Journal
MOLECULAR BIOLOGY REPORTS
Volume 47, Issue 1, Pages 785-807Publisher
SPRINGER
DOI: 10.1007/s11033-019-05142-6
Keywords
Pumilio; Puf family; RNA binding proteins; Post-transcriptional gene regulation; 3 ' UTR
Categories
Funding
- Department of Science and Technology, Govt. of India [SB/YS/LS-188/2014]
- Department of Biotechnology, Govt. of India [BT/Bio-CARe/02/10,078/2013-14]
- DST-INSPIRE Fellowship from Department of Science and Technology, Govt. of India [IF170376]
Ask authors/readers for more resources
The Pumilio (Pum)/Puf family proteins are ubiquitously present across eukaryotes, including yeast, plants and humans. They generally bind to the 3 ' untranslated regions of single stranded RNA targets in a sequence specific manner and destabilize them, although a few reports suggest their role in stabilizing the target transcripts. The Pum isoforms are implicated in a wide array of biological processes including stem cell maintenance, development, ribosome biogenesis as well as human diseases. Further studies on Pum would be interesting and important to understand their evolutionarily conserved and divergent features across species, which can have potential implications in medicine, plant sciences as well as basic molecular and cell biological studies. A large number of research reports exists, pertaining to various aspects of Pum, in individual experimental systems. This review is a comprehensive summary of the functions, types, mechanism of action as well as the regulation of Pum in various species. Also, the research questions to be addressed in future are discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available