Review
Chemistry, Multidisciplinary
Chun Xu, Chang Lei, Yue Wang, Chengzhong Yu
Summary: Dendritic mesoporous silica nanoparticles have attracted attention due to their wide applications, but the terminology used is ambiguous. This review provides a critical analysis of reported dendritic silica nanoparticles according to their structural classification, updating the understanding of their formation mechanisms and the control of structural parameters. The review also focuses on the applications of dendritic mesoporous nanoparticles in the biomedical field, offering new insights into the structure-property relationship.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Ping Huang, Daizheng Lian, Hualin Ma, Nansha Gao, Limin Zhao, Ping Luan, Xiaowei Zeng
Summary: Mesoporous silica nanoparticles, with their simple synthesis, biocompatibility, and high surface area, have been developed as drug carriers for targeted and controlled drug release. By designing gated systems using various materials, these nanoparticles offer a new approach for selective delivery of antitumor drugs. Challenges and future prospects of gated mesoporous silica nanoparticles are discussed for their potential in drug delivery systems.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Analytical
Tianwei Jia, Ying Luo, Xiaolin Sheng, Jieqiong Fang, Didier Merlin, Suri S. Iyer
Summary: We developed a simple and low-cost assay utilizing mesoporous silica nanoparticles for detecting analytes. Palladium nanoparticles covered with mesoporous silica (Pd@mSiO(2)) were used, and specific proteins or DNA were capped onto the nanoparticles to prevent catalyzation. When target antigens or complementary DNA sequences were present, the cap dissociated, allowing the conversion of non-fluorescent molecules to fluorescent molecules. The assay showed a wide detection range and has the potential for point of care diagnostics in low-resource settings.
Article
Materials Science, Ceramics
Eva Krakor, Sven Saniternik, Isabel Gessner, Robert Frohnhoven, Michael Wilhelm, Marco Drexelius, Nurgul Tosun, Ines Neundorf, Sanjay Mathur
Summary: Intensive and overuse of antibiotics have led to a rise in antibiotic resistance globally, creating a demand for alternative treatments. Metal ions like copper, silver, and zinc have been used to inhibit microorganism growth for centuries. This study focuses on the synthesis of metal and oxide nanoparticles immobilized on hollow mesoporous silica capsules (HMSCs) for efficient antimicrobial effects against both Gram-positive and Gram-negative bacteria. The results show promising potential for metal-loaded capsules as antibacterial delivery vehicles, providing sustained bacterial inhibition over several hours.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Materials Science, Multidisciplinary
Federico Olivieri, Fabio Scherillo, Rachele Castaldo, Mariacristina Cocca, Antonino Squillace, Gennaro Gentile, Marino Lavorgna
Summary: In this study, high-surface-area amino-functionalized mesoporous silica nanoparticles (MSN-NH2) were synthesized and functionalized with benzoyl chloride (MSN-BC) for the release of benzoic acid (BA) in response to acidic and alkaline conditions. These MSN-BC nanoparticles were embedded in acrylic coatings for corrosion protection of aluminum alloys. The coatings showed long-lasting efficiency and were validated through morphological and electrochemical impedance spectroscopy (EIS) measurements, demonstrating their potential for aluminum alloy protection.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Spectroscopy
Jing Huang, Hai-Bo Liu, Jing Wang
Summary: PyU-SBA-15 is a hybrid fluorescent sensor with excellent ability to detect Hg2+ and high selectivity, while the control material, PyH-SBA-15, lacks metal-ion selectivity. The fluorescence emission intensities of PyU-SBA-15 gradually decrease with increasing Hg2+ concentration, showing a linear relationship at 379 nm.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Materials Science, Multidisciplinary
Guochao Xu, Shuang Song, Muhammad Azhar Hayat Nawaz, Junying Lv, Cong Yu, Xing Jin
Summary: Mesoporous silica nanoparticles with fluorescent and tumor targeting functions were synthesized and loaded with paclitaxel to create smart composite materials for targeted chemotherapy and tumor imaging. Results showed the potential applicability of PTX-YMSN for tumor treatment, combining the advantages of drug delivery nanosystem and organic fluorophore.
Article
Chemistry, Inorganic & Nuclear
Israel T. Pulido-Diaz, Alejandro Serrano-Maldonado, Carlos Cesar Lopez-Suarez, Pedro A. Mendez-Ocampo, Benjamin Portales-Martinez, Aida Gutierrez-Alejandre, Karla P. Salas-Martin, Itzel Guerrero-Rios
Summary: The study demonstrates that nicotinamide groups grafted on ordered mesoporous silica (OMS) can serve as stabilizers for RhNPs used as catalysts, forming spherical rhodium nanoparticles with a narrow size distribution. On the contrary, amine-functionalized OMS tends to form RhNP aggregates after catalytic reactions, affecting the reaction efficiency. Supported RhNPs also exhibit selective reduction of different groups and show high activity in reductive amination reactions.
DALTON TRANSACTIONS
(2021)
Article
Spectroscopy
Zhaleh Ghafary, Rahman Hallaj, Abdollah Salimi, Sudabeh Mafakheri
Summary: A novel, highly sensitive, simple and amplified fluorescence immunosensing strategy was designed for HBsAg detection using a sandwich type probe. The probe utilized MSN-Rh.B as a fluorescent mesoporous capsule and signal amplifier site, and Fe3O4 MNP as a probe collector site.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Nanoscience & Nanotechnology
Jan Grzelak, Jaume Gazquez, Alba Grayston, Mariana Teles, Fernando Herranz, Nerea Roher, Anna Rosell, Anna Roig, Marti Gich
Summary: Multifunctional magnetic nanocomposites based on mesoporous silica have a wide range of potential applications in various fields. By controlling the structure, nanoparticles with different shapes can be prepared to respond to external magnetic fields. The application of these nanoparticles in biomedicine is particularly promising, but research on nanorods is currently limited.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Inorganic & Nuclear
Selvakumari Ulagesan, Madhappan Santhamoorthy, Thi Phan Vy Phan, Krishnapandi Alagumalai, Kokila Thirupathi, Seong-Cheol Kim, Taek-Jeong Nam, Youn-Hee Choi
Summary: In this study, a mesoporous silica material containing amidoxime ligand groups was successfully synthesized through surface modification. The resulting SBA-15@AMI NPs exhibited a high concentration of amidoxime ligands on the surface, making them suitable for pH-responsive drug delivery applications in cancer therapy.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Food Science & Technology
Qin Ouyang, Mingming Zhang, Yongcun Yang, Zia-ud Din, Quansheng Chen
Summary: In this study, a novel fluorescence biosensor was designed for the rapid detection of Staphylococcus aureus in meat. By using mesoporous silica-modified upconversion nanoparticles, the biosensor achieved low detection limits and wide detection range. The results showed that the biosensor had comparable performance to the traditional plate counting method in detecting S. aureus in meat.
Article
Chemistry, Multidisciplinary
Alba Garcia-Fernandez, Monica Sancho, Viviana Bisbal, Pedro Amoros, Maria D. Marcos, Mar Orzaez, Felix Sancenon, Ramon Martinez-Manez
Summary: The new mesoporous silica nanoparticles-based nanodevice can target lung inflammation and reduce cytokine levels, showing promising anti-inflammatory effects in an ALI mouse model, which could be used for improving ALI treatment methods.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Nicolas Jackson, Andrea C. C. Ortiz, Alejandro Jerez, Javier Morales, Francisco Arriagada
Summary: Stimuli-responsive nanomaterials have been studied as a promising strategy for anticancer therapy, with pH-responsive silica nanocarriers being particularly effective in controlled drug delivery in acidic tumor microenvironments. The design of the nanocarrier and drug release mechanisms play a crucial role in optimizing efficacy, and this study provides new insights into the behavior of a hydrophobic drug released from a pH-sensitive nanosystem.
Article
Engineering, Biomedical
Shiwei Niu, Xuejing Zhang, Gareth R. Williams, Jianrong Wu, Feng Gao, Zi Fu, Xia Chen, Sheng Lu, Li-Min Zhu
Summary: The study encapsulated the anticancer drug doxorubicin (DOX) in chitosan (CS)-modified hollow mesoporous silica nanoparticles (HMSNs), with CuS nanodots generating energy under near infrared laser (NIR) irradiation to accelerate drug release, achieving targeted drug delivery to the tumor microenvironment while demonstrating excellent photothermal therapy and dual-imaging properties.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Beatriz Lozano-Torres, Juan F. Blandez, Alba Garcia-Fernandez, Felix Sancenon, Ramon Martinez-Manez
Summary: This study describes a new method for senescent cell detection based on lipofuscin labeling using a biorthogonal reaction. The method involves a two-step reaction that forms a clear fluorescence pattern in senescent cells, providing an alternative tool for senescent cell detection.
