Journal
SMALL
Volume 15, Issue 50, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201905080
Keywords
aggregation-induced emission; photodynamic therapy; stereotactic therapy; two-photon
Categories
Funding
- National Natural Science Foundation of China [81672076, 81802116, 81871735, 21788102, 51620105009, 21877040, 21602063]
- Medical Science and Technology Research Foundation of Guangdong Province [A2017326]
- Science and Technology Program of Guangzhou [201510010097]
- Major Program of Health Care and Innovation of Guangzhou Project [201704020213, 201604020015]
- Pearl River S&T Nova Program of Guangzhou [201806010152]
- Natural Science Foundation of Guangdong Province [2016A030313852]
- Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University [2018J002]
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Two-photon photodynamic therapy (TP-PDT) is emerging as a powerful strategy for stereotactic targeting of diseased areas, but ideal photosensitizers (PSs) are currently lacking. This work reports a smart PS with aggregation-induced emission (AIE) feature, namely DPASP, for TP-PDT with excellent performances. DPASP exhibits high affinity to mitochondria, superior photostability, large two-photon absorption cross section as well as efficient reactive oxygen species generation, enabling it to achieve photosensitization both in vitro and in vivo under two-photon excitation. Moreover, its capability of stereotactic ablation of targeted cells with high-precision is also successfully demonstrated. All these merits make DPASP a promising TP-PDT candidate for accurate ablation of abnormal tissues with minimal damages to surrounding areas in the treatment of various diseases.
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