Oxidative Stress and Microvascular Alterations in Diabetic Retinopathy: Future Therapies

Hyperglycemia Induces Neutrophil Extracellular Traps Formation Through an NADPH Oxidase-Dependent Pathway in Diabetic Retinopathy

(2019) Luoziyi Wang et al.   Frontiers in Immunology

Perturbed Biochemical Pathways and Associated Oxidative Stress Lead to Vascular Dysfunctions in Diabetic Retinopathy

(2019) Nidhi Mahajan et al.   Oxidative Medicine and Cellular Longevity

Health Benefits of Polyphenols and Carotenoids in Age-Related Eye Diseases

(2019) Simona Bungau et al.   Oxidative Medicine and Cellular Longevity

Effect of Fenofibrate on the Expression of Inflammatory Mediators in a Diabetic Rat Model

(2019) Po-Ting Yeh et al.   CURRENT EYE RESEARCH

Diabetic retinopathy, a vascular and inflammatory disease: Therapeutic implications

(2019) F. Semeraro et al.   DIABETES & METABOLISM

Diabetic Retinopathy in the Context of Patients with Diabetes

(2019) Olga Simó-Servat et al.   OPHTHALMIC RESEARCH

Cost Effectiveness of Treatments for Diabetic Retinopathy: A Systematic Literature Review

(2019) Nikolaos Maniadakis et al.   PHARMACOECONOMICS

Lipid-Lowering Medications are Associated with Lower Risk of Retinopathy and Ophthalmic Interventions among U.S. Patients with Diabetes

(2019) Daniel Vail et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Diabetic retinopathy: Focus on NADPH oxidase and its potential as therapeutic target

(2019) Jing-Jie Peng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Epigallocatechin-3-gallate stimulates autophagy and reduces apoptosis levels in retinal Müller cells under high-glucose conditions

(2019) Li Wang et al.   EXPERIMENTAL CELL RESEARCH

Statin use and vitreoretinal surgery: Findings from a Finnish population-based cohort study

(2018) Sirpa Loukovaara et al.   ACTA OPHTHALMOLOGICA

Involvement of Advanced Glycation End Products in the Pathogenesis of Diabetic Retinopathy

(2018) Jing Xu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

‘Statins in retinal disease’

(2018) Ahmed Al-Janabi et al.   EYE

Role of Inflammation in Diabetic Retinopathy

(2018) Anne Rübsam et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Diabetic retinopathy pathogenesis and the ameliorating effects of melatonin; involvement of autophagy, inflammation and oxidative stress

(2018) Ehsan Dehdashtian et al.   LIFE SCIENCES

Inhibition of α-glucosidase, α-amylase, and aldose reductase by potato polyphenolic compounds

(2018) Diganta Kalita et al.   PLoS One

Sweet Stress: Coping With Vascular Dysfunction in Diabetic Retinopathy

(2018) Ana R. Santiago et al.   Frontiers in Physiology

Molecular pathways associated with oxidative stress in diabetes mellitus

(2018) Osasenaga Macdonald Ighodaro   BIOMEDICINE & PHARMACOTHERAPY

Relationship between dyslipidemia and diabetic retinopathy

(2018) Yue Zhou et al.   MEDICINE

Chrysin Ameliorates Malfunction of Retinoid Visual Cycle through Blocking Activation of AGE-RAGE-ER Stress in Glucose-Stimulated Retinal Pigment Epithelial Cells and Diabetic Eyes

(2018) Min-Kyung Kang et al.   Nutrients

Methylglyoxal induces retinopathy-type lesions in the absence of hyperglycemia: studies in a rat model

(2018) Andrea Schlotterer et al.   FASEB JOURNAL

Association between microRNAs expression and signaling pathways of inflammatory markers in diabetic retinopathy

(2018) Rana Shafabakhsh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis

(2018) Takae Kiyama et al.   Molecular Neurodegeneration

Tannins and vascular complications of Diabetes: An update

(2018) Ankit P. Laddha et al.   PHYTOMEDICINE

Role of pterostilbene in attenuating immune mediated devastation of pancreatic beta cells via Nrf2 signaling cascade

(2017) Dornadula Sireesh et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Mitochondrial dysfunction and diabetic retinopathy

(2017) Toke Bek   MITOCHONDRION

Resveratrol Prevents ROS-Induced Apoptosis in High Glucose-Treated Retinal Capillary Endothelial Cells via the Activation of AMPK/Sirt1/PGC-1α Pathway

(2017) Jun Li et al.   Oxidative Medicine and Cellular Longevity

Diabetic retinopathy, metabolic memory and epigenetic modifications

(2017) Renu A. Kowluru   VISION RESEARCH

Whole exome sequencing identification of novel candidate genes in patients with proliferative diabetic retinopathy

(2017) Cindy Ung et al.   VISION RESEARCH

The “Metabolic Memory” Theory and the Early Treatment of Hyperglycemia in Prevention of Diabetic Complications

(2017) Roberto Testa et al.   Nutrients

Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis

(2017) Seth R Flaxman et al.   Lancet Global Health

Ameliorative potential of rutin in combination with nimesulide in STZ model of diabetic neuropathy: targeting Nrf2/HO-1/NF-kB and COX signalling pathway

(2017) Ruchika Mittal et al.   INFLAMMOPHARMACOLOGY

Regulation of autophagy by polyphenols: Paving the road for treatment of neurodegeneration

(2017) Seyed Fazel Nabavi et al.   BIOTECHNOLOGY ADVANCES

Resveratrol reverses the adverse effects of bevacizumab on cultured ARPE-19 cells

(2017) Murali Subramani et al.   Scientific Reports

Vitreous levels of vascular endothelial growth factor-B in proliferative diabetic retinopathy

(2016) Satoshi Kinoshita et al.   ACTA OPHTHALMOLOGICA

Diabetic retinopathy: global prevalence, major risk factors, screening practices and public health challenges: a review

(2016) Daniel Shu Wei Ting et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Nrf2 as molecular target for polyphenols: A novel therapeutic strategy in diabetic retinopathy

(2016) Seyed Fazel Nabavi et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Extravascular modified lipoproteins: a role in the propagation of diabetic retinopathy in a mouse model of type 1 diabetes

(2016) Jeremy Y. Yu et al.   DIABETOLOGIA

Consumption of polyphenol-rich Morus alba leaves extract attenuates early diabetic retinopathy: the underlying mechanism

(2016) Ayman M. Mahmoud et al.   EUROPEAN JOURNAL OF NUTRITION

The glucagon like peptide 1 analogue, exendin-4, attenuates oxidative stress-induced retinal cell death in early diabetic rats through promoting Sirt1 and Sirt3 expression

(2016) Ying Zeng et al.   EXPERIMENTAL EYE RESEARCH

Nrf2 protects mitochondrial decay by oxidative stress

(2016) Joshua Strom et al.   FASEB JOURNAL

Nrf2 promotes reparative angiogenesis through regulation of NADPH oxidase-2 in oxygen-induced retinopathy

(2016) Yanhong Wei et al.   FREE RADICAL BIOLOGY AND MEDICINE

Methylglyoxal induces cell death through endoplasmic reticulum stress-associated ROS production and mitochondrial dysfunction

(2016) Chi-Ming Chan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Angiogenesis and Inflammation Crosstalk in Diabetic Retinopathy

(2016) Margarida Capitão et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1

(2016) Jean-Sébastien Joyal et al.   NATURE MEDICINE

Role of Natural Stilbenes in the Prevention of Cancer

(2016) J. Antoni Sirerol et al.   Oxidative Medicine and Cellular Longevity

The progress in understanding and treatment of diabetic retinopathy

(2016) Alan W. Stitt et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Implication of oxidative stress in progression of diabetic retinopathy

(2016) Tapan Behl et al.   SURVEY OF OPHTHALMOLOGY

Resveratrol and Ophthalmic Diseases

(2016) Khaled Abu-Amero et al.   Nutrients

Oxidative stress, mitochondrial damage and diabetic retinopathy

(2015) Renu A. Kowluru et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aldose reductase inhibition alleviates hyperglycemic effects on human retinal pigment epithelial cells

(2015) Kun-Che Chang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Topical administration of GLP-1 receptor agonists prevents retinal neurodegeneration in experimental diabetes

(2015) Cristina Hernández et al.   DIABETES

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

(2015) Lauren E. Tebay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural basis of Keap1 interactions with Nrf2

(2015) Peter Canning et al.   FREE RADICAL BIOLOGY AND MEDICINE

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria

(2015) Ken Itoh et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

The role of Nrf2 in oxidative stress-induced endothelial injuries

(2015) B. Chen et al.   JOURNAL OF ENDOCRINOLOGY

Polyphenol-enriched cocoa protects the diabetic retina from glial reaction through the sirtuin pathway

(2015) Diego A. Duarte et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Serum Lipids and Proliferative Diabetic Retinopathy and Macular Edema in Persons With Long-term Type 1 Diabetes Mellitus

(2015) Barbara E. K. Klein et al.   JAMA Ophthalmology

Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis

(2015) Rui-Ming Liu et al.   Redox Biology

Therapeutic potential of pterostilbene against pancreatic beta-cell apoptosis mediated through Nrf2

(2014) Elango Bhakkiyalakshmi et al.   BRITISH JOURNAL OF PHARMACOLOGY

The interleukin-1 receptor antagonist anakinra improves endothelial dysfunction in streptozotocin-induced diabetic rats

(2014) Susana Vallejo et al.   Cardiovascular Diabetology

Anti-inflammatory properties of resveratrol in the retinas of type 2 diabetic rats

(2014) Farhad Ghadiri Soufi et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Impact of HbA1c, Followed From Onset of Type 1 Diabetes, on the Development of Severe Retinopathy and Nephropathy: The VISS Study (Vascular Diabetic Complications in Southeast Sweden)

(2014) Maria Nordwall et al.   DIABETES CARE

Exendin-4 alleviates retinal vascular leakage by protecting the blood–retinal barrier and reducing retinal vascular permeability in diabetic Goto-Kakizaki rats

(2014) Yichao Fan et al.   EXPERIMENTAL EYE RESEARCH

Retinal neuroprotective effects of quercetin in streptozotocin-induced diabetic rats

(2014) Binit Kumar et al.   EXPERIMENTAL EYE RESEARCH

Epigalloccatechin-3-gallate Inhibits Ocular Neovascularization and Vascular Permeability in Human Retinal Pigment Epithelial and Human Retinal Microvascular Endothelial Cells via Suppression of MMP-9 and VEGF Activation

(2014) Hak Lee et al.   MOLECULES

Resveratrol improves diabetic retinopathy possibly through oxidative stress – nuclear factor κB – apoptosis pathway

(2014) Farhad Ghadiri Soufi et al.   Pharmacological Reports

Emerging role of advanced glycation-end products (AGEs) in the pathobiology of eye diseases

(2014) Stylianos A. Kandarakis et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Combating oxidative stress in diabetic complications with Nrf2 activators: How much is too much?

(2014) Sih Min Tan et al.   REDOX REPORT

Molecular Mechanisms of Diabetic Retinopathy, General Preventive Strategies, and Novel Therapeutic Targets

(2014) Sher Zaman Safi et al.   Biomed Research International

Oscillating high glucose enhances oxidative stress and apoptosis in human coronary artery endothelial cells

(2014) Ting-song Liu et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Role of advanced glycation end products in cellular signaling

(2014) Christiane Ott et al.   Redox Biology

Association Between Plasma Triglycerides and High-Density Lipoprotein Cholesterol and Microvascular Kidney Disease and Retinopathy in Type 2 Diabetes Mellitus

(2013) Frank M. Sacks et al.   CIRCULATION

Advances in our understanding of diabetic retinopathy

(2013) Alan W. Stitt et al.   CLINICAL SCIENCE

Diabetic Retinopathy

(2013) Daniel F. Rosberger   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Oxidative Stress in Cardiovascular Diseases and Obesity: Role of p66Shc and Protein Kinase C

(2013) Elena De Marchi et al.   Oxidative Medicine and Cellular Longevity

The role of VEGF165b in pathophysiology

(2013) Maria Peiris-Pagès   Cell Adhesion & Migration

Costs, outcomes and challenges for diabetes care in Spain

(2013) Julio Lopez-Bastida et al.   Globalization and Health

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

trans-Resveratrol Protects Ischemic PC12 Cells by Inhibiting the Hypoxia Associated Transcription Factors and Increasing the Levels of Antioxidant Defense Enzymes

(2012) Megha Agrawal et al.   ACS Chemical Neuroscience

Pathophysiology and treatment of diabetic retinopathy

(2012) Francesco Bandello et al.   ACTA DIABETOLOGICA

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Potential Role of Glucagon-Like Peptide-1 (GLP-1) in Neuroprotection

(2012) Christian Hölscher   CNS DRUGS

The Role of Toll-Like Receptors in Diabetes-Induced Inflammation: Implications for Vascular Complications

(2012) Ishwarlal Jialal et al.   Current Diabetes Reports

Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on progression of diabetic neuropathy and other microvascular complications: multivariate epidemiological analysis based on patient background factors and severity of diabetic neurop

(2012) N. Hotta et al.   DIABETIC MEDICINE

Resveratrol Mitigates Rat Retinal Ischemic Injury: The Roles of Matrix Metalloproteinase-9, Inducible Nitric Oxide, and Heme Oxygenase-1

(2012) Xiao-Qian Liu et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Usefulness of the Vitreous Fluid Analysis in the Translational Research of Diabetic Retinopathy

(2012) Olga Simó-Servat et al.   MEDIATORS OF INFLAMMATION

Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes

(2012) Carolina E. Hagberg et al.   NATURE

Metabolic stress response implicated in diabetic retinopathy: The role of calpain, and the therapeutic impact of calpain inhibitor

(2012) Ahmed Y. Shanab et al.   NEUROBIOLOGY OF DISEASE

The electrotonic architecture of the retinal microvasculature: Diabetes-induced alteration

(2012) Atsuko Nakaizumi et al.   NEUROCHEMISTRY INTERNATIONAL

O-linked β-N-acetylglucosamine supports p38 MAPK activation by high glucose in glomerular mesangial cells

(2011) Howard Goldberg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia

(2011) Zoltan Ungvari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2–Keap1 signaling

(2011) P. Palsamy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Lipid metabolites in the pathogenesis and treatment of neovascular eye disease

(2011) A. Stahl et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

AGEs, RAGE, and Diabetic Retinopathy

(2011) Hongliang Zong et al.   Current Diabetes Reports

Retinal Redox Stress and Remodeling in Cardiometabolic Syndrome and Diabetes

(2011) Ying Yang et al.   Oxidative Medicine and Cellular Longevity

Inflammation in diabetic retinopathy

(2011) Johnny Tang et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Glutathione in Cancer Cell Death

(2011) Angel L. Ortega et al.   Cancers

Redox Control of Protein Kinase C: Cell- and Disease-Specific Aspects

(2010) Carlotta Giorgi et al.   ANTIOXIDANTS & REDOX SIGNALING

Impaired Redox Signaling and Antioxidant Gene Expression in Endothelial Cells in Diabetes: A Role for Mitochondria and the Nuclear Factor-E2-Related Factor 2-Kelch-Like ECH-Associated Protein 1 Defense Pathway

(2010) Xinghua Cheng et al.   ANTIOXIDANTS & REDOX SIGNALING

Activation of Protein Kinase C Isoforms and Its Impact on Diabetic Complications

(2010) Pedro Geraldes et al.   CIRCULATION RESEARCH

Prevalence and healthcare costs of diabetic retinopathy: a population-based register study in Sweden

(2010) E. Heintz et al.   DIABETOLOGIA

Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cells

(2010) Tim U. Krohne et al.   EXPERIMENTAL EYE RESEARCH

trans-Resveratrol Inhibits Hyperglycemia-Induced Inflammation and Connexin Downregulation in Retinal Pigment Epithelial Cells

(2010) Jack N. Losso et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Temporal requirement of RPE-derived VEGF in the development of choroidal vasculature

(2010) Yun-Zheng Le et al.   JOURNAL OF NEUROCHEMISTRY

Resveratrol Reverses Endothelial Nitric-Oxide Synthase Uncoupling in Apolipoprotein E Knockout Mice

(2010) N. Xia et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Diabetic retinopathy

(2010) Ning Cheung et al.   LANCET

Influence of Serum Lipids on Clinically Significant versus Nonclinically Significant Macular Edema

(2010) Rajiv Raman et al.   OPHTHALMOLOGY

Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signalling

(2009) L. Gao et al.   CARDIOVASCULAR RESEARCH

Diabetic retinopathy screening: a systematic review of the economic evidence

(2009) S. Jones et al.   DIABETIC MEDICINE

Microvascular lesions of diabetic retinopathy: clues towards understanding pathogenesis?

(2009) T M Curtis et al.   EYE

Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy

(2009) Pedro Geraldes et al.   NATURE MEDICINE

The Wisconsin Epidemiologic Study of Diabetic Retinopathy XXIII: The Twenty-five-Year Incidence of Macular Edema in Persons with Type 1 Diabetes

(2009) Ronald Klein et al.   OPHTHALMOLOGY

Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations

(2008) Anna Csiszar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis

(2008) Wenge Li et al.   BIOCHEMICAL PHARMACOLOGY

Glucolipotoxicity: Fuel Excess and β-Cell Dysfunction

(2008) Vincent Poitout et al.   ENDOCRINE REVIEWS

Oxidative stress in environmental-induced carcinogenesis

(2008) Salvador Mena et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Prevalence and Risk Factors for Diabetic Retinopathy

(2008) Tien Y. Wong et al.   OPHTHALMOLOGY

The Wisconsin Epidemiologic Study of Diabetic Retinopathy XXII

(2008) Ronald Klein et al.   OPHTHALMOLOGY

Intravitreal Steroids for Macular Edema: The Past, the Present, and the Future

(2008) Matthew A. Cunningham et al.   SURVEY OF OPHTHALMOLOGY