molecular weight hyaluronic acid limits astrocyte activation and scar formation after spinal cord injury

(2011) Zin Z Khaing et al.   Journal of Neural Engineering

Chondroitinase Combined with Rehabilitation Promotes Recovery of Forelimb Function in Rats with Chronic Spinal Cord Injury

(2011) D. Wang et al.   JOURNAL OF NEUROSCIENCE

Rapid and Efficient Generation of Functional Motor Neurons From Human Pluripotent Stem Cells Using Gene Delivered Transcription Factor Codes

(2011) Mark E Hester et al.   MOLECULAR THERAPY

MicroRNA-mediated conversion of human fibroblasts to neurons

(2011) Andrew S. Yoo et al.   NATURE

Direct generation of functional dopaminergic neurons from mouse and human fibroblasts

(2011) Massimiliano Caiazzo et al.   NATURE

Directed differentiation of functional astroglial subtypes from human pluripotent stem cells

(2011) Robert Krencik et al.   Nature Protocols

The role of propriospinal interneurons in recovery from spinal cord injury

(2011) Jamie R. Flynn et al.   NEUROPHARMACOLOGY

Direct reprogramming of mouse fibroblasts to neural progenitors

(2011) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice

(2011) S. Nori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenic enrichment of mouse embryonic stem cell-derived progenitor motor neurons

(2011) Dylan A. McCreedy et al.   Stem Cell Research

Efficient Differentiation of Human Embryonic and Induced Pluripotent Stem Cells into Functional Astrocytes

(2011) Luni Emdad et al.   STEM CELLS AND DEVELOPMENT

Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state

(2011) R. Patani et al.   Nature Communications

The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein and an EGFR neutralizing antibody

(2010) Qianqian Han et al.   BIOMATERIALS

Origin of New Glial Cells in Intact and Injured Adult Spinal Cord

(2010) Fanie Barnabé-Heider et al.   Cell Stem Cell

Functional Diversity of ESC-Derived Motor Neuron Subtypes Revealed through Intraspinal Transplantation

(2010) Mirza Peljto et al.   Cell Stem Cell

Controlled Release of Neurotrophin-3 and Platelet-Derived Growth Factor from Fibrin Scaffolds Containing Neural Progenitor Cells Enhances Survival and Differentiation into Neurons in a Subacute Model of SCI

(2010) Philip J. Johnson et al.   CELL TRANSPLANTATION

Astrocyte heterogeneity: an underappreciated topic in neurobiology

(2010) Ye Zhang et al.   CURRENT OPINION IN NEUROBIOLOGY

Synergistic Effects of Transplanted Adult Neural Stem/Progenitor Cells, Chondroitinase, and Growth Factors Promote Functional Repair and Plasticity of the Chronically Injured Spinal Cord

(2010) S. Karimi-Abdolrezaee et al.   JOURNAL OF NEUROSCIENCE

Suspension Matrices for Improved Schwann-Cell Survival after Implantation into the Injured Rat Spinal Cord

(2010) Vivek Patel et al.   JOURNAL OF NEUROTRAUMA

A Systematic Review of Cellular Transplantation Therapies for Spinal Cord Injury

(2010) Wolfram Tetzlaff et al.   JOURNAL OF NEUROTRAUMA

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Histological and Functional Benefit Following Transplantation of Motor Neuron Progenitors to the Injured Rat Spinal Cord

(2010) Sharyn L. Rossi et al.   PLoS One

Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency

(2010) B.-Y. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-engineered fibrin scaffolds containing neural progenitors enhance functional recovery in a subacute model of SCI

(2010) Philip J. Johnson et al.   Soft Matter

Transplanted Oligodendrocytes and Motoneuron Progenitors Generated from Human Embryonic Stem Cells Promote Locomotor Recovery After Spinal Cord Transection

(2010) Slaven Erceg et al.   STEM CELLS

Dynamic Assignment and Maintenance of Positional Identity in the Ventral Neural Tube by the Morphogen Sonic Hedgehog

(2010) Eric Dessaud et al.   PLOS BIOLOGY

The Glial Nature of Embryonic and Adult Neural Stem Cells

(2009) Arnold Kriegstein et al.   Annual Review of Neuroscience

Controlled release of neurotrophin-3 from fibrin-based tissue engineering scaffolds enhances neural fiber sprouting following subacute spinal cord injury

(2009) Philip J. Johnson et al.   BIOTECHNOLOGY AND BIOENGINEERING

Human embryonic stem cell-derived neural precursor transplants in collagen scaffolds promote recovery in injured rat spinal cord

(2009) Maryam Hatami et al.   CYTOTHERAPY

Regulation of mouse embryonic stem cell neural differentiation by retinoic acid

(2009) Mijeong Kim et al.   DEVELOPMENTAL BIOLOGY

Fibrin-based tissue engineering scaffolds enhance neural fiber sprouting and delay the accumulation of reactive astrocytes at the lesion in a subacute model of spinal cord injury

(2009) Philip J. Johnson et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Biomaterial Design Strategies for the Treatment of Spinal Cord Injuries

(2009) Karin S. Straley et al.   JOURNAL OF NEUROTRAUMA

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

A chemical platform for improved induction of human iPSCs

(2009) Tongxiang Lin et al.   NATURE METHODS

Transformation of nonfunctional spinal circuits into functional states after the loss of brain input

(2009) Grégoire Courtine et al.   NATURE NEUROSCIENCE

The bright side of the glial scar in CNS repair

(2009) Asya Rolls et al.   NATURE REVIEWS NEUROSCIENCE

Fibrin matrix provides a suitable scaffold for bone marrow stromal cells transplanted into injured spinal cord: A novel material for CNS tissue engineering

(2009) Hiroyuki Itosaka et al.   NEUROPATHOLOGY

Activin/Nodal Inhibition Alone Accelerates Highly Efficient Neural Conversion from Human Embryonic Stem Cells and Imposes a Caudal Positional Identity

(2009) Rickie Patani et al.   PLoS One

Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury

(2009) Hyunjung Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activated Spinal Cord Ependymal Stem Cells Rescue Neurological Function

(2009) Victoria Moreno-Manzano et al.   STEM CELLS

Neural Stem Cell– and Schwann Cell–Loaded Biodegradable Polymer Scaffolds Support Axonal Regeneration in the Transected Spinal Cord

(2009) Heather E. Olson et al.   TISSUE ENGINEERING PART A

Embryoid body formation from embryonic and induced pluripotent stem cells: Benefits of bioreactors

(2009) Sasitorn Rungarunlert   World Journal of Stem Cells

Immunological Barriers to Embryonic Stem Cell-Derived Therapies

(2008) Tomo Šarić et al.   CELLS TISSUES ORGANS

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

(2008) Danwei Huangfu et al.   NATURE BIOTECHNOLOGY

Transplanted adult spinal cord–derived neural stem/progenitor cells promote early functional recovery after rat spinal cord injury

(2008) A.M. Parr et al.   NEUROSCIENCE

The effect of controlled growth factor delivery on embryonic stem cell differentiation inside fibrin scaffolds

(2008) Stephanie M. Willerth et al.   Stem Cell Research

Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells

(2008) Konstantinos Meletis et al.   PLOS BIOLOGY

Inhibition of Activin/Nodal signaling promotes specification of human embryonic stem cells into neuroectoderm

(2007) Joseph R. Smith et al.   DEVELOPMENTAL BIOLOGY

Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury

(2007) Gregoire Courtine et al.   NATURE MEDICINE