Vildagliptin Attenuates Huntington’s Disease through Activation of GLP-1 Receptor/PI3K/Akt/BDNF Pathway in 3-Nitropropionic Acid Rat Model

Angiotensin 1-7 ameliorates 6-hydroxydopamine lesions in hemiparkinsonian rats through activation of MAS receptor/PI3K/Akt/BDNF pathway and inhibition of angiotensin II type-1 receptor/NF-κB axis

(2018) Mostafa A. Rabie et al.   BIOCHEMICAL PHARMACOLOGY

Possible role of DPP4 inhibitors to promote hippocampal neurogenesis in Alzheimer’s disease

(2018) Nehru Sai Suresh Chalichem et al.   JOURNAL OF DRUG TARGETING

Neuroprotective effect of vildagliptin against cerebral ischemia in rats

(2018) Salma A. El-Marasy et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Tackling dipeptidyl peptidase IV in neurological disorders

(2018) Alessandro Castorina et al.   Neural Regeneration Research

In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus

(2018) Raimunda S. S. Azevedo et al.   Scientific Reports

The crosstalk between Sirt1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-β1 expressions in rat glomerular mesangial cells

(2017) Kaipeng Huang et al.   EXPERIMENTAL CELL RESEARCH

Nrf2, cellular redox regulation, and neurologic implications

(2017) Eduardo E. Benarroch   NEUROLOGY

The Role of Nrf2 in Cardiovascular Function and Disease

(2017) Sandro Satta et al.   Oxidative Medicine and Cellular Longevity

SGLT2-inhibitor and DPP-4 inhibitor improve brain function via attenuating mitochondrial dysfunction, insulin resistance, inflammation, and apoptosis in HFD-induced obese rats

(2017) Piangkwan Sa-nguanmoo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effect of embelin against 3-nitropropionic acid-induced Huntington's disease in rats

(2016) Shivsharan B. Dhadde et al.   BIOMEDICINE & PHARMACOTHERAPY

Dipeptidyl peptidase-4 inhibitor improved exercise capacity and mitochondrial biogenesis in mice with heart failure via activation of glucagon-like peptide-1 receptor signalling

(2016) Shingo Takada et al.   CARDIOVASCULAR RESEARCH

The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action

(2016) Dilan Athauda et al.   DRUG DISCOVERY TODAY

SIRT1 exerts protective effects against paraquat-induced injury in mouse type II alveolar epithelial cells by deacetylating NRF2 in vitro

(2016) YING-WEI DING et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Effect of rutin against a mitochondrial toxin, 3-nitropropionicacid induced biochemical, behavioral and histological alterations-a pilot study on Huntington’s disease model in rats

(2016) Sarumani Natarajan Suganya et al.   METABOLIC BRAIN DISEASE

Baicalin Attenuates Ketamine-Induced Neurotoxicity in the Developing Rats: Involvement of PI3K/Akt and CREB/BDNF/Bcl-2 Pathways

(2016) Daiying Zuo et al.   NEUROTOXICITY RESEARCH

The Neuroprotection of Liraglutide Against Ischaemia-induced Apoptosis through the Activation of the PI3K/AKT and MAPK Pathways

(2016) Huili Zhu et al.   Scientific Reports

Glutamate and GABA Imbalance Following Traumatic Brain Injury

(2015) Réjean M. Guerriero et al.   Current Neurology and Neuroscience Reports

Mitochondrial succinate dehydrogenase is involved in stimulus-secretion coupling and endogenous ROS formation in murine beta cells

(2015) Armin Edalat et al.   DIABETOLOGIA

Amelioration of cyclosporine induced nephrotoxicity by dipeptidyl peptidase inhibitor vildagliptin

(2015) Hayam Ateyya   INTERNATIONAL IMMUNOPHARMACOLOGY

Neuroprotective effects of vildagliptin in rat rotenone Parkinson's disease model: role of RAGE-NFκB and Nrf2-antioxidant signaling pathways

(2015) Rania M. Abdelsalam et al.   JOURNAL OF NEUROCHEMISTRY

Role of Rho Kinase Inhibition in the Protective Effect of Fasudil and Simvastatin Against 3-Nitropropionic Acid-Induced Striatal Neurodegeneration and Mitochondrial Dysfunction in Rats

(2015) Lamiaa A. Ahmed et al.   MOLECULAR NEUROBIOLOGY

Saxagliptin: A novel antiparkinsonian approach

(2015) Noha N. Nassar et al.   NEUROPHARMACOLOGY

The Striatum: Where Skills and Habits Meet

(2015) Ann M. Graybiel et al.   Cold Spring Harbor Perspectives in Biology

Phosphodiesterases as Therapeutic Targets for Huntington’s Disease

(2014) Francesca Fusco et al.   CURRENT PHARMACEUTICAL DESIGN

Huntington disease: natural history, biomarkers and prospects for therapeutics

(2014) Christopher A. Ross et al.   Nature Reviews Neurology

DPP-4 Inhibition and Neuroprotection: Do Mechanisms Matter?

(2013) R. P. Shannon   DIABETES

PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model

(2013) Albert Giralt et al.   HIPPOCAMPUS

BDNF mediates adaptive brain and body responses to energetic challenges

(2013) Krisztina Marosi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitochondrial-Associated Metabolic Changes and Neurodegeneration in Huntingtons Disease - from Clinical Features to the Bench

(2012) Tatiana R. Rosenstock et al.   CURRENT DRUG TARGETS

Glucagon Like Peptide-1-Induced Glucose Metabolism in Differentiated Human Muscle Satellite Cells Is Attenuated by Hyperglycemia

(2012) Charlotte J. Green et al.   PLoS One

Contributions of the striatum to learning, motivation, and performance: an associative account

(2012) Mimi Liljeholm et al.   TRENDS IN COGNITIVE SCIENCES

Role of LOX/COX pathways in 3-nitropropionic acid-induced Huntington's Disease-like symptoms in rats: protective effect of licofelone

(2011) Puneet Kumar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Brain-derived Neurotrophic Factor (BDNF) Enhances GABA Transport by Modulating the Trafficking of GABA Transporter-1 (GAT-1) from the Plasma Membrane of Rat Cortical Astrocytes

(2011) Sandra H. Vaz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Possible Neuroprotective Action of a Vinylic Telluride against Mn-Induced Neurotoxicity

(2010) Daiana S. Ávila et al.   TOXICOLOGICAL SCIENCES

Incretin Therapies: Effects Beyond Glycemic Control

(2009) Sunder Mudaliar et al.   AMERICAN JOURNAL OF MEDICINE

Fifty-two-week efficacy and safety of vildagliptin vs. glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy

(2009) E. Ferrannini et al.   DIABETES OBESITY & METABOLISM

Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease

(2009) Paula L. McClean et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Developmental omega-3 supplementation improves motor skills in juvenile-adult rats

(2009) Addolorata Coluccia et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Phosphodiesterase 10 inhibition reduces striatal excitotoxicity in the quinolinic acid model of Huntington's disease

(2009) Carmela Giampà et al.   NEUROBIOLOGY OF DISEASE

Exendin-4 Improves Glycemic Control, Ameliorates Brain and Pancreatic Pathologies, and Extends Survival in a Mouse Model of Huntington's Disease

(2008) B. Martin et al.   DIABETES

BDNF and the diseased nervous system: a delicate balance between adaptive and pathological processes of gene regulation

(2008) Yinghui Hu et al.   JOURNAL OF NEUROCHEMISTRY