Physiologically Based Pharmacokinetic Modeling of Oxycodone in Children to Support Pediatric Dosing Optimization

Updated Clinical Pharmacokinetics and Pharmacodynamics of Oxycodone

(2019) Mari Kinnunen et al.   CLINICAL PHARMACOKINETICS

Physiologically-based pharmacokinetics of ziprasidone in pregnant women

(2019) Carla Biesdorf et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Kidney cortical transporter expression across species using quantitative proteomics

(2019) Abdul Basit et al.   DRUG METABOLISM AND DISPOSITION

PBPK and its Virtual Populations: the Impact of Physiology on Pediatric Pharmacokinetic Predictions of Tramadol

(2018) Huybrecht T’jollyn et al.   AAPS Journal

Physiologically Based Pharmacokinetic Modeling in Regulatory Science: An Update From the U.S. Food and Drug Administration’s Office of Clinical Pharmacology

(2018) Manuela Grimstein et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferases

(2017) Stéphanie Romand et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Physiologically based pharmacokinetic modeling in regulatory decision-making at the European Medicines Agency

(2016) E Luzon et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Ontogeny of oral drug absorption processes in children

(2012) Miriam G Mooij et al.   Expert Opinion on Drug Metabolism & Toxicology

Developmental expression of drug metabolizing enzymes: Impact on disposition in neonates and young children

(2012) R.N. Hines   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Randomized, Double-Blind, Placebo-Controlled Study of the Abuse Potential of Different Formulations of Oral Oxycodone

(2012) Lynn R. Webster et al.   PAIN MEDICINE

Miconazole Oral Gel Increases Exposure to Oral Oxycodone by Inhibition of CYP2D6 and CYP3A4

(2010) Juha Grönlund et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Grapefruit Juice Enhances the Exposure to Oral Oxycodone

(2010) Tuija H. Nieminen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone

(2010) Juha Grönlund et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone

(2010) CF Samer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of Inhibition of Cytochrome P450 Enzymes 2D6 and 3A4 on the Pharmacokinetics of Intravenous Oxycodone

(2010) Juha Grönlund et al.   CLINICAL DRUG INVESTIGATION

Effects of itraconazole on the pharmacokinetics and pharmacodynamics of intravenously and orally administered oxycodone

(2010) Teijo I. Saari et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

St John's wort greatly reduces the concentrations of oral oxycodone

(2010) Tuija H. Nieminen et al.   EUROPEAN JOURNAL OF PAIN

Rifampin Greatly Reduces the Plasma Concentrations of Intravenous and Oral Oxycodone

(2009) Tuija H. Nieminen et al.   ANESTHESIOLOGY

Mechanistic Basis of Using Body Size and Maturation to Predict Clearance in Humans

(2009) Brian J. Anderson et al.   Drug Metabolism and Pharmacokinetics

Effect of Telithromycin on the Pharmacokinetics and Pharmacodynamics of Oral Oxycodone

(2009) Juha Grönlund et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Physiologically Based Predictions of the Impact of Inhibition of Intestinal and Hepatic Metabolism on Human Pharmacokinetics of CYP3A Substrates

(2009) Frederique Fenneteau et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Plasma Concentrations of Oral Oxycodone Are Greatly Increased in the Elderly

(2008) A Liukas et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Voriconazole drastically increases exposure to oral oxycodone

(2008) Nora M. Hagelberg et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Human renal function maturation: a quantitative description using weight and postmenstrual age

(2008) Malin M. Rhodin et al.   PEDIATRIC NEPHROLOGY