Article
Immunology
Xinming Li, Zongxin Cheng, Xiaohong Chen, Dejiang Yang, Huanhuan Li, Youqing Deng
Summary: This study found that Purpurogallin (PPG) has neuroprotective effects on cerebral ischemia/reperfusion (I/R) injury. PPG attenuates brain I/R damage by suppressing endoplasmic reticulum (ER) stress and neuroinflammation via inactivation of the TLR4/NF-kappa B pathway. PPG may be a potential candidate drug for treating cerebral I/R injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Zhenyang Guo, Xueting Yu, Shuang Zhao, Xin Zhong, Dong Huang, Runyang Feng, Peng Li, Zheyan Fang, Yiqing Hu, Zhentao Zhang, Mukaddas Abdurahman, Lei Huang, Yun Zhao, Xiangdong Wang, Junbo Ge, Hua Li
Summary: This study revealed an epigenetic mechanism associated with SIRT6 and Ero1α expression, and highlighted the therapeutic potential of targeting the SIRT6-HIF1α/p300-Ero1α axis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yu Wu, Xiaomei Fan, Sha Chen, Ling Deng, Lu Jiang, Shaonan Yang, Zhi Dong
Summary: The aim of this study was to investigate the protective mechanism of geraniol against cerebral ischemia-reperfusion injury (CIRI). The results showed that geraniol effectively attenuated cerebral infarction and pathological injury, reduced ER-stress-related protein expression and apoptosis occurrence, and increased anti-apoptotic protein expression, suggesting a protective effect against CIRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Huizhi Fei, Pu Xiang, Wen Luo, Xiaodan Tan, Chao Gu, Maozhu Liu, Mengyuan Chen, Qiong Wang, Junqing Yang
Summary: This study found that CTRP1 protects against cerebral ischemia reperfusion injury by reducing apoptosis and inhibiting the PERK signaling pathway, suggesting its crucial role in the pathogenesis of CIRI.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yongmei Zhao, Mao Ding, Nan Yang, Yuyou Huang, Chengjiao Sun, Wenjuan Shi
Summary: Zinc accumulation in the central nervous system has been shown to play a role in neuronal death during cerebral ischemia. This study investigated the mechanisms behind zinc-induced neurotoxicity during cerebral ischemia/reperfusion (I/R) and found that excessive zinc activates endoplasmic reticulum (ER) stress, leading to ER stress-specific neuronal apoptosis in the ischemic penumbra. Chelating zinc with TPEN inhibited ER stress and decreased ER stress-associated neuronal apoptosis, providing a potential mechanism for the development of cerebral I/R injury.
NEUROCHEMICAL RESEARCH
(2022)
Article
Cell Biology
Jingwen Chen, Yang Liu, Defeng Pan, Tongda Xu, Yuanyuan Luo, Wanling Wu, Pei Wu, Hong Zhu, Dongye Li
Summary: The study showed that estrogen inhibits ER stress and attenuates MI/R injury by upregulating SERCA2a. These findings provide a new potential target for therapeutic intervention and drug discovery in coronary heart disease.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Endocrinology & Metabolism
Min-min Guo, Sheng-biao Qu, Hui-ling Lu, Wen-bo Wang, Mu-Liang He, Jian-Lin Su, Jian Chen, Yong Wang
Summary: Our study demonstrates that biochanin A can alleviate cerebral I/R-induced damage by suppressing apoptosis, ER stress, and p38 MAPK signaling.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Meihua Wang, Zhilin Chen, Lei Yang, Lei Ding
Summary: The study demonstrates that Sappanone A (SA) provides neuroprotective effects post ischemic stroke by reducing inflammation, oxidative stress, and cell apoptosis, thereby ameliorating cerebral ischemic injury.
Article
Neurosciences
Jiang-Wen Yin, Jia Li, Yi-Min Ren, Yan Li, Rui-Xue Wang, Sheng Wang, Yun-Xia Zuo
Summary: The study evaluated the effect of combination therapy with dexmedetomidine and Netrin-1 against ischemic brain injury, finding that the combination therapy can reduce infarct volume and neural damage, decrease apoptosis, and improve OPS recovery rate. The combination therapy also lowers the expression of GRP78 and CHOP, increases MEF2A expression, and promotes ERK5 phosphorylation.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Immunology
Shixia Zhang, Jilang Tang, Chen Sun, Nuannuan Zhang, Xiaqing Ning, Xueqin Li, Jiaqi Wang
Summary: Dexmedetomidine (DEX) protects the liver against ischemia-reperfusion injury (IRI) by reducing oxidative stress, endoplasmic reticulum stress (ERS), and apoptosis. DEX increases antioxidant activity and reduces oxidative damage in BRL-3A cells. It also inhibits MAPK signaling pathway activation and ERS to prevent cell apoptosis. Animal studies confirm that DEX alleviates histopathological injury and improves liver function.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Yingli Yu, Min Wang, Rongchang Chen, Xiao Sun, Guibo Sun, Xiaobo Sun
Summary: GP-17 provides cardioprotective effects by inhibiting myocardial apoptosis, reducing cardiac dysfunction, and improving contractile recovery. The study results demonstrate that GP-17 inhibits I/R-induced mitochondrial injury by delaying the onset of ER stress, which is controlled by the PI3K/AKT and P38 signaling pathways.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Medicine, Research & Experimental
Yu Gao, Libo Li, Jianbai Yu, Zhanwei Zhang
Summary: The study demonstrated that rosuvastatin can protect PC12 cells from hypoxia/reoxygenation-induced injury by inhibiting ERS-induced apoptosis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Immunology
Ya-lin Zhu, Jie Huang, Xue-ying Chen, Jian Xie, Qing Yang, Jia-feng Wang, Xiao-ming Deng
Summary: SEI alleviates renal injury induced by ischemia reperfusion with anti-inflammatory, anti-endoplasmic reticulum stress, anti-oxidative, and anti-apoptotic effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Juan Ignacio Elio Mariangelo, Carlos Alfredo Valverde, Leticia Vittone, Matilde Said, Cecilia Mundina-Weilenmann
Summary: This study found that blocking ER calcium efflux via the translocon can suppress ER stress and improve the mechanical performance and diastolic calcium handling of stunned myocardium. Therefore, modulation of translocon permeability may be a therapeutic approach to treat the functional abnormalities caused by ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Oncology
Dandan Xu, Tingting Kong, Baohua Cheng, Rumin Zhang, Chunqing Yang, Jing Chen, Chunmei Wang
Summary: Orexin-A (OXA) mitigates cerebral ischemia-reperfusion injury (CIRI) by inhibiting endoplasmic reticulum stress-induced apoptosis and downregulating related protein expression levels, providing a novel therapeutic direction for the treatment of CIRI.
MOLECULAR MEDICINE REPORTS
(2021)