Mutations of R882 change flanking sequence preferences of the DNA methyltransferase DNMT3A and cellular methylation patterns

Effect of Disease-Associated Germline Mutations on Structure Function Relationship of DNA Methyltransferases

(2019) Allison B. Norvil et al.   Genes

A 4-gene expression prognostic signature might guide post-remission therapy in patients with intermediate-risk cytogenetic acute myeloid leukemia

(2018) Montserrat Torrebadell et al.   LEUKEMIA & LYMPHOMA

Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome

(2018) Alexey A. Soshnev et al.   MOLECULAR CELL

Structural basis for DNMT3A-mediated de novo DNA methylation

(2018) Zhi-Min Zhang et al.   NATURE

The DNMT3A R882H mutant displays altered flanking sequence preferences

(2018) Max Emperle et al.   NUCLEIC ACIDS RESEARCH

The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update

(2018) Enis Afgan et al.   NUCLEIC ACIDS RESEARCH

Mammalian DNA methyltransferases: new discoveries and open questions

(2018) Humaira Gowher et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The DNMT3A R882H mutation does not cause dominant negative effects in purified mixed DNMT3A/R882H complexes

(2018) Max Emperle et al.   Scientific Reports

PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma

(2018) Feng Dong et al.   Nature Communications

Molecular Processes Connecting DNA Methylation Patterns with DNA Methyltransferases and Histone Modifications in Mammalian Genomes

(2018) Albert Jeltsch et al.   Genes

Clinical features and prognostic impact of PRDM16 expression in adult acute myeloid leukemia

(2017) Genki Yamato et al.   GENES CHROMOSOMES & CANCER

Dynamics and Context-Dependent Roles of DNA Methylation

(2017) Christina Ambrosi et al.   JOURNAL OF MOLECULAR BIOLOGY

Impact of cytosine methylation on DNA binding specificities of human transcription factors

(2017) Yimeng Yin et al.   SCIENCE

Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers

(2017) Jacob L. Glass et al.   Cancer Discovery

Quantitative Analysis of the DNA Methylation Sensitivity of Transcription Factor Complexes

(2017) Judith F. Kribelbauer et al.   Cell Reports

Wilms tumor 1 mutations in the pathogenesis of acute myeloid leukemia

(2016) R. Rampal et al.   HAEMATOLOGICA

Epigenetic modulators, modifiers and mediators in cancer aetiology and progression

(2016) Andrew P. Feinberg et al.   NATURE REVIEWS GENETICS

The molecular hallmarks of epigenetic control

(2016) C. David Allis et al.   NATURE REVIEWS GENETICS

Allosteric control of mammalian DNA methyltransferases – a new regulatory paradigm

(2016) Albert Jeltsch et al.   NUCLEIC ACIDS RESEARCH

The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins

(2016) Andrew D. Rouillard et al.   Database-The Journal of Biological Databases and Curation

Wilms tumor 1 mutations in the pathogenesis of acute myeloid leukemia

(2016) R. Rampal et al.   HAEMATOLOGICA

HighPRDM16expression identifies a prognostic subgroup of pediatric acute myeloid leukaemia correlated toFLT3-ITD,KMT2A-PTD, andNUP98-NSD1: the results of the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 trial

(2015) Norio Shiba et al.   BRITISH JOURNAL OF HAEMATOLOGY

Function and information content of DNA methylation

(2015) Dirk Schübeler   NATURE

Transcriptional plasticity promotes primary and acquired resistance to BET inhibition

(2015) Philipp Rathert et al.   NATURE

Genetic alterations of DNA methylation machinery in human diseases

(2015) Tewfik Hamidi et al.   Epigenomics

The R882H DNMT3A Mutation Associated with AML Dominantly Inhibits Wild-Type DNMT3A by Blocking Its Ability to Form Active Tetramers

(2014) David A. Russler-Germain et al.   CANCER CELL

Gene Body Methylation Can Alter Gene Expression and Is a Therapeutic Target in Cancer

(2014) Xiaojing Yang et al.   CANCER CELL

Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia

(2014) G. J. Liu et al.   GENES & DEVELOPMENT

Cooperative DNA Binding and Protein/DNA Fiber Formation Increases the Activity of the Dnmt3a DNA Methyltransferase

(2014) Max Emperle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells

(2013) S. J. Kim et al.   BLOOD

Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer

(2013) Christoph Plass et al.   NATURE REVIEWS GENETICS

DNA methylation dynamics in health and disease

(2013) Yehudit Bergman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNAshape: a method for the high-throughput prediction of DNA structural features on a genomic scale

(2013) Tianyin Zhou et al.   NUCLEIC ACIDS RESEARCH

Mutations in DNA Methyltransferase (DNMT3A) Observed in Acute Myeloid Leukemia Patients Disrupt Processive Methylation

(2012) Celeste Holz-Schietinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Approaches to Enzyme and Substrate Design of the Murine Dnmt3a DNA Methyltransferase

(2011) Renata Z. Jurkowska et al.   CHEMBIOCHEM

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

(2011) Xiao-Jing Yan et al.   NATURE GENETICS

Origins of Specificity in Protein-DNA Recognition

(2010) Remo Rohs et al.   Annual Review of Biochemistry

Structure and Function of Mammalian DNA Methyltransferases

(2010) Renata Zofia Jurkowska et al.   CHEMBIOCHEM

DNMT3L Modulates Significant and Distinct Flanking Sequence Preference for DNA Methylation by DNMT3A and DNMT3B In Vivo

(2010) Bethany L. Wienholz et al.   PLoS Genetics

PRDM6 is enriched in vascular precursors during development and inhibits endothelial cell proliferation, survival, and differentiation

(2007) Yaxu Wu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY