Article
Allergy
Lars Ahlbeck, Emelie Ahlberg, Janne Bjorkander, Caroline Alden, Georgia Papapavlou, Laura Palmberg, Ulla Nystrom, Pavlos Retsas, Patrik Nordenfelt, Totte Togo, Pal Johansen, Bo Rolander, Karel Duchen, Maria C. Jenmalm
Summary: Intralymphatic immunotherapy is a fast, efficient, and safe treatment method for severe allergic rhinitis patients. The study results showed that this treatment can significantly reduce symptoms, decrease medication use, and improve quality of life. The frequency of regulatory T cells increased, while birch-specific IgE levels decreased and IL-10 secretion increased after three years of treatment.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Review
Otorhinolaryngology
Sharmila Dhulipalla
Summary: This systematic review examines the effectiveness and safety of sublingual immunotherapy for allergic rhinoconjunctivitis caused by Ragweed. The results suggest that sublingual immunotherapy can improve symptoms, but more high-quality studies are needed to determine optimal dosing strategies.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Review
Cell Biology
Marina Izmailovich, Yuliya Semenova, Gulzada Abdushukurova, Ainur Mukhamejanova, Azhar Dyussupova, Raida Faizova, Meruert Gazaliyeva, Leila Akhvlediani, Natalya Glushkova, Sundetgali Kalmakhanov, Geir Bjorklund
Summary: A systematic review was conducted to explore the use of component-resolved diagnosis in identifying polysensitization in patients with seasonal allergic rhinitis. A total of 568 publications were identified and 12 were included in the review, with 3302 patients enrolled. The findings showed that component-resolved diagnostics changed the choice of relevant allergens for immunotherapy in at least 50% of cases and sensitization differed based on age, disease type, and disease duration.
Review
Allergy
Mariana Farraia, Ines Paciencia, Francisca Castro Mendes, Joao Cavaleiro Rufo, Mohamed Shamji, Ioana Agache, Andre Moreira
Summary: This study aimed to assess the preventive role of allergen immunotherapy (AIT) in asthma onset. The findings suggest a potential preventive effect of AIT in asthma onset, particularly in children completing 3 years of therapy and in mono-sensitized patients.
Article
Allergy
Conny Hoeflich, Galina Balakirski, Zuzanna Hajdu, Jens Malte Baron, Katharina Fietkau, Hans F. Merk, Ulrich Strassen, Henning Bier, Wolfgang Dott, Hans-Guido Muecke, Wolfgang Straff, Gerda Wurpts, Amir S. Yazdi, Adam Chaker, Stefani T. M. Roeseler
Summary: The study showed varying sensitization rates to both common and non-frequent pollen allergens in adult patients from two German federal states. Sensitization to non-frequent pollen allergens needs to be considered for patients with seasonal symptoms, and availability of test allergens for these less common allergies is important for patient management. Data on sensitization correlated partly with each other and with symptom periods, showing a seasonal pattern similar to pollen data.
CLINICAL AND TRANSLATIONAL ALLERGY
(2021)
Review
Pharmacology & Pharmacy
Poi Yi Aw Yong, Fahmida Islam, Hanis Hazeera Harith, Daud Ahmad Israf, Ji Wei Tan, Chau Ling Tham
Summary: Honey has been traditionally consumed as food, but its therapeutic properties have gained attention in the treatment of allergic diseases. Studies have shown that honey has the potential to alleviate allergic symptoms both in experimental models and clinical settings.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Yuan Wang, Xuan Li, Shuntong Gu, Junhong Fu
Summary: This study found differences in the composition and function of the conjunctival and nasal microbiome in patients with allergic rhinoconjunctivitis (ARC) or allergic rhinitis (AR), suggesting a relationship between allergic conditions and the local microbiome.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Otorhinolaryngology
Minh P. Hoang, Kachorn Seresirikachorn, Wirach Chitsuthipakorn, Kornkiat Snidvongs
Summary: ILIT demonstrated short-term benefits for seasonal ARC, but the sustained effects remain inconclusive. The therapy showed more significant effects on seasonal ARC compared to perennial ARC, and was safe and well tolerated.
Article
Immunology
Rui Tang, Shubin Lei, Liping Zhu, Yuzhen Lv, Hong Li
Summary: This study aimed to evaluate the preventative efficacy of omalizumab for seasonal allergic rhinoconjunctivitis (SARC) and explore its influencing factors. The retrospective analysis of patients' medical records found that pre-seasonal omalizumab treatment could significantly alleviate SARC-related symptoms and reduce medication use. The dosage and number of injections of omalizumab did not affect the preventative efficacy, with a single dose of 150mg achieving satisfactory outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Tiina Palmu, Jussi Lehtonen, Laura Korhonen, Suvi M. Virtanen, Onni Niemela, Jorma Toppari, Jorma Ilonen, Riitta Veijola, Mikael Knip, Olli H. Laitinen, Maria Lonnrot, Heikki Hyoty
Summary: This study found that there was no difference in the overall number of EV infections between children with s-IgE sensitization and those without. However, case children with allergic disease may have fewer EV infections than their controls. This observation was statistically significant for species A EVs in case children with atopic dermatitis compared to control children.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Mohamed A. Kamal, Robert Dingman, Claire Q. Wang, Ching-Ha Lai, Manoj Rajadhyaksha, Michelle DeVeaux, Jamie M. Orengo, Allen Radin, John D. Davis
Summary: REGN1908-1909, a 1:1 cocktail of two fully human IgG(4) monoclonal antibodies, shows linear and dose-proportional pharmacokinetics when used to treat cat allergy. A single dose of 600 mg can maintain therapeutic effects for 8-12 weeks.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Allergy
Lars Ahlbeck, Emelie Ahlberg, Linn Stuivers, Janne Bjorkander, Ulla Nystrom, Pavlos Retsas, Dhanapal Govindaraj, Maria C. Jenmalm, Karel Duchen
Summary: This study evaluated the safety and efficacy of intralymphatic immunotherapy (ILIT) for inducing tolerance in patients with allergic rhinitis. The results showed that two years after ILIT treatment, the actively treated group reported reduced symptoms, decreased medication use, and improved quality of life compared to the placebo group. Further studies are needed to confirm the efficacy of this treatment.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Review
Immunology
Chao Luo, Shunlin Peng, Mao Li, Xudong Ao, Zhiqing Liu
Summary: Probiotic supplements are effective in relieving symptoms of allergic rhinitis and improving the quality of life, but there is high heterogeneity in some results.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Allergy
Birgit Pfaller, Sarah Bendien, Agnes Ditisheim, Thomas Eiwegger
Summary: Managing allergic diseases during pregnancy presents challenges and potential risks for mother and child, especially with limited safety data on anti-allergic drugs during pregnancy.
Article
Otorhinolaryngology
Joo Hyun Jung, Kyeong Ah Kim, Yun Sook Choi, Seon Tae Kim
Summary: This study aimed to determine the efficacy of intralymphatic immunotherapy (ILIT) in a house dust mite (HDM) mouse model of allergic rhinitis. The results showed that ILIT decreased serum IgE level and eosinophil infiltration, and regulated the expression of various cytokines and T reg cells, indicating its potential as a treatment for allergic rhinitis.
ACTA OTO-LARYNGOLOGICA
(2023)
Article
Allergy
Charles F. Schuler, James L. Baldwin, Alan P. Baptist
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2018)
Article
Allergy
Sofija Volertas, Charles F. Schuler, Cem Akin
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
(2018)
Article
Allergy
Charles F. Schuler, Elisabeth A. Pedersen, Marc S. McMorris
ALLERGY AND ASTHMA PROCEEDINGS
(2019)
Article
Immunology
Wendy Fonseca, Carrie-Anne Malinczak, Charles F. Schuler, Shannon K. K. Best, Andrew J. Rasky, Susan B. Morris, Tracy X. Cui, Antonia P. Popova, Nicholas W. Lukacs
MUCOSAL IMMUNOLOGY
(2020)
Article
Allergy
Charles F. Schuler, Carrie-Anne Malinczak, Shannon K. K. Best, Susan B. Morris, Andrew J. Rasky, Catherine Ptaschinski, Nicholas W. Lukacs, Wendy Fonseca
Letter
Allergy
Michelle El-Hosni, Jenny M. Montejo, Charles F. Schuler
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2020)
Article
Allergy
Charles F. Schuler, Sofija Volertas, Dilawar Khokhar, Huseyin Yuce, Lu Chen, Onur Baser, Jenny M. Montejo, Cem Akin
Summary: Using an insurance claims database and a retrospective study at the University of Michigan, it was found that the prevalence of HVA in the US is lower than previously reported, while the prevalence of mastocytosis in patients with HVA is higher but still lower than previously reported. There was no correlation between tryptase level and reaction severity in patients undergoing VIT.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Charles F. Schuler, Carmen Gherasim, Kelly O'Shea, David M. Manthei, Jesse Chen, Don Giacherio, Jonathan P. Troost, James L. Baldwin, James R. Baker
Summary: The study conducted COVID-19 antibody testing in high-risk populations at the point of care, finding that finger-stick blood antibody testing was significantly effective in identifying antibodies from prior infections. Using serum did not improve the sensitivity or specificity of the testing, and almost all individuals with COVID-19 infection produced detectable antibodies to the virus.
Article
Virology
Carrie-Anne Malinczak, Charles F. Schuler, Angela J. Duran, Andrew J. Rasky, Mohamed M. Mire, Gabriel Nunez, Nicholas W. Lukacs, Wendy Fonseca
Summary: The activation of NLRP3 inflammasome plays a critical role in the pathogenesis of RSV infection, with inhibition leading to reduced lung immunopathology, mucus-associated gene expression, innate cytokine production, and inflammatory cell infiltration while increasing IFN-beta production. Inhibiting or deleting NLRP3 also diminishes viral-exacerbated allergic response in a mouse model of RSV-induced allergy exacerbation, demonstrating its potential as a therapeutic target for severe RSV disease and childhood asthma prevention.
Article
Microbiology
Charles F. Schuler, Carmen Gherasim, Kelly O'Shea, David M. Manthei, Jesse Chen, Cristyn Zettel, Jonathan P. Troost, Andrew A. Kennedy, Andrew W. Tai, Donald A. Giacherio, Riccardo Valdez, James L. Baldwin, James R. Baker
Summary: This study demonstrates that individuals with mild COVID-19 who produce antibodies are protected from reinfection for up to 6 months. The antibodies produced in this situation remain stable for up to 6 months and correlate well with neutralization activity.
MICROBIOLOGY SPECTRUM
(2021)
Article
Virology
Wendy Fonseca, Nobuhiro Asai, Kazuma Yagi, Carrie-Anne Malinczak, Gina Savickas, Christine C. Johnson, Shannon Murray, Edward M. Zoratti, Nicholas W. Lukacs, Jia Li, Charles F. Schuler
Summary: The study examined immune responses and renal injury markers in African American male patients hospitalized for COVID-19, finding that some patients had an increased risk of in-hospital mortality. Plasma analysis showed elevated levels of certain cytokines in ICU patients, and MCP-1 and GST may provide additional value for predicting in-hospital mortality from COVID-19.
Article
Allergy
Varsha Ganesan, Ankit Sharma, Sunil Tomar, Charles F. Schuler, Simon P. Hogan
Summary: Food allergy diagnosis and management pose challenges for individuals and their caregivers, leading to interest in predicting allergy severity and treatment outcomes. A murine model was used to study the effects of IL-4R alpha polymorphisms on clinical symptoms and treatment outcomes of food allergic reactions. The results show that IL-4R alpha polymorphisms can alter clinical symptoms, severity, and reactive dose of food allergic reactions in mice.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Alexandra Hua, Mohamad El-Zaatari, Elizabeth Hudson, Georgiana M. Sanders, Charles F. Schuler
Summary: The prevalence of trigger foods in food protein-induced enterocolitis syndrome (FPIES) may be changing over time, with most foods, including less commonly cited triggers, increasing in frequency. The most common initial trigger is oat. Subsequent reactions after education on trigger avoidance and safe home introduction of new foods were observed in 32.9% of patients, with 41% being reactions to new triggers and 45% to known triggers. Among those who reacted subsequently, 28% required emergency department visits. Egg and potato were the most common new triggers, while peanut commonly triggered reactions on oral food challenge.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Medicine, Research & Experimental
Charles F. Schuler, Kelly M. O'Shea, Jonathan P. Troost, Bridgette Kaul, Christopher M. Launius, Jayme Cannon, David M. Manthei, George E. Freigeh, Georgiana M. Sanders, Simon P. Hogan, Nicholas W. Lukacs, James R. Baker Jr
Summary: The study found that an increase in TEWL during OFCs could predict positive clinical challenges. TEWL provides a monitoring modality that may predict food anaphylaxis and facilitate improvements in OFC safety and tolerability.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Pediatrics
Rebecca R. Seltzer, Simone Thompson
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Kimberly E. Sawyer, Douglas J. Opel
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Micah Hester, Skye A. Miner
Summary: The process of soliciting a minor's assent has moral importance, even if it is not always required by regulations. It allows the child's opinion to be heard and respects their development and involvement in research. The extent of the child's involvement depends on their age, experience, and maturity.
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Nicholas A. Jabre, Margaret R. Moon
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Carrie M. Henderson, Renee D. Boss
Summary: An increasing number of children with serious/complex illness are living with long-term prognostic uncertainty, intensive interactions with medical systems, functional limitations, and the use of chronic medical technologies that affect their quality of life. These families often face multiple medical decision points and rely on intentional and iterative discussions to guide their care goals.
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Margaret R. Moon
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Mark T. Hughes
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
