LncRNA LEGLTBC Functions as a ceRNA to Antagonize the Effects of miR-34a on the Downregulation of SIRT1 in Glucolipotoxicity-Induced INS-1 Beta Cell Oxidative Stress and Apoptosis

miR-34a Promotes Vascular Smooth Muscle Cell Calcification by Downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase)

(2018) Ileana Badi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

High glucose up-regulates microRNA-34a-5p to aggravate fibrosis by targeting SIRT1 in HK-2 cells

(2018) Meng Xue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glucolipotoxic conditions induce β-cell iron import, cytosolic ROS formation and apoptosis

(2018) Jakob Bondo Hansen et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses

(2018) Vanesa Bellou et al.   PLoS One

LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling

(2018) Ailing Li et al.   Cell Death & Disease

Glucolipotoxicity-InhibitedmiR-299-5pRegulates Pancreatic β-Cell Function and Survival

(2018) Qiqing Huang et al.   DIABETES

LncRNA HOTAIR functions as a competing endogenous RNA to upregulate SIRT1 by sponging miR-34a in diabetic cardiomyopathy

(2018) Lu Gao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Temporal Proteomic Analysis of Pancreatic β-Cells in Response to Lipotoxicity and Glucolipotoxicity

(2018) Zonghong Li et al.   MOLECULAR & CELLULAR PROTEOMICS

LncRNA-MEG3 alleviates high glucose induced inflammation and apoptosis of retina epithelial cells via regulating miR-34a/SIRT1 axis

(2018) Ping Tong et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Polysiphonia japonica Extract Attenuates Palmitate-Induced Toxicity and Enhances Insulin Secretion in Pancreatic Beta-Cells

(2018) Seon-Heui Cha et al.   Oxidative Medicine and Cellular Longevity

Intracellular methylglyoxal induces oxidative damage to pancreatic beta cell line INS-1 cell through Ire1α-JNK and mitochondrial apoptotic pathway

(2017) Chongxiao Liu et al.   FREE RADICAL RESEARCH

Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions

(2017) Mohammed Bensellam et al.   JOURNAL OF ENDOCRINOLOGY

Activation of NLRP3 Inflammasome by Advanced Glycation End Products Promotes Pancreatic Islet Damage

(2017) Xiang Kong et al.   Oxidative Medicine and Cellular Longevity

Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells

(2017) Weijin Zhang et al.   Oxidative Medicine and Cellular Longevity

Stigmasterol prevents glucolipotoxicity induced defects in glucose-stimulated insulin secretion

(2017) Meliza G. Ward et al.   Scientific Reports

Downregulation of miR-139-5p contributes to the antiapoptotic effect of liraglutide on the diabetic rat pancreas and INS-1 cells by targeting IRS1

(2017) Jin Li et al.   PLoS One

Long noncoding RNAs are dynamically regulated during β-cell mass expansion in mouse pregnancy and control β-cell proliferation in vitro

(2017) Giorgia Sisino et al.   PLoS One

Palmitate-induced lipotoxicity alters acetylation of multiple proteins in clonal β cells and human pancreatic islets

(2017) Federica Ciregia et al.   Scientific Reports

miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling

(2016) Guangzhi Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Stress-impaired transcription factor expression and insulin secretion in transplanted human islets

(2016) Chunhua Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

Insights from lncRNAs Profiling of MIN6 Beta Cells Undergoing Inflammation

(2016) Chuntao Sun et al.   MEDIATORS OF INFLAMMATION

SIRT1/3 Activation by Resveratrol Attenuates Acute Kidney Injury in a Septic Rat Model

(2016) Siqi Xu et al.   Oxidative Medicine and Cellular Longevity

Glucolipotoxicity initiates pancreatic β-cell death through TNFR5/CD40-mediated STAT1 and NF-κB activation

(2016) Marta Bagnati et al.   Cell Death & Disease

Involvement of long non-coding RNAs in beta cell failure at the onset of type 1 diabetes in NOD mice

(2015) Anna Motterle et al.   DIABETOLOGIA

Natural history of β-cell adaptation and failure in type 2 diabetes

(2015) Emilyn U. Alejandro et al.   MOLECULAR ASPECTS OF MEDICINE

Sesamin Ameliorates Advanced Glycation End Products-Induced Pancreatic β-Cell Dysfunction and Apoptosis

(2015) Xiang Kong et al.   Nutrients

Downregulation of Bcl-2 Expression by miR-34a Mediates Palmitate-Induced Min6 Cells Apoptosis

(2014) Xiaojie Lin et al.   Journal of Diabetes Research

Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes

(2013) Valeria Nesca et al.   DIABETOLOGIA

Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process

(2013) Antero Salminen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of SIRT1 protects pancreatic β-cells against palmitate-induced dysfunction

(2012) Ling Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

(2011) Goodarz Danaei et al.   LANCET

Alterations in MicroRNA Expression Contribute to Fatty Acid-Induced Pancreatic  -Cell Dysfunction

(2008) P. Lovis et al.   DIABETES

Pioglitazone attenuates fatty acid–induced oxidative stress and apoptosis in pancreatic β-cells

(2007) Y. Saitoh et al.   DIABETES OBESITY & METABOLISM