Article
Chemistry, Multidisciplinary
Alejandra Estepa-Fernandez, Alba Garcia-Fernandez, Araceli Lerida-Viso, Angela Morella-Aucejo, Juan Jose Esteve-Moreno, Juan F. Blandez, Maria Alfonso, Vicente Candela-Noguera, Gema Vivo-Llorca, Felix Sancenon-Galarza, Mar Orzaez, Ramon Martinez-Manez
Summary: The engineering of nanoparticle communication has gained attention, but communication between nanoparticles and living systems is still understudied. This study explores a strategy that involves nanoparticle-cell-nanoparticle communication through modifying the environment. The targeted therapy through stigmergy communication effectively inhibits tumor growth and reduces metastases in a mouse model of triple-negative breast cancer with minimal side effects.
Article
Pharmacology & Pharmacy
Alejandra Estepa-Fernandez, Alba Garcia-Fernandez, Araceli Lerida-Viso, Juan F. Blandez, Irene Galiana, Felix Sancenon-Galarza, Mar Orzaez, Ramon Martinez-Manez
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited treatment options. Inducing senescence and removing senescent cells (senolysis) has been explored as a method to limit tumor progression. In this study, a combination treatment using palbociclib and navitoclax was found to delay tumor growth and reduce metastasis in a mouse model of aggressive TNBC.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Chemistry, Analytical
Eva Garrido, Guillermo Hernandez-Siguenza, Estela Climent, M. Dolores Marcos, Knut Rurack, Pablo Gavina, Margarita Parra, Felix Sancenon, Vicente Marti-Centelles, Ramon Martinez-Manez
Summary: The use of gamma-hydroxybutyric acid (GHB) in drug-facilitated sexual assault has increased, leading to the need for rapid GHB detection methods. A portable strip-based lateral flow assay (LFA) using a smartphone for fluorescence readout was developed for GHB analysis. This method is based on a Cu2+ complex with a tetradentate ligand and the fluorescent dye coumarin 343, and can detect GHB at concentrations as low as 0.03 μM in MES buffer solution and 0.1 μM in soft drinks and alcoholic beverages in just 1 min.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Physical
Migle Ziemyte, Andrea Escudero, Paula Diez, Maria D. Ferrer, Jose R. Murguia, Vicente Marti-Centelles, Alex Mira, Ramon Martinez-Manez
Summary: Development of bioinspired nanomotors with effective propulsion and cargo delivery capabilities has gained significant attention for potential biomedical applications. This study presents the design and application of a multifunctional gated Janus platinum-mesoporous silica nanomotor for disrupting bacterial biofilms. The nanomotor achieves high efficacy in EPS biomass disruption and reduction in cell viability, showcasing its potential as a promising strategy for biofilm elimination.
CHEMISTRY OF MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Goncalo A. Marcelo, David Montpeyo, Joana Galhano, Ramon Martinez-Manez, Jose Luis Capelo-Martinez, Julia Lorenzo, Carlos Lodeiro, Elisabete Oliveira
Summary: In this study, a combinatory antitumoral nanotherapy was developed using magneto-fluorescent nanoparticles as carriers for a combination of two drugs (doxorubicin and ofloxacin) and surface modification with two targeting agents (AZM-SH and Cetuximab). The results showed that the nanoparticles modified with AZM-SH had higher cellular uptake than those modified with Cetuximab, making them more effective for colorectal cancer cells. Furthermore, the oral administration of the nanoparticles with an enteric coating was successfully achieved under extreme conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Isabel Caballos, Maria Nieves Aranda, Alba Lopez-Palacios, Luis Pla, Sara Santiago-Felipe, Andy Hernandez-Montoto, Maria Angeles Tormo-Mas, Javier Peman, Maria Dolores Gomez-Ruiz, Eva Calabuig, Beatriz Sanchez-Sendra, Clara Frances-Gomez, Ron Geller, Elena Aznar, Ramon Martinez-Manez
Summary: The COVID-19 pandemic has emphasized the importance of testing and tracking infected individuals to mitigate the virus spread. This study introduces a biosensor that uses oligonucleotide-gated nanomaterials for specific detection of the SARS-CoV-2 spike protein. The biosensor showed high sensitivity and successfully detected low concentrations of the pseudotype virus. It was also tested on nasopharyngeal samples from suspected COVID-19 individuals.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Pharmacology & Pharmacy
Cristina de la Torre, Carmen Coll, Amelia Ultimo, Felix Sancenon, Ramon Martinez-Manez, Eduardo Ruiz-Hernandez
Summary: A novel combination of in situ-forming hydrogels and gated mesoporous materials was developed for designing depots that can locally sustainably release chemotherapeutics. The depot is composed of a hyaluronic-based gel loaded with redox-responsive mesoporous silica nanoparticles capped with polyethylene glycol chains containing a disulfide bond. The nanoparticles are able to deliver the cargo in the presence of the reducing agent glutathione, promoting pore opening and cargo delivery. Release studies and cellular assays demonstrated the successful liberation of the nanoparticles and their internalization into cells, leading to significant reduction in cell viability when loaded with doxorubicin. This research opens up possibilities for the development of new depots combining the tunable properties of hyaluronic gels with a wide range of gated materials for enhanced local controlled release of chemotherapeutics.
Article
Biotechnology & Applied Microbiology
Jose Manuel Terres-Haro, Javier Monreal-Trigo, Andy Hernandez-Montoto, Francisco Javier Ibanez-Civera, Rafael Masot-Peris, Ramon Martinez-Manez
Summary: In this study, a Finite Element Model is used to calculate the absorption and electric field enhancement of metal nanoparticles in an optical, electromagnetic field. The temperature rise caused by irradiating a suspension of nanoparticles was also measured and compared with experimental results.
BIOENGINEERING-BASEL
(2023)
Article
Nanoscience & Nanotechnology
Iris Garrido-Cano, Anna Adam-Artigues, Ana Lameirinhas, Juan F. F. Blandez, Vicente Candela-Noguera, Ana Lluch, Begona Bermejo, Felix Sancenon, Juan Miguel Cejalvo, Ramoin Martinez-Manez, Pilar Eroles
Summary: Despite advances in breast cancer treatment, it remains the leading cause of cancer-related death in women worldwide. In this study, a nanodevice using mesoporous silica nanoparticles for miR-200c-3p delivery was designed and validated. The nanodevice demonstrated biocompatibility, escape ability from endosomes/lysosomes, and inhibition of tumor progression, invasion, migration, and proliferation in vitro. In vivo experiments confirmed tumor targeting, effective miR-200c-3p delivery, therapeutic efficacy with reduced tumor size and lung metastasis, and no signs of toxicity. Overall, miR-200c-3p-loaded nanoparticles present a potential strategy for breast cancer therapy and safe tumor-targeted delivery of microRNAs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Irene Barguilla, Vicente Candela-Noguera, Patrick Oliver, Balasubramanyam Annangi, Paula Diez, Elena Aznar, Ramon Martinez-Manez, Ricard Marcos, Alba Hernandez, Maria Dolores Marcos
Summary: This study evaluated the genotoxicity and transforming ability of different functionalized mesoporous silica nanoparticles on human lung epithelial cells. The results showed that functionalized mesoporous silica nanoparticles induced some measurable adverse effects associated with tumorigenesis, but the toxicity was lower compared to other nanomaterials and certain drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Vicente Candela-Noguera, Maria Alfonso, Pedro Amoros, Elena Aznar, Maria Dolores Marcos, Ramon Martinez-Manez
Summary: This study comprehensively investigates the factors affecting the formation of MCM-41 type mesoporous silica nanoparticles (MSN). The hydrolysis and condensation rates are found to play a central role in nanoparticle formation, and disregarded parameters such as stirring strength and surfactant addition rate are shown to modulate nucleation and growth. Furthermore, the aging and evolution of MSN are studied through the analysis of silica framework consolidation over time, providing insights into obtaining reproducible, homogeneous, and tailored-made MCM-41 type MSN.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
