The Development of Novel Compounds Against Malaria: Quinolines, Triazolpyridines, Pyrazolopyridines and Pyrazolopyrimidines

Malaria Hybrids: A Chronological Evolution

(2019) Akranth Marella et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

New hybrid trifluoromethylquinolines as antiplasmodium agents

(2019) Renata M.R.J. da Silva et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New dimensions in the field of antimalarial research against malaria resurgence

(2019) Anudeep K. Narula et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of artemisinin resistance in malaria therapy

(2019) Janine Naß et al.   PHARMACOLOGICAL RESEARCH

No Evidence of Plasmodium falciparum k13 Artemisinin Resistance-Conferring Mutations over a 24-Year Analysis in Coastal Kenya but a Near Complete Reversion to Chloroquine-Sensitive Parasites

(2019) Kevin Wamae et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Combination Therapy Strategies for the Treatment of Malaria

(2019) Sibusiso Alven et al.   MOLECULES

Plasmodium falciparum dihydroorotate dehydrogenase: a drug target against malaria

(2018) Lucas VB Hoelz et al.   Future Medicinal Chemistry

Synthesis and anti-Plasmodium falciparum evaluation of novel pyrazolopyrimidine derivatives

(2018) Flávia F. Silveira et al.   MEDICINAL CHEMISTRY RESEARCH

A review on diverse heterocyclic compounds as the privileged scaffolds in antimalarial drug discovery

(2018) Piyush N. Kalaria et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of 7-arylaminopyrazolo[1,5- a ]pyrimidines as anti- Plasmodium falciparum , antimalarial, and Pf- dihydroorotate dehydrogenase inhibitors

(2017) Luís Felipe S.P. Azeredo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Quinoline-Based Hybrid Compounds with Antimalarial Activity

(2017) Xhamla Nqoro et al.   MOLECULES

Transmission-Blocking Potential of MEFAS, a Hybrid Compound Derived from Artesunate and Mefloquine

(2016) Julia Penna-Coutinho et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Design, synthesis and anti- P. falciparum activity of pyrazolopyridine–sulfonamide derivatives

(2016) Thais B. Silva et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New pentasubstituted pyrrole hybrid atorvastatin–quinoline derivatives with antiplasmodial activity

(2016) Rita C.C. Carvalho et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening

(2016) Elumalai Pavadai et al.   Journal of Chemical Information and Modeling

A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria

(2016) Margaret A. Phillips et al.   ACS Infectious Diseases

Quinoline-based antimalarial hybrid compounds

(2015) Stéphanie Vandekerckhove et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Anti- Plasmodium falciparum activity of quinoline–sulfonamide hybrids

(2015) Luiz C.S. Pinheiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Reemergence of chloroquine (CQ) analogs as multi-targeting antimalarial agents: A review

(2015) Md. Mushtaque et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fitness of artemisinin-resistantPlasmodium falciparum in vitro

(2015) Amanda Hott et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure–Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines

(2015) Claire Le Manach et al.   JOURNAL OF MEDICINAL CHEMISTRY

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

(2015) Alassane Mbengue et al.   NATURE

Malaria medicines: a glass half full?

(2015) Timothy N. C. Wells et al.   NATURE REVIEWS DRUG DISCOVERY

New Compounds Hybrids 1H-1,2,3-Triazole-Quinoline AgainstPlasmodium falciparum

(2014) Núbia Boechat et al.   Chemical Biology & Drug Design

“Recycling” Classical Drugs for Malaria

(2014) Cátia Teixeira et al.   CHEMICAL REVIEWS

Synthesis of 4-aminoquinoline–pyrimidine hybrids as potent antimalarials and their mode of action studies

(2013) Kamaljit Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Quinoline–Pyrimidine Hybrids: Synthesis, Antiplasmodial Activity, SAR, and Mode of Action Studies

(2013) Kamaljit Singh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reduced Artemisinin Susceptibility of Plasmodium falciparum Ring Stages in Western Cambodia

(2012) B. Witkowski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure–activity relationship and mode of action studies

(2012) Kamaljit Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An Efficient Synthesis of New 5-(1-Aryl-1H-pyrazole-4-yl)-1H-tetrazoles from 1-Aryl-1H-pyrazole-4-carbonitrilesvia[3 + 2] Cycloaddition Reaction

(2012) Maurício S. dos Santos et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

The global pipeline of new medicines for the control and elimination of malaria

(2012) Melinda P Anthony et al.   MALARIA JOURNAL

A framework for assessing the risk of resistance for anti-malarials in development

(2012) Xavier C Ding et al.   MALARIA JOURNAL

New Trifluoromethyl Triazolopyrimidines as Anti-Plasmodium falciparum Agents

(2012) Núbia Boechat et al.   MOLECULES

Synthesis of Some Novel Fused Azole Derivatives

(2012) A. M. Soliman et al.   SYNTHETIC COMMUNICATIONS

Road Towards New Antimalarials – Overview of the Strategies and their Chemical Progress

(2011) Tao Wu et al.   CURRENT MEDICINAL CHEMISTRY

Novel 1,2,3-Triazole Derivatives for Use againstMycobacterium tuberculosisH37Rv (ATCC 27294) Strain

(2011) Nubia Boechat et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lead Optimization of Aryl and Aralkyl Amine-Based Triazolopyrimidine Inhibitors ofPlasmodium falciparumDihydroorotate Dehydrogenase with Antimalarial Activity in Mice

(2011) Ramesh Gujjar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes

(2011) Nubia Boechat et al.   MOLECULES

Design, synthesis, and in vitro antiprotozoal, antimycobacterial activities of N-{2-[(7-chloroquinolin-4-yl)amino]ethyl}ureas

(2010) Carlos Nava-Zuazo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Trifluoromethylation of Carbonyl Compounds

(2010) N. Boechat et al.   CURRENT ORGANIC SYNTHESIS

Quinolines and structurally related heterocycles as antimalarials

(2010) Kirandeep Kaur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Next-generation antimalarial drugs: hybrid molecules as a new strategy in drug design

(2009) Francis W. Muregi et al.   DRUG DEVELOPMENT RESEARCH

Synthesis and Antiprotozoal Activity of Cationic 1,4-Diphenyl-1H-1,2,3-triazoles

(2009) Stanislav A. Bakunov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Antimalarial Activity, and Intracellular Targets of MEFAS, a New Hybrid Compound Derived from Mefloquine and Artesunate

(2008) F. de Pilla Varotti et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase from Y strain

(2008) Matheus P. Pinheiro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antibacterial profile against drug-resistant Staphylococcus epidermidis clinical strain and structure–activity relationship studies of 1H-pyrazolo[3,4-b]pyridine and thieno[2,3-b]pyridine derivatives

(2008) Bruno Leal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitors with Potent and Selective Activity against the Malaria ParasitePlasmodium falciparum

(2008) Margaret A. Phillips et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments

(2008) Kenneth L. Kirk   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS