Herbal medicinal products for inflammatory bowel disease: A focus on those assessed in double‐blind randomised controlled trials

Mechanisms of Disease: Inflammatory Bowel Diseases

(2019) Guilherme Piovezani Ramos et al.   MAYO CLINIC PROCEEDINGS

A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis

(2018) Peter M Irving et al.   INFLAMMATORY BOWEL DISEASES

The Use of Cannabinoids in Colitis: A Systematic Review and Meta-Analysis

(2018) Daniel G Couch et al.   INFLAMMATORY BOWEL DISEASES

The clinical efficacy of curcumin-containing nutraceuticals: An overview of systematic reviews

(2018) Ester Pagano et al.   PHARMACOLOGICAL RESEARCH

Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway

(2018) Kai Wang et al.   BIOCHEMICAL PHARMACOLOGY

Oral Adjuvant Curcumin Therapy for Attaining Clinical Remission in Ulcerative Colitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2018) Maria Grammatikopoulou et al.   Nutrients

Complementary and Alternative Medicines Used by Patients With Inflammatory Bowel Diseases

(2017) Adam S. Cheifetz et al.   GASTROENTEROLOGY

Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 2: Current Management

(2017) Marcus Harbord et al.   Journal of Crohns & Colitis

Inhibition of cytochrome P450 (CYP3A4) activity by extracts from 57 plants used in traditional chinese medicine (TCM)

(2017) Michael Wink et al.   Pharmacognosy Magazine

Chamomile Flower, Myrrh, and Coffee Charcoal, Components of a Traditional Herbal Medicinal Product, Diminish Proinflammatory Activation in Human Macrophages

(2017) Cica Vissiennon et al.   PLANTA MEDICA

Role of Cannabinoids in Gastrointestinal Mucosal Defense and Inflammation

(2016) Klára Gyires et al.   Current Neuropharmacology

3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn’s Disease 2016: Part 1: Diagnosis and Medical Management

(2016) Fernando Gomollón et al.   Journal of Crohns & Colitis

Apigenin supplementation protects the development of dextran sulfate sodium-induced murine experimental colitis by inhibiting canonical and non-canonical inflammasome signaling pathways

(2016) Yazmín K. Márquez-Flores et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology

(2016) Alessia Ligresti et al.   PHYSIOLOGICAL REVIEWS

Anti-inflammatory effect of cannabinoid agonist WIN55, 212 on mouse experimental colitis is related to inhibition of p38MAPK

(2016) Ya-Jing Feng et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Myrrh attenuates oxidative and inflammatory processes in acetic acid-induced ulcerative colitis

(2016) Amal Jamil Fatani et al.   Experimental and Therapeutic Medicine

An Orally Active Cannabis Extract with High Content in Cannabidiol attenuates Chemically-induced Intestinal Inflammation and Hypermotility in the Mouse

(2016) Ester Pagano et al.   Frontiers in Pharmacology

Intestinal anti-inflammatory activity of apigenin K in two rat colitis models induced by trinitrobenzenesulfonic acid and dextran sulphate sodium

(2015) Cristina Mascaraque et al.   BRITISH JOURNAL OF NUTRITION

Curcumin in Combination With Mesalamine Induces Remission in Patients With Mild-to-Moderate Ulcerative Colitis in a Randomized Controlled Trial

(2015) Alon Lang et al.   Clinical Gastroenterology and Hepatology

Cannabinoids for Medical Use

(2015) Penny F. Whiting et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sophora flavescens Ait.: Traditional usage, phytochemistry and pharmacology of an important traditional Chinese medicine

(2015) Xirui He et al.   JOURNAL OF ETHNOPHARMACOLOGY

The Medical Use of Wheatgrass: Review of the Gap Between Basic and Clinical Applications

(2015) Gil Bar-Sela et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Doctor communication quality and Friends' attitudes influence complementary medicine use in inflammatory bowel disease

(2015) Réme Mountifield   WORLD JOURNAL OF GASTROENTEROLOGY

Inhibitory effects of curcumin on activity of cytochrome P450 2C9 enzyme in human and 2C11 in rat liver microsomes

(2014) Zhe Wang et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Andrographolide sulfonate ameliorates experimental colitis in mice by inhibiting Th1/Th17 response

(2014) Wen Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Determination of six components of Andrographis paniculata extract and one major metabolite of andrographolide in rat plasma by liquid chromatography–tandem mass spectrometry

(2014) Jian Wang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

IBD and health-related quality of life — Discovering the true impact

(2014) Sanna Lönnfors et al.   Journal of Crohns & Colitis

Boswellia serratahas Beneficial Anti-Inflammatory and Antioxidant Properties in a Model of Experimental Colitis

(2014) Renata Minuzzo Hartmann et al.   PHYTOTHERAPY RESEARCH

Cannabinoids Alleviate Experimentally Induced Intestinal Inflammation by Acting at Central and Peripheral Receptors

(2014) Jakub Fichna et al.   PLoS One

Randomised clinical trial: a herbal preparation of myrrh, chamomile and coffee charcoal compared with mesalazine in maintaining remission in ulcerative colitis - a double-blind, double-dummy study

(2013) J. Langhorst et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease

(2013) Francesca Borrelli et al.   BIOCHEMICAL PHARMACOLOGY

The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis

(2013) B Romano et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabis Induces a Clinical Response in Patients With Crohn's Disease: A Prospective Placebo-Controlled Study

(2013) Timna Naftali et al.   Clinical Gastroenterology and Hepatology

Predictive factors of complementary and alternative medicine use for patients with inflammatory bowel disease in Korea

(2013) Dong Il Park et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Use and Predictors of Oral Complementary and Alternative Medicine by Patients With Inflammatory Bowel Disease

(2013) Marije Koning et al.   INFLAMMATORY BOWEL DISEASES

Comparison of Xilei-san, a Chinese Herbal Medicine, and Dexamethasone in Mild/Moderate Ulcerative Proctitis: A Double-Blind Randomized Clinical Trial

(2013) Fangbin Zhang et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Induction with NCB-02 (curcumin) enema for mild-to-moderate distal ulcerative colitis — A randomized, placebo-controlled, pilot study

(2013) Vikas Singla et al.   Journal of Crohns & Colitis

Inhibition of p38/Mk2 signaling pathway improves the anti-inflammatory effect of WIN55 on mouse experimental colitis

(2013) Yu Y Li et al.   LABORATORY INVESTIGATION

Andrographis paniculata Extract (HMPL-004) for Active Ulcerative Colitis

(2012) William J Sandborn et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Placebo controlled evaluation of Xilei San, a herbal preparation in patients with intractable ulcerative proctitis

(2012) Ken Fukunaga et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Ulcerative Colitis Impairs the Acylethanolamide-Based Anti-Inflammatory System Reversal by 5-Aminosalicylic Acid and Glucocorticoids

(2012) Juan Suárez et al.   PLoS One

Characterisation of complementary and alternative medicine use and its impact on medication adherence in inflammatory bowel disease

(2011) A. V. Weizman et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

β-Caryophyllene Inhibits Dextran Sulfate Sodium-Induced Colitis in Mice through CB2 Receptor Activation and PPARγ Pathway

(2011) Allisson Freire Bento et al.   AMERICAN JOURNAL OF PATHOLOGY

Boswellia serrata

(2011) Mona Abdel-Tawab et al.   CLINICAL PHARMACOKINETICS

Efficacy and safety of Fufangkushen colon-coated capsule in the treatment of ulcerative colitis compared with mesalazine: A double-blinded and randomized study

(2011) Yang Gong et al.   JOURNAL OF ETHNOPHARMACOLOGY

Dietary aloin, aloesin, or aloe-gel exerts anti-inflammatory activity in a rat colitis model

(2011) Mi-Young Park et al.   LIFE SCIENCES

The endogenous cannabinoid system in the gut of patients with inflammatory bowel disease

(2011) A Di Sabatino et al.   Mucosal Immunology

Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis - a double-blind comparison with sustained release mesalazine

(2010) T. Tang et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The effects of Δ9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation andin vitromotility disturbances in rat colitis

(2010) JM Jamontt et al.   BRITISH JOURNAL OF PHARMACOLOGY

Randomized, placebo-controlled, double-blind trial of Boswellia serrata in maintaining remission of Crohnʼs disease

(2010) Wolfgang Holtmeier et al.   INFLAMMATORY BOWEL DISEASES

Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a Peripherally Restricted Cannabinoid CB1/CB2 Receptor Agonist, Inhibits Gastrointestinal Motility but Has No Effect on Experimental Colitis in Mice

(2010) N. L. Cluny et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cannabinoids and the gut: New developments and emerging concepts

(2010) Angelo A. Izzo et al.   PHARMACOLOGY & THERAPEUTICS

Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation

(2009) Sumner H. Burstein et al.   AAPS Journal

Oral Administration of Curcumin Emulsified in Carboxymethyl Cellulose Has a Potent Anti-inflammatory Effect in the IL-10 Gene-Deficient Mouse Model of IBD

(2009) Victoria Y. L. Ung et al.   DIGESTIVE DISEASES AND SCIENCES

Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis

(2009) Francesca Borrelli et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Wormwood (Artemisia absinthium) suppresses tumour necrosis factor alpha and accelerates healing in patients with Crohn’s disease – A controlled clinical trial

(2009) Simone Krebs et al.   PHYTOMEDICINE

Limited effects of dietary curcumin on Th-1 driven colitis in IL-10 deficient mice suggest an IL-10-dependent mechanism of protection

(2008) C. B. Larmonier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Curcuminoids Inhibit Multiple Human Cytochromes P450, UDP-Glucuronosyltransferase, and Sulfotransferase Enzymes, whereas Piperine Is a Relatively Selective CYP3A4 Inhibitor

(2008) L. P. Volak et al.   DRUG METABOLISM AND DISPOSITION

Patient Disclosure about Herb and Supplement Use among Adults in the US

(2007) Jae Kennedy et al.   Evidence-based Complementary and Alternative Medicine

The effects of cardamonin on lipopolysaccharide-induced inflammatory protein production and MAP kinase and NFκB signalling pathways in monocytes/macrophages

(2006) S Hatziieremia et al.   BRITISH JOURNAL OF PHARMACOLOGY