Stigmasterol prevents glucolipotoxicity induced defects in glucose-stimulated insulin secretion

Chronic Exposure to Excess Nutrients Left-shifts the Concentration Dependence of Glucose-stimulated Insulin Secretion in Pancreatic β-Cells

(2015) Karel A. Erion et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fluvastatin Causes NLRP3 Inflammasome-Mediated Adipose Insulin Resistance

(2014) Brandyn D. Henriksbo et al.   DIABETES

Cholesterol reduction ameliorates glucose-induced calcium handling and insulin secretion in islets from low-density lipoprotein receptor knockout mice

(2013) J.C. Souza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Coordinate Changes in Histone Modifications, mRNA Levels, and Metabolite Profiles in Clonal INS-1 832/13 β-Cells Accompany Functional Adaptations to Lipotoxicity

(2013) Siri Malmgren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alteration of Endoplasmic Reticulum Lipid Rafts Contributes to Lipotoxicity in Pancreatic β-Cells

(2013) Ebru Boslem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dietary phytosterols modify the sterols and fatty acid profile in a tissue-specific pattern

(2013) Ramez Alhazzaa et al.   Journal of Functional Foods

Loss of Both ABCA1 and ABCG1 Results in Increased Disturbances in Islet Sterol Homeostasis, Inflammation, and Impaired  -Cell Function

(2012) J. K. Kruit et al.   DIABETES

Lactogens protect rodent and human beta cells against glucolipotoxicity-induced cell death through Janus kinase‐2 (JAK2)/signal transducer and activator of transcription-5 (STAT5) signalling

(2012) N. Guthalu Kondegowda et al.   DIABETOLOGIA

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

Cholesterol Accumulation Increases Insulin Granule Size and Impairs Membrane Trafficking

(2012) Jonathan S. Bogan et al.   TRAFFIC

SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset

(2011) A. M. Zawada et al.   BLOOD

Risk of Incident Diabetes With Intensive-Dose Compared With Moderate-Dose Statin Therapy

(2011) David Preiss   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Dual-mode of insulin action controls GLUT4 vesicle exocytosis

(2011) Yingke Xu et al.   JOURNAL OF CELL BIOLOGY

 -Cell Failure in Diet-Induced Obese Mice Stratified According to Body Weight Gain: Secretory Dysfunction and Altered Islet Lipid Metabolism Without Steatosis or Reduced  -Cell Mass

(2010) M.-L. Peyot et al.   DIABETES

Glucolipotoxicity Alters Lipid Partitioning and Causes Mitochondrial Dysfunction, Cholesterol, and Ceramide Deposition and Reactive Oxygen Species Production in INS832/13 ß-Cells

(2010) Wissal El-Assaad et al.   ENDOCRINOLOGY

Phytosterols differentially influence ABC transporter expression, cholesterol efflux and inflammatory cytokine secretion in macrophage foam cells

(2010) Nadezhda S. Sabeva et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials

(2010) Naveed Sattar et al.   LANCET

Statin Therapy and Risk of Developing Type 2 Diabetes: A Meta-Analysis

(2009) S. N. Rajpathak et al.   DIABETES CARE

Cholesterol Regulates Glucose-stimulated Insulin Secretion through Phosphatidylinositol 4,5-Bisphosphate

(2009) Mingming Hao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plant sterols/stanols as cholesterol lowering agents: a meta-analysis of randomized controlled trials

(2009) SuhadS. Abumweis et al.   Food & Nutrition Research

Glucolipotoxicity: Fuel Excess and β-Cell Dysfunction

(2008) Vincent Poitout et al.   ENDOCRINE REVIEWS

Thyroid inhibitory, antiperoxidative and hypoglycemic effects of stigmasterol isolated from Butea monosperma

(2008) S. Panda et al.   FITOTERAPIA

Filamentous Actin Regulates Insulin Exocytosis through Direct Interaction with Syntaxin 4

(2008) Jenna L. Jewell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol accumulation and diabetes in pancreatic β-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity

(2008) Mayumi Ishikawa et al.   JOURNAL OF LIPID RESEARCH

Phytosterols do not change susceptibility to obesity, insulin resistance, and diabetes induced by a high-fat diet in mice

(2008) L. Calpe-Berdiel et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Administration of phytosterols isolated from Aloe vera gel reduce visceral fat mass and improve hyperglycemia in Zucker diabetic fatty (ZDF) rats

(2008) Eriko Misawa et al.   Obesity Research & Clinical Practice