An immunoevasive strategy through clinically-relevant pan-cancer genomic and transcriptomic alterations of JAK-STAT signaling components

A novel signature derived from immunoregulatory and hypoxia genes predicts prognosis in liver and five other cancers

(2019) Wai Hoong Chang et al.   Journal of Translational Medicine

Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies

(2019) Wai Hoong Chang et al.   Journal of Translational Medicine

The pan‐cancer mutational landscape of the PPAR pathway reveals universal patterns of dysregulated metabolism and interactions with tumor immunity and hypoxia

(2019) Wai Hoong Chang et al.   Annals of the New York Academy of Sciences

Transcriptional landscape of DNA repair genes underpins a pan-cancer prognostic signature associated with cell cycle dysregulation and tumor hypoxia

(2019) Wai Hoong Chang et al.   DNA REPAIR

Dual prognostic role of 2-oxoglutarate-dependent oxygenases in ten cancer types: implications for cell cycle regulation and cell adhesion maintenance

(2019) Wai Hoong Chang et al.   Cancer Communications

Aberrations in Notch-Hedgehog signalling reveal cancer stem cells harbouring conserved oncogenic properties associated with hypoxia and immunoevasion

(2019) Wai Hoong Chang et al.   BRITISH JOURNAL OF CANCER

Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response

(2018) Nicholas M. Adams et al.   IMMUNITY

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells

(2016) Marco De Simone et al.   IMMUNITY

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

(2015) John J. O'Shea et al.   Annual Review of Medicine

Inhibition of JAK1, 2/STAT3 Signaling Induces Apoptosis, Cell Cycle Arrest, and Reduces Tumor Cell Invasion in Colorectal Cancer Cells

(2015) Hua Xiong et al.   NEOPLASIA

IRF-8 Controls Melanoma Progression by Regulating the Cross Talk between Cancer and Immune Cells within the Tumor Microenvironment

(2015) Fabrizio Mattei et al.   NEOPLASIA

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

The Cancer Genome Atlas Pan-Cancer analysis project

(2013) John N Weinstein et al.   NATURE GENETICS

Cancer and Inflammation: An Old Intuition with Rapidly Evolving New Concepts

(2012) Giorgio Trinchieri   Annual Review of Immunology

GeneCodis3: a non-redundant and modular enrichment analysis tool for functional genomics

(2012) D. Tabas-Madrid et al.   NUCLEIC ACIDS RESEARCH

Angiogenesis and immunity: a bidirectional link potentially relevant for the monitoring of antiangiogenic therapy and the development of novel therapeutic combination with immunotherapy

(2011) Eric Tartour et al.   CANCER AND METASTASIS REVIEWS

Loss of Nuclear Localized and Tyrosine Phosphorylated Stat5 in Breast Cancer Predicts Poor Clinical Outcome and Increased Risk of Antiestrogen Therapy Failure

(2011) Amy R. Peck et al.   JOURNAL OF CLINICAL ONCOLOGY

JAK/STAT/SOCS-signaling pathway and colon and rectal cancer

(2011) Martha L. Slattery et al.   MOLECULAR CARCINOGENESIS

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

(2011) Craig H Mermel et al.   GENOME BIOLOGY

STAT3 tyrosine phosphorylation influences survival in glioblastoma

(2010) Peter Birner et al.   JOURNAL OF NEURO-ONCOLOGY

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation

(2008) Lai Wei et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY