Article
Oncology
Seo Hee Choi, Chai Hong Rim, In-Soo Shin, Won Sup Yoon, Woong Sub Koom, Jinsil Seong
Summary: The study shows that adjuvant radiotherapy can improve overall survival in patients with extrahepatic cholangiocarcinoma, and further confirm this result in studies with reliable comparability.
Article
Oncology
Zhongquan Sun, Xin Han, Wanlu You, Jinlong Tang, Juehua Xu, Binglin Ye, Tengfei Li, Yixin Zhang, Kai Chen, Yuan Ding, Weilin Wang
Summary: This study aimed to investigate the efficacy of adjuvant therapy for patients with cholangiocarcinoma (CCA) and identify independent prognostic factors. The results showed that adjuvant therapy improved the prognosis of CCA patients, regardless of the disease stage.
FRONTIERS IN ONCOLOGY
(2023)
Article
Surgery
Qing Chen, Songping Cui, Jincan Huang, Jing Wang, Di Wang, Hanxuan Wang, Shaocheng Lyu, Ren Lang
Summary: This study investigated the prevalence, risk factors, and prognosis of venous thromboembolism (VTE) in distal cholangiocarcinoma (dCCA) surgery patients. The study found a high prevalence of VTE, which was associated with adverse outcomes. A nomogram assessing VTE risk was developed to help identify high-risk individuals and implement preventive measures.
ASIAN JOURNAL OF SURGERY
(2023)
Review
Oncology
Anastasios Gkountakos, Filippo M. M. Martelli, Nicola Silvestris, Michele Bevere, Mario De Bellis, Laura Alaimo, Elena Sapuppo, Francesca Masetto, Aldo Mombello, Michele Simbolo, Elena Bariani, Michele Milella, Matteo Fassan, Aldo Scarpa, Claudio Luchini
Summary: Pancreatic ductal adenocarcinoma (PDAC) and distal cholangiocarcinoma (dCCA) are aggressive tumors with limited treatment options. They share histomolecular features, making differential diagnosis challenging, but also have significant differences with clinical implications. PDAC and dCCA have different prognosis and oncogenic targets, highlighting the importance of accurate diagnosis and targeted treatments.
Review
Oncology
Chaoqun Han, Xin Ling, Liping Sheng, Ming Yang, Rong Lin, Zhen Ding
Summary: This article reports a case of distal extrahepatic cholangiocarcinoma mimicking groove pancreatitis, highlighting the fact that cholangiocarcinoma can mimic benign conditions. The case also raises concerns about performing stent placement through ERCP without a clear diagnosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Hyehyun Jeong, Kyu-pyo Kim, Jae Ho Jeong, Dae Wook Hwang, Jae Hoon Lee, Ki-Hun Kim, Deok-Bog Moon, Myung Ah Lee, Se Jun Park, Hong Jae Chon, Jin-hong Park, Ji Sung Lee, Baek-Yeol Ryoo, Changhoon Yoo
Summary: The effectiveness of adjuvant gemcitabine plus cisplatin (GemCis) therapy was evaluated in a homogeneous group of high-risk patients with resected, lymph node-positive extrahepatic cholangiocarcinoma. The study found that adjuvant GemCis did not improve survival outcomes compared with capecitabine in this patient population.
Article
Oncology
Jing-Jing Hou, Shishir K. Maithel, Sharon M. Weber, George Poultsides, Christopher L. Wolfgang, Ryan C. Fields, Jin He, Charles Scoggins, Kamron Idrees, Perry Shen, Xu-Feng Zhang, Timothy M. Pawlik
Summary: This study investigates the impact of adjuvant therapy (AT) on the long-term survival of patients who underwent curative resection for distal cholangiocarcinoma (DCC). The results show that AT is commonly used among patients with DCC, and it significantly improves long-term survival in patients with perineural invasion (PNI) or lymph node metastasis (LNM).
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Ravi Shridhar, Paige Blinn, Jamie Huston, Kenneth L. Meredith
Summary: This study is the first to show that adjuvant radiation therapy after chemotherapy can significantly improve overall survival in resected high-risk extrahepatic cholangiocarcinoma patients. Further clinical trials are needed to investigate the role of radiation therapy in this population.
Review
Oncology
Leila T. Tchelebi, Krishan R. Jethwa, Anna T. Levy, Christopher J. Anker, Timothy Kennedy, Elliot Grodstein, Christopher L. Hallemeier, Salma K. Jabbour, Ed Kim, Rachit Kumar, Percy Lee, William Small Jr, Vonetta M. Williams, Navesh Sharma, Suzanne Russo
Summary: Although rare, extrahepatic cholangiocarcinoma (EHCC) is a highly lethal malignancy with controversial treatment options. Surgery is the only potentially curative treatment, but only a few patients are eligible for upfront resection and high rates of both local and distant recurrence are observed post-resection. In this review, we systematically examine the available evidence on treatment approaches for EHCC patients, including surgery, radiation, and chemotherapy, using the Population, Intervention, Comparator, Outcome, and Study design (PICOS) framework. We provide a summary of recommendations based on the existing literature to guide clinical management of EHCC patients.
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2023)
Article
Surgery
Ryusei Yamamoto, Teiichi Sugiura, Ryo Ashida, Katsuhisa Ohgi, Mihoko Yamada, Shimpei Otsuka, Takeshi Aramaki, Koiku Asakura, Katsuhiko Uesaka
Summary: Carbohydrate antigen 19-9, periductal enation sign, mass-forming tumour, and luminal-occlusion tumour were identified as preoperative risk factors for early recurrence after resection of perihilar cholangiocarcinoma. Risk classification according to these factors was useful for predicting early recurrence.
Review
Gastroenterology & Hepatology
Xing Chen, Jinpeng Du, Jiwei Huang, Yong Zeng, Kefei Yuan
Summary: Intrahepatic cholangiocarcinoma (ICC) is a common type of primary liver cancer with increasing incidence. Due to the lack of specific manifestations and tools for early diagnosis, most patients are diagnosed at an advanced stage. Neoadjuvant and adjuvant therapies are necessary to improve the outcomes, but lag behind compared to other malignancies. Recent advances in neoadjuvant and adjuvant strategies for ICC are evaluated in this review.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Oncology
Daisuke Nagashima, Minoru Esaki, Satoshi Nara, Daisuke Ban, Takeshi Takamoto, Takahiro Mizui, Kazuaki Shimada, Nobuyoshi Hiraoka
Summary: In this study, the presence of intraepithelial spread (IES) was evaluated in 382 cases of extrahepatic cholangiocarcinoma (eCCA) and compared with other biliary tract cancers (BTCs). The results showed that IPNB had a higher rate of IES compared to conventional eCCAs, and the presence of IES was associated with a higher survival rate in distal eCCAs. The extension of IES also varied depending on the tumor location and type among BTCs.
FRONTIERS IN ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Muhammad Musaab Munir, Samantha M. Ruff, Yutaka Endo, Henrique A. Lima, Laura Alaimo, Zorays Moazzam, Chanza Shaikh, Timothy M. Pawlik
Summary: Adherence to evidence-based NCCN guidelines was associated with improved survival among low-risk CCA patients. Geographical disparities in the receipt of NCCN guideline-concordant care exist and may influence long-term outcomes among CCA patients.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Pharmacology & Pharmacy
Michele Simbolo, Samantha Bersani, Caterina Vicentini, Sergio Taormina, Chiara Ciaparrone, Fabio Bagante, Borislav Rusev, Giovanni Centonze, Marina Montresor, Matteo Brunelli, Serena Pedron, Andrea Mafficini, Gaetano Paolino, Paola Mattiolo, Simone Conci, Massimo Milione, Alfredo Guglielmi, Andrea Ruzzenente, Aldo Scarpa, Claudio Luchini
Summary: PHCC demonstrated more frequent KRAS mutations, while TP53 mutations were more common in DECC. Potentially actionable alterations included high tumor mutational burden and/or microsatellite instability (7.1%), PI3KCA mutations (8.1%), and MYC (10.1%) and ERBB2 amplification (5.1%). Transcriptomic profiles revealed three distinct clusters, corresponding to anatomical origin and differing in immune microenvironment. DECC appeared to consist of two distinct tumor subgroups, one enriched for druggable alterations and one lacking actionable opportunities.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
ChunMei Yang, Xin Quan, XinQiao Huang, ZhuoYue Tang, Jian Shu
Summary: The ADC value might be a potential imaging biomarker for predicting the malignancy of extrahepatic cholangiocarcinoma (ECC) and is significantly correlated with pathological differentiation degree. In addition, ADC value is negatively correlated with microvascular density and lesion size, but not with patient age.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Oncology
Adriana C. Gamboa, Rachel M. Lee, Michael K. Turgeon, Christopher Varlamos, Scott E. Regenbogen, Katherine A. Hrebinko, Jennifer Holder-Murray, Jason T. Wiseman, Aslam Ejaz, Michael P. Feng, Alexander T. Hawkins, Philip Bauer, Matthew Silviera, Shishir K. Maithel, Glen C. Balch
Summary: A review of the United States Rectal Cancer Consortium from 2007 to 2017 found a 46% rate of postoperative complications after rectal cancer surgery, with infectious complications having a negative impact on recurrence-free survival.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Nursing
Neha Sood, Rachel E. Lee, Justin K. To, Kelly L. Cervellione, Maria DeMarinis Smilios, Hajoon Chun, Ivan M. Ngai
Summary: The standardized perioperative bundle implemented in a maternity hospital significantly reduced surgical site infection rates in cesarean births, demonstrating its effectiveness in improving patient safety and quality of care.
BIRTH-ISSUES IN PERINATAL CARE
(2022)
Article
Oncology
Jocelyn C. Reader, Cong Fan, Eleanor Claire-Higgins Ory, Julia Ju, Rachel Lee, Michele I. Vitolo, Paige Smith, Sulan Wu, Mc Millan Nicol Ching, Emmanuel B. Asiedu, Christopher M. Jewell, Gautam G. Rao, Amy Fulton, Tonya J. Webb, Peixin Yang, Alessandro D. Santin, Huang-Chiao Huang, Stuart S. Martin, Dana M. Roque
Summary: Ovarian cancer can spread within the peritoneal cavity through exfoliation of malignant cells into ascites. Microtentacles (McTNs) are microtubule-based protrusions that may influence the metastatic potential and chemoresistance profile of free-floating cells. This study highlights the importance of McTNs as a therapeutic target for ovarian cancer and suggests that understanding their biology could lead to improved treatments.
Review
Psychiatry
Rachel Seungyun Lee, Hilary K. Brown, Sarah Salih, Anita C. Benoit
Summary: This study assessed the effects of psychological, psychosocial, educational, and alternative interventions on mental health outcomes of Indigenous adult populations in Australia, Canada, New Zealand, and the United States. The results showed that a wide range of interventions demonstrated improvements in mental health. However, due to heterogeneity among studies, it is difficult to draw generalizable conclusions on intervention effectiveness.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2022)
Review
Cell Biology
Michael A. Reiche, Jesse S. Aaron, Ulrike Boehm, Michael C. DeSantis, Chad M. Hobson, Satya Khuon, Rachel M. Lee, Teng-Leong Chew
Summary: Fluorescence microscopy images may not accurately represent biology due to various factors in the biospecimen itself that can significantly affect quantitative microscopy data. It is important to consider sample-related issues beyond commonly discussed ones, such as photobleaching and autofluorescence, in order to properly guide life scientists in understanding the intricacies of bioimaging.
JOURNAL OF CELL SCIENCE
(2022)
Article
Medical Informatics
Mollie Hobensack, Deborah R. Levy, Kenrick Cato, Don E. Detmer, Kevin B. Johnson, Jeffrey Williamson, Judy Murphy, Amanda Moy, Jennifer Withall, Rachel Lee, Sarah Collins Rossetti, Samuel Trent Rosenbloom
Summary: The high documentation requirements among United States clinicians have resulted in clinician burnout and suboptimal patient care. The 25 by 5 Symposium aimed to reduce documentation burden by providing a platform for experts to discuss the issue and identify specific actions. The symposium produced a list of interventions for short-, medium-, and long-term goals, with themes including accountability, evidence, education and training, and technology innovation.
APPLIED CLINICAL INFORMATICS
(2022)
Article
Oncology
Trevor J. Mathias, Julia A. Ju, Rachel M. Lee, Keyata N. Thompson, Makenzy L. Mull, David A. Annis, Katarina T. Chang, Eleanor C. Ory, Megan B. Stemberger, Takashi Hotta, Ryoma Ohi, Michele Vitolo, Marie-Jo Moutin, Stuart S. Martin
Summary: This article discusses the recent discovery of the genetic identity of tubulin carboxypeptidase (TCP) and its role in breast epithelial cells and breast cancer cells. The study found that increased deTyr-Tub induces apoptosis in normal breast cells and enhances focal gelatin degradation in breast cancer cells. These findings provide important insights for further research and treatment of breast cancer.
Editorial Material
Public, Environmental & Occupational Health
Rachel Seungyun Lee, Kimberlee Collins, Amaya Perez-Brumer
Summary: The Seasonal Agricultural Worker Program (SAWP) is a Canadian managed migration program that seeks to address labor shortages in the agricultural industry by employing Black and Brown workers from the global South. However, the operation of the SAWP during the COVID-19 pandemic has exacerbated the structural violence experienced by migrant workers. This highlights how the SAWP, as a component of globalized labor processes, dehumanizes workers and renders them disposable, rooted in colonialism and racial capitalism.
GLOBAL PUBLIC HEALTH
(2022)
Article
Surgery
Rachel M. Lee, Rapheisha Darby, Caroline R. Medin, Grace C. Haser, Meredith C. Mason, Lesley S. Miller, Charles A. Staley, Shishir K. Maithel, Maria C. Russell
Summary: Implementing an HCC screening program at a safety-net hospital is feasible and can facilitate early diagnosis. Patient navigation and tracking completion of imaging tests were critical components to the program's success.
Article
Oncology
Aleeza J. Leder Macek, Annie Wang, Michael K. Turgeon, Rachel M. Lee, Maria C. Russell, Matthew R. Porembka, Rodrigo Alterio, Michelle Ju, Joshua Kronenfeld, Neha Goel, Jashodeep Datta, Ajay Maker, Manuel Fernandez, Harry Richter, Russell S. Berman, Camilo Correa-Gallego, Ann Y. Lee
Summary: This study found that diagnostic laparoscopy (DL) is underutilized in patients with advanced gastric adenocarcinoma (GA). Lack of insurance was a major factor for the low utilization of DL, and patients from racial minority groups were more likely to undergo DL.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Shuyao Gu, Rachel M. Lee, Zackery Benson, Chenyi Ling, Michele Vitolo, Stuart S. Martin, Joe Chalfoun, Wolfgang Losert
Summary: Collective cell migration, a crucial factor in biological functions such as cancer metastasis, involves diverse cell behaviors. Researchers have developed an AI-based pipeline to segment and track cell nuclei, enabling quantification and analysis of collective motion. This approach, which does not require additional training data, has the potential to provide new insights into existing libraries of collective motion images and may serve as an indicator of metastatic potential.
Article
Neurosciences
Jessica L. Whitt, Gabrielle Ewall, Darpan Chakraborty, Ayorinde Adegbesan, Rachel Lee, Patrick O. Kanold, Hey-Kyoung Lee
Summary: Sensory loss leads to plastic changes in the inhibitory synaptic transmission in the thalamus, supporting cross-modal plasticity in the brain. These plastic changes occur at the level of the thalamus and involve increased neurotransmitter release and reduced short-term inhibition. These findings have important implications for understanding sensory processing and adaptive plasticity.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biodiversity Conservation
Rachel S. K. Lee, Calebe P. P. Mendes, Stacey S. Q. Liang, Vera W. X. Yang, Delaney K. L. Eng, Wei Bin Ong, Yen Kheng Chua, Greg Byrnes, Norman T. -L. Lim
Summary: Researchers developed a vector-based model and applied a genetic algorithm to determine optimal glide pole locations, improving connectivity for arboreal gliding mammals and mitigating negative impacts of road widening. By using the model, the number of installed glide poles increased by 10 times and filled connectivity gaps created by road widening. This model fills a knowledge gap in connectivity modelling for arboreal gliding mammals and is important for their conservation efforts.
JOURNAL OF APPLIED ECOLOGY
(2023)
Article
Ophthalmology
Rachel H. Lee, Richard K. Lee, Louis R. Pasquale
Summary: An evaluation study conducted in the United States showed that incisional glaucoma surgery performed after laser trabeculoplasty (LTP) did not alter the risk of surgery for suspected glaucoma patients or those with mild open-angle glaucoma (OAG). Regardless of LTP treatment, African heritage and OAG diagnosis status were risk factors for requiring glaucoma surgery.
OPHTHALMOLOGY GLAUCOMA
(2022)
Article
Oncology
Keyata N. Thompson, Julia A. Ju, Eleanor C. Ory, Stephen J. P. Pratt, Rachel M. Lee, Trevor J. Mathias, Katarina T. Chang, Cornell J. Lee, Olga G. Goloubeva, Patrick C. Bailey, Kristi R. Chakrabarti, Christopher M. Jewell, Michele Vitolo, Stuart S. Martin
Summary: Clinical cancer imaging focuses on tumor growth, not metastasis. This study found that the microtubule-depolymerizing drug Vinorelbine can effectively reduce metastatic phenotypes of tumor cells and extend the survival of metastatic tumors, even with short-term treatment. Additionally, the study demonstrates the feasibility of using a small number of tumor cells from patient biopsies for drug response detection.
BREAST CANCER RESEARCH
(2022)
Article
Oncology
Aradhya Nigam, Jason S. Hawksworth, Emily R. Winslow
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Article
Oncology
Mignote Yilma, Neil Mehta
Summary: Liver transplantation (LT) remains the optimal treatment for hepatocellular carcinoma (HCC), but considerations must be given to organ availability and risk of recurrence. In the United States, Milan criteria have been used to maximize the benefit of LT compared to alternative treatments. Advances in local regional therapy (LRT) have allowed us to downstage patients to meet Milan criteria, and newer selection criteria incorporating biomarkers and imaging are being developed to further optimize LT for HCC patients.
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Article
Oncology
Anthony Bejjani, Richard S. Finn
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Article
Oncology
Ifrah Fatima, Neehar D. Parikh, Alisa Likhitsup
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Article
Oncology
Victoria Chernyak
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Article
Oncology
Gloria Y. Chang, Adam C. Yopp
Summary: HCC is the third leading cause of cancer-related deaths worldwide and its prognosis is complex and diverse, requiring consideration of tumor burden, biology, liver function, and patient status in treatment decision-making.
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Article
Oncology
Mikin Patel, Anjana Pillai
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Article
Oncology
Zachary Whitham, David Hsiehchen
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
Article
Oncology
Mariana Chavez-Villa, Ismael Dominguez-Rosado
Summary: Over the past 40 years, multiple staging systems have been developed for hepatocellular carcinoma (HCC) to guide treatment and determine prognosis. However, the heterogeneity of HCC and advances in diagnostic and therapeutic tools have made staging algorithms and eligibility criteria more complex. Recent advances in neoadjuvant therapy, downstaging, and adjuvant therapy have challenged traditional paradigms but also raised new questions. Although there is no perfect or universal staging system yet, models will continue to be refined as evidence advances. Individualized decision making and multidisciplinary approaches will play key roles in the management of HCC.
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA
(2024)
