Co-delivery of PARP and PI3K inhibitors by nanoscale metal–organic frameworks for enhanced tumor chemoradiation

Micellar Formulation of Talazoparib and Buparlisib for Enhanced DNA Damage in Breast Cancer Chemoradiotherapy

(2019) Allison N. DuRoss et al.   ACS Applied Materials & Interfaces

Nanoparticles of Metal-Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

(2018) Teresa Simon-Yarza et al.   ADVANCED MATERIALS

Nanoscale Metal-Organic Frameworks for Therapeutic, Imaging, and Sensing Applications

(2018) Kuangda Lu et al.   ADVANCED MATERIALS

Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles

(2018) Isabel Abánades Lázaro et al.   CHEMICAL COMMUNICATIONS

Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy

(2018) Kaiyuan Ni et al.   Nature Communications

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

(2018) Theo A. Knijnenburg et al.   Cell Reports

Low-dose X-ray radiotherapy–radiodynamic therapy via nanoscale metal–organic frameworks enhances checkpoint blockade immunotherapy

(2018) Kuangda Lu et al.   Nature Biomedical Engineering

Nanoscale Mixed-Component Metal–Organic Frameworks with Photosensitizer Spatial-Arrangement-Dependent Photochemistry for Multimodal-Imaging-Guided Photothermal Therapy

(2018) Xiaohua Zheng et al.   CHEMISTRY OF MATERIALS

Hafnium Oxide Nanoparticle Activated By Radiation Therapy Generates an Anti-Tumor Immune Response

(2018) J. Galon et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Nanoscale Metal–Organic Layers for Radiotherapy–Radiodynamic Therapy

(2018) Guangxu Lan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

State-of-the-art strategies for targeting the DNA damage response in cancer

(2018) Patrick G. Pilié et al.   Nature Reviews Clinical Oncology

Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy

(2018) Kaiyuan Ni et al.   Nature Communications

Fast and scalable synthesis of uniform zirconium-, hafnium-based metal–organic framework nanocrystals

(2017) Ting He et al.   Nanoscale

Dispersion of Nanoparticles in Different Media Importantly Determines the Composition of Their Protein Corona

(2017) Klemen Strojan et al.   PLoS One

Nanoscale metal–organic frameworks for phototherapy of cancer

(2017) Guangxu Lan et al.   COORDINATION CHEMISTRY REVIEWS

Nanoscale metal−organic frameworks for combined photodynamic & radiation therapy in cancer treatment

(2016) Jingjing Liu et al.   BIOMATERIALS

PARP inhibitor combination therapy

(2016) Amy Dréan et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes

(2016) Dong Wang et al.   GYNECOLOGIC ONCOLOGY

Standards and Methodologies for Characterizing Radiobiological Impact of High-Z Nanoparticles

(2016) Anna Subiel et al.   Theranostics

Radiosensitization with combined use of olaparib and PI-103 in triple-negative breast cancer

(2015) Na Young Jang et al.   BMC CANCER

Nanomedicine Applications of Hybrid Nanomaterials Built from Metal–Ligand Coordination Bonds: Nanoscale Metal–Organic Frameworks and Nanoscale Coordination Polymers

(2015) Chunbai He et al.   CHEMICAL REVIEWS

DSPE-PEG: A Distinctive Component in Drug Delivery System

(2015) Jing Che et al.   CURRENT PHARMACEUTICAL DESIGN

PARP inhibitors: A new era of targeted therapy

(2015) Shifalika Tangutoori et al.   MATURITAS

Nanoscintillator-Mediated X-ray Inducible Photodynamic Therapy for In Vivo Cancer Treatment

(2015) Hongmin Chen et al.   NANO LETTERS

Opportunities and challenges of radiotherapy for treating cancer

(2015) Dörthe Schaue et al.   Nature Reviews Clinical Oncology

Insoluble drug delivery strategies: review of recent advances and business prospects

(2015) Sandeep Kalepu et al.   Acta Pharmaceutica Sinica B

Targeting DNA damage response in cancer therapy

(2014) Noriko Hosoya et al.   CANCER SCIENCE

Inherent anchorages in UiO-66 nanoparticles for efficient capture of alendronate and its mediated release

(2014) Xiangyang Zhu et al.   CHEMICAL COMMUNICATIONS

Rationale of Drug Encapsulation and Release from Biocompatible Porous Metal–Organic Frameworks

(2013) Denise Cunha et al.   CHEMISTRY OF MATERIALS

Quantitative Ultrasound Evaluation of Tumor Cell Death Response in Locally Advanced Breast Cancer Patients Receiving Chemotherapy

(2013) A. Sadeghi-Naini et al.   CLINICAL CANCER RESEARCH

The Chemistry and Applications of Metal-Organic Frameworks

(2013) H. Furukawa et al.   SCIENCE

In depth analysis of the in vivo toxicity of nanoparticles of porous iron(iii) metal–organic frameworks

(2013) Tarek Baati et al.   Chemical Science

Rationalization of the entrapping of bioactive molecules into a series of functionalized porous zirconium terephthalate MOFs

(2013) D. Cunha et al.   Journal of Materials Chemistry B

Nanoscale radiotherapy with hafnium oxide nanoparticles

(2012) Laurence Maggiorella et al.   Future Oncology

Zr- and Hf-based nanoscale metal–organic frameworks as contrast agents for computed tomography

(2012) Kathryn E. deKrafft et al.   JOURNAL OF MATERIALS CHEMISTRY

PI3K Inhibition Impairs BRCA1/2 Expression and Sensitizes BRCA-Proficient Triple-Negative Breast Cancer to PARP Inhibition

(2012) Yasir H. Ibrahim et al.   Cancer Discovery

Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer

(2012) Ashish Juvekar et al.   Cancer Discovery

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Modulated Synthesis of Zr-Based Metal-Organic Frameworks: From Nano to Single Crystals

(2011) Andreas Schaate et al.   CHEMISTRY-A EUROPEAN JOURNAL

Residual γH2AX foci as an indication of lethal DNA lesions

(2010) Judit P Banáth et al.   BMC CANCER

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Porous metal–organic-framework nanoscale carriers as a potential platform for drug delivery and imaging

(2009) Patricia Horcajada et al.   NATURE MATERIALS

Contributions of Direct and Indirect Actions in Cell Killing by High-LET Radiations

(2009) Ryoichi Hirayama et al.   RADIATION RESEARCH

A New Zirconium Inorganic Building Brick Forming Metal Organic Frameworks with Exceptional Stability

(2008) Jasmina Hafizovic Cavka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY