Article
Environmental Sciences
Nagwa Mohamed, Dalia H. El-Kashef, Ghada M. Suddek
Summary: Flavocoxid demonstrated a potential protective effect in acetic acid-induced colitis model, by attenuating oxidative stress, inflammation, and apoptosis in colonic tissues of rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Immunology
Nagwa I. Mohamed, Ghada M. Suddek, Dalia H. El-Kashef
Summary: In an experimental colitis model in rats, pretreatment with molsidomine significantly reduced disease activity index, colon mass index, colonic macroscopic and histological damage, while also influencing various biochemical markers.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Diva de Aguiar Magalhaes, Jalles Arruda Batista, Stefany Guimaraes Sousa, Jayro dos Santos Ferreira, Lauanda da Rocha Rodrigues, Cynthia Maria Carvalho Pereira, Jose Victor do Nascimento Lima, Ieda Figueira de Albuquerque, Nayonara Lanara Sousa Dutra Bezerra, Carlos Eduardo da Silva Monteiro, Alvaro Xavier Franco, Humberto Barbosa da Costa Filho, Francisco Cleber Silva Ferreira, Alexandre Havt, David Di Lenardo, Daniel Fernando Pereira Vasconcelos, Jefferson Soares de Oliveira, Pedro Marcos Gomes Soares, Andre Luiz dos Reis Barbosa
Summary: The study revealed that the M1 muscarinic acetylcholine receptor plays an anti-inflammatory role in experimental colitis, with McN-A-343 treatment significantly reducing intestinal damage and inflammation. Blocking the M1 receptor can lead to the failure of the anti-inflammatory response.
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Daniela Impellizzeri, Marika Cordaro, Rosalba Siracusa, Livia Interdonato, Rosalia Crupi, Enrico Gugliandolo, Francesco Macri, Davide Di Paola, Alessio Filippo Peritore, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: This study evaluated the effect of Boswellia serrata gum resin extract on endometriotic lesions in a rat model of endometriosis. The results showed that the extract reduced the size of the lesions and exerted antioxidant and antiapoptotic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Mohamed Shalaby, Rania R. Abdelaziz, Hamdy A. Ghoneim, Ghada M. Suddek
Summary: The study evaluated the effects of tyrosine kinase inhibitor (imatinib) on experimentally induced ulcerative colitis (UC) in rats. Imatinib pretreatment significantly reduced UC-induced damage and inflammation markers, as well as oxidative stress levels. Imatinib also suppressed the activity of the NF-kB/JAK2/ STAT3/COX2 signaling pathway. Therefore, imatinib may be a potential therapeutic option for UC.
Article
Biochemistry & Molecular Biology
Carla F. S. Guazelli, Victor Fattori, Camila R. Ferraz, Sergio M. Borghi, Rubia Casagrande, Marcela M. Baracat, Waldiceu A. Verri
Summary: Hesperidin methyl chalcone (HMC) exhibits significant protective effects in a mouse model of acetic acid-induced colitis, reducing neutrophil infiltration, edema, and colon damage while increasing antioxidant status. In addition, HMC inhibits pro-inflammatory cytokines in the colon, possibly through NF-kappa B inhibition. These findings suggest HMC as a promising therapeutic approach for the treatment of ulcerative colitis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Hongrui Guo, Hai Guo, Yue Xie, Yinyin Chen, Changfang Lu, Zhouping Yang, Yanqiu Zhu, Yujuan Ouyang, Yu Zhang, Xianxiang Wang
Summary: This study demonstrates that PMNFs have an inhibitory effect on ulcerative colitis by preventing oxidative damage, inflammation, and intestinal barrier breakdown. It activates the antioxidant pathway and suppresses the expression of pro-inflammatory factors, leading to the prevention of colitis. PMNFs also prevent the reduction of tight junction proteins and mucin-2 and the up-regulation of epithelial apoptosis caused by colitis. Thus, PMNFs have the potential to be applied in the treatment of various oxidative stress or inflammation-related diseases.
Article
Immunology
Michel Archange Fokam Tagne, Anatole Tchoffo, Paul Aime Noubissi, Aimee Gisolene Mazo, Blaise Kom, Joseph Ngakou Mukam, Selestin Sokeng Dongmo, Rene Kamgang
Summary: The study showed that the hydroethanolic extract of Maesa lanceolata leaves demonstrated significant efficacy in treating acetic acid-induced colitis in rats by reducing symptoms such as fever, diarrhea, mucus, and bloody stools, while increasing body weight. Additionally, the extract exhibited anti-inflammatory and antioxidant effects by reducing inflammatory markers and increasing antioxidant levels in the colon and blood.
INFLAMMOPHARMACOLOGY
(2021)
Article
Immunology
Maryam Ghasemi-Dehnoo, Hossein Amini-Khoei, Zahra Lorigooini, Maryam AnjomShoa, Elham Bijad, Mahmoud Rafieian-Kopaei
Summary: The study found that syringic acid significantly reduced inflammatory and apoptotic gene expressions in rats with UC, improved colon tissue damage, decreased oxidative stress and inflammation, and increased antioxidant capacity.
INFLAMMOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yong-Deok Jeon, Ji-Hyun Lee, Sa-Haeng Kang, Hyun Myung, Jong-Sik Jin
Summary: The study found that Lingonberry extract has potential therapeutic effects for patients with ulcerative colitis, as it can reduce weight loss, lengthen the colon, and improve the secretion of inflammatory cytokines.
APPLIED SCIENCES-BASEL
(2021)
Article
Immunology
Heba M. Hafez, Mohamed A. Ibrahim, Walaa Yehia Abdelzaher, Alyaa A. Gad, Sara Mohammed Naguib Abdel Hafez, Seham A. Abdel-Gaber
Summary: The study found that MRT has a protective effect against UC by reducing colonic damage and oxidative stress, as well as modulating the NLRP3/caspase-1 inflammatory pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kwang-Youn Kim, Jae Dong Son, Su-Jin Hwang, Jong Kwang Lee, Jae Young Park, Kwang Il Park, Tae Woo Oh
Summary: Fermented glutinous rice can improve ulcerative colitis by regulating the expression of tight junction proteins, reducing inflammation, and inhibiting apoptosis. The treatment with fermented glutinous rice can protect the intestinal barrier function, suppress inflammation, and prevent apoptosis, making it a potential candidate for treating and preventing inflammatory bowel disease.
Article
Food Science & Technology
Saber Jedidi, Houcem Sammari, Houcine Selmi, Karim Hosni, Kais Rtibi, Foued Aloui, Olfa Adouni, Hichem Sebai
Summary: The present research demonstrated that Salvia officinalis leaves decoction extract (SOLDE) exerted a potential protective effect against acetic acid-induced colitis in rats by reducing colonic mucosa lesions, counteracting lipid peroxidation, and increasing antioxidant enzyme activities.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Food Science & Technology
Joseph Festa, Mariasole Da Boit, Aamir Hussain, Harprit Singh
Summary: Cardiovascular disease is the leading cause of global death, with endothelial dysfunction being a predictor for most CVD. Polyphenols from sources like wine and grape extracts can help prevent endothelial dysfunction, while anthocyanin flavonoids found in berries also improve vascular function.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Nutrition & Dietetics
Agnieszka Zembron-Lacny, Edyta Wawrzyniak-Gramacka, Anna Ksiazek, Aleksandra Zagrodna, Wieslaw Kopec, Malgorzata Slowinska-Lisowska
Summary: Intense physical exercise leads to increased production of reactive oxygen and nitrogen species. This study examined the effects of dipeptide intake combined with exercise on the oxi-antioxidant response. The results showed that dipeptide intake led to a significant increase in the NO/H2O2 ratio after exercise, indicating enhanced antioxidant status. Additionally, dipeptides were found to reduce C-reactive protein levels, suggesting their anti-inflammatory properties. These findings suggest that dipeptides have potential in reducing oxidative stress and inflammation in physically active individuals.
Article
Nutrition & Dietetics
Rutiane Ullmann Thoen, Nathaniele Nebel Barther, Elizangela Schemitt, Silvia Bona, Sabrina Fernandes, Gabriela Coral, Norma Possa Marroni, Cristiane Tovo, Renata Padilha Guedes, Marilene Porawski
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2019)
Article
Pathology
Cristian Augusto Ostjen, Carlos Gustavo Sakuno Rosa, Renata Minuzzo Hartmann, Elizangela Goncalves Schemitt, Josieli Raskopf Colares, Norma Possa Marroni
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2019)
Article
Environmental Sciences
Joubert Aires De Sousa, Lismare da Silva Prado, Barbara Lopes Alderete, Fernanda Briao Menezes Boaretto, Mariangela C. Allgayer, Fabiano Moraes Miguel, Jayne Torres De Sousa, Norma Possa Marroni, Maria Luisa Brodt Lemes, Dione Silva Correa, Alexandre de Barros Falcao Ferraz, Jaqueline Nascimento Picada
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2019)
Article
Respiratory System
Adriane Dal Bosco, Filipe Boeira Schedler, Josieli Raskopf Colares, Elisangela Goncalves Schemitt, Renata Minuzzo Hartmann, Luiz Alberto Forgiarini Junior, Alexandre Simoes Dias, Norma Possa Marroni
JORNAL BRASILEIRO DE PNEUMOLOGIA
(2019)
Article
Cell Biology
Graziella Rodrigues, Andrea Janz Moreira, Silvia Bona, Elizangela Schemitt, Claudio Augusto Marroni, Fabio Cangeri Di Naso, Alexandre Simos Dias, Thienne Rocha Pires, Jaqueline Nascimento Picada, Norma Possa Marroni
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Environmental Sciences
Joubert Aires De Sousa, Jayne Torres De Sousa, Fernanda Briao Menezes Boaretto, Jeferson De Oliveira Salvi, Jean Fachini, Juliana Bondan Da Silva, Julia Pereira Unfer, Mariangela C. Allgayer, Maria Luisa Brodt Lemes, Norma Possa Marroni, Alexandre De Barros Falcao Ferraz, Jaqueline Nascimento Picada
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2019)
Article
Endocrinology & Metabolism
Flavia Tasmin Techera Antunes, Stephanie Gonsalves Angelo, Eliane Dallegrave, Jaqueline Nascimento Picada, Norma Possa Marroni, Elizangela Schemitt, Alice Gomes Ferraz, Marcus Vinicius Gomez, Alessandra Hubner de Souza
Article
Biochemistry & Molecular Biology
Eder Ricardo Petry, Diego de Freitas Dresch, Clarice Carvalho, Patricia Calcada Medeiros, Tatiana Gomes Rosa, Cleverson Morais de Oliveira, Leo Anderson Meira Martins, Elizangela Schemitt, Silvia Bona, Fatima Costa Rodrigues Guma, Norma Possas Marroni, Clovis Milton Duval Wannmacher
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Engineering, Environmental
Cristiano Brauner, Dvora Joveleviths, Mario R. Alvares-da-Silva, Norma Marroni, Silvia Bona, Elizangela Schemitt, Raissa Nardi
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
(2020)
Article
Pathology
Carlos Gustavo Sakuno Rosa, Josieli Raskopf Colares, Sandielly Rebeca Benitez da Fonseca, Gabriela dos Santos Martins, Fabiano Moraes Miguel, Alexandre Simoes Dias, Claudio Augusto Marroni, Jaqueline Nascimento Picada, Mauricio Lehmann, Norma Anair Possa Marroni
Summary: The study evaluated the effects of MLT and exercise on the quadriceps muscle in rats with biliary cirrhosis, suggesting that these treatments may contribute to reducing muscle changes in cirrhotic patients.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Engineering, Biomedical
Diogo Scalon, Jaqueline Nascimento Picada, Jayne Torres de Sousa, Ariane Taina da Silva, Josieli Raskopf Colares, Norma Anair Possa Marroni
Summary: Photobiomodulation (PBM) may be an effective intervention to alleviate sarcopenia in cirrhotic patients. The study evaluated the beneficial effects of PBM on the structural and functional properties of skeletal muscle in cirrhotic rats, showing improvements in locomotion, muscle fiber morphology, oxidative stress, and inflammation without causing DNA damage.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Gastroenterology & Hepatology
Josieli R. Colares, Renata M. Hartmann, Elizangela G. Schemitt, Sandielly R. B. Fonseca, Marilda S. Brasil, Jaqueline N. Picada, Alexandre S. Dias, Aline F. Bueno, Claudio A. Marroni, Norma P. Marroni
Summary: The study evaluated the effects of MLT on oxidative stress, inflammatory process, and DNA damage in an experimental model of secondary biliary cirrhosis. Administration of MLT significantly reduced inflammatory markers, oxidative stress levels, and DNA damage in the treated groups.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Nutrition & Dietetics
Joao C. Fernandes, Elizangela G. Schemitt, Juliana Da Silva, Norma P. Marroni, Ana Lima, Ricardo B. Ferreira
Summary: Our study found that the combination of trans-resveratrol and epsilon-viniferin can reduce oxidative damage, have a hepatoprotective effect, and regulate antioxidant pathways while inhibiting inflammatory development.
Article
Oncology
Carlos Gustavo S. Rosa, Elizangela G. Schemitt, Renate M. Hartmann, Josieli R. Colares, Jayne T. de Sousa, Silvia Bona, Andrea J. Moreira, Cristian Augusto Ostjen, Jaqueline N. Picada, Daniel P. Campani, Alexandre S. Dias, Norma Anair P. Marroni
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2019)
Article
Gastroenterology & Hepatology
Elizangela G. Schemitt, Renata M. Hartmann, Josieli R. Colares, Francielli Licks, Jeferson O. Salvi, Claudio A. Marroni, Norma P. Marroni
WORLD JOURNAL OF HEPATOLOGY
(2019)